Article
Peripheral Vascular Disease
Boran Katunaric, Gopika SenthilKumar, Mary E. Schulz, Nilto De Oliveira, Julie K. Freed
Summary: This study investigates the mechanism by which S1P regulates microvascular resistance and ultimately blood pressure in humans. The results suggest that S1P induces NO-mediated vasodilation through activation of S1PR(1) and S1PR(3) receptors in human arterioles without coronary artery disease. Additionally, the dilation in vessels from patients diagnosed with coronary artery disease is dependent on H2O2 alone and S1PR(3) activation.
Article
Multidisciplinary Sciences
A. Parker Ruhl, Neal Jeffries, Yu Yang, Orlando M. Gutierrez, Paul Muntner, Rakhi P. Naik, Lydia H. Pecker, Bryan T. Mott, Neil A. Zakai, Monika M. Safford, Leslie A. Lange, Cheryl A. Winkler, Marguerite R. Irvin, Mary Cushman, Hans C. Ackerman
Summary: Increased HBA copy number is not associated with the risk of hypertension among Black American adults.
Article
Cardiac & Cardiovascular Systems
Carla Letizia Busceti, Albino Carrizzo, Franca Bianchi, Massimiliano De Lucia, Antonio Damato, Chiara Cazzin, Eleonora Venturini, Paola Di Pietro, Roxana Paula Ginerete, Luisa Di Menna, Maria Cotugno, Rosita Stanzione, Simona Marchitti, Serena Migliarino, Michele Ciccarelli, Sebastiano Sciarretta, Valeria Bruno, Giuseppe Battaglia, Francesco Fornai, Massimo Volpe, Speranza Rubattu, Ferdinando Nicoletti, Carmine Vecchione
Summary: Dkk3 plays a crucial role in cardiovascular homeostasis, and its deficiency leads to hypertension and impaired vascular function, which can be rescued by restoring Dkk3 expression. This effect is achieved through promoting VEGF expression and activating the VEGF/Akt/eNOS hypotensive pathway.
CIRCULATION RESEARCH
(2023)
Article
Physiology
Janee D. Terwoord, Matthew L. Racine, Christopher M. Hearon, Gary J. Luckasen, Frank A. Dinenno
Summary: The study demonstrates that endothelium-dependent agonists interact to induce vasodilation and limit α-adrenergic vasoconstriction in humans.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Review
Multidisciplinary Sciences
Firoozeh Abbasian, Mohaddeseh Sadat Alavi, Ali Roohbakhsh
Summary: Hypertension is a major risk factor for cardiovascular diseases and premature death in older adults. Lifestyle improvements, including consuming high amounts of fruits and vegetables, can reduce the risk of high blood pressure. Carotenoids, natural pigments with high pharmacological potential and safety, have antihypertensive properties and provide additional benefits to the cardiovascular system.
Article
Peripheral Vascular Disease
Kristen J. Bubb, Owen Tang, Carmine Gentile, Seyed M. Moosavi, Thomas Hansen, Chia-Chi Liu, Belinda A. Di Bartolo, Gemma A. Figtree
Summary: FXYD1 plays a crucial role in protecting eNOS from oxidative stress and contributes to cardiovascular health; FXYD1 regulates oxidative dysregulation within caveolae where it is colocalized; In addition to impacting eNOS function, FXYD1 is closely associated with hypertension and diabetic vascular oxidative stress.
Article
Peripheral Vascular Disease
Fulye Argunhan, Dibesh Thapa, Aisah Aniisah Aubdool, Emanuele Carlini, Kate Arkless, Erica Ruth Hendrikse, Joao de Sousa Valente, Xenia Kodji, Brentton Barrett, Carlo Alberto Ricciardi, Luigi Gnudi, Debbie Lucy Hay, Susan Diana Brain
Summary: CGRP plays a protective role in cardiovascular function by restoring blood pressure and preventing cardiovascular remodeling when nitric oxide production is diminished. Endogenous CGRP acts to protect cardiovascular function, while exogenous CGRP can rescue affected mice.
Article
Pharmacology & Pharmacy
Naoto Fujii, Randeep Rakwal, Junko Shibato, Yoko Tanabe, Glen P. Kenny, Tatsuro Amano, Toby Mundel, Tze-Huan Lei, Koichi Watanabe, Narihiko Kondo, Takeshi Nishiyasu
Summary: This study found that activation of GAL3 receptors contributes to sweating but limits cutaneous vasodilation induced by heating, while GAL2 receptors do not contribute. Activation of GAL1 receptors attenuates both sweating and cutaneous vasodilation during heating.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Nutrition & Dietetics
Piotr Machowiec, Gabriela Reka, Marcela Maksymowicz, Halina Piecewicz-Szczesna, Agata Smolen
Summary: The study found that supplementation of Spirulina can significantly lower diastolic and systolic blood pressure, especially among hypertensive patients. This suggests that Spirulina administration may have a positive impact on the prevention and treatment of hypertension. Further, more precise randomized controlled trials are needed to confirm the effects of Spirulina supplementation on blood pressure.
Article
Engineering, Electrical & Electronic
Jukka-Pekka Sirkia, Tuukka Panula, Matti Kaisti
Summary: This work presents a method for extracting information from different depths of the cutaneous vasculature using an optical sensor with controllable external compression force. The experiments show that the optical channels can estimate blood pressure at different depths, including microvascular blood vessels. The results indicate that the method can obtain signals from large arteries deep in the skin to arterioles and capillaries close to the surface.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Peripheral Vascular Disease
Takeshi Tokudome, Kentaro Otani, Yuanjie Mao, Lars Jorn Jensen, Yuji Arai, Takahiro Miyazaki, Takashi Sonobe, James T. Pearson, Tsukasa Osaki, Naoto Minamino, Junji Ishida, Akiyoshi Fukamizu, Hayato Kawakami, Daisuke Onozuka, Kunihiro Nishimura, Mikiya Miyazato, Hirohito Nishimura
Summary: This study revealed the crucial role of vascular endothelial NPR1 in ANP-mediated blood pressure regulation. ANP lowers blood pressure by activating potassium channels and modulating G-protein signaling pathways in endothelial cells. Furthermore, ANP's blood pressure regulation depends on RGS2 in the acute phase but is independent of RGS2 in the chronic phase.
Article
Cardiac & Cardiovascular Systems
Kelly A. Stockelman, Anthony R. Bain, Caitlin A. Dow, Kyle J. Diehl, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza
Summary: Insufficient sleep is associated with endothelial dysfunction and increased cardiovascular risk, while regular aerobic exercise can improve endothelial function and reduce cardiovascular risk. In this study, aerobic exercise training was found to enhance endothelium-dependent vasodilation and reduce ET-1-mediated vasoconstriction in adults with habitual insufficient nightly sleep, regardless of changes in sleep duration. Regular aerobic exercise can potentially mitigate the cardiovascular risk associated with insufficient sleep-related endothelial dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Sport Sciences
Kanokwan Bunsawat, Elizabeth C. Lefferts, Georgios Grigoriadis, Sang Ouk Wee, Melissa M. Kilianek, Paul J. Fadel, Philip S. Clifford, Bo Fernhall, Tracy Baynard
Summary: The study found that although obesity did not impair postexercise hypotension, young adults with obesity exhibited smaller postexercise peripheral vasodilation compared with those without obesity, suggesting obesity-induced alterations in the peripheral vasculature after exercise.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Peripheral Vascular Disease
Zhen Cui, Bochuan Li, Yanhong Zhang, Jinlong He, Xuelian Shi, Hui Wang, Yinjiao Zhao, Liu Yao, Ding Ai, Xu Zhang, Yi Zhu
Summary: The study found that treatment with bosutinib increases blood pressure and impairs endothelium-dependent vasorelaxation. RNA sequencing revealed that the CYP metabolic pathway mediates the regulation of blood pressure by bosutinib. Bosutinib treatment increased arterial soluble epoxide hydrolase levels and decreased plasma eicosanoid metabolite content in mice.
Review
Peripheral Vascular Disease
Candee T. Barris, Jessica L. Faulkner, Eric J. Belin de Chantemele
Summary: Several clinical and large population studies have found that women are more salt-sensitive than men, and this sex difference is influenced by female sex chromosomes and hormones. Women of all ethnicities, both premenopausal and postmenopausal, are more salt-sensitive. Menopause exacerbates the severity and prevalence of salt-sensitive blood pressure (SSBP), indicating the role of sex hormones. Activation of aldosterone-ECMR axis and ENaC in females contribute to vascular dysfunction and SSBP. The increased prevalence and susceptibility of SSBP in women are influenced by sex hormones and sex chromosome complement.
Article
Materials Science, Multidisciplinary
Giovanni Falcone, Sonja Kuth, Aldo R. Boccaccini, Rita P. Aquino, Tiziana Esposito, Paola Russo
Summary: To fully utilize the potential of 3D printing, particularly in the case of semisolid extrusion (SSE), the technological challenges need to be addressed. This study focuses on investigating the physicochemical properties of natural polymers, specifically alginate hydrogel, for 3D printing tablets that are easy to swallow. By adding sorbitol as a plasticizer, the aim is to improve the swallowability of the tablets. Different concentrations of sorbitol solution are evaluated to determine the best composition in terms of printing and technological properties. The results highlight a predictable relationship between the amount of sorbitol loaded and the residual mass of the final platforms.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Nutrition & Dietetics
Silvana Mirella Aliberti, Richard H. W. Funk, Elena Ciaglia, Joseph Gonnella, Aldo Giudice, Carmine Vecchione, Annibale Alessandro Puca, Mario Capunzo
Summary: This study explored the association between tap drinking water and longevity in Cilento, Italy, and found that trace elements in tap water may have a positive influence on the lifespan and health of the local elderly population.
Review
Biochemistry & Molecular Biology
Paola Di Pietro, Carmine Izzo, Angela Carmelita Abate, Paola Iesu, Maria Rosaria Rusciano, Eleonora Venturini, Valeria Visco, Eduardo Sommella, Michele Ciccarelli, Albino Carrizzo, Carmine Vecchione
Summary: Cardiovascular diseases (CVDs) are the leading cause of death and illness worldwide, accounting for 47% of deaths in Europe. Bioactive sphingolipids, including ceramides and sphingosine-1-phosphate (S1P), have been identified as drivers of CVDs. Monitoring sphingolipid levels could provide insights into the progression and severity of cardiovascular diseases and may be a potential target for therapeutic intervention.
Article
Pharmacology & Pharmacy
Carmela Tommasino, Giulia Auriemma, Carla Sardo, Carmen Alvarez-Lorenzo, Emilia Garofalo, Silvana Morello, Giovanni Falcone, Rita P. Aquino
Summary: In this study, a PCL/INU-PLA hybrid biomaterial was prepared, which showed improved surface properties, swelling ability, and in vitro biodegradation rate compared to PCL alone. The 3D printed scaffolds exhibited dimensional and structural parameters close to the digital model and showed favorable results in biocompatibility and osteogenic activity tests.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Applied
Redouane Lemoui, Patrizia Picerno, Samira Benyahia, Teresa Mencherini, Antonio Vassallo, Maria Francesca Armentano, Labib Noman, Khaled Bouchama, Luca Rastrelli, Rita Patrizia Aquino
Summary: In this study, seven secondary metabolites were isolated and identified from the methanol extract of Stachys brachyclada de Noe ex Coss. leaves. The extract showed inhibition of alpha-glucosidase enzyme, radical scavenging activity, and reduction of oxidative stress level in Human Dermal Fibroblast. Stachysetin was identified as the major compound in the extract.
NATURAL PRODUCT RESEARCH
(2023)
Review
Medicine, General & Internal
Angelo Silverio, Francesco Paolo Cancro, Luca Esposito, Michele Bellino, Debora D'Elia, Monica Verdoia, Maria Giovanna Vassallo, Michele Ciccarelli, Carmine Vecchione, Gennaro Galasso, Giuseppe De Luca
Summary: The control of cardiovascular risk factors, promotion of a healthy lifestyle, and antithrombotic therapy are important for secondary prevention after acute coronary syndrome (ACS). Identification of novel risk factors and targets is essential to optimize preventive strategies for patients who have recurrent ischemic events despite optimal control of traditional risk factors and pharmacological therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Michele Bellino, Gennaro Galasso, Angelo Silverio, Michele Tedeschi, Ciro Formisano, Stefano Romei, Luca Esposito, Francesco Paolo Cancro, Maria Giovanna Vassallo, Giulio Accarino, Monica Verdoia, Francesca Maria Di Muro, Carmine Vecchione, Giuseppe De Luca
Summary: Current research on cardiovascular prevention focuses on risk-stratification and management of coronary artery disease (CAD) patients. The aim is to determine the causes and risk factors of CAD and to identify ways to counteract them. The role of LDL cholesterol (LDL-C) as a key factor in atherosclerotic cardiovascular disease (ASCVD) has been well established, and inhibiting PCSK9, a regulator of LDL-C levels, has shown promising results in reducing LDL-C.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Chiara Amante, Chiara De Soricellis, Gianni Luccheo, Luigi Luccheo, Paola Russo, Rita Patrizia Aquino, Pasquale Del Gaudio
Summary: The National Institute of Health has found that 80% of chronic infections are linked to biofilms, which contribute to bacterial resistance to antimicrobial agents. A novel mixture composed of N-acetylcysteine (NAC) and various natural ingredients has been developed to enhance NAC's activity against different bacteria and reduce biofilm formation. This mixture has shown increased NAC permeation, fibrinolytic activity, antibiofilm activity, and reduced bacterial adhesion.
Article
Biology
Alfonso Campanile, Valeria Visco, Stefania De Carlo, Germano Junior Ferruzzi, Costantino Mancusi, Carmine Izzo, Felice Mongiello, Paola Di Pietro, Nicola Virtuoso, Amelia Ravera, Domenico Bonadies, Carmine Vecchione, Michele Ciccarelli
Summary: This study compares the effects of Sac/Val and standard medical therapy on prognostically significant CPET parameters in HFrEF patients. After a median follow-up of 16 months, no significant differences were observed in peak VO2 and other CPET measures between Sac/Val and standard therapy.
Article
Plant Sciences
Tiziana Esposito, Simona Pisanti, Rosanna Martinelli, Rita Celano, Teresa Mencherini, Tania Re, Rita P. Aquino
Summary: This study compared the metabolite profile of Couroupita guianensis bark decoction produced by Amazonian shamans with that obtained under laboratory conditions and investigated their biological properties in wound healing and inflammation. The analysis revealed the presence of polyphenolic compounds and uncommon sulphated derivatives of ellagic acid in the decoction. A new sulphated molecule was identified as the potential active compound responsible for wound healing. The decoction also showed anti-inflammatory effects and potential therapeutic applications in skin diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Marianna Marino, Raffaella D'Auria, Elena Mele, Grazia Maria Giovanna Pastorino, Paola Di Pietro, Stefania D'Angelo, Natalia Della Rocca, Francesca Felicia Operto, Carmine Vecchione, Silvia Fasano, Riccardo Pierantoni, Andrea Viggiano, Rosaria Meccariello, Antonietta Santoro
Summary: For the first time in mammals, this study investigates the interaction between the endocannabinoid system and the kisspeptin system in the control of male reproduction. The results reveal the reciprocal modulation of these two systems. The findings suggest the involvement of kisspeptin in spermatogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Valeria Visco, Carmine Izzo, Davide Bonadies, Federica Di Feo, Giuseppe Caliendo, Francesco Loria, Costantino Mancusi, Pierpaolo Chivasso, Paola Di Pietro, Nicola Virtuoso, Albino Carrizzo, Carmine Vecchione, Michele Ciccarelli
Summary: Obesity is a global public health problem that is linked to lower life expectancy and increased cardiovascular risk. In addition to direct effects, obesity can indirectly contribute to cardiovascular disease through associated comorbidities. While diet and physical activity are important for preventing cardiovascular disease, other interventions like medication and surgery may be needed. This review examines various interventions for addressing cardiovascular risk in obese patients and emphasizes the importance of adherence to treatment.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
M. Maria Rosaria Rusciano, D. Sorriento, V. Valerio, A. L. Toni, V. Visco, P. Di Pietro, A. Carrizzo, G. Iaccarino, P. Poggio, C. Vecchione, M. Ciccarelli
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Graziano Sorvillo, Angelo Giano, Michele Manzo, Michele Ciccarelli, Gennaro Galasso, Carmine Vecchione, Cristina Esposito
Summary: A 70-year-old man presented with accidental gunshot wound in the left hemithorax and left shoulder/arm. The implantable cardioverter-defibrillator (ICD) previously implanted for ventricular tachycardia was burned and the battery exploded. Urgent chest CT scan showed left humeral fracture without significant arterial injury. ICD generator was removed, humeral fracture was fixed, and lead extraction was successfully performed.
GIORNALE ITALIANO DI CARDIOLOGIA
(2023)
Article
Public, Environmental & Occupational Health
Bruno Charlier, Albino Coglianese, Federica De Rosa, Armando Cozzolino, Giovanni Boccia, Anna Borrelli, Mario Capunzo, Giovanni Genovese, Francesco De Caro, Amelia Filippelli, Fabrizio Dal Piaz, Viviana Izzo
Summary: The exposure of healthcare workers to antineoplastic drugs can lead to adverse health events due to chemical contamination of work surfaces. A UHPLC-MS/MS based protocol was developed and applied for the environmental monitoring of hospital working areas contaminated with various chemotherapeutics. The study uncovered critical aspects in the working protocols and workspace organization, leading to improved safety for healthcare workers.
JOURNAL OF PUBLIC HEALTH RESEARCH
(2023)