Journal
DRUG DISCOVERY TODAY
Volume 24, Issue 5, Pages 1176-1183Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2019.02.014
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Funding
- Fundacao para a Ciencia e a Tecnologia with Portuguese Government funds through the CQM Strategic Project [PEst-OE/QUI/UI0674/2013]
- Agencia Regional para o Desenvolvimento da Investigacao Tecnologia [M1420-01-0145-FEDER-000005]
- Spanish Ministerio de Economia y Competitividad (MINECO/AEI/FEDER/UE) [SAF2017-89288-R]
- CNRS (France)
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Dendrimers are highly branched, star-shaped macromolecules with nanometer-scale dimensions that can be readily modified with a range of functional groups, thus modifying their physicochemical and biological properties. In nanomedicine, dendrimers can be used as vectors for the targeted delivery strategy of a variety of biologically active agents or can be used as drug per se. In the future, it will be necessary to designate and develop 'safe' dendrimers, which is currently a crucial concern. Here, we analyze the key in vitro physicochemical parameters to be considered for preclinical evaluation of biomedical dendrimers.
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