Article
Infectious Diseases
Timothy M. Rawson, David B. Antcliffe, Richard C. Wilson, Alireza Abdolrasouli, Luke S. P. Moore
Summary: Bacterial and fungal infections are common in ICU patients, and are associated with worse clinical outcomes. This article reviews the epidemiology of bacterial and fungal infection in the ICU, discussing risk factors, diagnosis and management approaches, as well as common strategies for infection prevention.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Endocrinology & Metabolism
Manel Puig-Domingo, Ignacio Bernabeu, Antonio Pico, Betina Biagetti, Joan Gil, Cristina Alvarez-Escola, Mireia Jorda, Montserrat Marques-Pamies, Berta Soldevila, Maria-Angeles Galvez, Rosa Camara, Javier Aller, Cristina Lamas, Monica Marazuela
Summary: This paper proposes including the clinico-pathologic phenotype in the therapeutic algorithm for acromegaly, utilizing biomarkers for personalized medicine to accelerate the implementation of precision medicine. Additionally, the development, validation, and clinical use of a pasireotide acute test is suggested to identify patients responsive to pasireotide LAR.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Eva C. Coopmans, Aart J. van der Lely, Sebastian J. C. M. M. Neggers
Summary: Acromegaly is a chronic disorder caused by GH-producing pituitary adenoma. While surgery and medical therapy are standard treatments, some tumors behave aggressively and are resistant to these therapies. In such cases, multimodal therapeutic strategies should be considered.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Nazanin Ershadinia, Nicholas A. Tritos
Summary: Acromegaly is a condition caused by a pituitary adenoma that secretes growth hormone, resulting in various complications. Early diagnosis and appropriate treatment are crucial. Diagnosis is confirmed through biochemical tests and MRI. Pituitary surgery is usually the first-line treatment, while medical therapy and radiation therapy can be used as adjunct options.
MAYO CLINIC PROCEEDINGS
(2022)
Review
Biochemistry & Molecular Biology
Roxana Daneshjou, Bryan He, David Ouyang, James Y. Zou
Summary: This article examines the application of deep learning algorithms in cancer diagnosis, emphasizing the improvement in predictive performance as data volume increases. Examples of deep learning algorithms in cancer diagnosis using clinical, radiological, and pathological image data are presented, along with a systematic approach for evaluating and implementing these algorithms. The future possibilities and roadmap for implementing deep learning in cancer diagnosis are also discussed based on current state of deep learning in medicine.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Endocrinology & Metabolism
Mirsala Solak, Ivana Kraljevic, Hrvoje Popovac, Lana Sambula, Tanja Skoric Polovina, Annemarie Balasko, Karin Zibar Tomsic, Tina Dusek, Anela Novak, Marija Tripolski, Darko Kastelan
Summary: This study aimed to evaluate the therapeutic outcomes of medical treatment for patients with acromegaly based on real-world data. The results showed that almost all patients with active acromegaly after pituitary surgery can achieve biochemical control with medical treatment.
Review
Endocrinology & Metabolism
Kevin C. J. Yuen, Susan L. Samson
Summary: Oral octreotide capsules (OOCs) are an effective treatment option for acromegaly, providing suppression of growth hormone and insulin-like growth factor 1 levels, maintaining disease control, and reducing symptoms. The safety profile of OOC therapy is comparable to injectable somatostatin receptor ligands (SRLs), and patients express a preference for oral administration.
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
Sabrina Chiloiro, Antonio Bianchi, Antonella Giampietro, Alfredo Pontecorvi, Gerald Raverot, Laura De Marinis
Summary: This review provides an overview of the second-line therapies for acromegaly, summarizing the evidence on clinical, molecular, and morphological aspects that can predict the response to these treatments and advocating for a patient-tailored therapeutic approach in clinical practice.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Pamela U. Freda
Summary: Acromegaly is a hormonal disorder characterized by excess hormone production, leading to a specific lipodystrophy and insulin resistance. Understanding the pathophysiology of this condition and its effects on adipose tissue metabolism and insulin resistance is important for optimizing treatment and long-term outcomes for patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Muhammad Javed Iqbal, Zeeshan Javed, Jesus Herrera-Bravo, Haleema Sadia, Faiza Anum, Shahid Raza, Arifa Tahir, Muhammad Naeem Shahwani, Javad Sharifi-Rad, Daniela Calina, William C. Cho
Summary: Recent technological advances in nanoscience and material design have led to the development of point-of-care devices for biomolecule sensing and cancer diagnosis, with improved sensitivity and specificity. These innovations show great promise for clinical breakthroughs in cancer detection and diagnosis.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Doreen G. Te Raa, Lina van der Straten, Michel van Gelder, Sabina Kersting, Mark-David Levin, Rogier Mous, Hanneke M. van der Straaten, Marten R. Nijziel, Ellen van der Spek, Eduardus F. M. Posthuma, Hein P. J. Visser, Marjolein van der Klift, Koen de Heer, Mar Bellido, Jeanette K. Doorduijn, Anke H. W. Bruns, Reinier A. P. Raijmakers, Arnon P. Kater
Summary: The management of patients with chronic lymphocytic leukemia (CLL) is changing due to advancements in therapeutic options. The Dutch CLL working group has revised the Dutch CLL guidelines, providing recommendations on diagnosis, treatment strategies, and supportive care measurements. The guidelines take into account efficacy, toxicity, treatment duration, and intensity.
LEUKEMIA & LYMPHOMA
(2022)
Article
Endocrinology & Metabolism
Naoki Yamamoto, Shin Urai, Hidenori Fukuoka, Masaaki Yamamoto, Kenichi Yoshida, Masaki Suzuki, Hiroki Shichi, Yasunori Fujita, Keitaro Kanie, Genzo Iguchi, Yutaka Takahashi, Wataru Ogawa
Summary: Factors associated with impaired QoL differed in young and middle-aged patients compared to older patients with acromegaly. In older patients, arthropathy and higher BMI were associated with poor QoL, indicating the importance of early diagnosis and appropriate treatment to prevent arthropathy in acromegaly.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Dawn Shao Ting Lim, Maria Fleseriu
Summary: Acromegaly is a condition that requires appropriate treatment to prevent significant morbidity and mortality. The treatment goals include normalization of insulin-like growth factor 1 and growth hormone, tumor shrinkage, symptom relief, complication management, and improvement of quality of life. Surgical resection is the first-line treatment option, and somatostatin receptor ligands (SRLs) are commonly used for medical therapy. However, SRL resistance can be predicted by certain factors, and alternative treatments such as growth hormone receptor antagonists or second-generation SRLs may be considered. Combination therapy can be pursued for patients who are not biochemically controlled or have residual tumor after monotherapy. Personalized management based on individual characteristics and preferences is important for achieving high-quality outcomes.
ENDOCRINE PRACTICE
(2022)
Review
Endocrinology & Metabolism
Artak Labadzhyan, Shlomo Melmed
Summary: Molecular therapeutic targets in growth hormone-secreting adenomas have potential for drug development, including surface receptors recognized by approved drugs and markers for new drug candidates. Current medical therapies control the disease in most patients but the degree of control varies and is related to disease aggressiveness and tumor factors. Understanding the mechanisms behind these molecular markers and their relationship to outcomes holds promise for expanding treatment options and personalized approaches.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Bart Koopman, Harry J. M. Groen, Marjolijn J. L. Ligtenberg, Katrien Grunberg, Kim Monkhorst, Adrianus J. de Langen, Mirjam C. Boelens, Marthe S. Paats, Jan H. von der Thusen, Winand N. M. Dinjens, Nienke Solleveld, Tom van Wezel, Hans Gelderblom, Lizza E. Hendriks, Ernst-Jan M. Speel, Tom E. Theunissen, Leonie I. Kroeze, Niven Mehra, Berber Piet, Anthonie J. van der Wekken, Arja ter Elst, Wim Timens, Stefan M. Willems, Ruud W. J. Meijers, Wendy W. J. de Leng, Anne S. R. van Lindert, Teodora Radonic, Sayed M. S. Hashemi, Danielle A. M. Heideman, Ed Schuuring, Leon C. van Kempen
Summary: This study evaluates the methods and agreement in treatment recommendations among Molecular Tumor Boards (MTBs) from tertiary cancer referral centers in The Netherlands. It found that these MTBs are similar in setup and demonstrate high agreement in recommendations for rare or complex mutational cancer profiles. The proposed Dutch MTB model focuses on collaborative and nationally aligned workflow with interinstitutional collaboration and data sharing.
Review
Nutrition & Dietetics
Pawel Pludowski, Beata Kos-Kudla, Mieczyslaw Walczak, Andrzej Fal, Dorota Zozulinska-Ziolkiewicz, Piotr Sieroszewski, Jaroslaw Peregud-Pogorzelski, Ryszard Lauterbach, Tomasz Targowski, Andrzej Lewinski, Robert Spaczynski, Miroslaw Wielgos, Jaroslaw Pinkas, Teresa Jackowska, Ewa Helwich, Artur Mazur, Marek Ruchala, Arkadiusz Zygmunt, Mieczyslaw Szalecki, Artur Bossowski, Justyna Czech-Kowalska, Marek Wojcik, Beata Pyrzak, Michal A. Zmijewski, Pawel Abramowicz, Jerzy Konstantynowicz, Ewa Marcinowska-Suchowierska, Andrius Bleizgys, Spirydon N. Karras, William B. Grant, Carsten Carlberg, Stefan Pilz, Michael F. Holick, Waldemar Misiorowski
Summary: It is found that vitamin D deficiency is prevalent among the Polish population based on epidemiological studies. To address this concern, a Polish multidisciplinary group reviewed the evidence and formulated recommendations for prevention and treatment of vitamin D deficiency. The final Polish recommendations included a range of serum vitamin D levels indicating deficiency, guidelines for prophylaxis and treatment, and the importance of improving the overall population's vitamin D status and treating at-risk patient groups.
Article
Biochemistry & Molecular Biology
Katarzyna Paczkowska, Dominik Rachon, Andrzej Berg, Jacek Rybka, Katarzyna Kapczynska, Marek Bolanowski, Jacek Daroszewski
Summary: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in women of reproductive age. A study investigated the levels of branch chain amino acids (BCAA) in women with PCOS and found significantly higher levels of BCAA compared to healthy controls. These elevated BCAA levels were associated with metabolic alterations and other disturbances in PCOS patients. The findings suggest that BCAA profiles could be used as a predictive factor for PCOS-related complications.
Article
Biochemistry & Molecular Biology
Diana Jedrzejuk, Pawel Poznanski, Pawel Szewczyk, Oktawia Mazanowska, Marek Bolanowski, Magdalena Krajewska, Dorota Kaminska
Summary: The popularity of living-donor organ donation has increased recently due to the growing need for organs and a shortage of deceased-donor organs. This procedure requires a comprehensive health assessment of candidates, who must be in good physical and mental health. We present a case of a potential living-kidney donor who was withdrawn from donation due to Paget's disease of bone, and various imaging and assessment techniques were used to thoroughly evaluate the affected vertebra.
Article
Immunology
Dariusz Kajdaniuk, Wanda Foltyn, Elzbieta Morawiec-Szymonik, Zenon Czuba, Ewa Szymonik, Beata Kos-Kudla, Bogdan Marek
Summary: The effects of specific cytokines produced by T cell subsets are diverse and depend on various factors. The balance of immune cells is necessary for immune homeostasis. Imbalances in T cell subsets can lead to autoimmune diseases. The aim of this study was to determine the cytokines and modulating factors in patients with pernicious anemia.
IMMUNOLOGIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Magdalena Basinska-Lewandowska, Krzysztof Lewandowski, Wojciech Horzelski, Andrzej Lewinski, Elzbieta Skowronska-Jozwiak
Summary: The study found a correlation between 25OHD concentrations below 12 ng/mL and an increased risk of COVID-19 infection. However, no significant increase in infection risk was observed for individuals with 25OHD concentrations above 20 ng/mL.
Article
Biochemistry & Molecular Biology
Violetta Rosiek, Ksenia Janas, Beata Kos-Kudla
Summary: This study aimed to assess the changes in angiogenic factors (AF) serum levels in neuroendocrine tumour (NET) patients treated with prolonged-acting somatostatin analogues (SSAs). The concentrations of vascular endothelial growth factor receptors 2, 3 (VEGF-R2, VEGF-R3), and vascular cell adhesion molecule-1 (VCAM-1) showed significant differences depending on the duration of SSA treatment. However, monitoring these biomarkers did not help in assessing the effectiveness of SSA treatment in NET patients.
Article
Biochemistry & Molecular Biology
Malgorzata Rolla, Aleksandra Jawiarczyk-Przybylowska, Katarzyna Kolackov, Agnieszka Zembska, Marek Bolanowski
Summary: This study investigated the expression of H19 RNA in acromegaly patients and found that it is not relevant for the diagnosis of acromegaly. Acromegaly patients have a higher risk of hypertension, goitre, and cholelithiasis, with cholelithiasis being associated with higher H19 RNA expression.
Review
Biochemistry & Molecular Biology
Aleksandra Piekarska, Marta Goral, Marta Kozula, Aleksandra Jawiarczyk-Przybylowska, Katarzyna Zawadzka, Marek Bolanowski
Summary: It is important to understand the impact of COVID-19 on the thyroid gland and the relationship between thyroid status and SARS-CoV-2 severity. The virus uses angiotensin-converting enzyme-2 as a receptor and can cause organ failures through a cytokine storm. Proinflammatory molecules are elevated in COVID-19 patients, but there is no evidence of a direct impact of thyroid dysfunctions on disease severity.
Editorial Material
Endocrinology & Metabolism
Grzegorz Erbert, Elzbieta Lomna-Bogdanov, Marek Bolanowski
ENDOKRYNOLOGIA POLSKA
(2023)
Article
Endocrinology & Metabolism
Beata Kos-Kudla, Justo P. Castano, Timm Denecke, Enrique Grande, Andreas Kjaer, Anna Koumarianou, Louis de Mestier, Stefano Partelli, Aurel Perren, Stefan Staettner, Juan W. Valle, Nicola Fazio
Summary: This ENETS guidance paper provides up-to-date and practical advice on the management of well-differentiated nonfunctioning pancreatic neuroendocrine tumours (NF-Pan-NET). The authors discuss 10 troublesome questions in everyday clinical practice based on their extensive experience. Multidisciplinary decision-making is still necessary for the treatment of NF-Pan-NEN.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Oncology
Agnes Bocian-Jastrzebska, Anna Malczewska-Herman, Violetta Rosiek, Beata Kos-Kudla
Summary: This study investigated the potential relationship between leptin, adiponectin, and the leptin-adiponectin ratio with the grade, stage, and metastases of PanNENs. It was found that adiponectin concentration was significantly higher in the control group compared to the study group, and both leptin and adiponectin levels were higher in females than males. An increased leptin-adiponectin ratio was observed in well-differentiated PanNENs and PanNENs with low Ki-67. Additionally, lower leptin levels and a decreased leptin-adiponectin ratio were found in PanNENs with distal disease. These findings suggest that leptin, adiponectin, and their ratio may serve as potential biomarkers for the diagnosis, prognosis, and prediction of PanNENs.
Article
Biochemistry & Molecular Biology
Aleksandra Jawiarczyk-Przybylowska, Justyna Kuliczkowska-Plaksej, Katarzyna Kolackov, Agnieszka Zembska, Jowita Halupczok-Zyla, Malgorzata Rolla, Michal Miner, Marcin Kaluzny, Marek Bolanowski
Summary: The study reveals that the polymorphisms of the FTO gene are associated with lipid metabolism and an increased risk of cardiovascular diseases in patients with acromegaly. Furthermore, these polymorphisms also have an impact on IGF-1 synthesis. Larger scale investigations are needed for more precise evidence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Katarzyna Miskiewicz-Orczyk, Wojciech Pluskiewicz, Beata Kos-Kudla, Maciej Misiolek
Summary: The aim of this study was to assess the prevalence of osteoporosis and 25(OH) vitamin D3 deficiency in patients with idiopathic BPPV. The results showed no significant relationships between age, BMI, or vitamin D3 levels and bone densitometry results in patients with idiopathic BPPV.
MEDICINA-LITHUANIA
(2023)
Article
Endocrinology & Metabolism
Tomasz Bednarczuk, Dariusz Kajdaniuk, Bogdan Marek, Marek Bolanowski, Marek Dedecjus, Aleksandra Gilis-Januszewska, Alicja Hubalewska-Dydejczyk, Barbara Jarzab, Roman Junik, Grzegorz Kaminski, Beata Kos-Kudla, Aldona Kowalska, Andrzej Lewinski, Beata Matyjaszek-Matuszek, Marek Ruchala, Lucyna Sieminska, Krzysztof Sworczak, Anhelli Syrenicz, Wojciech Zgliczynski
Summary: Medical practitioners should be aware of the potential adverse effects associated with the use of iodinated contrast media (ICM). Contrast-induced nephropathy is the most common adverse effect, while thyroidal adverse reactions remain a diagnostic and therapeutic challenge.
ENDOKRYNOLOGIA POLSKA
(2023)