Article
Oncology
Seungyeon Joe, Miseon Lee, Jun Kang, Joori Kim, Sook-Hee Hong, Sung Jong Lee, Keun Ho Lee, Ahwon Lee
Summary: The study utilized POLE ddPCR and L1CAM IHC as alternative methods for molecular classification in early-stage endometrial cancer, enhancing risk stratification and providing valuable information for treatment decisions and patient outcomes.
Article
Medicine, General & Internal
Dario de Biase, Thais Maloberti, Angelo Gianluca Corradini, Francesca Rosini, Marco Grillini, Martina Ruscelli, Sara Coluccelli, Annalisa Altimari, Elisa Gruppioni, Viviana Sanza, Daniela Turchetti, Andrea Galuppi, Martina Ferioli, Susanna Giunchi, Giulia Dondi, Marco Tesei, Gloria Ravegnini, Francesca Abbati, Daniela Rubino, Claudio Zamagni, Pierandrea De Iaco, Donatella Santini, Claudio Ceccarelli, Anna Myriam Perrone, Giovanni Tallini, Antonio De Leo
Summary: This study compares the new ESGO/ESTRO/ESP risk stratification system with the previous 2016 recommendations for endometrial carcinoma patients. The results show that the new system provides more accurate identification of low-risk and high-risk patients, potentially allowing a more specific selection of patients for post-operative adjuvant therapy.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Junhwan Kim, Se Ik Kim, Nae Ry Kim, Hyojin Kim, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Cheol Lee, Maria Lee
Summary: This study investigated the prognostic significance of L1 cell-adhesion molecule (L1CAM), β-catenin, and programmed death-ligand 1 (PD-L1) in endometrial cancer (EC) patients, with a focus on the p53 wild-type subgroup. The results showed that L1CAM positivity was associated with poor prognosis in EC and increased the risk of recurrence in the p53 wild-type subgroup.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fumitaka Ejima, Yoshihiko Fukukura, Kiyohisa Kamimura, Masatoyo Nakajo, Takuro Ayukawa, Fumiko Kanzaki, Shintaro Yanazume, Hiroaki Kobayashi, Ikumi Kitazono, Hiroshi Imai, Thorsten Feiweier, Takashi Yoshiura
Summary: The study found that the ADC ratio obtained via oscillating gradient and pulsed gradient DWIs may serve as useful imaging biomarkers for risk stratification in patients with endometrial cancer. Compared to conventional DWI methods, the ADC ratio showed stronger correlations with histological grade, FIGO stage, and prognostic risk classification. The results suggest that ADC ratio could potentially improve risk assessment in patients with endometrial cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Oncology
Regina Esi Mensimah Baiden-Amissah, Daniela Annibali, Sandra Tuyaerts, Frederic Amant
Summary: Endometrial carcinomas (EC) are traditionally classified based on histopathology into type I and type II. However, the current risk assessment approaches fail to accurately classify patients into low-and high-risk groups. Molecular characteristics may serve as a better base for patient risk stratification and treatment decisions, but they have not been systematically applied in clinics yet. The Cancer Genome Atlas (TCGA) has redefined EC into four molecular subgroups, which could potentially help in improving risk stratification and treatment strategies.
Article
Oncology
Christine S. Walsh, Kari E. Hacker, Angeles Alvarez Secord, Deborah F. DeLair, Carolyn McCourt, Renata Urban
Summary: The Cancer Genome Atlas publication identified four molecular subtypes of endometrial cancer with different prognoses. The Proactive Molecular Classifier for Endometrial Cancer facilitates the classification of endometrial cancers into similar subtypes more conveniently and inexpensively. In addition to these subtypes, other molecular biomarkers may impact clinical behavior and response to targeted therapies. The understanding of molecular classification is essential for clinicians treating endometrial cancer to guide appropriate testing and treatment decisions.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Guillaume Beinse, Marie-Aude Le Frere Belda, Pierre-Alexandre Just, Nahina Bekmezian, Meriem Koual, Simon Garinet, Karen Leroy, Franck Letourneur, Adele Lusson, Claire Mulot, Delphine Le Corre, Marie Metairie, Nicolas Delanoy, Helene Blons, Claire Gervais, Catherine Durdux, Charles Chapron, Francois Goldwasser, Benoit Terris, Cecile Badoual, Valerie Taly, Pierre Laurent-Puig, Bruno Borghese, Anne-Sophie Bats, Jerome Alexandre
Summary: This study aimed to evaluate the classification ability of RNA sequencing (RNA-seq) for prognosis prediction in endometrial carcinoma (EC) patients. The results showed that RNA-seq can provide additional prognostic information beyond established classification systems and has potential applications in therapeutic strategies for EC.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yasuhisa Kurata, Mizuho Nishio, Yusaku Moribata, Aki Kido, Yuki Himoto, Satoshi Otani, Koji Fujimoto, Masahiro Yakami, Sachiko Minamiguchi, Masaki Mandai, Yuji Nakamoto
Summary: Endometrial cancer (EC) is the most common gynecological tumor in developed countries, and preoperative risk stratification is essential for personalized medicine. A study using convolutional neural network for automatic segmentation of EC on MRI showed that using multi-sequence images and larger batch size improved segmentation accuracy, and the radiomics features exhibited high reliability.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Taylor J. Orellana, Hayeon Kim, Sushil Beriwal, Sarah E. Taylor, Kenneth J. Smith, Jamie L. Lesnock
Summary: In patients with stage III endometrial cancer, tumor molecular testing was found to be cost saving compared to no testing, with equivalent effectiveness. However, when compared to mismatch repair immunohistochemistry alone, tumor molecular testing was not cost-effective.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Biology
Erling A. Hoivik, Erlend Hodneland, Julie A. Dybvik, Kari S. Wagner-Larsen, Kristine E. Fasmer, Hege F. Berg, Mari K. Halle, Ingfrid S. Haldorsen, Camilla Krakstad
Summary: Utilizing radiogenomic analysis in endometrial cancer patients, high-risk tumor features were identified along with an 11-gene high-risk signature that was validated for prognostic assessment and guiding treatment strategies.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Yuanyuan Zhou, Xinping Wu, Yuzhi Zhang, Zhiqiang Li, Xia Ge, Hao Chen, Yuan Mao, Wenbo Ding
Summary: This study designed a multigene testing panel to identify benign and malignant thyroid nodules and provided evidence for using molecular risk stratification as a promising predictor of disease outcomes.
Article
Oncology
Petra Vinklerova, Petra Ovesna, Jitka Hausnerova, Johanna M. A. Pijnenborg, Peter J. F. Lucas, Casper Reijnen, Stephanie Vrede, Vit Weinberger
Summary: The study confirmed the good predictive ability of the ENDORISK model in low-risk patients, but further training/improvement is needed in high-risk and/or advanced stages.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fang Jiang, Shiyang Jiang, Dongyan Cao, Mingyi Mao, Yang Xiang
Summary: Current molecular classification approaches for endometrial cancer often employ multiple testing platforms. However, some subtypes still lack clear prognostic significance, indicating the need for further risk sub-stratification. This study investigates the feasibility of classifying EC using DNA sequencing and explores immunologic signatures and prognostic markers within subtypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Kelechi Njoku, Chloe E. Barr, Emma J. Crosbie
Summary: Endometrial cancer is the most common gynaecological malignancy in high income countries, and its incidence is increasing. Prognostic biomarkers can help identify high-risk patients and guide treatment strategies. Apart from genomic research, various blood-based biomarkers have shown potential for predicting the risk of endometrial cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. Ytre-Hauge, O. O. Salvesen, C. Krakstad, J. Trovik, I. S. Haldorsen
Summary: Texture analysis of preoperative CT images can predict prognostic histopathological features and outcomes in endometrial cancer patients. High tumour entropy is associated with deep myometrial invasion and cervical stroma invasion, high MPP value predicts high-risk histological subtype, and high tumour kurtosis may predict reduced recurrence- and progression-free survival.
CLINICAL RADIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Margo S. Harrison, Saskia Bunge-Montes, Claudia Rivera, Andrea Jimenez-Zambrano, Gretchen Heinrichs, Sharon Scarbro, Elizabeth Juarez-Colunga, Antonio Bolanos, Edwin Asturias, Stephen Berman, Jeanelle Sheeder
Summary: This study aimed to explore the feasibility, recruitment, and retention in a cluster-randomized trial conducted in rural Guatemala. The results showed that by bringing a range of contraceptives to women's homes, high enrollment and retention rates were achieved.
INTERNATIONAL HEALTH
(2022)
Article
Obstetrics & Gynecology
Ariel Sklar, Jeanelle Sheeder, Anne R. Davis, Carrie Wilson, Stephanie B. Teal
Summary: This study compared maternal morbidity in women with preterm premature rupture of membranes who chose either expectant management or termination of pregnancy. The results showed that women who chose expectant management had higher morbidity rates, with an increased risk of chorioamnionitis and postpartum hemorrhage compared to those who chose termination of pregnancy. Expectant management was also associated with a higher likelihood of admission to the maternal intensive care unit and unplanned hysterectomy. The study suggests that expectant management increases maternal morbidity compared to termination of pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal
Summary: This study assessed the variability of repeated measurements of serum etonogestrel concentration among contraceptive implant users and confirmed that single-time measurements are acceptable pharmacokinetic outcomes.
Meeting Abstract
Oncology
Jennifer Haag, Alexzandra Adler, Jeanelle Sheeder, Carolyn Lefkowits, Lindsay Brubaker
GYNECOLOGIC ONCOLOGY
(2022)
Meeting Abstract
Oncology
Breana Hill, Kelsey Goon, JoEllen Fresia, Jeanelle Sheeder, Rebecca Wolsky, Jill Alldredge
GYNECOLOGIC ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Jason G. Bunn, Jeanelle Sheeder, Jay Schulkin, Sindi Diko, Miriam Estin, Kathleen A. Connell, K. Joseph Hurt
Summary: In the United States, obstetricians inconsistently identify perineal and nonperineal lacerations, with important clinical knowledge gaps identified. Providers reporting fewer deliveries per month and fewer publicly insured patients earned higher diagnostic accuracy scores.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Obstetrics & Gynecology
Jennifer G. Haag, Rebecca J. Wolsky, Marisa R. Moroney, Jamie Sheren, Jeanelle Sheeder, Benjamin G. Bitler, Bradley R. Corr
Summary: This study aimed to investigate the correlation between CTNNB1 mutation and clinical outcomes in high-intermediate risk endometrial endometrioid carcinoma (HIR EEC). The results showed that there were no significant differences in recurrence rates and survival rates between CTNNB1 mutant (CTNNB1-mut) and wild-type (CTNNB1-WT) tumors. Mismatch repair deficiency was more prevalent in CTNNB1-WT tumors, while the prevalence of POLE mutations and aberrant p53 was not significantly different.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2023)
Article
Health Care Sciences & Services
Cara Clure, Jeanelle Sheeder, Stephanie Teal, Rebecca Cohen
Summary: This study aimed to evaluate rural Colorado women's access to and preferences for reproductive health care services. The survey found that most women identified barriers to obtaining reproductive care in their communities, with too few community-based providers and long distance to care being the most common barriers. More than half of the women were interested in using telemedicine for reproductive health care, but there was also a portion who were not interested.
JOURNAL OF RURAL HEALTH
(2023)
Article
Obstetrics & Gynecology
Jennifer G. Haag, Alexzandra D. Adler, Jeanelle Sheeder, Lindsay W. Brubaker, Carolyn Lefkowits
Summary: The study aimed to evaluate patterns of palliative care integration in patients with platinum resistant ovarian cancer. The findings suggest that referral patterns for palliative care are reactive to clinical decline rather than proactive, and there is a missed opportunity for concurrent palliative care and oncology care earlier in the disease course.
GYNECOLOGIC ONCOLOGY REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Virginia Lijewski, Taylor Lendrum, April Frey, Jeanelle Sheeder, Heather Straub
Summary: This study examined whether distractions affect sonographers' perceptions of the quality of an obstetric sonogram (OBS) and if clinic policies can mitigate this association. The results showed that higher distraction scores were associated with an increased number of sonographer reports of OBS quality concerns. Additionally, the lack of desired policies was associated with more distractions and quality concerns.
JOURNAL OF DIAGNOSTIC MEDICAL SONOGRAPHY
(2022)
Article
Obstetrics & Gynecology
Aaron Lazorwitz, Jeanelle Sheeder
Summary: This study aimed to confirm that 24-hour steady-state trough measurements (C24) are high-quality proxies for gold standard pharmacokinetic measurements (area under the curve [AUC]) in the study of combined oral contraceptive pills (COCP). The study found that C24 measurements were highly correlated with AUC values for both components of the COCP, supporting the use of C24 as a surrogate for AUC in large-scale pharmacokinetic studies.
Meeting Abstract
Oncology
Jessica Floyd, Kelsey Goon, Jennifer Haag, Jeanelle Sheeder, Lindsay Brubaker, Carolyn Lefkowits
GYNECOLOGIC ONCOLOGY
(2023)
Meeting Abstract
Oncology
Carolyn Lefkowits, Jessica Floyd, Kelsey Goon, Jennifer Haag, Jeanelle Sheeder, Lindsay Brubaker
GYNECOLOGIC ONCOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Dana R. Siegel, Joellen Fresia, Angela Fought, Jeanelle Sheeder, Karen Hampanda, Leslie Coker Appiah
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Julie C. Friedman, Jeanelle Sheeder, Aaron Lazorwitz, Alex J. Polotsky
REPRODUCTIVE SCIENCES
(2022)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)
