4.7 Article

Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7

Journal

ENVIRONMENTAL POLLUTION
Volume 246, Issue -, Pages 697-703

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2018.12.084

Keywords

Bisphenol S; DNA methylation; Gene expression profiling; Breast cancer cell

Funding

  1. National Natural Science Foundation of China [21507106, 21806135, 91543202]
  2. Hong Kong Research Grants Council-General Research Fund [1230195]
  3. Hong Kong Baptist University Strategic Development Fund [15-1012-P04]
  4. State-Key Laboratory Research Grant [SKLP-1617-P02]
  5. Hong Kong Scholars Program Fund [XJ2016010]

Ask authors/readers for more resources

In recent years, concerns about using Bisphenol A (BPA) in daily consume products and its effects in many chronic human diseases have prompted the removal of BPA. However, the widely used BPA alternatives, including Bisphenol S (BPS), have a high structural similarity with BPA, suggesting that they may have similar biological effects towards human beings. Indeed, BPS was also found to have endocrine disrupting effects. Epigenetic mechanism was reported to be involved in BPA-induced biological effects in both in vitro and in vivo models. However, there is no assessment on whether BPS could cause epigenetic changes. In this work, we investigated the possible epigenetic effects of BPS that might induce in human breast cancer cell line MCF-7. We found that BPS could change DNA methylation level of transposons. Besides, methylation status in promoter of breast cancer related genes CDH1, SFN, TNFRSF10C were also changed, which implied that BPS might play a role in the development of breast cancer. Gene expression profiling showed that some genes related to breast cancer progression were upregulated, including THBS4, PPARGC1A, CREB5, COL5A3. Gene ontology (GO) analysis of the differentially expressed genes revealed the significantly changes in PI3K-Akt signaling pathway and extracellular matrix, which were related to the proliferation, migration and invasion of breast cancer cells. These results illustrated that BPS exposure might play roles in the progression of breast cancer. (C) 2019 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Biochemistry & Molecular Biology

Arabidopsis EXTRA-LARGE G PROTEIN 1 (XLG1) functions together with XLG2 and XLG3 in PAMP-triggered MAPK activation and immunity

Yiping Wang, Hailei Zhang, Pengxi Wang, Huan Zhong, Wuzhen Liu, Shoudong Zhang, Liming Xiong, Yingying Wu, Yiji Xia

Summary: Pattern-triggered immunity (PTI) is a vital defense mechanism used by plants against pathogen attacks. Heterotrimeric G proteins, particularly XLG2 and XLG3, play a positive role in regulating plant immunity, while XLG1 was previously believed to be non-functional. However, this study shows that all three XLGs function redundantly in PAMP-triggered MAPK activation and plant immunity. The triple knockout mutants of xlg1 xlg2 xlg3 exhibited compromised resistance against pathogen infection.

JOURNAL OF INTEGRATIVE PLANT BIOLOGY (2023)

Article Chemistry, Analytical

Divide and Conquer: A Flexible Deep Learning Strategy for Exploring Metabolic Heterogeneity from Mass Spectrometry Imaging Data

Lei Guo, Jiyang Dong, Xiangnan Xu, Zhichao Wu, Yinbin Zhang, Yongwei Wang, Pengfei Li, Zhi Tang, Chao Zhao, Zongwei Cai

Summary: Research on metabolic heterogeneity is crucial for understanding the molecular mechanisms of diseases and developing personalized treatments. The use of mass spectrometry imaging (MSI) enables the identification of spatially contiguous or sporadic regions of interest, revealing the heterogeneity of an organism at a molecular level.

ANALYTICAL CHEMISTRY (2023)

Article Chemistry, Analytical

Derivatization of N-Acyl Glycines by 3-Nitrophenylhydrazine for Targeted Metabolomics Analysis and Their Application to the Study of Diabetes in Mice

Li Xiang, Yi Ru, Jingchun Shi, Li Wang, Hongzhi Zhao, Yu Huang, Zongwei Cai

Summary: In this study, a simple and sensitive method for the detection of N-acyl glycines (NAGlys) in plasma and urine samples using liquid chromatography-mass spectrometry (LC-MS) is described. The use of a derivatization reagent, 3-nitrophenylhydrazine, allows for quick reaction in aqueous solution without the need for a quenching step. NAGlys were first identified based on high-resolution LC-MS and subsequently quantified on triple quadrupole LC-MS. This approach enables a broader measurement of NAGlys and potential identification of diagnostic biomarkers for type II diabetes and diabetic complications.

ANALYTICAL CHEMISTRY (2023)

Article Engineering, Environmental

Contribution and Effects of PM2.5-Bound Lead to the Cardiovascular Risk of Workers in a Non-Ferrous Metal Smelting Area Considering Chemical Speciation and Bioavailability

Xiaochong He, Qiting Zhao, Xuyang Chai, Yuanyuan Song, Xuelan Li, Xingwen Lu, Shoupeng Li, Xin Chen, Yong Yuan, Zongwei Cai, Zenghua Qi

Summary: A study was conducted to analyze the concentration and chemical speciation of PM2.5-bound lead (PM2.5-Pb) at a non-ferrous metal smelting site. It was found that PM2.5-Pb exposure has a significant impact on human absorption of lead and can cause cardiovascular damage. Animal simulation experiments were used to evaluate the relationship between PM2.5-Pb exposure and cardiovascular damage, and a risk assessment model was established. This research provides accurate estimates of the risk of PM2.5-bound heavy metals on the cardiovascular system and offers a scientific basis for future prevention and therapy of PM2.5-Pb-related diseases.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2023)

Editorial Material Engineering, Environmental

Getting Health Hazards of Inhaled Nano/Microplastics into Focus: Expectations and Challenges

Guodong Cao, Zongwei Cai

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2023)

Article Chemistry, Analytical

Spatial lipidomics and metabolomics of multicellular tumor spheroids using MALDI-2 and trapped ion mobility imaging

Jing Chen, Peisi Xie, Qingyuan Dai, Pengfei Wu, Yu He, Zian Lin, Zongwei Cai

Summary: In this study, MALDI-2 and TIMS imaging were used to analyze lipids and metabolites in H295R adrenocortical MCTS. MALDI-2 detected more lipids and metabolites in MCTS compared to traditional MALDI, while TIMS successfully separated isomeric and isobaric ions in different regions of MCTS. MS/MS imaging experiments further confirmed the presence of these isomeric and isobaric ions. These findings demonstrate the potential of MALDI-2 and TIMS imaging as valuable tools for lipid and metabolite analysis in MCTS for various biological and medical research fields.

TALANTA (2023)

Article Engineering, Environmental

Identifying potential toxic organic substances in leachates from tire wear particles and their mechanisms of toxicity to Scenedesmus obliquus

Jie-Ru Jiang, Zhi-Feng Chen, Xiao-Liang Liao, Qian-Yi Liu, Jia-Ming Zhou, Shi-Ping Ou, Zongwei Cai

Summary: Tire wear particles (TWPs) are increasingly present in water, but little is known about their environmental consequences. In this study, TWP leachates were analyzed to identify potentially toxic organic substances using high-resolution mass spectrometry and toxicity identification. Thirteen substances were structurally identified, with cyclic amines found to be toxic to the tested algal species. Metabolomic analysis revealed differential metabolites associated with linoleic acid and purine metabolism, and oxidative stress was identified as a key factor in algal growth inhibition. This study highlights the risk posed by TWP leachable substances to aquatic organisms.

JOURNAL OF HAZARDOUS MATERIALS (2023)

Article Engineering, Environmental

Long-term percutaneous triclosan exposure induces thyroid damage in mice: Interpretation of toxicity mechanism from metabolic and proteomic perspectives

Yanshan Liang, Leiguang Li, Hongna Zhang, Qingyuan Dai, Guangshan Xie, Bo Lei, Zhu Yang, Zongwei Cai

Summary: Triclosan can cause thyroid damage and disrupt the synthesis and release of thyroid hormones, leading to hypothyroidism.

JOURNAL OF HAZARDOUS MATERIALS (2023)

Article Chemistry, Analytical

High-throughput profiling of RNA modifications by ultra-performance liquid chromatography coupled to complementary mass spectrometry: Methods, quality control, and applications

Gefei Huang, Feng Zhang, Dongying Xie, Yiming Ma, Pengxi Wang, Guodong Cao, Leijian Chen, Siyi Lin, Zhongying Zhao, Zongwei Cai

Summary: In this study, a high-throughput analytical platform combining ultra-performance liquid chromatography (UPLC) and complementary mass spectrometry (MS) was developed to identify and quantify RNA modifications. Sixty-four types of RNA modifications were successfully monitored within a 16-minute single run of UPLC-MS. The method can also aid in the discovery of RNA-modifying enzymes in genetic studies.

TALANTA (2023)

Article Engineering, Environmental

AI-guided electro-decomposition of persistent organic pollutants: a long-awaited vision becoming reality?

Lin Zhu, Lei Du, Guodong Cao, Zongwei Cai

Summary: Existing and emerging persistent organic pollutants (POPs) pose significant threats to human health and economies. The development of effective mitigation strategies to remove or degrade these chemicals in the environment is crucial due to their persistence. Although various methods for electrocatalytic degradation of POPs have been developed in lab conditions, challenges such as harmful byproducts and limited working time hinder their practical application. This perspective work highlights high-entropy alloys as ideal catalyst materials for electrocatalytic degradation and discusses the use of AI to facilitate the design and testing of electrocatalysts. The challenges, negative effects, and solutions of applying AI in this process are also addressed.

ENVIRONMENTAL SCIENCE-ADVANCES (2023)

Article Biochemical Research Methods

A digital microfluidic platform coupled with colorimetric loop-mediated isothermal amplification for on-site visual diagnosis of multiple diseases

Mei Xie, Tianlan Chen, Zongwei Cai, Bo Lei, Cheng Dong

Summary: Traditional diagnosis of infectious diseases relies on advanced analyzers in central hospitals, which is not sufficient for rapid control of epidemics, especially in resource-limited areas, raising the importance of the development of diagnostic systems for point-of-care testing (POCT). Here, researchers developed a simple and cost-effective digital microfluidic (DMF) platform in combination with colorimetric loop-mediated isothermal amplification (LAMP) for simple on-site diagnosis of diseases by the naked eye. The DMF-LAMP assay showed comparable sensitivity to conventional LAMP assay but was more efficient, and possessed a simple chip structure and high flexibility to integrate multiplex analysis.

LAB ON A CHIP (2023)

Article Chemistry, Analytical

Derivatization of N-Acyl Glycines by 3-Nitrophenylhydrazine for Targeted Metabolomics Analysis and Their Application to the Study of Diabetes Progression in Mice

Li Xiang, Yi Ru, Jingchun Shi, Hongzhi Zhao, Yu Huang, Zongwei Cai, Li Wang

Summary: N-Acyl glycines (NAGlys) are important metabolites in the human body's detoxification system, and can be used in the diagnosis of metabolic diseases. A simple and sensitive method of NAGlys detection by LC-MS in plasma and urine samples is described, using 3-nitrophenylhydrazine as a derivatization reagent. This approach allows for a broader measurement of NAGlys, especially in the absence of authentic standards. The identified NAGlys have the potential to be diagnostic biomarkers for type II diabetes and diabetic complications.

ANALYTICAL CHEMISTRY (2023)

Article Chemistry, Multidisciplinary

Constructing cactus-like mixed dimensional MOF@MOF as sorbent for extraction of bisphenols from environmental water

Peige Qin, Shiping Zhu, Mengyao Mu, Yanmei Gao, Zongwei Cai, Minghua Lu

Summary: A new hierarchical mixed-dimensional metal-organic framework (MOF@MOF) hybrid material was prepared for the removal and enrichment of environmental pollutants. The material exhibited excellent adsorption performance for bisphenols (BPs) due to its extensive mesoporous structures and large surface area.

CHINESE CHEMICAL LETTERS (2023)

Article Chemistry, Analytical

A reactive matrix for in situ chemical derivatisation and specific detection of cis-diol compounds by matrix-assisted laser desorption/ionisation mass spectrometry

Jiajing Chen, Huan Huang, Dan Ouyang, Jiali Lin, Zhuling Chen, Zongwei Cai, Zian Lin

Summary: Analysis of cis-diol compounds is crucial due to their important roles in various fields. Researchers have developed a matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) method to effectively analyse cis-diol compounds. This method utilizes a unique reactive matrix (BMQI) for in situ derivatization of cis-diol compounds, resulting in improved speed, reproducibility, and signal intensity, as well as reduced background interference. Additionally, the method has been successfully applied to the rapid screening and identification of sugar alcohols in different sugar-free foods.

ANALYST (2023)

Review Environmental Sciences

Efficiency of the bank filtration for removing organic priority substances and contaminants of emerging concern: A critical review

Attila Csaba Kondor, Anna Viktoria Vancsik, Laszlo Bauer, Lili Szabo, Zoltan Szalai, Gergely Jakab, Gabor Maasz, Marta Pedrosa, Maria Jose Sampaio, Ana Rita Lado Ribeiro

Summary: This review provides a critical overview of research on the removal efficiency of priority substances and compounds of emerging concern through bank filtration, discussing influencing factors and future challenges. The findings show that the efficiency of bank filtration is influenced by multiple factors and varies for different substances.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Association of exposure to ozone and fine particulate matter with ovarian reserve among women with infertility

Xinyan Wang, Shuai Zhang, Huihui Yan, Zhao Ma, Yunshan Zhang, Haining Luo, Xueli Yang

Summary: This study investigated the association between ambient PM2.5, O3 pollution, and ovarian reserve in reproductive-aged Chinese women. The results showed that increased exposure to PM2.5 and O3 was associated with decreased AMH levels, indicating reduced ovarian reserve. Notably, the effects of O3 exposure on ovarian reserve were different from those of PM2.5 exposure.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Effects of acute and chronic chromium stress on the expression of heat shock protein genes and activities of antioxidant enzymes in larvae of Orthetrum albistylum

Tingting Ma, Yanjuan Ding, Fengjiao Xu, Chen Zhang, Min Zhou, Ya Tang, Yanrong Chen, Yating Wen, Rufei Chen, Bin Tang, Shigui Wang

Summary: The dragonfly species Orthetrum albistylum can accumulate heavy metals, and its heat shock protein genes have the potential to serve as biomarkers for monitoring environmental pollutants.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Can warming accelerate the decline of Odonata species in experimental paddies due to insecticide fipronil exposure?

Naoto Ishiwaka, Koya Hashimoto, Masayoshi K. Hiraiwa, Francisco Sanchez-Bayo, Taku Kadoya, Daisuke Hayasaka

Summary: Systemic insecticides and rising temperatures have combined effects on the abundance of Odonata nymphs in paddy fields. The standalone effect of insecticide exposure decreased the Odonata community, while nymphs decreased synergistically with temperature rise in paddy water. However, the impacts of each stressor alone varied among species.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

The seasonal change of PAHs in Svalbard surface snow

Marco Vecchiato, Carlo Barbante, Elena Barbaro, Francois Burgay, Warren R. L. Cairns, Alice Callegaro, David Cappelletti, Federico Dallo, Marianna D'Amico, Matteo Feltracco, Jean-Charles Gallet, Andrea Gambaro, Catherine Larose, Niccolo Maffezzoli, Mauro Mazzola, Ivan Sartorato, Federico Scoto, Clara Turetta, Massimiliano Varde, Zhiyong Xie, Andrea Spolaor

Summary: The Arctic region is facing contamination from long-range pollution and local human activities. Polycyclic Aromatic Hydrocarbons (PAHs) are used as environmental indicators for emission, transport, and deposition processes. Research conducted in the Arctic surface snow in Ny-Ålesund, Svalbard from October 2018 to May 2019 shows that long-range inputs of PAHs mainly occur in winter, while the most abundant analyte retene exhibits opposite seasonal trends.

ENVIRONMENTAL POLLUTION (2024)

Review Environmental Sciences

A broad horizon for sustainable catalytic oxidation of microplastics

Maoshui Zhuo, Zhijie Chen, Xiaoqing Liu, Wei Wei, Yansong Shen, Bing-Jie Ni

Summary: This paper discusses the application of three catalytic processes (photocatalysis, electrocatalysis, and biocatalysis) in the management of microplastic pollution, and introduces the efficiency and catalytic mechanisms of different catalysts. It also proposes the development prospects for sustainable management of microplastic pollution.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

A physiologically based pharmacokinetic model of diethyl phthalates in humans

Shiyu Chen, Zhenzhen Shi, Qiang Zhang

Summary: In this study, a human physiologically based pharmacokinetic (PBPK) model of diethyl phthalate (DEP) was developed to assess its toxicity. The model considers the distribution and metabolism of DEP and its active metabolite monoethyl phthalate (MEP) in different tissue compartments. Sensitivity analysis and Bayesian Markov chain Monte Carlo (MCMC) simulations were performed to evaluate the uncertainty and variability of the model parameters. The results suggest that dermal absorption is an important route of exposure to DEP in the environment.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Exploring a chemical input free advanced oxidation process based on nanobubble technology to treat organic micropollutants

Bangguo Wang, Lijing Wang, Wenxi Cen, Tao Lyu, Peter Jarvis, Yang Zhang, Yuanxun Zhang, Yinghui Han, Lei Wang, Gang Pan, Kaili Zhang, Wei Fan

Summary: This study investigates the feasibility and mechanisms of a chemical-free nanobubble-based AOP for treating organic micropollutants in water. The results show that the oxygen nanobubble AOP has a significantly higher removal efficiency compared to air and nitrogen nanobubbles. The treatment performance is not affected by pH and the presence of ions. Higher initial concentrations of the micropollutant lead to slower treatment processes, but similar removal performance is achieved in the end. The presence of organic matter reduces the removal rate of the micropollutant. The results have practical feasibility for water and wastewater treatment.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Insights into the reduction of methylmercury accumulation in rice grains through biochar application: Hg transformation, isotope fractionation, and transcriptomic analysis

Yingmei Huang, Jicai Yi, Yao Huang, Songxiong Zhong, Bin Zhao, Jing Zhou, Yuxuan Wang, Yiwen Zhu, Yanhong Du, Fangbai Li

Summary: This study investigates the impact of biochar on methylmercury (MeHg) accumulation in rice. The results show that biochar reduces MeHg levels in paddy soils by decreasing bioavailable Hg and microbial Hg methylation. Additionally, biochar decreases the uptake and translocation of MeHg in rice plants, resulting in a reduction of MeHg accumulation in rice grains.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Expeditious profiling of polycyclic aromatic hydrocarbons transport and obstruction mechanisms in crop xylem sap proteins via proteomics and molecular docking

Nengde Zeng, Fei Huang, Jiani Du, Chenghao Huang, Qian Yang, Xinhua Zhan, Baoshan Xing

Summary: This study investigates the protein targets and protein-ligand interactions related to PAH contamination in crop xylem sap using computational tools. The results show that phenanthrene has a more pronounced effect on the xylem sap proteins of maize and wheat, with maize DEPs associated with lipid biosynthesis and wheat DEPs exhibiting an increase in ABC transporters. This study provides insights into the regulation and movement of PAHs within plant xylem.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Plasma-assisted assembly of Co3O4/TiO2-NRs for photoelectrocatalytic degradation of bisphenol A in solution and muddy systems

Xinwei Chen, Hao Ma, Run Wang, Man Wang, Binbin Zhu, Yanqing Cong, Xiayue Zhu, Guoqin Wang, Yi Zhang

Summary: Co3O4/TiO2-NRs electrodes with excellent photoresponse were prepared via plasma-assisted modification of Co3O4 on TiO2. The combination of Co3O4 and TiO2 improved the light utilization efficiency and showed potential for degradation of pollutants.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Carbon emissions from various natural gas end-use sectors for 31 Chinese provinces between 2017 and 2021

Wenjing Ji, Liying Song, Jing Wang, Hongqing Song

Summary: This study conducted a life-cycle assessment to examine the correlation between natural gas consumption and carbon emissions in different end uses in China. The results showed that both natural gas consumption and life-cycle carbon emissions have been increasing since 2017. Significant variations in NG life-cycle carbon emissions were found across different provinces and sectors, highlighting the need for targeted efforts to reduce carbon emissions.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Synergistic effects of trace sulfadiazine and corrosion scales on disinfection by-product formation in bulk water of cast iron pipe

Youyi Chen, Boxuan Zhang, Pojun Zhang, Guogui Shi, Hao Liang, Wu Cai, Jingyu Gao, Sumin Zhuang, Kaiyin Luo, Jiaqi Zhu, Chaoxiang Chen, Kunyu Ma, Jinrong Chen, Chun Hu, Xueci Xing

Summary: The synergistic effects of trace sulfadiazine and cast-iron corrosion scales on the formation of disinfection by-products in drinking water distribution systems were investigated. The presence of magnetite resulted in increased concentrations of DBPs due to the higher microbial activity and enhanced microbial extracellular electron transport pathway. The study highlights the importance of considering trace antibiotics pollution and corrosion scales in water sources for DBP control.

ENVIRONMENTAL POLLUTION (2024)

Review Environmental Sciences

The update and transport of aluminum nanoparticles in plants and their biochemical and molecular phototoxicity on plant growth and development: A systematic review

Bishwa Raj Pokharel, Vijay Sheri, Manoj Kumar, Zhiyong Zhang, Baohong Zhang

Summary: This review summarizes the interactions, uptake, and transport of aluminum nanoparticles (Al-NPs) in plants, highlighting their negative effects on plant growth and development, as well as their potential to alter plant defense systems and gene expression.

ENVIRONMENTAL POLLUTION (2024)

Article Environmental Sciences

Disturbance mitigation of thiencarbazone-methyl•isoxaflutole on bacterial communities through nitrification inhibitor and attapulgite

Yonglu Wang, Fengsong Zhang, Xiaoyong Liao, Xiao Yang, Guixiang Zhang, Liyun Zhang, Chaojun Wei, Pengge Shi, Jiongxin Wen, Xiaorong Ju, Can Xu, Yang Liu, Ying Lan

Summary: This study aims to explore the effects of thiencarbazone-methyl center dot isoxaflutole on soil microflora and the potential mitigation mechanisms to bacterial communities. It was found that increasing the application of thiencarbazone-methyl center dot isoxaflutole resulted in increased stress on soil bacterial community structure and diversity. Increasing soil pH was recognized as a key factor in improving the diversity and structure of soil microflora. Supplemental use of nitrapyrin or modified attapulgite can increase soil pH and improve bacterial diversity.

ENVIRONMENTAL POLLUTION (2024)