Article
Neurosciences
Joao C. Callera, Laurival A. De Luca, Jose V. Menani
Summary: In this study, it was found that GABAA receptor activation with the agonist muscimol in the lateral parabrachial nucleus can induce the intake of 0.3 M NaCl. Endogenous vasopressin in the LPBN facilitates the effects of GABAergic activation driving cell-dehydrated male rats to ingest 0.3 M NaCl.
NEUROSCIENCE LETTERS
(2022)
Review
Veterinary Sciences
Luca Todini, Francesco Fantuz
Summary: Animals can detect changes in their internal needs and respond with specific physiological and behavioral reactions to maintain homeostasis, particularly with regards to water-saline balance. Thirst is regulated by neural and chemical signals in the central nervous system, driving animals to seek and consume water. The mechanisms of water and electrolyte homeostasis are finely tuned, primarily influenced by plasma Na+ concentration and osmotic pressure, as well as blood volume and arterial pressure. Other factors, such as food intake and circadian rhythms, also play a role in thirst regulation.
VETERINARY RESEARCH COMMUNICATIONS
(2023)
Article
Veterinary Sciences
Jasmin Nessler, Christian Wunderlich, Deborah Eikelberg, Andreas Beineke, Jonathan Raue, Martin Runge, Andrea Tipold, Martin Ganter, Juergen Rehage
Summary: This case report describes the clinical findings, MRI, and necropsy results of a Belted Galloway heifer with severe dehydration and hypernatremia, but concurrent adipsia and isosthenuria. The postmortem examination revealed a complex forebrain malformation that may be involved in the development of hypernatremia and adipsia in bovines.
BMC VETERINARY RESEARCH
(2022)
Article
Pediatrics
Ankit Kumar Meena, Pamali Mahasweta Nanda, Rajni Sharma, Biswaroop Chakrabarty, Sheffali Gulati
Summary: Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a common cause of euvolemic hyponatremia in hospitalized children. It is characterized by increased serum ADH, leading to water retention through V2 receptors in the distal renal tubules. The conventional treatment for SIADH includes fluid restriction and salt supplementation, but pharmacological therapy may be required in some cases. Limited experience exists with the use of V2-receptor antagonists in the pediatric population. In this case report, a girl with corpus callosum agenesis and severe symptomatic hyponatremia due to SIADH was successfully managed with the V2-receptor antagonist tolvaptan.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Veterinary Sciences
Darcy Adin, Clarke Atkins, Leonel Londono, Bruna Del Nero
Summary: Hypochloremia associated with congestive heart failure in dogs is likely multifactorial, with loop diuretics causing sodium and chloride loss while water retention leads to dilution. Corrected chloride levels were higher in dogs with refractory CHF, indicating relative water excess. Although corrected chloride levels were higher than measured levels in Stage D dogs, hypochloremia persisted due to the effects of loop diuretics.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Anesthesiology
Anna Foerch, Phillip Deetjen, Axel R. R. Heller
Summary: Changes in serum sodium concentrations are common among anesthesiologists and can lead to serious neurological complications. Dysnatremia and water balance disturbances are closely related, but assessment of volume status and extracellular volume can be challenging. Treatment for severe symptomatic hyponatremia involves administering hypertonic saline solution, while the cause should be investigated before treating hypernatremia. A careful and controlled approach is necessary to avoid neurological complications, and an algorithm has been developed to guide diagnosis and treatment in clinical practice.
Article
Biology
Shigenori Nobata, Yoshio Takei
Summary: In this study, it was found that isotocin is the potent dipsogenic hormone in eels, while vasopressin and oxytocin are not dipsogenic in mammals. Isotocin induces copious drinking through its action on the AP, while AngII may induce drinking through its action on a different circumventricular site.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Urology & Nephrology
Yoko Shirai, Kenichiro Miura, Akari Nakamura-Utsunomiya, Kiyonobu Ishizuka, Miku Hattori, Motoshi Hattori
Summary: Patients with adipsic hypernatremia present with chronic hypernatremia due to defects in thirst sensation and dysregulated salt appetite, with no demonstrable hypothalamic structural lesions. The pathophysiology of water and electrolyte imbalance in this disease remains unclear. A certain amount of vasopressin release regardless of serum sodium concentrations, absence of thirst sensation, and normal plasma vasopressin concentrations after serum sodium normalization are characteristic features of adipsic hypernatremia.
Editorial Material
Neurosciences
Neha Vyas, Jenna A. McHenry
Summary: A study reveals that task performance and sensory motor cortical encoding are impaired under low and high motivational states but improve with physiological adaption.
Article
Chemistry, Multidisciplinary
Dong-Hun Choi, Joon-Yong Cho, Jung-Hoon Koo, Tae-Kyung Kim
Summary: The study showed that consuming an electrolyte drink before and after exhaustive exercise can increase the body's water retention capacity, improve exercise ability, and reduce exercise-related fatigue.
APPLIED SCIENCES-BASEL
(2021)
Editorial Material
Health Care Sciences & Services
Russell A. Wilke
Summary: SIADH is a common cause of hyponatremia, especially in elderly patients, and severe hyponatremia can have serious consequences. Further research is needed to develop decision support tools for identifying high-risk patients based on pharmacogenetic testing.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Sara Fill Malfertheiner, Evelyn Bataiosu-Zimmer, Holger Michel, Sotirios Fouzas, Luca Bernasconi, Christoph Buehrer, Sven Wellmann
Summary: The study aimed to investigate the levels of AVP and OT in response to birth stress in infants and to characterize AVP secretion by comparing with plasma copeptin. The results showed that AVP and copeptin concentrations were significantly higher in infants born vaginally, while OT levels did not differ between vaginal delivery and cesarean section. AVP was found to indicate acute stress events, while copeptin provided information on cumulative stress events over a longer period, showing that AVP signaling mediates birth stress response in infants.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Pediatrics
Jane E. Driano, Aida N. Lteif, Ana L. Creo
Summary: Pediatric vasopressin-dependent disorders, such as diabetes insipidus and syndrome of inappropriate secretion of antidiuretic hormone, are challenging to diagnose and treat. Recent developments in diagnostic methods and treatments may improve outcomes and quality of life for affected children.
Article
Veterinary Sciences
Alessandro Migliorisi, Anne Barger, Scott Austin, Jonathan H. Foreman, Pamela Wilkins
Summary: This study found that hyponatremia at admission in horses is associated with the presence of inflammation, systemic inflammatory response syndrome (SIRS), and longer duration of hospitalization.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Mari Mori, Satoru Takeshita, Nami Nakamura, Yuki Mizuno, Akiko Tomita, Mineyoshi Aoyama, Hiroki Kakita, Yasumasa Yamada
Summary: This report demonstrates the safety and efficacy of tolvaptan in an infant with HPE-associated SIADH.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Peripheral Vascular Disease
Matthew C. Babcock, Austin T. Robinson, Kamila U. Migdal, Joseph C. Watso, Megan M. Wenner, Sean D. Stocker, William B. Farquhar
Article
Physiology
Joseph C. Watso, Matthew C. Babcock, Austin T. Robinson, Kamila U. Migdal, Megan M. Wenner, Sean D. Stocker, William B. Farquhar
JOURNAL OF APPLIED PHYSIOLOGY
(2019)
Article
Neurosciences
Jason Ong, Brian J. Kinsman, Alan F. Sved, Brittney M. Rush, Roderick J. Tan, Marcelo D. Carattino, Sean D. Stocker
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Review
Neurosciences
Sean D. Stocker, Alan F. Sved, Michael C. Andresen
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Nicolas Montalbetti, Sean D. Stocker, Gerard Apodaca, Sheldon Bastacky, Marcelo D. Carattino
SCIENTIFIC REPORTS
(2019)
Article
Physiology
Joseph C. Watso, Austin T. Robinson, Matthew C. Babcock, Kamila U. Migdal, Megan M. Wenner, Sean D. Stocker, William B. Farquhar
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2020)
Article
Neurosciences
Brian J. Kinsman, Sarah S. Simmonds, Kirsteen N. Browning, Megan M. Wenner, William B. Farquhar, Sean D. Stocker
JOURNAL OF NEUROSCIENCE
(2020)
Article
Pharmacology & Pharmacy
Joseph C. Galley, Scott A. Hahn, Megan P. Miller, Brittany G. Durgin, Edwin K. Jackson, Sean D. Stocker, Adam C. Straub
Summary: In the study, it was found that reduced renal blood flow activates the RAAS system, leading to renovascular hypertension. Ang II was shown to affect sGC expression through an AT(1) receptor-FoxO transcription factor mechanism, both in vivo and in vitro. This up-regulation of sGC led to increased downstream cGMP signaling, suggesting a protective mechanism to improve renal blood flow in the uninjured contralateral renal artery.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Leon J. DeLalio, Sean D. Stocker
Summary: The study revealed that anesthesia has an impact on sympathetic nerve activity (SNA) and arterial blood pressure (ABP) responses to chemosensory and mechanosensory renal stimuli, with sex playing a lesser role. Different anesthesia states resulted in varied SNA responses to renal stimuli.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Sean D. Stocker, Megan M. Wenner, William B. Farquhar, Kirsteen N. Browning
Summary: This study found that activation of OVLT neurons leads to hypertension through sympathetic nerve activation.
Article
Cardiac & Cardiovascular Systems
Leon J. DeLalio, Sean D. Stocker
Summary: The circadian cycle affects sympathetic and hemodynamic responses to activation of renal chemosensitive sensory fibers. Responses to intrarenal bradykinin or capsaicin infusion were exaggerated during nighttime, but responses to elevated renal pelvic pressure were not. Importantly, renal afferent nerve responses were not different between nighttime and daytime.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Sean D. Stocker
Summary: This study found that a high salt diet activates NaCl-responsive neurons in the OVLT and leads to salt-sensitive hypertension. Inhibiting the activity of OVLT neurons can decrease sympathetic nerve activity and blood pressure in salt-sensitive hypertensive rats.
Article
Peripheral Vascular Disease
Sean D. Stocker, Jacob B. Sullivan
Summary: TRPV1 channels are involved in 2K1C renovascular hypertension, regulating renal afferent and sympathetic nerve activity, glomerular filtration rate, and arterial blood pressure.
Article
Neurosciences
Laura Anselmi, Guillaume P. Ducrocq, Victor Ruiz-Velasco, Sean D. Stocker, Shannon P. Higgins, Marc P. Kaufman
Summary: The role of the TRPV1 channel in evoking the exercise pressor reflex is controversial. This study found that TRPV1 is not necessary for the reflex in rats.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Physiology
Joseph C. Watso, Austin T. Robinson, Matthew C. Babcock, Kamila U. Migdal, Melissa A. H. Witman, Megan M. Wenner, Sean D. Stocker, William B. Farquhar
PHYSIOLOGICAL REPORTS
(2020)
