Article
Oncology
Khemanat Khemworapong, Atthapon Jaishuen, Pisutt Srichaikul, Perapong Inthasorn, Boonlert Viriyapak, Vuthinun Achariyapota, Nida Jareemit, Malee Warnnissorn, Suchanan Hanamornroongruang, Jumnanja Sukmee
Summary: The objective of this study was to assess the effectiveness and accuracy of sentinel lymph node (SLN) biopsy in patients with endometrial cancer. The results showed that SLN biopsy had a high detection rate and accuracy, but surgical expertise and a learning curve were required.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Aharon Dick, Tamar Perri, Liron Kogan, Benny Brandt, Raanan Meyer, Gabriel Levin
Summary: The guidelines for sentinel lymph node mapping in endometrial cancer are comparable in terms of surgical technique, ultrastaging, and management in case of failed mapping. However, there are some variations in the management of high-grade histology and positive pelvic lymph nodes.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Wan-Hua Ting, Shu-Wei Hsieh, Hui-Hua Chen, Ming-Chow Wei, Ho-Hsiung Lin, Sheng-Mou Hsiao
Summary: This retrospective study aimed to identify predictors for cancer recurrence in women with endometrial cancer and compare the clinical outcomes of sentinel lymph node (SLN) mapping and traditional lymphadenectomy. The study found that para-aortic lymph node metastasis was the sole predictor for cancer recurrence and cytokeratin immunohistochemistry stain detected more lymph node metastases. Additionally, SLN mapping and traditional lymphadenectomy had similar probabilities of cancer recurrence.
Article
Oncology
Khaled Ghoniem, Alyssa M. Larish, Giorgia Dinoi, Xun Clare Zhou, Mariam Alhilli, Sumer Wallace, Christoph Wohlmuth, Glauco Baiocchi, Nedim Tokgozoglu, Francesco Raspagliesi, Alessandro Buda, Vanna Zanagnolo, Ignacio Zapardiel, Nisha Jagasia, Robert Giuntoli, Ariel Glickman, Michele Peiretti, Maximillian Lanner, Enrique Chacon, Julian Di Guilmi, Augusto Pereira, Enora Laas, Ami Fishman, Caroline C. Nitschmann, Susan Parker, Amy Joehlin-Price, Brittany Lees, Allan Covens, Louise De Brot, Cagatay Taskiran, Giorgio Bogani, Cristiana Paniga, Francesco Multinu, Alicia Hernandez-Gutierrez, Amy L. Weaver, Michaela E. McGree, Andrea Mariani
Summary: The study evaluated oncologic outcomes in endometrial cancer patients with low-volume metastasis in the sentinel lymph nodes, finding that Non-endometrioid histology, lymphovascular space invasion, and uterine serosal invasion were independent risk factors for recurrence. Patients with any of these risk factors had poor prognosis even with adjuvant therapy. On the other hand, patients with isolated tumor cell and grade 1 endometrioid disease had favorable prognosis even without adjuvant therapy, suggesting a potential for withholding adjuvant therapy in this low-risk subgroup.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Nicolo Bizzarri, Andrea Rosati, Giovanni Scambia, Francesco Fanfani
Summary: Occult endometrial cancer after supracervical hysterectomy is rare, and restaging should be considered for optimal management. A case report described a patient with metastatic parametrium after laparoscopic surgery, highlighting the feasibility of SLN mapping with cervical injection even without the uterine corpus.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Lirong Zhai, Xiwen Zhang, Manhua Cui, Jianliu Wang
Summary: Endometrial cancer is a common gynecological malignancy with increasing incidence rates annually. Lymph node status is crucial for prognosis evaluation and treatment selection. Sentinel lymph node mapping (SLNM) in early-stage lower risk EC patients has shown high detection rate and sensitivity without compromising patient survival.
FRONTIERS IN ONCOLOGY
(2021)
Review
Obstetrics & Gynecology
Florin Andrei Taran, Lisa Jung, Julia Waldschmidt, Sarah Isabelle Huwer, Ingolf Juhasz-Boess
Summary: The role of lymphadenectomy in surgical staging of endometrial cancer is still controversial, while sentinel lymph node biopsy may offer a promising alternative with reduced postoperative complications.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2021)
Article
Oncology
Lukas Dostalek, Klara Benesova, Jaroslav Klat, Sarah H. Kim, Henrik Falconer, Jan Kostun, Ricardo dos Reis, Ignacio Zapardiel, Fabio Landoni, David Isla Ortizj, Luc R. C. W. van Lonkhuijzen, Aldo Lopez, Diego Odetto, Martina Borcinova, Jiri Jarkovsky, Sahar Salehi, Kristyna Nemejcova, Sylva Bajsova, Kay J. Park, Veronika Javurkova, Nadeem R. Abu-Rustum, Pavel Dundr, David Cibula
Summary: This study aimed to determine whether the size of lymph node metastasis is associated with prognosis in cervical cancer patients. The results showed that lymph node metastasis ≥0.4 mm was significantly associated with shorter disease-free survival, but no cut-off value for size was found that had a better prognosis than N1. Traditional metastasis stratification based on size is clinically irrelevant.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Nan Song, Hong Zheng, Yunong Gao, Min Gao
Summary: This study aimed to understand the use of sentinel lymph node mapping in endometrial cancer staging by Chinese oncologists and analyze the factors influencing its application. Questionnaires were used to evaluate the characteristics of the participating oncologists and factors associated with the use of sentinel lymph node mapping. Results showed that 35.4% of doctors employed this method for endometrial cancer staging. Factors such as cancer research center, familiarity with the technique, and use of ultrastaging were found to be related to the selection of sentinel lymph node mapping. The study also revealed significant differences in surgical procedures and reasons for not using the technique before and after the symposium. In conclusion, theoretical knowledge, use of ultrastaging, and being associated with a cancer research center were found to be related to a higher acceptance of sentinel lymph node mapping. Distance learning was found to be helpful in promoting this technology.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Oncology
Victor Lago, Beatriz Montero, Susana Lopez, Pablo Padilla-Iserte, Luis Matute, Tiermes Marina, Marta Gurrea, Guillermina Montoliu, Pilar Bello, Santiago Domingo
Summary: The objective of this study is to determine the role of sentinel lymph node ultrastaging in apparent early-stage ovarian cancer. The study shows that a uniform protocol for ultrastaging is essential for lower-volume metastasis detection and to provide reproducible information for future studies.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Leah A. Marsh, Emeline M. Aviki, Jason D. Wright, Ling Chen, Nadeem Abu-Rustum, Ritu Salani
Summary: This study estimates the annual cost of wasted indocyanine green (ICG) used for sentinel lymph node mapping in patients with endometrial cancer. The findings show that the current manufactured vial size of ICG leads to wasted costs exceeding $2 million for hospitals and $13.3-$17.7 million for patients annually. The study suggests packaging ICG in smaller vials to avoid drug waste and financial impact.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Basile Pache, Matteo Tantari, Benedetta Guani, Patrice Mathevet, Laurent Magaud, Fabrice Lecuru, Vincent Balaya
Summary: This study aimed to identify the risk factors for metastasis in non-sentinel lymph nodes (SNL) in cases of positive sentinel lymph node (SLN) in early-stage cervical cancer. Age and lympho-vascular invasion were found to be predictive of non-SLN metastasis in patients with SLN metastasis.
Article
Obstetrics & Gynecology
Koji Matsuo, Maximilian Klar, Varun U. Khetan, Caroline J. Violette, Ariane C. Youssefzadeh, Annie A. Yessaian, Lynda D. Roman
Summary: This study suggests that sentinel lymph node biopsy may be effective in identifying micrometastasis in early stage endometrial cancer. The role of increased utilization of sentinel lymph node biopsy in shifting disease stage needs further investigation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Oncology
Lina Salman, Maria C. Cusimano, Zibi Marchocki, Sarah E. Ferguson
Summary: Sentinel lymph node mapping is a viable alternative to full lymphadenectomy for evaluating lymphatic spread in clinical stage I endometrial cancer. While lymphadenectomy provides valuable information, most patients do not benefit from this procedure. SLN mapping offers prognostic information and avoids postoperative complications.
Article
Oncology
Giorgio Bogani, Andrea Papadia, Alessandro Buda, Jvan Casarin, Violante Di Donato, Maria Luisa Gasparri, Francesco Plotti, Ciro Pinelli, Maria Chiara Paderno, Salvatore Lopez, Anna Myriam Perrone, Fabio Barra, Rocco Guerrisi, Claudia Brusadelli, Antonella Cromi, Debora Ferrari, Valentina Chiapp, Mauro Signorelli, Umberto Leone Roberti Maggiore, Antonino Ditto, Innocenza Palaia, Simone Ferrero, Pierandrea De Iaco, Roberto Angioli, Pierluigi Benedetti Panici, Fabio Ghezzi, Fabio Landoni, Michael D. Mueller, Francesco Raspagliesi
Summary: This study evaluated the outcomes of high-risk EC patients undergoing SNM, with or without back-up lymphadenectomy, and found that the type of nodal assessment did not impact survival outcomes. Back-up lymphadenectomy may help remove positive nodes, but its therapeutic value remains controversial.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Giorgio Bogani, Valentina Chiappa, Marta Bini, Dominique Ronzulli, Alice Indini, Elena Conca, Francesco Raspagliesi
Summary: The study reports the preliminary experience of using BYL719 (alpelisib) in patients with advanced/recurrent cervical cancer who have failed at least two lines of treatment. The results show a high level of efficacy and tolerability of alpelisib in this patient population. Further trials are needed to assess the safety and effectiveness of alpelisib in PIK3CA-mutated recurrent/advanced cervical cancer.
Review
Pharmacology & Pharmacy
Giorgio Bogani, Innocenza Palaia, Giorgia Perniola, Federica Tomao, Antonella Giancotti, Daniele Di Mascio, Giuseppe Capalbo, Ludovico Muzii, Pierluigi Benedetti Panici, Violante Di Donato
Summary: There is limited consensus on pharmacotherapy for patients with locally advanced, recurrent, or metastatic vulvar cancer. Chemotherapy and immune checkpoint inhibitors may be promising treatment options.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Obstetrics & Gynecology
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Barbara Gardella, Giorgio Bogani, Ermelinda Monti, Carlo Antonio Liverani, Elena Roncella, Francesco Raspagliesi, Arsenio Spinillo, Paolo Vercellini, Andrea Ciavattini
Summary: This study aimed to evaluate the independent variables associated with positive endocervical margin (EM) in women with high-grade cervical intraepithelial neoplasia (CIN) and fully visible transformation zone (TZ). The study found that TZ type and lesion extension were positively associated with positive EM, while cone depth was inversely related to positive EM. In women with TZ type 2 and lesion extension ≥2 cervical quadrants, an 8-mm cone depth provided a good cutoff value.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Oncology
Giorgio Bogani, Isabelle Ray-Coquard, Nicole Concin, Natalie Yan Li Ngoi, Philippe Morice, Giuseppe Caruso, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Domenica Lorusso, Robert Coleman, Michelle M. Vaughan, Masashi Takano, Diane Michele Provencher, Satoru Sagae, Pauline Wimberger, Robert Poka, Yakir Segev, Se Ik Kim, Jae-Weon Kim, Francisco Jose Candido dos Reis, Pedro T. Ramirez, Andrea Mariani, Mario Leitao, Vicky Makker, Nadeem R. Abu-Rustum, Ignace Vergote, Gianfranco Zannoni, David Tan, Mary McCormack, Biagio Paolini, Marta Bini, Francesco Raspagliesi, Pierluigi Benedetti Panici, Violante Di Donato, Ludovico Muzii, Nicoletta Colombo, Sandro Pignata, Giovanni Scambia, Bradley J. Monk
Summary: Endometrial carcinosarcoma is a rare and aggressive type of cancer, with clinical presentation and diagnostic methods similar to the more common endometrioid carcinoma. It is characterized by the presence of both carcinomatous and sarcomatous elements, and the majority of cases have p53 abnormalities. Treatment involves a multimodal approach for non-metastatic disease and palliative chemotherapy for metastatic or recurrent disease.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Review
Oncology
Giorgio Bogani, Alessandro Ghelardi, Francesco Sopracordevole, Marco Annoni, Andrea Ciavattini, Luca Giannella, Rosa De Vincenzo, Paolo Cattani, Maggiorino Barbero, Paolo Vercellini, Francesco Raspagliesi, Paolo Bonanni, Giovanni Scambia
Summary: Human papillomavirus (HPV) is a common sexually transmitted infection that can cause various diseases, including cervical cancer. Prophylactic HPV vaccines have been developed to prevent the spread of HPV and reduce the prevalence of HPV-related diseases. Despite their high efficacy, HPV vaccines are underutilized in Italy, with decreasing coverage rates. Action is needed to improve HPV awareness and education to promote widespread adoption of HPV vaccination.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Review
Oncology
Stefano Restaino, Chiara Paglietti, Martina Arcieri, Anna Biasioli, Monica Della Martina, Laura Mariuzzi, Claudia Andreetta, Francesca Titone, Giorgio Bogani, Diego Raimondo, Federica Perelli, Alessandro Buda, Marco Petrillo, Pantaleo Greco, Alfredo Ercoli, Francesco Fanfani, Giovanni Scambia, Lorenza Driul, Giuseppe Vizzielli
Summary: This article compares the guidelines released by different international gynecological societies and highlights the differences, aiming to provide a useful tool for clinicians. It emphasizes the importance of managing patients diagnosed with endometrial cancer.
Article
Oncology
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Francesco Sopracordevole, Nicolo Clemente, Giorgio Giorda, Rosa Pasqualina De Vincenzo, Maria Teresa Evangelista, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Chiara Alessi, Lara Alessandrini, Alessio Pagan, Marta Caretto, Alessandro Ghelardi, Andrea Amadori, Massimo Origoni, Maggiorino Barbero, Francesco Raspagliesi, Tommaso Simoncini, Paolo Vercellini, Giovanni Scambia, Andrea Ciavattini
Summary: This study examined the impact of HPV status on the prognosis of early stage cervical glandular lesions. The results showed that HPV status did not affect the recurrence rate, but most adenocarcinomas were positive for high-risk HPV.
Editorial Material
Biochemistry & Molecular Biology
Tullio Golia D'Auge, Ilaria Cuccu, Giusi Santangelo, Ludovico Muzii, Andrea Giannini, Giorgio Bogani, Violante Di Donato
Review
Health Care Sciences & Services
Ilaria Cuccu, Ottavia D'Oria, Ludovica Sgamba, Emanuele De Angelis, Tullio Golia D'Auge, Camilla Turetta, Camilla Di Dio, Maria Scudo, Giorgio Bogani, Violante Di Donato, Innocenza Palaia, Giorgia Perniola, Federica Tomao, Ludovico Muzii, Andrea Giannini
Summary: Endometrial cancer (EC) is a common gynecological malignancy, and molecular and genomic profiling have shown promise in predicting recurrence risk. However, there is limited data on therapeutic value. Ongoing studies are focused on identifying appropriate adjuvant strategies, especially for patients with positive nodes and low volume disease. Molecular classification has the potential to improve risk stratification and management in EC patients. This review aims to explore the evolution of molecular classification and its impact on research and clinical management.
Article
Oncology
Giorgio Bogani, Francesco Sopracordevole, Andrea Ciavattini, Enrico Vizza, Paolo Vercellini, Fabio Ghezzi, Giovanni Scambia, Violante Di Donato, Andrea Giannini, Francesco Raspagliesi
Summary: HPV is the primary cause of cervical dysplasia and cervical cancer, and efforts are needed to better categorize patients with HPV to provide useful information.
CANCER CYTOPATHOLOGY
(2023)
Article
Oncology
Giorgio Bogani, Isabelle Ray-Coquard, David Mutch, Ignace Vergote, Pedro T. Ramirez, Jaime Prat, Nicole Concin, Natalie Yan Li Ngoi, Robert L. Coleman, Takayuki Enomoto, Kazuhiro Takehara, Hannelore Denys, Domenica Lorusso, Masashi Takano, Satoru Sagae, Pauline Wimberger, Yakir Segev, Se Ik Kim, Jae-Weon Kim, Fernanda Herrera, Andrea Mariani, Rebecca A. Brooks, David Tan, Biagio Paolini, Valentina Chiappa, Mariangela Longo, Francesco Raspagliesi, Pierluigi Benedetti Panici, Violante Di Donato, Giuseppe Caruso, Nicoletta Colombo, Sandro Pignata, Gianfranco Zannoni, Giovanni Scambia, Bradley J. Monk
Summary: Gestational choriocarcinoma is a rare form of gestational trophoblastic neoplasms, accounting for 5% of cases. The FIGO scoring system categorizes patients into low and high-risk groups, with different chemotherapy approaches. Immunotherapy shows promising results but requires further evaluation and research.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Medicine, General & Internal
Valentina Chiappa, Giorgio Bogani, Matteo Interlenghi, Giulia Vittori Antisari, Christian Salvatore, Lucia Zanchi, Manuela Ludovisi, Umberto Leone Roberti Maggiore, Giuseppina Calareso, Edward Haeusler, Francesco Raspagliesi, Isabella Castiglioni
Summary: Neoadjuvant chemotherapy plus radical surgery may be a safe option for cervical cancer patients who are unwilling to undergo radiotherapy. A machine learning model based on cervix MRI images was developed to stratify the risk of cervical cancer in individual subjects. The response to neoadjuvant chemotherapy was found to be the main factor affecting treatment requirements and survival.
Article
Oncology
Giovanni Delli Carpini, Paolo Giorgi Rossi, Luca Giannella, Jacopo Di Giuseppe, Nicolo Clemente, Francesco Sopracordevole, Maggiorino Barbero, Giorgio Bogani, Rosa De Vincenzo, Massimo Origoni, Francesco Cantatore, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Carlo Antonio Liverani, Anna Viscardi, Alessio Pagan, Andrea Amadori, Chiara Alessi, Matteo Andolfatto, Paolo Cattani, Annalisa Pieralli, Guido Stevenazzi, Andrea Ciavattini
Summary: This study evaluates the impact of healthcare reorganization during the COVID-19 pandemic on Italian colposcopy clinic activities, specifically focusing on cervical excision procedures, follow-ups for conservative management of low-grade lesions, and follow-ups post cervical excision. The results show a reduction in the number of cervical excisions by 8.8% during the pandemic period compared to pre-pandemic. There were also significant reductions in the follow-ups for low-grade lesion management and follow-up appointments after cervical excision.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Letter
Obstetrics & Gynecology
Francesco Raspagliesi, William Creasman, Giorgio Bogani, Sergio Pecorelli
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
