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Title
A patent update on PDK1 inhibitors (2015-present)
Authors
Keywords
-
Journal
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume -, Issue -, Pages 1-12
Publisher
Informa UK Limited
Online
2019-03-22
DOI
10.1080/13543776.2019.1597852
References
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Note: Only part of the references are listed.- The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1
- (2019) Xinyuan Xu et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
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- (2018) Chuan Xing Wu et al. Theranostics
- Design, synthesis, crystal structures and anticancer activity of 4-substituted quinolines to target PDK1
- (2018) K.N. Vennila et al. BIOORGANIC CHEMISTRY
- New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective
- (2018) Simona Sestito et al. Frontiers in Pharmacology
- Cancer stem cells revisited
- (2017) Eduard Batlle et al. NATURE MEDICINE
- Targeting PDK1 for Chemosensitization of Cancer Cells
- (2017) Aikaterini Emmanouilidi et al. Cancers
- Serine/Threonine Kinase 3-Phosphoinositide-Dependent Protein Kinase-1 (PDK1) as a Key Regulator of Cell Migration and Cancer Dissemination
- (2017) Laura Di Blasio et al. Cancers
- Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells
- (2016) Simona Daniele et al. ACS Chemical Neuroscience
- The PI3K/AKT Pathway as a Target for Cancer Treatment
- (2016) Ingrid A. Mayer et al. Annual Review of Medicine
- PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition
- (2016) Pau Castel et al. CANCER CELL
- Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma
- (2016) Simona Sestito et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Dual Kinase-Bromodomain Inhibitors in Anticancer Drug Discovery: A Structural and Pharmacological Perspective
- (2016) Luca Carlino et al. JOURNAL OF MEDICINAL CHEMISTRY
- PDK1–Akt pathway regulates radial neuronal migration and microtubules in the developing mouse neocortex
- (2016) Yasuhiro Itoh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
- (2016) Linda S. Steelman et al. Aging-US
- PDK1: A signaling hub for cell migration and tumor invasion
- (2015) Paolo Armando Gagliardi et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- PDK1 disruptors and modulators: a patent review
- (2015) Muhammad Jahangir Hossen et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- PDK1 regulates focal adhesion disassembly by modulating endocytosis of v 3 integrin
- (2015) L. di Blasio et al. JOURNAL OF CELL SCIENCE
- Endomembrane PtdIns(3,4,5)P3 activates the PI3K-Akt pathway
- (2015) N. Jethwa et al. JOURNAL OF CELL SCIENCE
- PDK1 promotes tumor growth and metastasis in a spontaneous breast cancer model
- (2015) J Du et al. ONCOGENE
- Allosteric small-molecule kinase inhibitors
- (2015) Peng Wu et al. PHARMACOLOGY & THERAPEUTICS
- MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
- (2015) Todd B. Sells et al. ACS Medicinal Chemistry Letters
- 3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner
- (2015) Paolo Armando Gagliardi et al. NEOPLASIA
- Acute regulation of PDK1 by a complex interplay of molecular switches
- (2014) Veronique Calleja et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Cancer stem cells - important players in tumor therapy resistance
- (2014) Selcuk Colak et al. FEBS Journal
- PDK1-mediated activation of MRCKα regulates directional cell migration and lamellipodia retraction
- (2014) Paolo Armando Gagliardi et al. JOURNAL OF CELL BIOLOGY
- Emerging role of the KRAS-PDK1 axis in pancreatic cancer
- (2014) Riccardo Ferro WORLD JOURNAL OF GASTROENTEROLOGY
- Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo
- (2014) M Signore et al. Cell Death & Disease
- PIF-Pocket as a Target for C. albicans Pkh Selective Inhibitors
- (2013) Daniel Pastor-Flores et al. ACS Chemical Biology
- Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
- (2013) Eeva M. Sommer et al. BIOCHEMICAL JOURNAL
- AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases
- (2013) José M. Arencibia et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Ins and Outs of Kinase DFG Motifs
- (2013) Daniel K. Treiber et al. CHEMISTRY & BIOLOGY
- RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer
- (2013) Violeta Serra et al. JOURNAL OF CLINICAL INVESTIGATION
- Selective 3-Phosphoinositide-Dependent Kinase 1 (PDK1) Inhibitors: Dissecting the Function and Pharmacology of PDK1
- (2013) Jesús R. Medina JOURNAL OF MEDICINAL CHEMISTRY
- Mutational landscape and significance across 12 major cancer types
- (2013) Cyriac Kandoth et al. NATURE
- Cancer stem cells and their role in metastasis
- (2013) Yusuke Shiozawa et al. PHARMACOLOGY & THERAPEUTICS
- Substrate-Selective Inhibition of Protein Kinase PDK1 by Small Compounds that Bind to the PIF-Pocket Allosteric Docking Site
- (2012) Katrien Busschots et al. CHEMISTRY & BIOLOGY
- Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1
- (2012) Florian Lang et al. FASEB JOURNAL
- A novel regulatory mechanism links PLCγ1 to PDK1
- (2012) Claudio Raimondi et al. JOURNAL OF CELL SCIENCE
- IgE and mast cells in allergic disease
- (2012) Stephen J Galli et al. NATURE MEDICINE
- Identification,in VitroActivity and Mode of Action of Phosphoinositide-Dependent-1 Kinase Inhibitors as Antifungal Molecules
- (2011) Bonnie K. Baxter et al. ACS Chemical Biology
- Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery
- (2011) Daniel A. Erlanson et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia
- (2011) S. Elf et al. BLOOD
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- (2011) J. D. Sadowsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Integrins in Cell Migration
- (2011) A. Huttenlocher et al. Cold Spring Harbor Perspectives in Biology
- Phosphoinositide-dependent Kinase PDK1 in the Regulation of Ca2+ Entry into Mast Cells
- (2010) Ekaterina Shumilina et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Genetic and Pharmacological Inhibition of PDK1 in Cancer Cells
- (2010) Kumiko Nagashima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Allosteric PIF-Pocket Ligands for PDK1 using NMR-Based Fragment Screening and1H-15N TROSY Experiments
- (2009) Brian J. Stockman et al. Chemical Biology & Drug Design
- 3,5-Diphenylpent-2-enoic Acids as Allosteric Activators of the Protein Kinase PDK1: Structure−Activity Relationships and Thermodynamic Characterization of Binding as Paradigms for PIF-Binding Pocket-Targeting Compounds†† PDB code of2Zwith PDK1: 3HRF.
- (2009) Adriana Stroba et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fibroblast Growth Factor Receptor 3 Associates with and Tyrosine Phosphorylates p90 RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation
- (2009) S. Kang et al. MOLECULAR AND CELLULAR BIOLOGY
- Caught in the activation
- (2009) Yi Liu NATURE
- The nuts and bolts of AGC protein kinases
- (2009) Laura R. Pearce et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Small-Molecule Inhibitors of PDK1
- (2008) Christian Peifer et al. ChemMedChem
- p53: A Guide to Apoptosis
- (2008) Erik Meulmeester et al. CURRENT CANCER DRUG TARGETS
- From Single- to Multi-Target Drugs in Cancer Therapy: When Aspecificity Becomes an Advantage
- (2008) S. Giordano et al. CURRENT MEDICINAL CHEMISTRY
- PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE
- (2008) Sophie Pinner et al. NATURE CELL BIOLOGY
- Drug discovery approaches targeting the PI3K/Akt pathway in cancer
- (2008) C Garcia-Echeverria et al. ONCOGENE
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