Article
Cardiac & Cardiovascular Systems
Santeri Tarvainen, Galina Wirth, Greta Juusola, Olli Hautero, Kari Kalliokoski, Tanja Sjoros, Veikko Nikulainen, Jouni Taavitsainen, Jarkko Hytonen, Crister Frimodig, Krista Happonen, Tuomas Selander, Tomi Laitinen, Harri H. Hakovirta, Juhani Knuuti, Nihay Laham-Karam, Juha Hartikainen, Kimmo Makinen, Seppo Yla-Herttuala, Petra Korpisalo
Summary: This explorative study aimed to investigate the role of microvasculature in critical limb-threatening ischaemia (CLTI) pathology. High-resolution imaging of CLTI patients and muscle samples from amputated limbs were used to describe microvascular pathology. The findings suggest that CLTI muscles have altered blood flow dynamics and tissue damage due to hypoxia-driven capillary enlargement.
EUROPEAN HEART JOURNAL
(2023)
Article
Polymer Science
Caroline Herron, Conn L. Hastings, Clodagh Herron-Rice, Helena M. Kelly, Joanne O'Dwyer, Garry P. Duffy
Summary: The study showed that the chitosan/beta-GP hydrogel has the potential to alleviate critical limb ischaemia, significantly improving blood flow and increasing vessel number.
Article
Medicine, General & Internal
Marco Meloni, Laura Giurato, Aikaterini Andreadi, Ermanno Bellizzi, Alfonso Bellia, Davide Lauro, Luigi Uccioli
Summary: The current study evaluated the effectiveness of PB-MNC therapy as adjuvant treatment for patients with DFUs and NO-CLI. The results showed that adjuvant PB-MNC therapy promoted healing and improved tissue perfusion in patients with NO-CLI and neuro-ischaemic DFUs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Grove Vejlstrup Bager, Jeppe Kofoed Petersen, Eva Havers-Borgersen, Timothy Resch, Kim G. Smolderen, Carlos Mena-Hurtado, Jonas Eiberg, Lars Kober, Emil Loldrup Fosbol
Summary: This study aimed to describe the practice patterns of evidence-based medical therapy (EBM) and overall mortality in high-risk patients with critical limb-threatening ischaemia (CLTI), compared with patients with myocardial infarction (MI). The results showed that, despite similar treatment guidelines, patients with CLTI were undertreated with EBM and had a higher risk of death, compared with patients with MI.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cell & Tissue Engineering
Hao Liu, Yifan Liu, Tianyue Pan, Yuan Fang, Gang Fang, Xiaolang Jiang, Bin Chen, Zheng Wei, Shiyang Gu, Peng Liu, Weiguo Fu, Zhihui Dong
Summary: This study found that younger angiitis-induced critical limb ischaemia (AICLI) patients who underwent cell transplantation had a higher likelihood of returning to work after the procedure. Prevention of limb infection during the perioperative period is crucial for patients' ability to work.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Lucia Beltran-Camacho, Marta Rojas-Torres, Ma Carmen Duran-Ruiz
Summary: Critical limb ischemia is the most severe form of peripheral arterial disease, commonly caused by atherosclerosis leading to progressive blockage of arterial vessels. For patients not suitable for surgical intervention, angiogenic cell therapy has emerged as a promising alternative, showing potential for enhancing revascularization by promoting vessel formation and blood flow recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Gianmarco de Donato, Edoardo Pasqui, Massimo Sponza, Francesco Intrieri, Angelo Spinazzola, Roberto Silingardi, Giuseppe Guzzardi, Maria Antonella Ruffino, Giancarlo Palasciano, Carlo Setacci
Summary: The study evaluated the short term safety and effectiveness of the Penumbra/Indigo aspiration thrombectomy Systems in patients with acute lower limb ischaemia, with a primary focus on vessel patency and technical success rate. The results showed that the system is safe and effective for revascularisation of ALLI as a primary therapy.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Review
Cell & Tissue Engineering
Zeinab Shirbaghaee, Mohammad Hassani, Saeed Heidari Keshel, Masoud Soleimani
Summary: This article reviews the immunomodulatory features of mesenchymal stem cells (MSCs) and their potential applications as therapeutic agents in the treatment of critical limb ischemia (CLI). Despite advances in clinical research, MSC therapy is still considered experimental and not recommended for regular clinical use. The article provides recommendations to improve the efficacy of cell therapy for CLI patients.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Endocrinology & Metabolism
Qi Yang, Liang Li, Yunfei Zha, Yuchen Yan, Dong Xing, Huan Liu, Liu Yang, Lin Peng, Yubiao Zhang
Summary: Quantitative DCE-MRI parameters can evaluate microvascular permeability of skeletal muscles in diabetic rabbits with critical limb ischemia, and texture analysis based on DCE-MRI K-trans allows for evaluation of early slight skeletal muscle structural changes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Paolo Cimaglia, Luca Dalla Paola, Anna Carone, Giuseppe Scavone, Marco Manfrini, Simona Brogneri, Elena Tenti, Rita Pavasini, Davide Bernucci, Giulia Passarini, Francesco Vitali, Eleonora Gaudenzi, Roberto Ferrari, Gianluca Campo
Summary: In diabetic patients with CLI and foot lesions, high-sensitivity cardiac troponin T (hs-TnT) has been identified as a powerful biomarker for predicting major cardiovascular events (MACE) and all-cause mortality independently of CAD diagnosis. The optimal cutoff values for hs-TnT in predicting these adverse outcomes differ between patients with and without established CAD. The addition of hs-TnT to the prognostic evaluation can improve risk stratification and assist in identifying high-risk patients who may benefit from tailored intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell & Tissue Engineering
Pegah Nammian, Seyedeh-Leili Asadi-Yousefabad, Sajad Daneshi, Mohammad Hasan Sheikhha, Seyed Mohammad Bagher Tabei, Vahid Razban
Summary: The study compared the effects of allogeneic bone marrow mesenchymal stem cells (BM-MSCs) and adipose tissue mesenchymal stem cells (AT-MSCs) in the treatment of critical limb ischemia (CLI). The results indicated that BM-MSCs had a stronger effect on endothelial cell migration, muscle restructure, functional improvements, and neovascularization in ischemic tissues compared to AT-MSCs. This suggests that BM-MSC transplantation could be a more effective therapy for diseases with insufficient angiogenesis, such as hindlimb ischemia.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Peripheral Vascular Disease
Yuan Fang, Hao Liu, Tianyue Pan, Gang Fang, Weiguo Fu, Jiang Lin, Junzhen Liu, Zhihui Dong
Summary: This study aimed to compare the image quality of ischaemic lower limb blood vessels shown on volumetric CT-based time maximum intensity projection CT perfusion (t-MIP CTP) versus single-phase CTA (sCTA). The t-MIP CTP technique can accurately show the dynamic change in blood flow from before to after cell therapy and predict the prognosis of patients with NO-CLI. The 1-month vascular volume increase ratio can predict the 3-month prognosis more precisely.
Article
Immunology
Adwan Sofia, AlSmady Moaath, Al-Qatawneh Omar, Zaza Rand, Jafar Hanan, Malkawi Amir, Awidi Abdalla
Summary: This study investigated the safety and preliminary efficacy of platelet lysate (PL) in patients with critical limb ischaemia (CLI) who were not suitable for standard revascularization. The results showed that autologous intramuscular injections of PL were well tolerated and led to clinical improvement in the patients.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Dermatology
Nuttawut Sermsathanasawadi, Kanin Pruekprasert, Nuttapol Chruewkamlow, Kulvara Kittisares, Thanatphak Warinpong, Khamin Chinsakchai, Chumpol Wongwanit, Chanean Ruangsetakit, Pramook Mutirangura
Summary: Local intramuscular transplantation of G-CSF-mobilised PB-MNCs may be a safe and effective treatment for patients with no-option CLI, improving pain relief, promoting ulcer healing, and reducing the amputation rate.
JOURNAL OF WOUND CARE
(2021)
Article
Surgery
Andrea Vacirca, Gianluca Faggioli, Alessia Pini, Rodolfo Pini, Mohammad Abualhin, Alessia Sonetto, Paolo Spath, Mauro Gargiulo
Summary: The study aimed to analyze the outcome of patients with CLTI and N-PPA after a proximal revascularization. The results showed that N-PPA did not affect technical success, primary patency, and midterm survival. However, limb salvage rate was significantly lower in N-PPA patients, and it was associated with factors such as age and hemodialysis, which should be considered in the decision-making process.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Adi Lahiani, Efrat Zahavi, Nir Netzer, Racheli Ofir, Lena Pinzur, Shani Raveh, Hadar Arien-Zakay, Ephraim Yavin, Philip Lazarovici
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Article
Medicine, Research & Experimental
Piyali Chatterjee, Valorie L. Chiasson, Lena Pinzur, Shani Raveh, Eytan Abraham, Kathleen A. Jones, Kelsey R. Bounds, Racheli Ofir, Liat Flaishon, Ayelet Chajut, Brett M. Mitchell
Article
Cell & Tissue Engineering
C. Consentius, L. Akyuez, J. A. Schmidt-Lucke, C. Tschoepe, L. Pinzur, R. Ofir, P. Reinke, H. -D. Volk, K. Juelke
Review
Cell & Tissue Engineering
Noa Sher, Racheli Ofir
CELL TRANSPLANTATION
(2018)
Article
Multidisciplinary Sciences
Hoshea Allen, Niva Shraga-Heled, Michel Blumenfeld, Tamar Dego-Ashto, Dana Fuchs-Telem, Ariel Gilert, Zami Aberman, Racheli Ofir
SCIENTIFIC REPORTS
(2018)
Article
Geriatrics & Gerontology
Tobias Winkler, Carsten Perka, Philipp von Roth, Alison N. Agres, Henning Plage, Bernd Preininger, Matthias Pumberger, Sven Geissler, Esther Lukasiewicz Hagai, Racheli Ofir, Lena Pinzur, Eli Eyal, Gisela Stoltenburg-Didinger, Christian Meisel, Christine Consentius, Mathias Streitz, Petra Reinke, Georg N. Duda, Hans-Dieter Volk
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2018)
Article
Geriatrics & Gerontology
Lena Pinzur, Levent Akyuez, Lilia Levdansky, Michal Blumenfeld, Evgenia Volinsky, Zami Aberman, Petra Reinke, Racheli Ofir, Hans-Dieter Volk, Raphael Gorodetsky
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2018)
Article
Cell Biology
Andrea Papait, Elsa Vertua, Marta Magatti, Sabrina Ceccariglia, Silvia De Munari, Antonietta Rosa Silini, Michal Sheleg, Racheli Ofir, Ornella Parolini
Review
Biotechnology & Applied Microbiology
Andrea Papait, Anna Cargnoni, Michal Sheleg, Antonietta R. Silini, Gilad Kunis, Racheli Ofir, Ornella Parolini
Summary: The COVID-19 pandemic has highlighted the lack of specific drugs or preventive treatments, with the immune system's response and inflammatory reactions playing a key role in the severity of the disease. Perinatal cells are being explored for their potential immunomodulatory, antibacterial, and antiviral effects in treating COVID-19 patients, particularly those with ARDS and sepsis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Linda Rubinstein, Amber M. Paul, Charles Houseman, Metadel Abegaz, Steffy Tabares Ruiz, Nathan O'Neil, Gilad Kunis, Racheli Ofir, Jacob Cohen, April E. Ronca, Ruth K. Globus, Candice G. T. Tahimic
Summary: The study demonstrates that placenta-derived stromal cells partially mitigated some physiological deficits under simulated weightlessness, but did not have an effect on all affected functions, indicating that multiple countermeasures are required for comprehensive protection from the deleterious effects of prolonged spaceflight.
Article
Medicine, General & Internal
Gady Goldsobel, Christoph von Herrath, Stephan Schlickeiser, Nicola Brindle, Frauke Staehler, Petra Reinke, Zami Aberman, Racheli Ofir, Gabriella Dessole, Stefano Benvenuti, Nuno M. Neves, Rui L. Reis, Guido Moll, Hans-Dieter Volk
Summary: Advanced therapy medicinal products (ATMPs) are considered potential game changers in modern medical care, with many European citizens supporting increased public funding for technologies in the field of ATMPs and reimbursement strategies for expensive ATMPs within the European healthcare system.
FRONTIERS IN MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hilla Pe'er-Nissan, Hadas Ahdoot-Levi, Oshra Betzer, Pnina Shirel Itzhak, Niva Shraga-Heled, Iris Gispan, Menachem Motiei, Arthur Doroshev, Yaakov Anker, Rachela Popovtzer, Racheli Ofir, Gal Yadid
Summary: Recent research suggests that mesenchymal stem cells, especially placenta-derived mesenchymal stromal-like cells (PLX-PAD), have potential in treating neurological disorders, particularly drug addiction. In a rat model for cocaine addiction, the administration of PLX-PAD cells through intracerebroventricular or intranasal routes attenuated cocaine-seeking behavior by migrating to specific mesolimbic regions, homing on the hippocampus, and restoring neurogenesis. The findings suggest that intranasal cell therapy could be a safe and effective approach to treating addiction and may provide a novel and efficient method for rehabilitation.
Article
Medicine, General & Internal
Leland Metheny, Saada Eid, Karen Lingas, Racheli Ofir, Lena Pinzur, Howard Meyerson, Hillard M. Lazarus, Alex Y. Huang
FRONTIERS IN MEDICINE
(2018)
Article
Cell & Tissue Engineering
Efrat Zahavi-Goldstein, Michal Blumenfeld, Dana Fuchs-Telem, Lena Pinzur, Shy Rubin, Zami Aberman, Noa Sher, Racheli Ofir