Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 163, Issue -, Pages 413-427Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2018.11.072
Keywords
Immuno-oncology; Immunity protein kinases; Small-molecules inhibitors
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Funding
- Natural Science Foundation of Jiangsu Province [BK20141349]
- China National Key Hi-Tech Innovation Project for the R&D of Novel Drugs [2013ZX09301303-002]
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With the rise of immuno-oncology, small-molecule modulators targeting immune system and inflammatory processes are becoming a research hotspot. This work mainly focuses on key kinases acting as central nodes in immune signaling pathways. Although over thirty small-molecule kinase inhibitors have been approved by FDA for the treatment of various cancers, only a few are associated with immuno-oncology. With the going deep of the research work, more and more immunity protein kinase inhibitors are approved for clinical trials to treat solid tumors and hematologic malignancies by FDA, which remain good prospects. Meanwhile, in-depth understanding of biological function of immunity protein kinases in immune system is pushing the field forward. This article focuses on the development of safe and effective small-molecule immunity protein kinase inhibitors and further work needs to keep the promises of these inhibitors for patients' welfare. (C) 2018 Published by Elsevier Masson SAS.
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