Article
Multidisciplinary Sciences
Seung Min Baik, Na Rae Yang, Tae Yoon Kim, Kyung Sook Hong
Summary: This study aimed to compare the experience of open surgical ICU (OSICU) and closed surgical ICU (CSICU) systems in order to propose a better ICU system for critically ill patients. The results showed that a closed surgical ICU system is more beneficial for critically ill patients.
Article
Rheumatology
Arvind Bhargav, Venkateswaran Ramanathan, Ramu Ramadoss, Chengappa Kavadichanda, Christina M. Mariaselvam, Vir S. Negi, Molly M. Thabah
Summary: This study analyzed the clinical outcomes of systemic lupus erythematosus (SLE) patients admitted to the intensive care unit (ICU) and evaluated the prognostic role of high-density lipoprotein (HDL) and procalcitonin. The results showed that infections were the main cause of death in SLE patients in the ICU. Low HDL and high procalcitonin may serve as potential biomarkers to identify critically ill SLE patients.
Article
Immunology
Francois Mallet, Lea Diouf, Boris Meunier, Magali Perret, Frederic Reynier, Philippe Leissner, Laurence Quemeneur, Andrew D. Griffiths, Virginie Moucadel, Alexandre Pachot, Fabienne Venet, Guillaume Monneret, Alain Lepape, Thomas Rimmele, Lionel K. Tan, Karen Brengel-Pesce, Julien Textoris
Summary: The study analyzed blood DNAemia of TTV and herpesviruses in critically ill patients, finding a higher prevalence of herpesvirus DNAemia in sepsis patients and a potential delay in the return of immune homeostasis associated with herpesvirus DNAemia. EBV and TTV may serve as additional markers to predict clinical deterioration in ICU patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Rakhi Maiwall, Samba Siva Rao Pasupuleti, Harsh Vardhan Tevethia, Shiv Kumar Sarin
Summary: This study developed a dynamic model called PIRO-CIC for predicting mortality and determining futility of care in critically ill patients with cirrhosis. The model incorporated various factors including coagulation function, kidney function, and inflammatory response. The results showed that the PIRO-CIC model accurately predicted one-month mortality and outperformed other prognostic scores. The limitations of the study were its inapplicability to acute-on-chronic liver failure and patients requiring emergency liver transplant.
HEPATOLOGY INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Rachael Cusack, Alexis Garduno, Khalid Elkholy, Ignacio Martin-Loeches
Summary: The prevalence of ventilator-associated pneumonia (VAP) has been highlighted by the Covid-19 pandemic, underscoring the need for new antimicrobial approaches. This narrative review examines novel investigational drugs for VAP in the ICU setting, including monoclonal antibody treatments and phage antibiotic synthesis. The post-antibiotic era is approaching, emphasizing the importance of infection control measures and personalized medicine for severe infections.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2022)
Article
Nutrition & Dietetics
Boshen Yang, Yuankang Zhu, Xinjie Zheng, Taixi Li, Kaifan Niu, Zhixiang Wang, Xia Lu, Yan Zhang, Chengxing Shen
Summary: This retrospective cohort study investigated the effects of vitamin D supplementation on the prognosis of adult patients with sepsis. The results showed that vitamin D supplementation was associated with improved outcomes, including lower in-hospital, 28-day, and 90-day mortality rates, but had no influence on the length of stay in the hospital or ICU.
Article
Medicine, General & Internal
Seong Ho Kim, Ji Young Kim, Eun Song Kim, Il Rae Park, Eun Yeong Ha, Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Summary: This study found that early glycaemic variability (GV) is associated with increased 28-day mortality and prolonged ICU stay in critically ill patients with pneumonia. The presence of diabetes or HbA1c levels alone cannot predict the mortality and ICU stay in these patients. Patients with high GV, especially those with diabetes or low HbA1c levels, should be carefully treated to reduce mortality and prolong ICU stay.
ANNALS OF MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Minjee Kim, Filipe S. Cardoso, Anna Pawlowski, Richard Wunderink, Daniela P. Ladner, Juan G. Abraldes, Constantine J. Karvellas
Summary: This observational cohort study examined the impact of MDR colonization and MDR infection on survival in critically ill cirrhosis patients. The results showed that MDR colonization and MDR infection were associated with lower transplant-free survival in these patients.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Infectious Diseases
Ata Mahmoodpoor, Kamran Shadvar, Sarvin Sanaie, Mir Reza Hadipoor, Mohammad Ata Pourmoghaddam, Seied Hadi Saghaleini
Summary: This study examined the effects of high-dose intravenous vitamin C administration on critically ill patients with severe pneumonia. The results showed that it was safe and could reduce inflammation, duration of mechanical ventilation, and vasopressor use, with no significant effect on mortality.
BMC INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Chaisith Sivakorn, Jutamas Dechsanga, Lawan Jamjumrus, Kobporn Boonnak, Marcus J. Schultz, Arjen M. Dorndorp, Weerapong Phumratanaprapin, Ranistha Ratanarat, Thummaporn Naorungroj, Patchrapa Wattanawinitchai, Tanaya Siripoon, Chatnapa Duangdee, Tachpon Techarang
Summary: The study investigated prognostic biomarkers, HMGB1 and IL-6, at the time of admission in ICU for severe COVID-19 patients. Elevated levels of HMGB1 and IL-6 were associated with severity of illness and poor prognosis in these patients. Plasma HMGB1 and IL-6 levels at ICU admission may serve as prognostic biomarkers for critically ill COVID-19 patients.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Clinical Neurology
Prerna Gupta, Jennifer L. Martin, Atul Malhotra, Jaclyn Bergstrom, Michael A. Grandner, Biren B. Kamdar
Summary: This study evaluated the circadian rest-activity rhythms in critically ill patients and their association with baseline and clinical variables. It was found that critically ill patients commonly experienced misalignment of their circadian rhythms, which was associated with factors such as age and mechanical ventilation.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Critical Care Medicine
Maxime Bodinier, Guillaume Monneret, Marie Casimir, Aurore Fleurie, Filippo Conti, Fabienne Venet, Marie-Angelique Cazalis, Elisabeth Cerrato, Estelle Peronnet, Thomas Rimmele, Anne-Claire Lukaszewicz, Karen Brengel-Pesce, Jean-Francois Llitjos
Summary: The aim of this study is to develop a transcriptomic score based on immune-related genes to evaluate the disease risk of septic patients. By using a prototype multiplex PCR tool to detect immune-related genes, a scoring model was established and its effectiveness in high-risk patient selection and prediction of intensive care unit-acquired infections (IAI) was validated.
Article
Immunology
Yuan Cheng, Yang Chen, Mengxia Mao, Ruixuan Wang, Jun Zhu, Qing He
Summary: This study aimed to investigate the association between composite inflammatory indicators and ICU mortality in ICU patients with CHD, and develop a predictive model. The results showed a significant association between various inflammatory indicators and ICU mortality in ICU patients with CHD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Beatrice Vergnano, Davide Signori, Annalisa Benini, Serena Calcinati, Francesca Bettini, Luisa Verga, Lorenza Maria Borin, Fabrizio Cavalca, Carlo Gambacorti-Passerini, Giacomo Bellani, Giuseppe Foti
Summary: Early intensive interventions provided by MET can improve the survival rate of hematological critically ill patients and reduce the ICU admission rate. SOFA and MEWS scores are effective tools for prognostication.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Kay Choong See
Summary: Current guidelines for critically ill patients aim to standardize protocols for conditions such as stroke, ARDS, etc. However, personalizing care for individual patients may be necessary for optimal outcomes. This can be achieved through the use of genomics, transcriptomics, proteomics, and metabolomics to identify biomarkers and tailor treatments.
Article
Immunology
Bastiaan W. Haak, Xanthe Brands, Mark Davids, Hessel Peters-Sengers, Robert F. J. Kullberg, Robin van Houdt, Floor Hugenholtz, Daniel R. Faber, Hans L. Zaaijer, Brendon P. Scicluna, Tom van der Poll, W. Joost Wiersinga
Summary: Shifting composition of the nasopharyngeal microbial communities can be used as diagnostic biomarkers for community-acquired pneumonia (CAP) and identify the causative agent(s) in adult patients. Microbiota-based diagnostic panels can improve the specificity, efficiency, and antimicrobial stewardship practices for diagnosing CAP.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Respiratory System
Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Joe Butler, Lonneke A. van Vught, Katie L. Burnham, Emma E. Davenport, Julian C. Knight, Olaf L. Cremer, Marcus J. Schultz, Marc M. J. Bonten, Brendon P. Scicluna, Tom van der Poll
Summary: The host immune response does not differ between patients with community-acquired pneumonia (CAP) caused by gram-positive or gram-negative bacteria upon admission to the intensive care unit (ICU).
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Critical Care Medicine
Jenny Juschten, Lieuwe D. J. Bos, Harm-Jan De Grooth, Ulrich Beuers, Armand R. J. Girbes, Nicole P. Juffermans, Stephan A. Loer, Tom van der Poll, Olaf L. Cremer, Marc J. M. Bonten, Marcus J. Schultz, Pieter Roel Tuinman
Summary: This study investigates the incidence, clinical characteristics, and outcomes of early hyperbilirubinemia in critically ill patients. The results show that early hyperbilirubinemia is associated with higher disease severity, increased incidence of sepsis and organ failure, and mortality within 30 days, especially in patients with concomitant thrombocytopenia.
Article
Cell Biology
Wiwat Chancharoenthana, Asada Leelahavanichkul, Marcus J. Schultz, Arjen M. Dondorp
Summary: Leptospirosis is a global zoonotic and waterborne disease that poses a significant public health problem. It is often difficult to diagnose due to its similarity to other tropical diseases, and there is increasing evidence of chronic symptoms that can go unrecognized. Kidney involvement is common in leptospirosis, and early recognition of severe cases is crucial for reducing morbidity and mortality. This review highlights the spectrum of characteristics seen in leptospirosis kidney disease, as well as the diagnostic and treatment methods.
Correction
Multidisciplinary Sciences
James D. Mills, Anand M. Iyer, Jackelien van Scheppingen, Anika Bongaarts, Jasper J. Anink, Bart Janssen, Till S. Zimmer, Wim G. Spliet, Peter C. van Rijen, Floor E. Jansen, Martha Feucht, Johannes A. Hainfellner, Pavel Krsek, Josef Zamecnik, Katarzyna Kotulska, Sergiusz Jozwiak, Anna Jansen, Lieven Lagae, Paolo Curatolo, David J. Kwiatkowski, R. Jeroen Pasterkamp, Ketharini Senthilkumar, Lars von Oerthel, Marco F. Hoekman, Jan A. Gorter, Peter B. Crino, Angelika Muhlebner, Brendon P. Scicluna, Eleonora Aronica
SCIENTIFIC REPORTS
(2022)
Review
Critical Care Medicine
Lara C. A. Pladet, Jaimie M. M. Barten, Lisette M. Vernooij, Carlos V. Elzo Kraemer, Jeroen J. H. Bunge, Erik Scholten, Leon J. Montenij, Marijn Kuijpers, Dirk W. Donker, Olaf L. Cremer, Christiaan L. Meuwese
Summary: The purpose of this study was to provide an overview and evaluate the performance of mortality prediction models for patients requiring extracorporeal membrane oxygenation (ECMO) support. A large number of models have been developed, but only a minority has been externally validated. The models showed only moderate predictive performance and poor methodological quality overall.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Daan F. L. Filippini, Laura A. Hagens, Nanon F. L. Heijnen, Claudio Zimatore, Leila N. Atmowihardjo, Ronny M. Schnabel, Marcus J. Schultz, Dennis C. J. J. Bergmans, Lieuwe D. J. Bos, Marry R. Smit
Summary: The RALE score is not universally prognostic in mechanically ventilated ICU patients, but early changes in RALE score are associated with mortality in ARDS patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Anesthesiology
Marcelo Gama de Abreu, Marcus J. Schultz, Ary Serpa Neto
Summary: Spin and fragility are common in randomised controlled trials published in anaesthesia journals. Staying with the facts and addressing only the primary endpoint in the conclusion of clinical research reports might help reduce spin. Routinely reporting the fragility index, in turn, could deliver information about robustness, enhancing the transparency of positive dichotomous results. It is in the best interest of clinical research that authors, reviewers, and journals come together to reduce spin and address the fragility of randomised controlled trials.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Critical Care Medicine
Aranka Akkermans, Sanne Prins, Amber S. Spijkers, Jean Wagemans, Nanon H. M. Labrie, Dick L. Willems, Marcus J. Schultz, Thomas G. V. Cherpanath, Job B. M. van Woensel, Marc van Heerde, Anton H. van Kaam, Moniek van de Loo, Anne Stiggelbout, Ellen M. A. Smets, Mirjam A. de Vos
Summary: This study examines the argumentative practices of doctors and families in making decisions about life-sustaining treatment in ICUs. The research identifies the arguments used by both parties and explores how they structure their arguments during conversations. The study reveals that there is limited and brief exchange of arguments, although the types of arguments presented by doctors and families largely overlap.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
L. Robin Goossen, Marielle Verboom, Marielle Blacha, Illaa Smesseim, Ludo F. M. Beenen, David M. P. van Meenen, Frederique Paulus, J. Marcus Schultz
Summary: In this single-center cohort study in the Netherlands, the incidence of air leaks, including subcutaneous emphysema, pneumothorax, and pneumomediastinum, was found to be 8.4% in patients with COVID-19, which was comparable to previous reports in patients with acute hypoxemic respiratory failure.
Editorial Material
Respiratory System
M. J. Schultza, P. J. van Oostena, L. Hol
Article
Biochemistry & Molecular Biology
Luis Enrique Olmedilla Arnal, Oscar Diaz Cambronero, Guido Mazzinari, Jose Maria Perez Pena, Jaime Zorrilla Ortuzar, Marcos Rodriguez Martin, Maria Vila J. Montanes, Marcus Schultz, Lucas Rovira, Maria Pilar Argente Navarro
Summary: High intra-abdominal pressure during laparoscopic surgery is associated with reduced splanchnic blood flow. This study found that an individualized low-pneumoperitoneum-pressure strategy may prevent a reduction in liver perfusion.
Article
Critical Care Medicine
Rombout B. E. van Amstel, Jason N. Kennedy, Brendon P. Scicluna, Lieuwe D. J. Bos, Hessel Peters-Sengers, Joe M. Butler, Eddie Cano-Gamez, Julian C. Knight, Alexander P. J. Vlaar, Olaf L. Cremer, Derek C. Angus, Tom van der Poll, Christopher W. Seymour, Lonneke A. van Vught
Summary: Among critically ill patients with sepsis, subtype strategies using clinical, biomarker, and transcriptomic data do not identify comparable patient populations and are likely to reflect disparate clinical characteristics and underlying biology.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Liselotte J. Hol, Marcus Schultz, Ignacio Martin-Loeches, David M. P. van Meenen, Ary Serpa Neto, Frederique Paulus
Summary: The aim of this analysis was to compare ventilation management and outcomes in invasively ventilated patients with acute hypoxemic respiratory failure due to COVID-19 between the first and second wave in the Netherlands. The study found that patients in the second wave were sicker, had more comorbidities, and had worse oxygenation parameters. Changes in ventilation management were observed, such as lower positive end-expiratory pressure and higher fraction inspired oxygen. Duration of ventilation was shorter, but mortality rates were similar.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Athiwat Tripipitsiriwat, Orawan Suppapueng, David M. P. van Meenen, Frederique Paulus, Markus W. Hollmann, Chaisith Sivakorn, Marcus J. Schultz, PRoVENT COVID Investigators
Summary: This study found that patients with chronic obstructive pulmonary disease (COPD) have a higher mortality rate in COVID-19 and higher 28-day mortality compared to non-COPD patients. The ventilation management and the use of prone positioning differed slightly between COPD and non-COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)