Discovery of novel anti-influenza agents via contemporary medicinal chemistry strategies (2014–2018 update)

Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses

(2018) Xin Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prodrugs of the Phosphoribosylated Forms of Hydroxypyrazinecarboxamide Pseudobase T-705 and Its De-Fluoro Analogue T-1105 as Potent Influenza Virus Inhibitors

(2018) Johanna Huchting et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant

(2018) Jian Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

From naproxen repurposing to naproxen analogues and their antiviral activity against Influenza A virus.

(2018) Sébastien Dilly et al.   JOURNAL OF MEDICINAL CHEMISTRY

Boronic Acid Modifications Enhance the Anti-Influenza A Virus Activities of Novel Quindoline Derivatives

(2017) Wei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion

(2017) Rosana Leiva et al.   JOURNAL OF MEDICINAL CHEMISTRY

4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA–PB1 Protein–Protein Interaction: Structure–Activity Relationships Exploration with the Aid of Molecular Modeling

(2016) Iuni M. L. Trist et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues

(2016) Guangyi Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

(2016) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

(2016) Fang Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Tetravalent Zanamivir with Potent Inhibitory Activity against Drug-Resistant Influenza Viruses

(2016) Lifeng Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peramivir Phosphonate Derivatives as Influenza Neuraminidase Inhibitors

(2016) Peng-Cheng Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

(2015) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Novel Potent Orally Bioavailable Oseltamivir Derivatives Active against Resistant Influenza A

(2014) Dennis Schade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oseltamivir Analogues Bearing N-Substituted Guanidines as Potent Neuraminidase Inhibitors

(2014) Caitlin A. Mooney et al.   JOURNAL OF MEDICINAL CHEMISTRY

Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus

(2014) Matias Rey-Carrizo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Pentacyclic Triterpenoids as Potential Entry Inhibitors of Influenza Viruses

(2014) Maorong Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phenyl Substituted 4-Hydroxypyridazin-3(2H)-ones and 5-Hydroxypyrimidin-4(3H)-ones: Inhibitors of Influenza A Endonuclease

(2014) Hye Yeon Sagong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

(2014) Michael P. Clark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Aminoadamantanes with Persistent in Vitro Efficacy against H1N1 (2009) Influenza A

(2014) Antonios Kolocouris et al.   JOURNAL OF MEDICINAL CHEMISTRY