Critical Genomic Networks and Vasoreactive Variants in Idiopathic Pulmonary Arterial Hypertension

Rare Variants inRTEL1Are Associated with Familial Interstitial Pneumonia

(2015) Joy D. Cogan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acute Vasodilator Responsiveness and Microvascular Recruitment in Idiopathic Pulmonary Arterial Hypertension

(2015) David Langleben et al.   ANNALS OF INTERNAL MEDICINE

Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension

(2015) John H. Newman et al.   Nature Communications

Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension

(2014) James D. West et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Whole-Exome Sequencing RevealsTopBP1as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension

(2014) Vinicio A. de Jesus Perez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dysfunctional Resident Lung Mesenchymal Stem Cells Contribute to Pulmonary Microvascular Remodeling

(2014) Kelsey Chow et al.   Pulmonary Circulation

Correction of NonsenseBMPR2andSMAD9Mutations by Ataluren in Pulmonary Arterial Hypertension

(2013) Kylie M. Drake et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathway Commons at Virtual Cell: use of pathway data for mathematical modeling

(2013) M. L. Blinov et al.   BIOINFORMATICS

EIF2AK4 Mutations in Pulmonary Capillary Hemangiomatosis

(2013) D. Hunter Best et al.   CHEST

Dihydropyridine Ca 2+ Channel Blockers Increase Cytosolic [Ca 2+ ] by Activating Ca 2+ -sensing Receptors in Pulmonary Arterial Smooth Muscle Cells

(2013) Aya Yamamura et al.   CIRCULATION RESEARCH

Inhibition of the Ca2+-sensing receptor rescues pulmonary hypertension in rats and mice

(2013) Qiang Guo et al.   HYPERTENSION RESEARCH

Updated Treatment Algorithm of Pulmonary Arterial Hypertension

(2013) Nazzareno Galiè et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Definitions and Diagnosis of Pulmonary Hypertension

(2013) Marius M. Hoeper et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Updated Clinical Classification of Pulmonary Hypertension

(2013) Gerald Simonneau et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension

(2013) Marine Germain et al.   NATURE GENETICS

EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension

(2013) Mélanie Eyries et al.   NATURE GENETICS

A Novel Channelopathy in Pulmonary Arterial Hypertension

(2013) Lijiang Ma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension

(2012) Eric D. Austin et al.   Circulation-Cardiovascular Genetics

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

(2012) Stephan J. Sanders et al.   NATURE

Exome sequencing and the genetic basis of complex traits

(2012) Adam Kiezun et al.   NATURE GENETICS

Mitochondrial genomes gleaned from human whole-exome sequencing

(2012) Ernesto Picardi et al.   NATURE METHODS

Common genetic variants, acting additively, are a major source of risk for autism

(2012) Lambertus Klei et al.   Molecular Autism

Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy

(2011) Nadine Norton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension

(2011) Jennifer A. Johnson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

BR-squared: a practical solution to the winner’s curse in genome-wide scans

(2011) Lei Sun et al.   HUMAN GENETICS

Performance comparison of whole-genome sequencing platforms

(2011) Hugo Y K Lam et al.   NATURE BIOTECHNOLOGY

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

KOBAS 2.0: a web server for annotation and identification of enriched pathways and diseases

(2011) Chen Xie et al.   NUCLEIC ACIDS RESEARCH

A flexible genome-wide bootstrap method that accounts for rankingand threshold-selection bias in GWAS interpretation and replication study design

(2011) Laura L. Faye et al.   STATISTICS IN MEDICINE

Idiopathic and Heritable PAH Perturb Common Molecular Pathways, Correlated with Increased MSX1 Expression

(2011) Eric D. Austin et al.   Pulmonary Circulation

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

(2010) Sarah B Ng et al.   NATURE GENETICS

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Unbiased estimation of odds ratios: combining genomewide association scans with replication studies

(2009) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways

(2009) Vinicio A. de Jesus Perez et al.   JOURNAL OF CELL BIOLOGY

Exome sequencing identifies the cause of a mendelian disorder

(2009) Sarah B Ng et al.   NATURE GENETICS

Estimating Odds Ratios in Genome Scans: An Approximate Conditional Likelihood Approach

(2008) Arpita Ghosh et al.   AMERICAN JOURNAL OF HUMAN GENETICS