Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 169, Issue -, Pages 687-695Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2018.11.037
Keywords
PM2.5; Maternal exposure; Locomotor activity; Metabolomics
Categories
Funding
- National Key Research and Development (R&D) Plan of China [2017YFC0211600, 2017YFC0211603]
- Major Research Plan of the National Natural Science Foundation (training program) of China [91743112, 91643109]
- State Key Program of National Natural Science Foundation of China [81730088]
- Thousand Talent Program for Young Outstanding Scientists of China
- National Institute of Environmental Health Sciences (NIEHS), USA [R01 ES10563, R01 ES07331, R01 ES020852]
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Reproductive epidemiological studies have suggested associations between perinatal exposure to fine particulate matter (PM2.5) and adverse birth outcomes. To explore the effects of early prenatal exposure to PM2.5 on subsequent generations, pregnant mice were exposed to PM2.5 or filtered clean air in whole body dynamic exposure chambers for 14 consecutive days from gestation day (GD) 1.5 to GD15.5. Neurobehavioral tests showed that spontaneous locomotion and exploratory behaviors in the offspring were significantly enhanced in the open field test. Meanwhile, metabolomics analysis suggested activation of dopamine pathway while inhibition of glycine pathway in murine brains. Administration of the DRD4 antagonist, clozapine; or supplementation of glycine receptor agonist, taurine, to mice offspring attenuated the locomotor hyperactivities to levels indistinguishable from controls. These data provide strong evidence that maternal exposure to air pollution might increase the risk for neural disorders in the offspring during critical periods of brain development.
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