Article
Surgery
Carter J. Boyd, Ara A. Salibian, Jonathan M. Bekisz, Deborah M. Axelrod, Amber A. Guth, Richard L. Shapiro, Freya R. Schnabel, Nolan S. Karp, Mihye Choi
Summary: This study analyzed the breast cancer recurrence in patients who underwent therapeutic nipple-sparing mastectomy with a median follow-up of 10 years. The results showed low overall recurrence rates, but close surveillance is still necessary to promptly identify potential recurrence.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Urology & Nephrology
Steven C. Campbell, Peter E. Clark, Sam S. Chang, Jose A. Karam, Lesley Souter, Robert G. Uzzo
Summary: Significant progress has been made in the evaluation and management of clinically-localized renal masses. These guidelines offer updated, evidence-based recommendations on evaluation and counseling, highlighting the evolving role of renal-mass-biopsy (RMB).
JOURNAL OF UROLOGY
(2021)
Article
Mathematics
Alvaro Bevia-Romero, Francisco Quereda-Flores, Javier Diaz-Carnicero, Francisco Gomez-Palomo, Maria Ramos-Cebrian, Joaquin Espinosa-Vano, Dario J. Castillo-Anton, Enrique Broseta-Rico, David Vivas-Consuelo, Alberto Budia-Alba
Summary: The aim of this study was to analyze the survival of recipients and grafts after kidney transplant over a three-year period and to identify predictive factors over a follow-up of up to 10 years. In a retrospective consecutive cohort study of 250 kidney transplant recipients between 2010 and 2012, it was found that the mean follow-up was 8.1 +/- 3.2 years. Graft survival rates at 2, 5, and 10 years were 89.0%, 85.1%, and 78.4% respectively. Risk factors for graft loss included diabetic nephropathy, delayed graft function, chronic kidney rejection, and early surgical complications, while combined transplant was a protective factor. The recipient patient survival rates at 2, 5, and 10 years were 94.3%, 90.0%, and 76.6% respectively. Mortality risk factors included older recipient age, combined transplant, and opportunistic infections.
Article
Surgery
Yukinori Kurokawa, Yuichiro Doki, Junki Mizusawa, Takaki Yoshikawa, Takanobu Yamada, Yutaka Kimura, Shuji Takiguchi, Yasunori Nishida, Norimasa Fukushima, Haruhiko Cho, Masahide Kaji, Motohiro Hirao, Mitsuru Sasako, Masanori Terashima
Summary: This study aims to compare the efficacy and safety of bursectomy and omentectomy alone in gastric cancer surgery. The results showed that bursectomy did not improve the overall survival rate of patients with gastric cancer, and it also increased the risk of intra-abdominal infection.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Nutrition & Dietetics
Jun-Qi Zhao, Qi-Peng Ma, Yi-Fan Wei, Gang Zheng, Bing-Jie Zou, Zong-Da Du, Song Gao, Shi Yan, Xue Qin, Ting-Ting Gong, Yu-Hong Zhao, Qi-Jun Wu
Summary: This study evaluated the associations between nutrients-rich food (NRF) index scores and overall survival (OS) in ovarian cancer (OC) patients. The results showed that higher NRF index scores were correlated with improved OS, with a linear trend. Interestingly, a non-linear association was also observed between NRF6.3 index score and OC survival. This study is important as it reveals the impact of diet quality on the survival of OC patients.
Article
Oncology
So-Youn Jung, Young Ae Kim, Dong-Eun Lee, Jungnam Joo, Joung Hwan Back, Sun-Young Kong, Eun Sook Lee
Summary: This study in Korea evaluated follow-up imaging after breast cancer surgery and found that frequent mammography reduced mortality, but frequent imaging with other modalities did not show the same effect. The findings support the importance of adhering to current guidelines for surveillance after breast cancer surgery.
Article
Cardiac & Cardiovascular Systems
Jeremy Bernard, Dimitri Kalavrouziotis, Mohamed Marzouk, Joseph Nader, Mathieu Bernier, Philippe Pibarot, Siamak Mohammadi
Summary: This study aimed to evaluate and compare short- and long-term outcomes after mitral valve replacement using biological or mechanical prostheses in patients with severe ischemic mitral regurgitation. The results showed that short-term outcomes were similar between the groups, but long-term outcomes revealed that patients with mechanical prostheses were more likely to be readmitted for cardiovascular causes, including stroke and non-neurological bleeding. Overall, the type of prosthesis did not affect long-term survival, but there may be an increased risk of neurologic events and serious bleeding associated with mechanical prostheses.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Urology & Nephrology
Anna Julie Peired, Elena Lazzeri, Francesco Guzzi, Hans-Joachim Anders, Paola Romagnani
Summary: Epidemiologic studies have shown strong associations between acute or chronic kidney injury and kidney tumors, but the causation and direction of these associations remain unclear. Accumulating data suggest that mechanisms of kidney damage and repair during acute and chronic injury may trigger DNA damage and promote malignant cell clone expansion.
KIDNEY INTERNATIONAL
(2021)
Article
Surgery
Elise A. J. de Savornin Lohman, T. J. J. de Bitter, G. Hannink, M. F. T. Wietsma, E. Vink-Borger, I. D. Nagtegaal, T. J. Hugh, A. J. Gill, N. Bhimani, M. Seyed Ahadi, R. S. van der Post, Philip R. de Reuver
Summary: The study aimed to develop and validate a clinical prediction model for overall survival in patients with nonmetastatic, resected gallbladder cancer (GBC). Data from a Dutch cohort was used for development and an Australian cohort for external validation. The proposed model demonstrated superior discriminatory capacity compared to the AJCC staging system and can be a useful tool for physicians and patients.
Article
Oncology
Violante Di Donato, Giorgio Bogani, Jvan Casarin, Fabio Ghezzi, Mario Malzoni, Francesca Falcone, Marco Petrillo, Giampiero Capobianco, Filippo Calo, Tullio Golia D'Auge, Ludovico Muzii, Pierluigi Benedetti Panici, Elisa Ervas, Antonino Ditto, Francesco Raspagliesi, Francesco Sopracordevole, Enrico Vizza, Andrea Giannini
Summary: This study compared the outcomes of minimally invasive and open radical hysterectomy in low-risk early-stage cervical cancer patients. It found that minimally invasive surgery had advantages in terms of operative time, blood loss, and length of hospital stay. The 10-year follow-up showed similar outcomes between the two approaches.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Yizhen Fu, Xia Li, Zhenyun Yang, Shaoqiang Li, Yangxun Pan, Jinbin Chen, Juncheng Wang, Dandan Hu, Zhongguo Zhou, Li Xu, Minshan Chen, Yaojun Zhang
Summary: This study aimed to establish a risk-based post-resection follow-up strategy for hepatocellular carcinoma (HCC) patients. The results showed that this strategy could detect tumor relapse earlier and reduce the number of follow-ups without compromising on survival.
Article
Multidisciplinary Sciences
Jose Francisco Suarez, Victor Zamora, Olatz Garin, Cristina Gutierrez, Angels Pont, Yolanda Pardo, Alai Goni, Alfonso Marino, Asuncion Hervas, Ismael Herruzo, Patricia Cabrera, Gemma Sancho, Javier Ponce de Leon, Victor Macias, Ferran Guedea, Francesc Vigues, Manuel Castells, Montse Ferrer
Summary: This study compared the effectiveness of radical prostatectomy, brachytherapy, and external radiotherapy at ten years of follow-up. The findings showed that brachytherapy and external radiotherapy were not associated with decreased overall survival but had higher risk of biochemical recurrence compared to radical prostatectomy. External radiotherapy also had higher prostate cancer-specific mortality. These results provide valuable information for clinical decision-making.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yusuke Noda, Taku Naiki, Yosuke Sugiyama, Takashi Nagai, Aya Naiki-Ito, Tatsuya Kawai, Shuzo Hamamoto, Toshiki Etani, Keitaro Iida, Nami Tomiyama, Maria Aoki, Nobuhiko Shimizu, Yoshinobu Moritoki, Hidetoshi Akita, Ryosuke Ando, Noriyasu Kawai, Takahiro Yasui
Summary: This study evaluated the oncological outcomes of patients with bladder cancer after RP-LRC and assessed the impact of mGPS on patient outcomes. The results showed that >= cT3 stage, worse clinical N stage, and poor mGPS status were significant prognostic factors for short-term disease-free survival and cancer-specific survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
I-Lun Shih, Rouh-Fang Yen, Chi-An Chen, Wen-Fang Cheng, Bang-Bin Chen, Yu-Hsuan Chang, Mei-Fang Cheng, Tiffany Ting-Fang Shih
Summary: PET/MRI biomarkers of cervical cancer are associated with tumor stage and survival. SUVmax and ADCmin are independent predictors of PFS and OS, respectively.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Oncology
Liming Jiang, Chengcheng Wang, Yuexin Tong, Jiajia Jiang, Dongxu Zhao
Summary: This study aimed to construct a nomogram to predict overall survival in elderly kidney cancer patients after surgery. Data of primary kidney cancer patients aged over 65 years who underwent surgery between 2010 and 2015 were analyzed. The nomogram showed excellent predictive accuracy and outperformed the TNM staging system in clinical benefits and predictive efficacy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Urology & Nephrology
Patrick Juliebo-Jones, Etienne Xavier Keller, Julie Noss Haugland, Mathias Sorstrand AEsoy, Christian Beisland, Bhaskar K. Somani, Oyvind Ulvik
Summary: Ureteroscopy has made significant advancements in recent decades, allowing for the treatment of a wider range of patient groups. These advancements include new laser technologies and improved ureteroscopes. This article provides an up-to-date guide on these topics.
JOURNAL OF CLINICAL UROLOGY
(2023)
Editorial Material
Urology & Nephrology
Umberto Capitanio, Jens Bedke, Laurence Albiges, Alessandro Volpe, Rachel H. Giles, Milan Hora, Lorenzo Marconi, Tobias Klatte, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernandez Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Thomas Powles, Borje Ljungberg, Axel Bex
Article
Urology & Nephrology
Jens Bedke, Laurence Albiges, Umberto Capitanio, Rachel H. Giles, Milan Hora, Borje Ljungberg, Lorenzo Marconi, Tobias Klatte, Alessandro Volpe, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernandez-Pello, Fabian Hofmann, Teele Kuusk, Rana Tahbaz, Thomas Powles, Axel Bex
Summary: In the KEYNOTE-564 trial, adjuvant pembrolizumab showed significant improvement in disease-free survival (DFS) for localized clear-cell renal cell carcinoma (ccRCC) with a high risk of relapse. However, other immunotherapies, such as adjuvant atezolizumab, adjuvant nivolumab plus ipilimumab, and perioperative nivolumab did not meet the primary DFS endpoints. A meta-analysis is not recommended due to heterogeneity. Pembrolizumab remains the only recommended immune checkpoint inhibitor for this indication, but overall survival data are still immature and predictive biomarkers are lacking. Treatment decisions should be made cautiously and with patient involvement.
Editorial Material
Medicine, General & Internal
Vasco Quaresma, Lorenzo Marconi, Roberto Jarimba, Joao Lima, Arnaldo Figueiredo
ACTA MEDICA PORTUGUESA
(2023)
Article
Oncology
Ariane A. A. van Loevezijn, Charissa S. S. Geluk, Marieke J. J. van den Berg, Erik D. D. van Werkhoven, Marie-Jeanne T. F. D. Vrancken Peeters, Frederieke H. H. van Duijnhoven, Marije J. J. Hoornweg
Summary: This study aimed to evaluate the surgical outcomes of immediate and delayed oncoplastic surgery (OPS). The study found that selecting delayed OPS allowed for re-excision of margins without dismantling the reconstruction, achieving excellent breast conservation rates.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Letter
Urology & Nephrology
Umberto Capitanio, Jens Bedke, Laurence Albiges, Alessandro Volpe, Rachel H. Giles, Milan Hora, Lorenzo Marconi, Tobias Klatte, Yasmin Abu-Ghanem, Saeed Dabestani, Sergio Fernandez Pello, Fabian Hofmann, Teele Kuusk, Riccardo Campi, Rana Tahbaz, Thomas Powles, Boerje Ljungberg, Axel Bex
Article
Oncology
A. Vera de Jonge, Erik van Werkhoven, Avinash G. Dinmohamed, Marcel Nijland, Aeilko H. Zwinderman, Patrick M. Bossuyt, Martine S. Veldhuis, Emma G. G. M. Rutten, Rogier Mous, Joost S. P. Vermaat, Yorick Sandberg, Eva de Jongh, Yavuz M. Bilgin, Rinske Boersma, Harry Koene, Marie Jose Kersten, Daphne de Jong, Martine E. D. Chamuleau
Summary: In a study conducted in the Netherlands, researchers found that R2CHOP treatment significantly improved the prognosis of DLBCL patients compared to R-CHOP treatment, based on a non-randomized risk-adjusted comparison.
BLOOD CANCER JOURNAL
(2023)
Article
Medicine, Research & Experimental
Andre Mansinho, Andreia Cruz, Lorenzo Marconi, Cidalia Pinto, Isabel Augusto
Summary: This work provides a summary of guideline recommendations and an expert position on the use of maintenance avelumab therapy for locally advanced or metastatic urothelial carcinoma (UC) based on a review of current international clinical practice guidelines. The expert panel recommends maintenance avelumab therapy in patients with response/stable disease following chemotherapy (regardless of PD-L1 status) for locally advanced or metastatic UC.
ADVANCES IN THERAPY
(2023)
Article
Oncology
Sonja Vliek, Florentine S. Hilbers, Erik van Werkhoven, Ingrid Mandjes, Rob Kessels, Sieta Kleiterp, Esther H. Lips, Lennart Mulder, Mutamba T. Kayembe, Claudette E. Loo, Nicola S. Russell, Marie-Jeanne T. F. D. Vrancken Peeters, Marjo J. Holtkamp, Margaret Schot, Joke W. Baars, Aafke H. Honkoop, Annelie J. E. Vulink, Alex L. T. Imholz, Suzan Vrijaldenhoven, Franchette W. P. J. van den Berkmortel, Jetske M. Meerum Terwogt, Jolanda G. Schrama, Philomeen Kuijer, Judith R. Kroep, Annemieke van der Padt-pruijsten, Jelle Wesseling, Gabe S. Sonke, Kenneth G. A. Gilhuijs, Agnes Jager, Petra Nederlof, Sabine C. Linn
Summary: This study aimed to investigate the sensitivity of BRCA-altered breast cancer to high-dose alkylating chemotherapy. The results showed no significant difference in neoadjuvant response, recurrence-free survival, and overall survival between high-dose and conventional chemotherapy in patients with BRCA-altered tumors. Further research is needed to determine if there are patients with BRCA-altered breast cancer who can benefit from high-dose chemotherapy.
Article
Urology & Nephrology
Lorenzo Marconi, Teele Kuusk, Umberto Capitanio, Christian Beisland, Thomas Lam, Sergio Fernandez Pello, Grant D. Stewart, Tobias Klatte, Alessandro Volpe, Borje Ljungberg, Saeed Dabestani, Axel Bex
Summary: This study evaluated the effectiveness of local treatment for resectable recurrent renal cell carcinoma after surgical treatment of the primary kidney tumor. The results showed that local treatment could improve patients' survival, regardless of the risk of recurrence.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Review
Urology & Nephrology
Katharina Beyer, Christiaan Widdershoven, Lisa M. Wintner, Saeed Dabestani, Lorenzo Marconi, Charlotte Moss, Netty Kinsella, Yuhong Yuan, Rachel H. Giles, Ravi Barod, Mieke Van Hemelrijck, Axel Bex, Patricia Zondervan, Steven MacLennan
Summary: This study investigates the heterogeneity in outcome reporting in effectiveness trials and observational studies in localized renal cell carcinoma. The results show inconsistency in outcome reporting across studies and variability in definitions for conceptually similar outcomes.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)