Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 26, Issue 8, Pages 1098-1104Publisher
WILEY
DOI: 10.1111/ene.13945
Keywords
biological markers; early-onset Alzheimer's disease; frontotemporal dementia; neuroimaging
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Funding
- Spanish Ministry of Economy and Competitiveness-Instituto de Salud Carlos III
- Spanish Ministry of Economy and Competitiveness-Fondo Europeo de Desarrollo Regional (FEDER)
- Union Europea, 'Una manera de hacer Europa' [PI14/00282]
- PERIS 2016-2020 Departament de Salut de la Generalitat de Catalunya [SLT002/16/00408]
- CERCA Programme/Generalitat de Catalunya
- Hospital Clinic Barcelona
- Departament de Salut de la Generalitat de Catalunya (PERIS 2016-2020) [SLT002/16/00329]
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Background and purpose Several diagnostic biomarkers are currently available for clinical use in early-onset cognitive impairment. The decision on which biomarker is used in each patient depends on several factors such as its predictive value or tolerability. Methods There were a total of 40 subjects with early-onset cognitive complaints (<65 years of age): 26 with Alzheimer's disease (AD), five with frontotemporal dementia and nine with diagnostic suspicion of non-neurodegenerative disorder. Clinical and neuropsychological evaluation, lumbar puncture for cerebrospinal fluid (CSF) AD core biochemical marker determination, medial temporal atrophy evaluation on magnetic resonance imaging, amyloid-positron emission tomography (PET) and F-18-fluorodeoxyglucose-PET were performed. Neurologists provided pre- and post-biomarker diagnosis, together with diagnostic confidence and clinical/therapeutic management. Patients scored the tolerability of each procedure. Results Cerebrospinal fluid biomarkers and amyloid-PET increased diagnostic confidence in AD (77.4%-86.2% after CSF, 92.4% after amyloid-PET, P < 0.01) and non-neurodegenerative conditions (53.6%-75% after CSF, 95% after amyloid-PET, P < 0.05). Biomarker results led to diagnostic (32.5%) and treatment (32.5%) changes. All tests were well tolerated. Conclusions Biomarker procedures are well tolerated and have an important diagnostic/therapeutic impact on early-onset cognitive impairment.
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