Journal
FUTURE ONCOLOGY
Volume 15, Issue 14, Pages 1577-1591Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fon-2018-0575
Keywords
3 '-UTR; cervical carcinoma; epithelial-to-mesenchymal transition; invasion; metastasis; miR-526b; miRNA-526; PBX3; proliferation; tumor metastasis
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Funding
- Key Research and Development Plan of Gansu Province [17YF1FA141]
- Gansu Key Laboratory of Gynecologic Oncology
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Aim: Research on novel mutant genes may develop the treatment of cervical cancer (CC). The role of miRNA-526b in epithelial-mesenchymal transition (EMT) of CC was investigated. Methods: The role and the molecular mechanism of miRNA-526b in CC and its effect on EMT were analyzed in clinical specimens and oncology experiments. Results: miRNA-526b was proved to be decreased in CC and associated with malignant clinicopathological characters. The character of miRNA-526b in EMT was also inspected in CC cells and tumor models. miRNA-526b was found to be able to inhibit the EMT property of CC cells by directly targeting PBX3. Conclusion: miRNA-526b restoration may be deliberated as a new treatment strategy of CC.
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