Review
Biochemistry & Molecular Biology
Andrea Lavorato, Stefania Raimondo, Marina Boido, Luisa Muratori, Giorgia Durante, Fabio Cofano, Francesca Vincitorio, Salvatore Petrone, Paolo Titolo, Fulvio Tartara, Alessandro Vercelli, Diego Garbossa
Summary: The study discusses the features and applications of different types of mesenchymal stem cells in peripheral nerve regeneration after nerve injury. ADSCs are considered the most suitable MSCs for recovery from peripheral nerve lesions due to their excellent support and stimulation of axonal growth, remarkable paracrine activity, differentiation potential, low immunogenicity, and high survival rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Julius M. Mayer, Christian Krug, Maximilian M. Saller, Annette Feuchtinger, Riccardo E. Giunta, Elias Volkmer, Thomas Holzbach
Summary: Recent research highlights the beneficial effects of hypoxia-preconditioned adipose-derived multipotent stem/progenitor cells (ADSPCs) in peripheral nerve regeneration. The study investigated the use of a custom-made fibrin conduit seeded with hypoxic pre-conditioned ADSPCs for autologous sciatic nerve graft in rats. Compared to other treatment modes, the hypoxic pre-conditioned group showed faster functional regeneration, increased axon outgrowth/branching and density, remyelination, and reduced connective tissue area. Further studies are needed to explore the cellular mechanism and potential clinical applications.
NEURAL REGENERATION RESEARCH
(2023)
Article
Engineering, Biomedical
Injoo Hwang, Eun Ju Lee, Hyomin Park, Dodam Moon, Jong Nam Park, Keun Cheon Kim, Areum Cha, Hyunji Yun, Jaewon Lee, Hwan-Woo Park, Mi-Sook Chang, Hyo-Soo Kim
Summary: The application of EDN1 in treating hMSC organotypic spinal cord slice cultures enhances neuronal outgrowth through whole-genome demethylation and euchromatin. APOBEC1 is identified as a key player in global demethylation and OCT4 gene activation induced by EDN1, suggesting a potential novel therapeutic target for improving hMSC regenerative capability.
Article
Medicine, General & Internal
Daisuke Maki, Tetsuro Tamaki, Tsuyoshi Fukuzawa, Toshiharu Natsume, Ippei Yamato, Yoshiyasu Uchiyama, Kosuke Saito, Kenji Okami
Summary: This study demonstrated the facilitation effect of peripheral nerve regeneration using a cytokine cocktail secreted by Sk-MSCs in a mouse model with sciatic nerve injury. The cytokine cocktail led to significantly higher tension output and numerical recovery of axon and myelinated fibers at the damaged site compared to the control group. Additionally, 17 candidate factors likely included in the cocktail were identified.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Young Jun Kim, Kyu Jin Kim, Jae Hoon Lee, Seong-Uk Park, Seung-Yeon Cho
Summary: Experimental studies using herbal extracts in a rat sciatic nerve injury model showed that Coptis japonica extract increased nerve conduction velocity, Aconitum carmichaelii extract increased proximal and distal amplitudes, while decreasing neuroma and scar tissue formation.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Review
Chemistry, Multidisciplinary
Faranak Mankavi, Rana Ibrahim, Hongjun Wang
Summary: This article summarizes the recent advances in nerve guidance conduits (NGCs) for peripheral nerve regeneration and repair, including biomaterial innovations, structural design, advanced fabrication technologies, and cellular responses to biomimetic cues.
Review
Cell & Tissue Engineering
Wen-Bo Xing, Shu-Ting Wu, Xin-Xin Wang, Fen-Yao Li, Ruo-Xuan Wang, Ji-Hui He, Jiao Fu, Yan He
Summary: Dental pulp stem cells (DPSCs) are adult pluripotent stem cells derived from the neuroectoderm, and they have significant potential in the field of neural tissue engineering. DPSCs have advantages such as easy isolation, multidifferentiation potential, low immunogenicity, and low transplant rejection rate, making them promising in the treatment of peripheral nerve injuries.
WORLD JOURNAL OF STEM CELLS
(2023)
Review
Cell & Tissue Engineering
Xiangling Li, Yanjun Guan, Chaochao Li, Tieyuan Zhang, Fanqi Meng, Jian Zhang, Junyang Li, Shengfeng Chen, Qi Wang, Yi Wang, Jiang Peng, Jinshu Tang
Summary: The article summarizes the interactions between MSCs, immune cells, and inflammatory cytokines following PNI, with a focus on the immunosuppressive role of MSCs. Additionally, the immunomodulatory potential of MSC-derived extracellular vesicles as a cell-free treatment for PNI is discussed.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Su-Long Wang, Xi-Lin Liu, Zhi-Chen Kang, Yue-Shu Wang
Summary: The effect of platelet-rich plasma on nerve regeneration in a rabbit model of sciatic nerve small-gap defects with preserved epineurium was investigated. Results showed that platelet-rich plasma with specific concentrations of whole blood platelets promoted repair of sciatic nerve injury. Proteomics analysis revealed that platelet-rich plasma affects angiogenesis and intracellular ubiquitin levels in the regeneration process.
NEURAL REGENERATION RESEARCH
(2023)
Article
Neurosciences
Jiaqing Wu, Yajun Zhang, Xiaoyuan Zhang, Zhiyu Lin, Guangxue Li
Summary: RPNI is an emerging method for neuroma prevention, which effectively prevents the formation of neuromas and improves the quality of life of amputees.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Binghui Jin, Yunru Yu, Xiangxiang Chen, Yanhong Yang, Yushan Xiong, Young Jun Im, Yuanjin Zhao, Jian Xiao
Summary: The study proposes a novel microtube for sciatic nerve regeneration using gradient decellularized porcine sciatic nerve extracellular matrix hydrogel (pDScNM-gel). The pDScNM is shown to enhance cell proliferation and migration, improve axon growth, and these effects can also be achieved through coculture in a gradient pDScNM microtube. In vivo sciatic nerve regeneration and functional recovery are demonstrated by assembling the gradient pDScNM microtubes with a medical silicon tube.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Arezou Zarepour, Ayca Bal Ozturk, Duygu Koyuncu Irmak, Gokcen Yasayan, Aylin Gokmen, Erdal Karaoz, Atefeh Zarepour, Ali Zarrabi, Ebrahim Mostafavi
Summary: Spinal cord injury (SCI) has a significant impact on patients' quality of life and is known as one of the most challenging diseases in the world. Different therapeutic strategies, including the use of stem cells and nanomaterials, show promising potential for SCI treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Cell Biology
Sara Saffari, Tiam M. Saffari, Dietmar J. O. Ulrich, Steven E. R. Hovius, Alexander Y. Shin
Summary: The microenvironment at the site of injury plays a crucial role in altering the degree of nerve regeneration after peripheral nerve injury. Stem cells and vascularity are proposed to be important factors in enhancing peripheral nerve regeneration, with stem cells secreting various angiogenic factors and regulating angiogenesis to promote nerve regeneration and vascular expansion.
NEURAL REGENERATION RESEARCH
(2021)
Review
Endocrinology & Metabolism
Molly Monsour, Cesar Borlongan
Summary: Stroke pathology and treatments usually focus on the brain, but inflammation in peripheral organs also plays a significant role. This review discusses the robust inflammatory response in peripheral organs to stroke and innovative stroke therapies that target peripheral inflammation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
Yajuan Wu, Xuejia Liu, Yu Han, Luxi Li, Mingjiang Jian, Guangfeng Sun, Jing Nie
Summary: The study demonstrates that peripheral blood mononuclear cells (PBMCs) can promote nerve regeneration and functional recovery in rats with sciatic nerve injury. Proteomics analysis reveals that PBMCs regulate pathways involved in complement and coagulation cascade, notch signaling, and other metabolic processes, contributing to the improvement of nerve injury treatment.
Article
Otorhinolaryngology
Alia Saberi, Seyed Hashem Pourshafie, Ehsan Kazemnejad-Leili, Shadman Nemati, Sara Sutohian, Sara Sayad-Fathi
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Mehrdad Moosazadeh Moghaddam, Shahin Bonakdar, Mohammad Ali Shokrgozar, Arash Zaminy, Hojatollah Vali, Shahab Faghihi
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Article
Anatomy & Morphology
Zohreh Jahromi, Fahimeh Mohammadghasemi, Farshad Moharrami Kasmaie, Arash Zaminy
CELLS TISSUES ORGANS
(2020)
Article
Anatomy & Morphology
Mohammad Hadi Bahadori, Zoleikha Azari, Arash Zaminy, Sara Dabirian, Seyed Mojtaba Mehrdad, Bahman Jalali Kondori
Summary: This study evaluated the effect of hull-less pumpkin seed extract on the proliferation of papillary thyroid carcinoma (PTC) cells. The results showed that the extract had a significant impact on PTC cells in laboratory conditions, indicating a potential for treatment. However, further molecular investigations are needed to confirm its effectiveness.
ANATOMY & CELL BIOLOGY
(2021)
Article
Engineering, Biomedical
Farshad Moharrami Kasmaie, Fatemeh Zamani, Sara Sayad-Fathi, Arash Zaminy
Summary: This study designed and developed PLGA-PCL aligned nanofibers, which were implanted into a rat model of nerve injury, showing acceptable improvement after eight weeks.
PROGRESS IN BIOMATERIALS
(2021)
Article
Cell Biology
Arash Zaminy, Sara Sayad-Fathi, Farshad Moharrami Kasmaie, Zohreh Jahromi, Adib Zendedel
Summary: The study showed that decellularized bovine-derived nerves using the modified Hudson's protocol could be effective in repairing rat sciatic nerve injury, with similar outcomes to nerve allograft transplantation, indicating the potential of this method in peripheral nerve injury repair.
NEURAL REGENERATION RESEARCH
(2021)
Article
Biology
Sara Sayad-Fathi, Arash Zaminy, Parvin Babaei, Fatemeh Yousefbeyk, Nasib Eh Azizi, Ebrahim Nasiri
Article
Anatomy & Morphology
Fatemeh Niknezhad, Sara Sayad-Fathi, Arezoo Karimzadeh, Marjan Ghorbani-Anarkooli, Fatemeh Yousefbeyk, Ebrahim Nasiri
ANATOMY & CELL BIOLOGY
(2019)
Article
Biology
Farshad Moharrami Kasmaie, Zohreh Jahromi, Rouhollah Gazor, Arash Zaminy