Developing RNA aptamers for potential treatment of neurological diseases

Aptamers: Uptake mechanisms and intracellular applications

(2018) Sorah Yoon et al.   ADVANCED DRUG DELIVERY REVIEWS

DNA-Encoded Chemical Libraries: A Selection System Based on Endowing Organic Compounds with Amplifiable Information

(2018) Dario Neri et al.   Annual Review of Biochemistry

Tapping the RNA world for therapeutics

(2018) Judy Lieberman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tapping the RNA world for therapeutics

(2018) Judy Lieberman   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of oligonucleotide aptamers targeting the 5′-UTR from dengue virus

(2017) Elismar JN Cnossen et al.   Future Medicinal Chemistry

Identification and characterization of RNA aptamers: A long aptamer blocks the AMPA receptor and a short aptamer blocks both AMPA and kainate receptors

(2017) William J. Jaremko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aptamers provide superior stainings of cellular receptors studied under super-resolution microscopy

(2017) Maria Angela Gomes de Castro et al.   PLoS One

The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer

(2016) Jennifer L. Hsu et al.   CANCER AND METASTASIS REVIEWS

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor

(2016) Alem W Kahsai et al.   Nature Chemical Biology

Small molecules, big targets: drug discovery faces the protein–protein interaction challenge

(2016) Duncan E. Scott et al.   NATURE REVIEWS DRUG DISCOVERY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Atomic-level analysis of membrane-protein structure

(2016) Wayne A Hendrickson   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic-level analysis of membrane-protein structure

(2016) Wayne A Hendrickson   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Chemical Space Project

(2015) Jean-Louis Reymond   ACCOUNTS OF CHEMICAL RESEARCH

Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like disorder caused by loss-of-function mutations in LRBA

(2015) Louis-Marie Charbonnier et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Two decades of new drug development for central nervous system disorders

(2015) Aaron S. Kesselheim et al.   NATURE REVIEWS DRUG DISCOVERY

Aptamer Selection Technology and Recent Advances

(2015) Michael Blind et al.   Molecular Therapy-Nucleic Acids

A Mass Spectrometric-Derived Cell Surface Protein Atlas

(2015) Damaris Bausch-Fluck et al.   PLoS One

DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

(2014) Raphael M. Franzini et al.   ACCOUNTS OF CHEMICAL RESEARCH

Aging-related dysregulation of dopamine and angiotensin receptor interaction

(2014) Begoña Villar-Cheda et al.   NEUROBIOLOGY OF AGING

Improving and Accelerating Drug Development for Nervous System Disorders

(2014) Diana E. Pankevich et al.   NEURON

Preclinical pharmacology of perampanel, a selective non-competitive AMPA receptor antagonist

(2013) M. A. Rogawski et al.   ACTA NEUROLOGICA SCANDINAVICA

Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?

(2013) Jörg Kreuter   ADVANCED DRUG DELIVERY REVIEWS

Personalized medicine using DNA biomarkers: a review

(2012) Andreas Ziegler et al.   HUMAN GENETICS

Enumeration of 166 Billion Organic Small Molecules in the Chemical Universe Database GDB-17

(2012) Lars Ruddigkeit et al.   Journal of Chemical Information and Modeling

Aptamer That Binds to the gD Protein of Herpes Simplex Virus 1 and Efficiently Inhibits Viral Entry

(2012) S. C. B. Gopinath et al.   JOURNAL OF VIROLOGY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Structure-based druggability assessment—identifying suitable targets for small molecule therapeutics

(2011) Eric B Fauman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

What makes a good drug target?

(2011) Isabella Gashaw et al.   DRUG DISCOVERY TODAY

Potent and Selective Inhibition of a Single α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit by an RNA Aptamer

(2011) Jae-Seon Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent and Selective Inhibition of the Open-Channel Conformation of AMPA Receptors by an RNA Aptamer

(2010) Zhen Huang et al.   BIOCHEMISTRY

DNA-Encoded Chemical Libraries: A Tool for Drug Discovery and for Chemical Biology

(2010) Jörg Scheuermann et al.   CHEMBIOCHEM

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms

(2010) Erik Wallin et al.   PROTEIN SCIENCE

High-throughput crystallography for structural genomics☆

(2009) Andrzej Joachimiak   CURRENT OPINION IN STRUCTURAL BIOLOGY

One RNA aptamer sequence, two structures: a collaborating pair that inhibits AMPA receptors

(2009) Zhen Huang et al.   NUCLEIC ACIDS RESEARCH

Application of Combinatorial Chemistry Science on Modern Drug Discovery

(2008) J. Phillip Kennedy et al.   JOURNAL OF COMBINATORIAL CHEMISTRY

Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving

(2008) Kelly L. Conrad et al.   NATURE

Glutamate Receptor Expression in Multiple Sclerosis Lesions

(2007) Jia Newcombe et al.   BRAIN PATHOLOGY