Article
Cardiac & Cardiovascular Systems
Jens Johansson Ramgren, Shahab Nozohoor, Igor Zindovic, Ronny Gustafsson, Nina Hakacova, Johan Sjogren
Summary: After repair of complete atrioventricular septal defect, there was no difference in 30-day mortality between young and older infants, with an overall 20-year survival rate of 95.1% and 92.6% freedom from left atrioventricular valve-related reoperation. Risk factors for poor survival included additional ventricular septal defect, previous coarctation of the aorta, persistent left superior vena cava, and genetic syndromes other than Trisomy 21.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Pediatrics
Erik Wiezell, Janus F. Gudnason, Mats Synnergren, Jan Sunnegardh
Summary: The aim of the study was to investigate the long-term outcomes of surgery for pulmonary atresia and ventricular septal defect (PA-VSD), specifically looking at the contribution of major aorto-pulmonary collateral arteries (MAPCAs) to pulmonary blood flow, comorbidities, and causes of death. Retrospective analysis of patients who underwent surgery for PA-VSD between 1994 and 2017 revealed that 59% of patients had pulmonary blood flow originating from a patent ductus arteriosus (PDA), while 41% had contribution from MAPCAs. The study found that long-term survival did not differ between patients with and without MAPCAs, nor was there a difference in mortality based on the presence of syndromes or extracardiac diseases.
Article
Cardiac & Cardiovascular Systems
Ali Houeijeh, Clement Batteux, Clement Karsenty, Nassima Ramdane, Florence Lecerf, Estibaliz Valdeolmillos, Julie Lourtet-Hascoet, Sarah Cohen, Emre Belli, Jerome Petit, Sebastien Hascoet
Summary: This study investigated the long-term outcomes of transcatheter pulmonary valve implantation in treating right ventricular outflow tract dysfunction. The results showed that residual obstruction and infective endocarditis contribute to a higher incidence of secondary valve replacement.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jana Rubackova Popelova, Marketa Tomkova, Jakub Tomek, Renata Zivna
Summary: ASD closure appears to be associated with improved long-term survival independently of age, PH, and other clinical variables.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Ilias Iliopoulos, Christopher W. Mastropietro, Saul Flores, Eva Cheung, Venugopal Amula, Monique Radman, David Kwiatkowski, Bao Nguyen Puente, Jason R. Buckley, Kiona Y. Allen, Rohit Loomba, Karan B. Karki, Saurabh Chiwane, Katherine Cashen, Kurt Piggott, Yamini Kapileshwarkar, Keshava Murty Narayana Gowda, Aditya Badheka, Rahul Raman, Huaiyu Zang, John M. Costello
Summary: This study reviewed 295 neonates with pulmonary atresia with intact ventricular septum and identified factors associated with outcomes and transplant-free survival. The study found a negative correlation between tricuspid valve Z-score and the risk of death or transplantation, and a positive correlation between coronary atresia and the risk of death or transplantation. Right ventricular coronary dependency and left coronary atresia significantly worsened transplant-free survival.
PEDIATRIC CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ashish H. Shah, Erwin Oechslin, Lee Benson, Andrew M. Crean, Candice Silversides, Yvonne Bach, Rachel M. Wald, S. Lucy Roche, Mark Osten, Alexander Van De Bruaene, Jack Colman, Burhan Goraya, Lusine Abrahamyan, Kate Hanneman, Elsie Nguyen, Eric Horlick
Summary: This study aimed to expand the understanding of the clinical outcomes of patients with isolated partial anomalous pulmonary venous connection. It is generally believed that patients with this condition are usually asymptomatic and surgical repair is rarely justified.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Obstetrics & Gynecology
Shannon L. Son, Lauren L. Hosek, Miranda C. Stein, Amanda A. Allshouse, Anna B. Catino, Arvind K. Hoskoppal, Daniel A. Cox, Kevin J. Whitehead, Ian M. Lindsay, Sean Esplin, Torri D. Metz
Summary: This retrospective longitudinal cohort study found an association between pregnancy and subsequent long-term adverse cardiovascular outcomes in individuals with congenital heart disease. These findings can provide important information for counseling and guidance of individuals with congenital heart disease who are considering pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Samuel J. Macalister, Edward Buratto, Phillip S. Naimo, Xin Tao Ye, Nicholas Fulkoski, Robert G. Weintraub, Christian P. Brizard, Igor E. Konstantinov
Summary: This study reviewed the records of 107 patients with pulmonary atresia and ventricular septal defect who were managed with systemic-to-pulmonary shunts. The results showed that using smaller shunts resulted in earlier complete repair but increased the risk of complications for the patients.
ANNALS OF THORACIC SURGERY
(2023)
Review
Pediatrics
Eric N. Feins, Ryan Callahan, Christopher W. Baird
Summary: Pulmonary vein stenosis is a challenging clinical problem in congenital heart disease, requiring multimodal therapy. Surgical therapy has evolved significantly over the years, with recent anatomic-based approaches showing promise in managing PVS effectively.
Article
Cardiac & Cardiovascular Systems
Szymon Pawlak, Joanna Sliwka, Arkadiusz Wierzyk, Roman Przybylski, Jerzy Czapla, Boguslawa Krol, Piotr Przybylowski
Summary: This article summarizes the experience of heart transplantation in children, and the results show that the survival rate of pediatric heart transplantation is relatively high and comparable to that of foreign centers.
KARDIOLOGIA POLSKA
(2023)
Review
Pediatrics
Shoji Fukuoka, Kenichiro Yamamura, Hazumu Nagata, Daisuke Toyomura, Yusaku Nagatomo, Yoshimi Eguchi, Kiyoshi Uike, Yuichiro Hirata, Hirosuke Inoue, Masayuki Ochiai, Shouichi Ohga
Summary: Pulmonary agenesis is the complete absence of pulmonary parenchyma, airways, and vasculature on one or both sides. This study aimed to assess the clinical features of pulmonary agenesis through a comprehensive literature review. The study identified a significant number of patients with additional anomalies in unilateral cases. Compared to left-sided agenesis, right-sided agenesis was more frequently associated with tracheal stenosis. Tracheal stenosis and gastrointestinal anomalies were identified as poor prognostic factors.
PEDIATRIC PULMONOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Akito Hiraoka, Rolf Symons, Julie A. Bogaert, Pedro Morais, Alexander Van De Bruaene, Werner Budts, Jan Bogaert
Summary: This study evaluated the impact of left-to-right shunt in type II atrial septal defect patients on left and right ventricular volumes, function, and strain using cardiovascular magnetic resonance imaging. The findings showed that the shunt resulted in RV overfilling, LV underfilling, and impaired systolic RV performance associated with longitudinal dysfunction of the interventricular septum.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Naoki Nishiura, Takeshi Kitai, Taiji Okada, Madoka Sano, Norihisa Miyawaki, Kitae Kim, Ryosuke Murai, Toshiaki Toyota, Yasuhiro Sasaki, Natsuhiko Ehara, Atsushi Kobori, Makoto Kinoshita, Tadaaki Koyama, Yutaka Furukawa
Summary: This study aimed to investigate the natural history and optimal interventional timing in patients with isolated severe tricuspid regurgitation (TR). The results showed that TR pressure gradient, blood urea nitrogen, left atrial volume index, and serum albumin were independent predictors of adverse events. The prognosis of isolated severe TR is not always favorable, and careful attention should be paid to patients with concomitant risk factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jianrui Ma, Tong Tan, Shuai Zhang, Wen Xie, Yinru He, Miao Tian, Zichao Tujia, Xinming Li, Xiaobing Liu, Jimei Chen, Jian Zhuang, Jianzheng Cen, Shusheng Wen, Haiyun Yuan
Summary: This study compared the long-term outcomes of different initial rehabilitative surgical ages in patients with pulmonary atresia with ventricular septal defect (PAVSD). The results showed that patients younger than 6.4 months had similar pulmonary vasculature development and survival probability as those older than 6.4 months, but had an improved probability of complete repair.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jan D. Schmitto, Steven Shaw, Jens Garbade, Finn Gustafsson, Michiel Morshuis, Daniel Zimpfer, Jacob Lavee, Yuriy Pya, Michael Berchtold-Herz, Aijia Wang, Carlo Gazzola, Evgenij Potapov, Diyar Saeed
Summary: The long-term survival rate for primary implants of HeartMate 3 is 63.3%, and improvements in adverse events reduction, quality of life, and functional capacity were observed in patients with advanced heart failure during extended follow-up.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Bahaaldin Alsoufi, Jessica H. Knight, James St Louis, Geetha Raghuveer, Lazaros Kochilas
Summary: The study found that aortic valve replacement in young children presents technical difficulties and potential risks. Mechanical prostheses are less commonly used compared to the Ross operation. Although there were no significant differences in hospital mortality and 15-year transplant-free survival between Ross and MP recipients, long-term follow-up revealed lower survival rates in the MP group, with a higher need for redo aortic valve replacement.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Amanda S. Thomas, Alice Chan, Bahaaldin Alsoufi, Jeffrey M. Vinocur, Lazaros Kochilas
Summary: This study examined the outcomes of children who underwent ALCAPA surgery. The results showed that coronary artery reimplantation had a positive impact on long-term survival, and performing MV surgery for moderate/severe MR reduced the risk of in-hospital mortality. However, the severity of MR was not associated with in-hospital or longer-term outcomes.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Andrew Tran, Lazaros Kochilas, Amanda S. Thomas, Varun Aggarwal
Summary: This study evaluated the outcomes of patients who underwent surgical repair for ARCAPA within the Pediatric Cardiac Care Consortium (PCCC). The study found that patients had excellent outcomes after surgery, with good survival rates even up to 25 years of follow-up.
CARDIOLOGY IN THE YOUNG
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica H. Knight, Amber Leila Sarvestani, Chizitam Ibezim, Elizabeth Turk, Courtney E. McCracken, Bahaaldin Alsoufi, James St Louis, James H. Moller, Geetha Raghuveer, Lazaros K. Kochilas
Summary: This study analyzed the 25-year survival outcomes of children with congenital aortic valve disease who underwent different types of valve replacement surgeries, finding that pulmonic valve autograft provided the best long-term outcomes, while mechanical prosthetic valves were associated with a higher risk of mortality/transplant. Surgical outcomes may depend on the experience of the treatment center and patient selection.
Article
Cardiac & Cardiovascular Systems
Bahaaldin Alsoufi, Jessica H. Knight, James St Louis, Geetha Raghuveer, Lazaros Kochilas
Summary: This study examined the long-term outcomes and factors affecting survival in children with repaired conotruncal anomalies who underwent aortic valve replacement (AVR). The results showed that 6% of patients died or received transplantation within 5 years after AVR, and 20% required reoperation. The 20-year transplant-free survival in the conotruncal anomalies group was lower than that in matched children with congenital non-conotruncal disease undergoing AVR. This suggests that long-term survival following AVR in children with conotruncal anomalies is inferior and is linked to the underlying cardiac defect.
WORLD JOURNAL FOR PEDIATRIC AND CONGENITAL HEART SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Amanda S. Thomas, Erin E. Falk, Sarah Mahoney, Jessica H. Knight, Lazaros K. Kochilas
Summary: This retrospective study examines the long-term outcomes of pediatric patients who underwent their first surgery for connective tissue-related cardiovascular conditions. The study found that non-infantile patients had relatively high postdischarge survival rates, but there was still a risk of death due to cardiovascular-related pathology.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tawanda Zinyandu, Alejandro J. Montero, Amanda S. Thomas, Leandros Sassis, Pelagia Kefala-Karli, Jessica Knight, Lazaros K. Kochilas
Summary: This is a retrospective cohort study examining the 30-year survival outcomes of children with Williams-Beuren syndrome (WBS) who underwent interventions for congenital heart disease (CHD). The study found that the overall 30-year survival rate was 90%, with varying survival rates among different subgroups.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Pediatrics
Lydia K. Wright, Robert J. Gajarski, Christina Phelps, Timothy M. Hoffman, Irene D. Lytrivi, Defne A. Magnetta, Fawwaz R. Shaw, Consuela Thompson, Molly Weisert, Deipanjan Nandi
Summary: The revision of the US Pediatric Heart Allocation Policy (PHAP) has led to increased waitlist mortality for non-white children, widening racial disparities.
PEDIATRIC TRANSPLANTATION
(2023)
Editorial Material
Pediatrics
Lydia K. Wright, Robert J. Gajarski
PEDIATRIC TRANSPLANTATION
(2023)
Review
Pathology
Burcin Pehlivanoglu, Gizem Akkas, Bahar Memis, Olca Basturk, Michelle D. Reid, Burcu Saka, Nevra Dursun, Pelin Bagci, Serdar Balci, Juan Sarmiento, Shishir K. Maithel, Sudeshna Bandyopadhyay, Oscar Tapia Escalona, Juan Carlos Araya, Hector Losada, Michael Goodman, Jessica Holley Knight, Juan Carlos Roa, Volkan Adsay
Summary: Conflicting data exist regarding the frequency, prognosis and management of pT1b-gallbladder carcinoma (GBC). A study re-evaluated 473 GBC cases from the USA and Chile and found that only 5% of invasive GBCs were pT1b, with a 5-year survival rate of >90%. The study supports the inclusion of pT1b in the early GBC category and highlights the importance of accurate staging and long-term surveillance.
Article
Cardiac & Cardiovascular Systems
Lydia K. Wright, Stacey Culp, Robert J. Gajarski, Deipanjan Nandi
Summary: The revision of the US Pediatric Heart Allocation Policy in 2016 led to an increased demand for status exceptions, with potential disparities based on race and socioeconomic status affecting waitlist outcomes. By analyzing data from the Scientific Registry for Transplant Recipients, it was found that race and neighborhood SES were associated with the use of exceptions in Era 2, leading to worsened racial disparities in waitlist mortality among children with lower priority status.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Pediatrics
Lydia K. Wright, Erin B. Stallings, Janet D. Cragan, Laura J. Pabst, Clinton J. Alverson, Matthew E. Oster
Summary: This study evaluated the survival rates of individuals with Down syndrome (DS) and congenital heart defects (CHDs) born from 1979 to 2018. The findings showed that the 5-year survival rate for DS individuals with CHDs has improved over the past decades and approached the survival rate of DS individuals without CHDs. It was also observed that CHDs did not significantly affect the mortality rate of DS individuals born in 2010 or later.
JOURNAL OF PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
William H. Marshall, May Ling Mah, Jennifer Desalvo, Saurabh Rajpal, Lauren T. Lastinger, Arash Salavitabar, Aimee K. Armstrong, Darren Berman, Brent Lampert, Lydia K. Wright, Jenne Hickey, Rachel Metzger, Deipanjan Nandi, Robert Gajarski, Curt J. Daniels
Summary: This study describes novel uses of implantable invasive hemodynamic monitoring (IHM) in patients with subaortic right ventricles (sRV), which may minimize the need for serial catheterizations and improve management in a population where pulmonary hypertension (PH) is prevalent. The findings suggest that IHM can be used for medical therapy titration, medical management after ventricular assist device, and serial monitoring of pulmonary artery pressures. There were low rates of heart failure hospitalization and device-related complications, indicating that IHM is a safe and effective tool in this patient population.