Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Lucia E. Rosas, Lauren M. Doolittle, Lisa M. Joseph, Hasan El-Musa, Michael Novotny, Judy M. Hickman-Davis, R. Duncan Hite, Ian C. Davis
Summary: Supplementation of parenteral liponucleotides can attenuate ARDS induced by influenza in mice, including improving lung function, reducing hypoxemia, and pulmonary edema. Co-administration of CDP-diacylglycerol with CDP-choline has enhanced therapeutic effects, and single-dose treatment also shows benefits in alleviating symptoms.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rene Roy, Ayed Allawzi, Nana Burns, Christina Sul, Victoria Rubio, Jessica Graham, Kurt Stenmark, Eva Nozik, Rubin Tuder, Christine Vohwinkel
Summary: This study reveals that lactate produced by alveolar type II cells (ATII) in acute lung injury (ALI) can shift alveolar macrophages (AM) towards an anti-inflammatory phenotype, thereby mitigating excessive inflammation.
Article
Cell Biology
A. S. Chernov, A. A. Minakov, V. A. Kazakov, M. Rodionov, I. N. Rybalkin, T. N. Vlasik, D. Yashin, L. P. Saschenko, A. A. Kudriaeva, A. A. Belogurov, I. Smirnov, S. Ya Loginova, V. N. Schukina, S. Savenko, S. Borisevich, K. A. Zykov, A. G. Gabibov, G. B. Telegin
Summary: The study introduces a new mouse model of diffuse alveolar damage, which achieves more serious and uniform lung injury through intrabronchial administration. This model can be used to evaluate the efficacy of innovative drugs and is significant for research on infectious respiratory diseases.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Pei-Yao Liu, Chih-Yuan Chen, Yu-Lung Lin, Chien-Ming Lin, Wen-Chiuan Tsai, Yu-Ling Tsai, Gu-Jiun Lin, Yu-Guang Chen, Shih-Yun Wang, Rui-Nong Sun, Yu-Chuan Huang, Hung Chang, Ying-Chuan Chen
Summary: Acute lung injury (ALI) is a severe condition characterized by pulmonary inflammation, barrier disruption, and oedema. This study identifies RNF128 as a negative regulator of ALI by inhibiting neutrophil activation, reducing pro-inflammatory cytokines, and targeting TLR4 for degradation. Overexpression of RNF128 alleviates lung damage and reduces inflammatory cell infiltration, suggesting its potential as a therapeutic candidate for ALI.
CELL DEATH & DISEASE
(2023)
Article
Plant Sciences
Fei He, Fengjuan Gao, Nan Cai, Min Jiang, Chao Wu
Summary: This study found that CGA enhances alveolar macrophages phagocytosis by upregulating GPR37 expression, thus attenuating lung inflammatory injury.
Article
Immunology
Jose Alberto Choreno-Parra, Luis Armando Jimenez-Alvarez, Gustavo Ramirez-Martinez, Alfredo Cruz-Lagunas, Mahima Thapa, Luis Alejandro Fernandez-Lopez, Martha Carnalla-Cortes, Eduardo M. Choreno-Parra, Lourdes Mena-Hernandez, Montserrat Sandoval-Vega, Erika Mariana Hernandez-Montiel, Diana Lizzeth Hernandez-Garcia, Jazmin Ariadna Ramirez-Noyola, Cynthia Estefania Reyes-Lopez, Andrea Dominguez-Faure, Guillermo Yamil Zamudio-Lopez, Eduardo Marquez-Garcia, Angelica Moncada-Morales, Criselda Mendoza-Milla, Diana Cervantes-Rosete, Marcela Munoz-Torrico, Cesar Luna-Rivero, Ethel A. Garcia-Latorre, Parmenides Guadarrama-Ortiz, Federico Avila-Moreno, Guillermo Dominguez-Cherit, Tatiana Sofia Rodriguez-Reyna, Philip A. Mudd, Carmen Margarita Hernandez-Cardenas, Shabaana A. Khader, Joaquin Zuniga
Summary: Surfactant protein D (SP-D) may help differentiate severe pandemic influenza from COVID-19, with high serum SP-D levels possibly associated with death and renal failure in severe pandemic influenza cases. However, SP-D levels do not distinguish seasonal influenza from COVID-19 in mild-to-moderate disease.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Pediatrics
Arielle L. Olicker, Thomas M. Raffay, Rita M. Ryan
Summary: Infants born through meconium-stained amniotic fluid (MSAF) are more likely to develop respiratory distress, with meconium aspiration syndrome (MAS) being a common cause treated with supportive therapy; long-term prognosis is more related to initial hypoxemia severity and possible neurological insult.
Article
Medicine, General & Internal
Qing Qing, Ping Zha, Li-Ying Dai, Yang Wang
Summary: This study investigated the clinical efficacy of different ventilation strategies combined with pulmonary surfactant (PS) therapy in the treatment of neonatal respiratory distress syndrome (NRDS). The findings showed that the integration of high-frequency oscillatory ventilation (HFOV) with PS effectively expedited the treatment duration, decreased the occurrence of complications, and secured therapeutic efficacy in managing NRDS.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Medicine, General & Internal
Ko-Wei Chang, Shaw-Woei Leu, Shih-Wei Lin, Shinn-Jye Liang, Kuang-Yao Yang, Ming-Cheng Chan, Wei-Chih Chen, Han-Chung Hu, Wen-Feng Fang, Yu-Mu Chen, Chau-Chyun Sheu, Ming-Ju Tsai, Hao-Chien Wang, Ying-Chun Chien, Chung-Kan Peng, Chieh-Liang Wu, Kuo-Chin Kao
Summary: In patients with influenza pneumonia-related ARDS, the mortality rate is significantly higher in those requiring RRT for AKI than those not requiring RRT. Predictors for AKI requiring RRT include chronic liver disease and C-reactive protein, while predictors for mortality include pneumonia severity index, tidal volume, and continuous renal replacement therapy. Patients with ESRD did not show a significant difference in mortality compared to other patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Lars Mense, Tim Hansmann, Barbara Seipolt, Maxi Kaufmann, Mario Ruediger
Summary: DD-SURF is a novel surfactant administration method that combines the benefits of INSURE and LISA. It has been proven to be effective and safe in reducing the need for mechanical ventilation.
Review
Cell Biology
Huan Tao, Younian Xu, Shihai Zhang
Summary: Acute lung injury (ALI) usually leads to acute respiratory distress syndrome (ARDS) or even death in critically ill patients. The infiltration of immune cells in the inflamed lungs is a significant characteristic of ARDS. Macrophages, a type of immune cell, play a crucial role in the progression of ARDS through their interactions with lung alveolar epithelial cells (AECs).
Article
Critical Care Medicine
Richard K. Albert
Summary: This Perspective summarizes the mechanisms by which continuous volume-targeted ventilation (CVTV) causes ventilator-induced lung injury (VILI) by affecting surfactant function.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Manuela Cucerea, Mihaela Moscalu, Elena Moldovan, Reka Santa, Zsuzsanna Gall, Laura Mihaela Suciu, Marta Simon
Summary: This study aimed to compare different methods of surfactant administration to determine which is associated with fewer morbidities. The results showed that the LISA method of administration can reduce the need for mechanical ventilation within 72 hours, as well as decrease morbidity and mortality rates. The study suggests that the LISA procedure may be a good choice for spontaneously breathing preterm infants, regardless of gestational age.
Article
Pediatrics
Lucia Lanciotti, Alessio Correani, Matteo Pasqualini, Luca Antognoli, Valentina G. Dell'Orto, Chiara Giorgetti, Sara Colombo, Maria L. Palazzi, Clementina Rondina, Ilaria Burattini, Virgilio P. Carnielli
Summary: Switching the dose of surfactant from 100 mg/kg to 200 mg/kg is associated with a significant reduction in the need for surfactant redosing, respiratory support, and the incidence of bronchopulmonary dysplasia.
PEDIATRIC PULMONOLOGY
(2022)