Article
Biotechnology & Applied Microbiology
Min Li, Yanqin Xu, Jie Liang, Hao Lin, Xinyue Qi, Fanlin Li, Ping Han, Yanfeng Gao, Xuanming Yang
Summary: The study utilized CRISPR-Cas9 technology to screen melanoma cells, revealing that deletion or overexpression of specific genes can affect cell sensitivity to T cell-mediated killing. USP22 may regulate tumor cell escape ability through the interferon pathway. This research uncovers a novel immune evasion mechanism.
Article
Plant Sciences
Manman Guo, Zhongda Wang, Jinya Dai, Haizhen Fan, Ningning Yuan, Liming Gao, Huiping Peng, Xiaolan Cheng
Summary: This study found that glycyrrhizic acid (GA) attenuated liver fibrosis by promoting CUGBP1-mediated IFN-gamma/STAT1/Smad7 signaling pathway, thereby reducing liver damage. GA may be a potential candidate compound for preventing or relieving liver fibrosis.
Article
Cell Biology
Shuang Shang, Yu-wei Yang, Fei Chen, Liang Yu, Shuo-hao Shen, Ke Li, Bing Cui, Xiao-Xi Lv, Cheng Zhang, Chen Yang, Jing Liu, Jiao-jiao Yu, Xiao-wei Zhang, Ping-ping Li, Sheng-tao Zhu, Hai-zeng Zhang, Fang Hua
Summary: TRIB3 inhibits CD8(+) T cell infiltration in colorectal cancer by inhibiting STAT1 activation and reducing tumor-infiltrating T cells. Acetyltransferase P300 acetylates TRIB3 and prevents its ubiquitination and degradation. Genetic ablation of TRIB3 or pharmacological acceleration of TRIB3 degradation with a P300 inhibitor increases T cell recruitment and sensitizes colorectal cancers to immune checkpoint blockade therapy.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zhou Huang, Hejun Liu, Jay Nix, Rui Xu, Catherine R. Knoverek, Gregory R. Bowman, Gaya K. Amarasinghe, L. David Sibley
Summary: The study revealed that the protein TgIST from Toxoplasma gondii blocks interferon-induced gene expression by binding to the STAT1 dimer interface, thus inhibiting the expression of immunity genes.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Fanghua Ye, Wen Zhang, Jiajia Dong, Min Peng, Chenying Fan, Wenjun Deng, Hui Zhang, Liangchun Yang
Summary: This study identified a novel genetic cause of MSMD, a rare immune deficiency, which is a loss-of-function mutation in the STAT1 gene. Functional assays confirmed that the mutation leads to impaired response to IFN-gamma and compromised mycobacterial immunity, resulting in the development of MSMD.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Neurosciences
Yuta Morisaki, Motoki Ohshima, Hikaru Suzuki, Hidemi Misawa
Summary: This study found that LAG-3 expression in microglia is induced by the IFN-gamma-STAT1 pathway, and the production of soluble LAG-3 is regulated by cleavage by metalloproteinases.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Hitoshi Murata, Yu Yasui, Kazuma Oiso, Toshiki Ochi, Nahoko Tomonobu, Ken-ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi
Summary: NAD(+) biosynthetic and consuming enzymes play a role in various intracellular events. Alterations in their expression contribute to axonal stability of neurons. Interferon-gamma increases the expression of NMNAT2, while suppressing SARM1 phosphorylation, leading to protection against axonal degeneration and cell death.
CELLULAR SIGNALLING
(2023)
Article
Cardiac & Cardiovascular Systems
Jiajia Jin, Liaomei Gao, Xiuli Zou, Yun Zhang, Zhijian Zheng, Xinjie Zhang, Jiaxuan Li, Zhenyu Tian, Xiaowei Wang, Junfei Gu, Cheng Zhang, Tiejun Wu, Zhe Wang, Qunye Zhan
Summary: The study revealed gut microbiota dysbiosis in preeclamptic patients, with reductions in specific bacteria and short-chain fatty acids. Experiments on preeclamptic rats showed that gut microbiota from healthy pregnant women had protective effects, while specific microbes and metabolites could alleviate preeclampsia symptoms.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Zhenxing Liu, Mi Zhou, Chao Yuan, Zhengyi Ni, Wenqiang Liu, Yang Tan, Dazhi Zhang, Xiaopei Zhou, Tingting Zou, Jiarui Wang, Meiqi Hou, Xuejie Peng, Xianqin Zhang
Summary: This study investigated the pathogenic genes and molecular mechanisms of Mendelian susceptibility to mycobacterial disease (MSMD) patients. Two novel mutations in the STAT1 gene were identified, which affected the binding ability of STAT1 protein to target DNA and the translocation of STAT1 protein into the nucleus, leading to the occurrence of MSMD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Immunology
Yoko Mizoguchi, Satoshi Okada
Summary: STAT1 is a crucial transcription factor activated by various stimuli, and mutations in human STAT1 immunity can lead to different disorders. The distinct clinical manifestations of each type of STAT1 deficiency highlight the diverse roles of STAT1 in host immune systems.
CURRENT OPINION IN IMMUNOLOGY
(2021)
Article
Cell Biology
Giuseppina Raspaglio, Marianna Buttarelli, Flavia Filippetti, Alessandra Battaglia, Alexia Buzzonetti, Giovanni Scambia, Daniela Gallo
Summary: Cervical cancer is a common cause of cancer-related death in women, with treatments for locally advanced cancer remaining a challenge. Studies suggest that STAT1 may have a radiosensitizing effect on PARP1 levels, potentially improving the efficacy of chemoradiation therapy.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Carlos S. Subauste
Summary: Toxoplasma gondii is an intracellular protozoan that can cause encephalitis and retinitis in humans, depending on its ability to form a parasitophorous vacuole for protection and replication. The vacuole can be targeted by autophagy, but the parasite has developed strategies to preserve its integrity. Recent advances have highlighted the importance of autophagy in regulating invasion into the brain and retina by T. gondii, with potential therapeutic applications being explored.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Qi Li, Simeng Wei, Yue Li, Fengjiao Wu, Xiaoling Qin, Zhongsha Li, Jingyu Li, Chang Chen
Summary: Blocking of PD-L1 promotes CD8+IFN-gamma+ T cell-mediated immune responses, exacerbating inflammation and increasing the burden of atherosclerosis under high-cholesterol diet. However, further studies are needed to explore whether PD-L1 activation could be a novel immunotherapy strategy for atherosclerosis.
INFLAMMATION RESEARCH
(2023)
Article
Medicine, Research & Experimental
Caisheng Lu, Huihui Ma, Liangsong Song, Hui Wang, Lily Wang, Shirong Li, Stephen M. Lagana, Antonia R. Sepulveda, Kasper Hoebe, Samuel S. Pan, Yong-Guang Yang, Suzanne Lentzsch, Markus Y. Mapara
Summary: The absence of IFN-gamma receptor or STAT1 signaling in donor cells reduces the risk of acute graft-versus-host disease (GVHD). However, this study unexpectedly found that IFN-gamma R/STAT1-deficient recipient mice experienced increased activation and expansion of donor lymphocytes, leading to rapid mortality after GVHD induction.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Andrii Slonchak, Xiaohui Wang, Julio Aguado, Julian D. J. Sng, Harman Chaggar, Morgan E. Freney, Kexin Yan, Francisco J. Torres, Alberto A. Amarilla, Rickyle Balea, Yin Xiang Setoh, Nias Peng, Daniel Watterson, Ernst Wolvetang, Andreas Suhrbier, Alexander A. Khromykh
Summary: sfRNA plays an important role in the transmission of Zika virus, facilitating the virus to pass through the placenta and infect the fetal brain. It also induces apoptosis of neural progenitor cells in human brain organoids. In infected human placental cells, sfRNA inhibits multiple antiviral pathways and promotes apoptosis, with STAT1 identified as a key factor. Phosphorylation and nuclear translocation of STAT1 are reduced due to sfRNA binding to and stabilizing viral protein NS5.