Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling: Pathomechanisms, perspectives, and therapeutic implications

Cerebral Vascular Injury in Traumatic Brain Injury

(2016) Kimbra Kenney et al.   EXPERIMENTAL NEUROLOGY

Chronic cerebrovascular dysfunction after traumatic brain injury

(2016) Amandine Jullienne et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Neuropathology of Chronic Traumatic Encephalopathy

(2015) Ann C. McKee et al.   BRAIN PATHOLOGY

Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions

(2015) Jason M. Hinzman et al.   EXPERIMENTAL NEUROLOGY

Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

(2015) Giuseppe Faraco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pharmacologically-Induced Neurovascular Uncoupling is Associated with Cognitive Impairment in Mice

(2015) Stefano Tarantini et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Chloride Cotransporters as a Molecular Mechanism underlying Spreading Depolarization-Induced Dendritic Beading

(2015) A. B. Steffensen et al.   JOURNAL OF NEUROSCIENCE

Endothelial Nitric Oxide Synthase Mediates Arteriolar Vasodilatation after Traumatic Brain Injury in Mice

(2015) Susanne M. Schwarzmaier et al.   JOURNAL OF NEUROTRAUMA

Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries: Figure 1.

(2015) Zsolt Springo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Blood–brain barrier dysfunction following traumatic brain injury

(2015) Himakarnika Alluri et al.   METABOLIC BRAIN DISEASE

The Role of Nitric Oxide and Sympathetic Control in Cerebral Autoregulation in the Setting of Subarachnoid Hemorrhage and Traumatic Brain Injury

(2015) Zhen-Ni Guo et al.   MOLECULAR NEUROBIOLOGY

High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain

(2015) Ákos Menyhárt et al.   NEUROBIOLOGY OF AGING

Supply-Demand Mismatch Transients in Susceptible Peri-infarct Hot Zones Explain the Origins of Spreading Injury Depolarizations

(2015) Daniel von Bornstädt et al.   NEURON

Hypothermia for Intracranial Hypertension after Traumatic Brain Injury

(2015) Peter J.D. Andrews et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature

(2015) Cenk Ayata et al.   PHYSIOLOGICAL REVIEWS

Localized TRPA1 channel Ca2+signals stimulated by reactive oxygen species promote cerebral artery dilation

(2015) Michelle N. Sullivan et al.   Science Signaling

Localized TRPA1 channel Ca2+signals stimulated by reactive oxygen species promote cerebral artery dilation

(2015) Michelle N. Sullivan et al.   Science Signaling

Spreading depression in continuous electroencephalography of brain trauma

(2014) Jed A. Hartings et al.   ANNALS OF NEUROLOGY

Inverse neurovascular coupling to cortical spreading depolarizations in severe brain trauma

(2014) Jason M. Hinzman et al.   BRAIN

Increased pressure-induced tone in rat parenchymal arterioles vs. middle cerebral arteries: role of ion channels and calcium sensitivity

(2014) Marilyn J. Cipolla et al.   JOURNAL OF APPLIED PHYSIOLOGY

Juvenile Traumatic Brain Injury Induces Long-Term Perivascular Matrix Changes Alongside Amyloid-Beta Accumulation

(2014) Amandine Jullienne et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

IGF-1 Deficiency Impairs Cerebral Myogenic Autoregulation in Hypertensive Mice

(2014) Peter Toth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Impaired Neurovascular Unit Function Contributes to Persistent Symptoms after Concussion: A Pilot Study

(2014) Brenda L. Bartnik-Olson et al.   JOURNAL OF NEUROTRAUMA

Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations

(2014) Daniela Pietrobon et al.   NATURE REVIEWS NEUROSCIENCE

Optimal cerebral perfusion pressure: are we ready for it?

(2014) Christos Lazaridis et al.   NEUROLOGICAL RESEARCH

Age-Dependent Neurovascular Dysfunction and Damage in a Mouse Model of Cerebral Amyloid Angiopathy

(2014) Laibaik Park et al.   STROKE

Traumatic Brain Injury Disrupts Cerebrovascular Tone Through Endothelial Inducible Nitric Oxide Synthase Expression and Nitric Oxide Gain of Function

(2014) Nuria Villalba et al.   Journal of the American Heart Association

Continuous Online Microdialysis Using Microfluidic Sensors: Dynamic Neurometabolic Changes during Spreading Depolarization

(2013) Michelle L. Rogers et al.   ACS Chemical Neuroscience

Resveratrol treatment rescues neurovascular coupling in aged mice: role of improved cerebromicrovascular endothelial function and downregulation of NADPH oxidase

(2013) Peter Toth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Prostaglandin E2, a Postulated Astrocyte-Derived Neurovascular Coupling Agent, Constricts Rather than Dilates Parenchymal Arterioles

(2013) Fabrice Dabertrand et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Age-Related Autoregulatory Dysfunction and Cerebromicrovascular Injury in Mice with Angiotensin II-induced Hypertension

(2013) Peter Toth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Surgical management of traumatic brain injury: a comparative-effectiveness study of 2 centers

(2013) Jed A. Hartings et al.   JOURNAL OF NEUROSURGERY

tPA-S481A Prevents Impairment of Cerebrovascular Autoregulation by Endogenous tPA after Traumatic Brain Injury by Upregulating p38 MAPK and Inhibiting ET-1

(2013) William M. Armstead et al.   JOURNAL OF NEUROTRAUMA

Traumatic Brain Injury In Vivo and In Vitro Contributes to Cerebral Vascular Dysfunction through Impaired Gap Junction Communication between Vascular Smooth Muscle Cells

(2013) Guang-Xiang Yu et al.   JOURNAL OF NEUROTRAUMA

Changing patterns in the epidemiology of traumatic brain injury

(2013) Bob Roozenbeek et al.   Nature Reviews Neurology

Propagation of cortical spreading depolarization in the human cortex after malignant stroke

(2013) J. Woitzik et al.   NEUROLOGY

Correlates of spreading depolarization in human scalp electroencephalography

(2012) C. Drenckhahn et al.   BRAIN

Impaired cerebral haemodynamic function associated with chronic traumatic brain injury in professional boxers

(2012) Damian M. Bailey et al.   CLINICAL SCIENCE

Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury*

(2012) Marcel J. H. Aries et al.   CRITICAL CARE MEDICINE

Persistent astroglial swelling accompanies rapid reversible dendritic injury during stroke-induced spreading depolarizations

(2012) W. Christopher Risher et al.   GLIA

Effects of Hypothermia on Cerebral Autoregulatory Vascular Responses in Two Rodent Models of Traumatic Brain Injury

(2012) Motoki Fujita et al.   JOURNAL OF NEUROTRAUMA

Design of Poly(ethylene Glycol)-Functionalized Hydrophilic Carbon Clusters for Targeted Therapy of Cerebrovascular Dysfunction in Mild Traumatic Brain Injury

(2012) Daniela C. Marcano et al.   JOURNAL OF NEUROTRAUMA

Combination therapy with glucagon and a novel plasminogen activator inhibitor-1-derived peptide enhances protection against impaired cerebrovasodilation during hypotension after traumatic brain injury through inhibition of ERK and JNK MAPK

(2012) William M Armstead et al.   NEUROLOGICAL RESEARCH

The Relationship Between Cerebral Blood Flow Autoregulation and Cerebrovascular Pressure Reactivity After Traumatic Brain Injury

(2012) Karol P. Budohoski et al.   NEUROSURGERY

Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone

(2012) P. Bagher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow

(2011) David R. Harder et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Spreading depolarizations have prolonged direct current shifts and are associated with poor outcome in brain trauma

(2011) Jed A. Hartings et al.   BRAIN

Isolated Human and Rat Cerebral Arteries Constrict to Increases in Flow: Role of 20-HETE and TP Receptors

(2011) Peter Toth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spreading depolarisations and outcome after traumatic brain injury: a prospective observational study

(2011) Jed A Hartings et al.   LANCET NEUROLOGY

Perspective: Physiological Role(s) of the Vascular Myogenic Response

(2011) MICHAEL J. DAVIS   MICROCIRCULATION

The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease

(2011) Jens P Dreier   NATURE MEDICINE

Monitoring cerebral autoregulation after head injury. Which component of transcranial Doppler flow velocity is optimal?

(2011) Karol P. Budohoski et al.   Neurocritical Care

Favorable Outcome in Traumatic Brain Injury Patients With Impaired Cerebral Pressure Autoregulation When Treated at Low Cerebral Perfusion Pressure Levels

(2011) Ulf Johnson et al.   NEUROSURGERY

Position Statement: Definition of Traumatic Brain Injury

(2010) David K. Menon et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Recurrent Spontaneous Spreading Depolarizations Facilitate Acute Dendritic Injury in the Ischemic Penumbra

(2010) W. C. Risher et al.   JOURNAL OF NEUROSCIENCE

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage

(2009) J. P. Dreier et al.   BRAIN

Hypermetabolism following Moderate to Severe Traumatic Acute Brain Injury: A Systematic Review

(2009) Norine Foley et al.   JOURNAL OF NEUROTRAUMA

Spreading Depolarizations and Late Secondary Insults after Traumatic Brain Injury

(2009) Jed A. Hartings et al.   JOURNAL OF NEUROTRAUMA

Temporal Profile of Thrombogenesis in the Cerebral Microcirculation after Traumatic Brain Injury in Mice

(2009) Susanne M. Schwarzmaier et al.   JOURNAL OF NEUROTRAUMA

TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNELS, VASCULAR TONE AND AUTOREGULATION OF CEREBRAL BLOOD FLOW

(2008) Joseph E Brayden et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Persisting Depletion of Brain Glucose following Cortical Spreading Depression, despite Apparent Hyperaemia: Evidence for Risk of an Adverse Effect of Leão's Spreading Depression

(2008) Parastoo Hashemi et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral Autoregulation: An Overview of Current Concepts and Methodology with Special Focus on the Elderly

(2008) Arenda HEA van Beek et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral pressure autoregulation in traumatic brain injury

(2008) Leonardo Rangel-Castilla et al.   Neurosurgical Focus

The Sit-to-Stand Technique for the Measurement of Dynamic Cerebral Autoregulation

(2008) Farzaneh A. Sorond et al.   ULTRASOUND IN MEDICINE AND BIOLOGY