Article
Endocrinology & Metabolism
Xiaoqing Li, Xiaomin Xu, Wenhuan Wang, Congcong Sun, Hai Wang, Jiayong Zheng
Summary: This study aimed to investigate the mechanism of lymphocyte immunotherapy (LIT) in the treatment of unexplained recurrent spontaneous abortion (URSA). The results showed that the proportion of Th1 cells increased significantly after LIT and the Th1/Th2 balance decreased significantly. Additionally, the proportion of Th1 and Th2 cells was significantly higher in patients with successful pregnancies, while the Th17/Treg balance decreased in successful pregnancy after LIT.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Immunology
Sudong Liu, Xiaodong Gu, Ruiqiang Weng
Summary: The study found that Lymphocyte immunotherapy (LIT) treatment is effective for patients with unexplained recurrent spontaneous abortion (URSA), significantly improving pregnancy and live birth rates. Younger maternal age and positive blocking antibody (BA) were identified as independent predictors of LIT success.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Biochemical Research Methods
Lei Zhang, Qian Li, Yan Su, Xinyuan Zhang, Jialin Qu, Dan Liao, Qin Zou, Hua Zou, Xiaoli Liu, Chunli Li, Junlin He
Summary: This study aimed to reveal the pathogenesis of unexplained recurrent spontaneous abortion (URSA) by analyzing differential protein expression profiles in decidual tissue. The findings highlighted the potential role of cytoskeletal remodeling disorder in the failure of decidualization and provided valuable information for further research and potential therapeutic interventions.
JOURNAL OF PROTEOMICS
(2023)
Article
Environmental Sciences
Min Nian, Xiaona Huo, Jiangtao Zhang, Yuchan Mao, Fan Jin, Yuhua Shi, Jun Zhang
Summary: Emerging PFAS alternatives may be an important risk factor for URSA. Exposure to 6:2 Cl-PFESA and HFPO-DA is significantly associated with increased risks of URSA. The association between PFAS and URSA is stronger in women with older age.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Immunology
Marcelo Borges Cavalcante, Pedro Henrique Alcantara da Silva, Olga Goiana Martins Sampaio, Fernanda Eunice Araujo Camara, Candice Torres de Melo Bezerra Cavalcante, Ricardo Barini
Summary: This study investigated the efficacy of immunotherapies in treating patients with recurrent miscarriages and evaluated the quality of systematic reviews and meta-analyses. It was found that the quality of systematic reviews on intravenous immunoglobulin, lymphocyte immunotherapy, lipid emulsion therapy, and corticosteroids as treatments for recurrent miscarriages has improved.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Minyue Tang, Qingfang Li, Shan Wan, Qingqing Chen, Shujun Feng, Jiali You, Wei Wang, Yimin Zhu
Summary: This study identified distinct mRNA and lncRNA expression profiles in URSA placental villus through ceRNA microarray. A co-dysregulated ceRNA network was constructed and validated key genes involved in URSA, suggesting potential therapeutic targets.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Xiaofeng Xu, Jing Wang, Damin Zhu, Jiaqian Yin, Jinxian Liu, Xiao Wu, Wenjuan Yang, Qian Hu, Yu Ren, Zhiguo Zhang, Ping Zhou, Zhaolian Wei, Huijuan Zou, Yunxia Cao
Summary: This study found that the levels of HMGB1 were significantly higher in URSA patients, and low-dose aspirin can decrease the concentrations of HMGB1 and IFN-γ, providing a protective effect.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Lin Zhao, Li Han, Guozhen Hei, Ran Wei, Zhen Zhang, Xiaoxiao Zhu, Qiang Guo, Chu Chu, Xiaoxiao Fu, Ke Xu, Xia Li
Summary: Unexplained recurrent spontaneous abortion (URSA) is a common condition that significantly affects women's reproductive health. This study demonstrates that downregulated miR-374c-5p is involved in the pathogenesis of URSA by enhancing IL-6 expression, suggesting that modulation of miR-374c-5p expression may be a potential therapeutic target for URSA.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Immunology
Heng Gu, Longyu Li, Mengxuan Du, Hang Xu, Mengge Gao, Xiaohua Liu, Xiangcai Wei, Xingming Zhong
Summary: This study investigated the differential expression of immunoregulatory genes in unexplained recurrent spontaneous abortion (URSA), identifying specific genes associated with immune cell functions and pathways related to URSA. The findings suggest a potential link between abnormal expression of immunoregulatory genes and URSA, with IFNG playing a key role in regulating maternal immune response. Further research is needed to validate these results and provide insights into the pathogenesis of recurrent spontaneous abortion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Alla Arefieva, Marina Nikolaeva, Elena Stepanova, Lubov Krechetova, Elena Golubeva, Nana Tetruashvili, Gennady Sukhikh
Summary: The study found that the intensity of CD200 expression and the Th1/Th2 cytokine ratios after LIT were significant predictors of pregnancy establishment. Elevated CD200 expression on allogeneic lymphocytes is likely to suppress the pro-inflammatory Th1-type immunity needed for successful embryo implantation.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Immunology
Hong-xia Ye, Guang-neng Liao, Ya-jun Dong, Lan Li, Xue-mei Wang, Jin Shu, Qu Zheng, Yan Jia
Summary: The down-regulation of miR-146a-5p in decidual macrophages is associated with M1/M2 polarization disorder in URSA. miR-146a-5p inhibits M1 polarization, promotes M2 polarization, and generates an anti-inflammatory microenvironment in vitro. In a murine model of URSA, intravenous injection of miR-146a-5p reduces embryo resorption rate and promotes M2 polarization of decidual macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Developmental Biology
Shuyun Zhang, Yi Xiao, Yunjie Wang, Chenyue Qian, Rong Zhang, Juanjuan Liu, Qin Wang, Hong Zhang
Summary: This study aimed to investigate the role of kisspeptin in uterine decidualization during recurrent spontaneous abortion (RSA) and its underlying mechanism. The study found that kisspeptin is involved in promoting uterine decidualization through the ERK1/2 signaling pathway.
Article
Immunology
Ming-Ming Li, Jie Lin, Hai-Fan Wu, Guo-Jun Zheng, Ruo-Nan Cai
Summary: The risk factors for URSA include the number of SAs, levels of autoantibodies and TNF-alpha, and the MTHFR C677T T allele; while 25-(OH)D is a protective factor. Women diagnosed with URSA should receive early intervention to actively reduce the occurrence of recurrent SA.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Meilan Liu, Dongyan Wang, Liqiong Zhu, Jianlan Yin, Xiaohui Ji, Yilei Zhong, Yuan Gao, Jianping Zhang, Yukun Liu, Rui Zhang, Hui Chen
Summary: Thyroid peroxidase antibodies are associated with the first trimester miscarriage rate in euthyroid women with unexplained recurrent spontaneous abortion.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Yizhi Peng, Sheng Yin, Min Wang
Summary: The study found that the level of IL-6 in the peripheral blood of the ad-pregnancy group was significantly higher than in the other two groups, and the ratio of IFN-gamma/IL-4 in the URSA group was significantly higher than that of the pregnancy group. The IFN-gamma/IL-4 ratio had high diagnostic efficiency with a sensitivity of 84.09%.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)