Article
Chemistry, Applied
Wenqing Yu, Peihua Ma, Jiping Sheng, Lin Shen
Summary: The ethylene signaling pathway plays a crucial role in maintaining fruit quality during long-term cold storage of tomatoes. Specifically, the partial loss of function in the ethylene response factor 2 (SlERF2) gene can worsen fruit quality by affecting membrane damage and reactive oxygen species metabolism. Furthermore, the mutation of SlERF2 gene also alters the transcription of genes related to abscisic acid biosynthesis and signaling, as well as the C-repeat/dehydration-responsive binding factor (CBF) cold signaling pathway.
Article
Biochemistry & Molecular Biology
Wenjing Shi, Michael Riemann, Sophie-Marie Rieger, Peter Nick
Summary: CBF4 is an important transcriptional activator in plant responses to low temperature. In this study, the functions of CBF4 from grapevine were explored. Overexpression of VvCBF4 in tobacco BY-2 cells conferred cold tolerance and the protein shuttled from the cytoplasm to the nucleus in response to cold stress. The regulation of CBF4 differed between chilling and freezing and was regulated by upstream signalling involving oxidative burst, proteasome activity and jasmonate synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Wenji Li, Suping Gao, Ting Lei, Liqiong Jiang, Yifan Duan, Zian Zhao, Jiani Li, Lisha Shi, Lijuan Yang
Summary: This study identified the key transcription factor PaDREB1A involved in the response to cold stress in the tropical plant Plumbago auriculata. Overexpression of PaDREB1A enhanced freezing resistance and protected the photosynthetic system under cold stress. This research provides important insights into the cold tolerance mechanisms of tropical plants and can serve as a reference for introducing tropical plants to low-temperature regions.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Delight Hwarari, Yuanlin Guan, Baseer Ahmad, Ali Movahedi, Tian Min, Zhaodong Hao, Ye Lu, Jinhui Chen, Liming Yang
Summary: Plants have evolved complex mechanisms to adapt to cold stress, regulated by the ICE-CBF-COR signaling pathway. This pathway regulates the expression of transcription factors and proteins, enhancing cold stress tolerance in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Jianing Song, Rui Lin, Mingjia Tang, Lingyu Wang, Pengxiang Fan, Xiaojian Xia, Jingquan Yu, Yanhong Zhou
Summary: In this study, it was found that the BBX transcription factor, SlBBX17, positively regulates cold tolerance in tomato plants by interacting with SlHY5 and SlMPK1/2, thus increasing the transcriptional activity of SlCBF genes. These findings provide insights into the molecular mechanisms of how plants respond to cold stress through multiple transcription factors.
Article
Agronomy
Wenqing Yu, Xiaoxue Jia, Lin Shen, Jiping Sheng
Summary: This study investigated the effect of inhibiting ethylene perception on fruit quality and cold responses of stored tomato fruit using Nr and WT tomato fruit as inhibited- and normal-ethylene perception models. The results showed that inhibiting ethylene perception deteriorated fruit quality and aggravated cell membrane damage during cold storage. Additionally, the study found changes in endogenous hormones and gene expression in Nr fruit compared to WT fruit. These findings highlight the crucial role of ethylene perception in maintaining fruit quality during cold storage.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Review
Plant Sciences
Yiwei Cao, Delight Hwarari, Yasmina Radani, Yuanlin Guan, Liming Yang
Summary: Low temperature stress is a key factor that limits plant growth and distribution. Plants have evolved cold acclimation strategies to adapt to low temperature. Current studies show that annual herbaceous and perennial woody plants share similar mechanisms of cold acclimation. However, woody perennials also need extra resilience to survive cold winters. This review systematically describes how woody plants perceive and respond to cold stress, including physiological changes, gene expression, epigenetic modification, and the role of endogenous phytohormones.
PHYTON-INTERNATIONAL JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Xing Han, Fei Yao, Ting-ting Xue, Zhi-lei Wang, Ying Wang, Xiao Cao, Miao Hui, Dong Wu, Yi-han Li, Hua Wang, Hua Li
Summary: The application of Biodegradable Liquid Film (BLF) reduces the semi-lethal temperatures and mortality rates of wine grapes in cold environments. BLF treatment increases the levels of soluble protein and soluble sugar, while decreasing the content of superoxide anion and malondialdehyde. The study also found that BLF treatment upregulates the expression levels of certain genes related to freezing tolerance.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Pingping Fang, Yu Wang, Mengqi Wang, Feng Wang, Cheng Chi, Yanhong Zhou, Jie Zhou, Kai Shi, Xiaojian Xia, Christine Helen Foyer, Jingquan Yu
Summary: This study reveals that the crosstalk between BZR1 and reactive oxygen species mediates cold- and BR-activated CBF expression, leading to enhanced cold tolerance in tomato.
Article
Plant Sciences
Bohao Geng, Qi Wang, Risheng Huang, Yajie Liu, Zhenfei Guo, Shaoyun Lu
Summary: The study identified a cold tolerance gene MtCTLK1 in Medicago truncatula and demonstrated its role in regulating cold tolerance through the CBF pathway, antioxidant defense system, and proline accumulation. This provides a valuable gene for molecular breeding programs aiming to improve cold tolerance in crops.
Article
Biochemistry & Molecular Biology
J. Silva-Navas, N. Salvador, J. C. del Pozo, C. Benito, F. J. Gallego
Summary: The ScSTOP1 gene from rye enhances plants' tolerance to aluminum and low pH stress, possibly through activating ScALMT1.
Review
Cell Biology
Giovanni Caccialupi, Justyna Milc, Federica Caradonia, Muhammad Fazail Nasar, Enrico Francia
Summary: The crucial role of CBF/DREB1 transcription factors in Triticeae crops' response to abiotic stress is emphasized. The ICE-CBF-COR pathway, in which CBFs play a significant role, is a key mechanism for activating the adaptive response to cold and drought in wheat, barley, and rye. Understanding the mechanisms and regulation of the CBF gene cluster on homoeologous chromosome group 5 has great potential for genetic improvement of small grain cereals. Triticeae crops share common mechanisms but also have some unique aspects in their response to stress, including single-nucleotide variants and copy number variations involving CBF members of subgroup IV. Furthermore, the involvement of the ICE factor may explain the greater tolerance of rye. By unraveling the genetic basis of abiotic stress tolerance, researchers can develop resilient varieties that can better withstand extreme environmental conditions. Therefore, advancing our understanding of CBFs and their interactions holds promise for improving crop resilience and ensuring food security.
Review
Plant Sciences
Lekshmi S. Manasa, Madhusmita Panigrahy, Kishore C. S. Panigrahi, Gyana R. Rout
Summary: Cold stress has significant impacts on plant physiology, growth and productivity, with signals recognized by receptors on cell membrane and transduced by cold responsive genes, calcium and transcription factors. The response mechanisms are closely related to factors like light and temperature.
Article
Plant Sciences
Changwei Ge, Li Wang, Yongfei Yang, Ruihua Liu, Shaodong Liu, Jing Chen, Qian Shen, Huijuan Ma, Li Yang, Siping Zhang, Chaoyou Pang
Summary: GhSAD1 regulates cold stress responses in cotton by modulating the activity of C-repeat binding factors, regulating COLD-REGULATED genes and ABA signaling. Overexpression of GhSAD1 increases cold tolerance and ABA content, while silencing of GhSAD1 decreases ABA content. GhSAD1 also induces the expression of COLD-REGULATED genes and increases metabolites associated with cold stress tolerance. These findings contribute to our understanding of the molecular mechanisms underlying cold stress responses in cotton mediated by GhSAD1.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Xiaohan Yang, Yunchen Luo, Huiru Bai, Xin Li, Si Tang, Xiaoqin Liao, Lei Zhang, Qinglin Liu
Summary: In this study, a cold-induced MYB transcription factor, DgMYB2, was found to enhance cold tolerance in chrysanthemum by increasing the activity of glutathione peroxidase and reducing reactive oxygen species accumulation.
HORTICULTURE RESEARCH
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.