Article
Medicine, Research & Experimental
Miguel Regueiro, Theresa Hunter, Rina Lukanova, Mingyang Shan, Rosie Wild, Hannah Knight, Priyanka Bannikoppa, April N. Naegeli
Summary: This study assessed the prevalence of fatigue and its association with disease activity and patient-reported outcomes among patients with ulcerative colitis (UC) or Crohn's disease (CD). The results showed that fatigue is a common symptom among patients with UC or CD and is associated with higher disease activity levels and decreased work productivity. Managing fatigue may require a multidisciplinary approach.
ADVANCES IN THERAPY
(2023)
Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Julien Kirchgesner, Rishi J. Desai, Maria C. Schneeweiss, Laurent Beaugerie, Sebastian Schneeweiss, Seoyoung C. Kim
Summary: Combination therapy with vedolizumab and thiopurines is associated with a lower risk of treatment failure compared to vedolizumab monotherapy in patients with CD, but the effect is less pronounced in UC.
Article
Psychology, Multidisciplinary
Felicitas Engel, Sabrina Berens, Annika Gauss, Rainer Schaefert, Wolfgang Eich, Jonas Tesarz
Summary: The study found that patients with CD/UC have higher levels of depression and anxiety compared to HC, and there are differences in personality functioning in the domain of self-perception and regulation. Minor differences were found in mentalization and attachment between CD/UC and HC.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Immunology
Reza Yarani, Ali Shojaeian, Oana Palasca, Nadezhda T. Doncheva, Lars Juhl Jensen, Jan Gorodkin, Flemming Pociot
Summary: This review discusses the differential regulation of miRNAs in inflammatory bowel disease (IBD) and their potential diagnostic and therapeutic applications. Through literature curation and computational analysis, a consensus set of differentially expressed miRNAs in mucosal tissues was obtained. The role of these miRNAs and their potential targets in IBD are highlighted.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tatsuki Noguchi, Soichiro Ishihara, Motoi Uchino, Hiroki Ikeuchi, Koji Okabayashi, Kitaro Futami, Shinji Tanaka, Hiroki Ohge, Hisashi Nagahara, Kazuhiro Watanabe, Michio Itabashi, Kinya Okamoto, Yoshiki Okita, Tsunekazu Mizushima, Yusuke Mizuuchi, Kazutaka Yamada, Yoshifumi Shimada, Yu Sato, Hideaki Kimura, Kenichi Takahashi, Koya Hida, Yusuke Kinugasa, Junji Okuda, Koji Daito, Fumikazu Koyama, Hideki Ueno, Takayuki Yamamoto, Tsunekazu Hanai, Atsuo Maemoto, Koji Oba, Yoichi Ajioka, Kenichi Sugihara
Summary: Patients with longstanding inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, are at high risk of developing intestinal cancers. This study found significant differences between intestinal cancers associated with ulcerative colitis and Crohn's disease. Crohn's disease-associated cancers were diagnosed at more advanced stages, detected less frequently by surveillance, and had a poorer prognosis compared to those associated with ulcerative colitis.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemical Research Methods
Florent Clerc, Karli R. Reiding, Noortje de Haan, Carolien A. M. Koeleman, Agnes L. Hipgrave Ederveen, Natalia Manetti, Viktoria Dotz, Vito Annese, Manfred Wuhrer
Summary: This study investigates the associations of immunoglobulin A1 and A2 glycosylation with inflammatory bowel diseases (IBD). Differences in IgA O- and N-glycosylation between patient groups were found to be associated with the diseases, and a statistical model was constructed to predict the disease group of the patients. These findings contribute to the development of noninvasive biomarkers for IBD and improvement in patient care.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Amy L. Lightner, Sarah Vogler, John McMichael, Xue Jia, Miguel Regueiro, Taha Qazi, Scott R. Steele
Summary: While UC patients were more likely to have neoplasia detected during colonoscopy, the rates of progression from LGD and HGD to adenocarcinoma were equivalent in UC and CD, suggesting consistent endoscopic surveillance strategies for all IBD patients.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Public, Environmental & Occupational Health
Kasper Monsted Pedersen, Yunus Colak, Signe Vedel-Krogh, Camilla Jannie Kobylecki, Stig Egil Bojesen, Borge Gronne Nordestgaard
Summary: The study found that smoking was associated with an increased risk of ulcerative colitis, while offering potential protection against Crohn's disease. However, genetic evidence did not support a causal relationship between smoking intensity and the development of these inflammatory bowel diseases.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Antoine Meyer, Catherine Dong, Corinne Casagrande, Simon S. M. Chan, Inge Huybrechts, Genevieve Nicolas, Fernanda Rauber, Renata Bertazzi Levy, Christopher Millett, Bas Oldenburg, Elisabete Weiderpass, Alicia K. Heath, Tammy Y. N. Tong, Anne Tjonneland, Cecilie Kyro, Rudolf Kaaks, Verena A. Katzke, Manuela M. Bergman, Domenico Palli, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Sandra M. Colorado-Yohar, Maria-Jose Sanchez, Olof Grip, Stefan Lindgren, Robert Luben, Marc J. Gunter, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel
Summary: The study found that consuming unprocessed/minimally processed foods is associated with a lower risk of Crohn's disease, but not with the risk of ulcerative colitis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Julian Hercun, Justin Cote-Daigneault, Raymond G. Lahaie, Carole Richard, Ramses Wassef, Pierre Poitras
Summary: The study found that Crohn's disease can develop postoperatively with an increasing cumulative incidence over time. Preoperative predictive factors are limited and should not determine candidacy for surgery. Most patients have favorable outcomes with medical therapy, while 16% of Crohn's disease patients require pouch removal.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Gastroenterology & Hepatology
Scott Friedberg, David Choi, Thomas Hunold, Natalie K. Choi, Nicole M. Garcia, Emma A. Picker, Nathaniel A. Cohen, Russell D. Cohen, Sushila R. Dalal, Joel Pekow, Atsushi Sakuraba, Noa Krugliak Cleveland, David T. Rubin
Summary: In this study, the authors reported a large real-world experience with the use of upadacitinib in patients with ulcerative colitis and Crohn's disease. They found that upadacitinib was rapidly effective and safe, even in patients who had prior exposure to tofacitinib.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hamed Khalili, Niclas Hakansson, Kevin Casey, Emily Lopes, Jonas F. Ludvigsson, Andrew T. Chan, Simon S. M. Chan, Ola Olen, Alicja Wolk
Summary: This study found that certain healthy eating patterns were associated with a lower risk of older-onset Crohn's disease, but not with the risk of ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Shahana Prakash, Tomohiro Tanaka, Divya Ashat
Summary: Indeterminate colitis (IC) is a subtype of inflammatory bowel disease (IBD) with features of both Crohn's disease (CD) and ulcerative colitis (UC). This study examines the characteristics of patients hospitalized with IC in the United States (US) and compares them with patients admitted with CD and UC. The study also analyzes trends in cost and length of stay.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Linmin Hu, Siqing Wu, Yuelong Shu, Kai Su, Chunliang Wang, Danni Wang, Qiangsheng He, Xinyu Chen, Wenjing Li, Ningning Mi, Peng Xie, Jinyu Zhao, Shiyong Zhang, Jinqiu Yuan, Jianbang Xiang, Bin Xia
Summary: Maternal smoking during pregnancy has an impact on the risk of Crohn's disease in adult offspring. Personal smoking and genetic risk amplify this effect.
JOURNAL OF CROHNS & COLITIS
(2023)
Editorial Material
Gastroenterology & Hepatology
Geert D'Haens, Florian Rieder, Brian G. Feagan, Peter D. R. Higgins, Julian Panes, Christian Maaser, Gerhard Rogler, Mark Lowenberg, Robbert van der Voort, Massimo Pinzani, Laurent Peyrin-Biroulet, Silvio Danese
Letter
Gastroenterology & Hepatology
Paulo Gustavo Kotze, Laurent Peyrin-Biroulet, Silvio Danese
Review
Gastroenterology & Hepatology
Ferdinando D'Amico, Stephane Nancey, Silvio Danese, Laurent Peyrin-Biroulet
Summary: This study aimed to provide a clinician's guide on practical information for FC measurement to reduce confounding factors, minimize dosage variability, and ensure better interpretation of results. Further studies are needed to compare commercially available tests and identify the best tools for precise and accurate FC measurement.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Gastroenterology & Hepatology
Anne Hu, Paulo Gustavo Kotze, Alice Burgevin, Willam Tan, Alison Jess, Pei-Shun Li, Karen Kroeker, Brendan Halloran, Remo Panaccione, Laurent Peyrin-Biroulet, Christopher Ma, Ashwin N. Ananthakrishnan
Summary: This study found that combination therapy with immunomodulators did not increase rates of clinical remission or response, endoscopic remission, or persistence of therapy in patients with CD or UC receiving ustekinumab or vedolizumab therapy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
David Laharie, Arnaud Bourreille, Julien Branche, Matthieu Allez, Yoram Bouhnik, Jerome Filippi, Frank Zerbib, Guillaume Savoye, Lucine Vuitton, Jacques Moreau, Aurelien Amiot, Laurent Beaugerie, Elena Ricart, Olivier Dewit, Antonio Lopez-Sanroman, Mathurin Fumery, Franck Carbonnel, Anthony Buisson, Benoit Coffin, Xavier Roblin, Gert van Assche, Maria Esteve, Martti Farkkila, Javier P. Gisbert, Philippe Marteau, Stephane Nahon, Martine de Vos, Laurent Peyrin-Biroulet, Jean-Yves Mary
Summary: In patients with steroid-refractory ASUC responding to second-line medical therapy, the process of endoscopic remission started with bleeding remission and was not achieved in half the patients at day 98 for vascular pattern. Infliximab provided a higher endoscopic remission rate than cyclosporine at day 98.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Gastroenterology & Hepatology
Walter Reinisch, Krisztina Gecse, Jonas Halfvarson, Peter M. Irving, Jorgen Jahnsen, Laurent Peyrin-Biroulet, Gerhard Rogler, Stefan Schreiber, Silvio Danese
Summary: The introduction of TNF inhibitors has revolutionized the treatment of Crohn's disease, but there are still differences in the actual application of evidence-based guidelines, leading to treatment disparities between countries. The availability of biosimilars can help reduce health inequalities caused by variations in drug availability.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Marion Schaefer, Valerie Laurent, Aurelie Grandmougin, Lucine Vuitton, Arnaud Bourreille, Amandine Luc, Isabelle Clerc-Urmes, Xavier Orry, Eric Frampas, Marjolaine De Billy, Lieven Pouillon, Catherine Le Berre, Claire Gay, Jeremy Meyer, Cedric Baumann, Laurent Peyrin-Biroulet
Summary: A magnetic resonance imaging-based index was developed and validated to predict Crohn's disease postoperative recurrence. The index demonstrated high accuracy and reliability in predicting postoperative recurrence of CD. The MONITOR index can be used in clinical practice to predict the POR of CD.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Catherine Le Berre, Amanda Ricciuto, Laurent Peyrin-Biroulet, Dan Turner
Summary: Short- and long-term treatment targets in inflammatory bowel diseases (IBDs) have shifted from symptom control to endoscopic healing and patient-centered parameters. The impact of early treatment on IBD remains unclear, highlighting the need for prospective disease-modification trials. The SPIRIT consensus has defined the targets for these trials to evaluate the long-term effects of early treatment on quality of life, disability, complications, neoplastic lesions, and mortality.
Article
Gastroenterology & Hepatology
Lucas Guillo, Aurelien Amiot, Melanie Serrero, Romain Altwegg, Xavier Roblin, Calina Atanasiu, Anthony Buisson, Catherine Le Berre, Catherine Reenaers, Jean-Marc Gornet, David Laharie, Vered Abitbol, Amelie Biron, Benedicte Caron, Stephane Nancey, Antoine Chupin, Antoine Blain, Lucine Vuitton, Ludovic Caillo, Julien Kirchgesner, Maria Nachury, Laurent Peyrin-Biroulet
Summary: This is the first study specifically designed to assess VTE and CVD risks in patients with UC. Over one third of patients had no CVRF and approximately three quarters had <= 1 CVRF. Moreover, over nine out of ten patients had no VTE strong risk factor and <= 1 moderate risk factor.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Mathurin Fumery, Antoine Defrance, Xavier Roblin, Romain Altwegg, Benedicte Caron, Xavier Hebuterne, Carmen Stefanescu, Antoine Meyer, Maria Nachury, David Laharie, Stephane Nancey, Catherine Le Berre, Melanie Serrero, Sophie Geyl, Cyrielle Giletta, Philippe Ah-Soune, Nicolas Duveau, Mathieu Uzzan, Vered Abitbol, Amelie Biron, My-Linh Tran-Minh, Thierry Paupard, Lucine Vuitton, Yasmine Elgharabawy, Laurent Peyrin-Biroulet
Summary: This study evaluated the short-term effectiveness and safety of risankizumab in patients with moderate-to-severe Crohn's disease (CD). The results showed that risankizumab treatment provided clinical response in approximately 78.5% of patients and steroid-free clinical remission in approximately 45.8% of patients at 12 weeks. Adverse events were observed, but were relatively rare.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Aurelien Amiot, Sayma Chaibi, Yoram Bouhnik, Melanie Serrero, Jerome Filippi, Xavier Roblin, Anne Bourrier, Guillaume Bouguen, Denis Franchimont, Guillaume Savoye, Anthony Buisson, Edouard Louis, Stephane Nancey, Vered Abitbol, Jean-Marie Reimund, Olivier DeWit, Lucine Vuitton, Nicolas Mathieu, Laurent Peyrin-Biroulet, Cyrielle Gilletta, Matthieu Allez, Stephanie Viennot, Catherine Le Berre, Nina Dib, Hedia Brixi, Claire Painchart, Laurianne Plastaras, Romain Altwegg, Mathurin Fumery, Ludovic Caillo, David Laharie, Maria Nachury
Summary: In this study, fatigue in patients with inflammatory bowel disease was found to be associated with age, gender, and disease activity. The determinants of fatigue were not limited to disease-related factors, but also included social factors, sleep, and emotional disturbances. Therefore, a holistic approach to care should be employed for IBD patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Review
Gastroenterology & Hepatology
Catherine Le Berre, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Inflammatory bowel diseases (IBD) are chronic lifelong diseases characterized by inflammation and irreversible damage to the gastrointestinal tract. The impact of early initiation of IBD-specific therapy on long-term disease progression needs to be further explored. Surgery and hospitalization rates have been used as surrogate markers to measure disease progression in IBD, but they may not accurately reflect the effectiveness of medical therapies.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Margaux Lelong, Stephane Nancey, Guillaume Bouguen, Matthieu Allez, Melanie Serrero, Antoine Chupin, Ludovic Caillo, Stephanie Viennot, Pierre Blanc, Jean-Marie Reimund, David Laharie, Raphael Olivier, Laurent Peyrin-Biroulet, Nina Dib, Astrid de Maissin, Celine Montuclard, Caroline Trang-Poisson, Geraldine Gallot, Celine Bressollette-Bodin, Mathilde Berthome, Marianne Burel, Fabienne Vavasseur, Arnaud Bourreille, Catherine Le Berre
Meeting Abstract
Gastroenterology & Hepatology
M. Lelong, S. Nancey, G. Bouguen, M. Allez, M. Serrero, A. Chupin, L. Caillo, S. Viennot, P. Blanc, J. M. Reimund, D. Laharie, R. Olivier, P. B. Laurent, N. Dib, A. De Maissin, C. Montuclard, C. Trang-Poisson, G. Gaillot, C. Bressollette-Bodin, M. Berthome, M. Burel, F. Vavasseur, A. Bourreille, C. Le Berre
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Yoram Bouhnik, Catherine Le Berre, Magaly Zappa, Maite Lewin, Mourad Boudiaf, Anne Marie Zagdanski, Eric Frampas, Ammar Oudjit, Beatrice Scotto, Muriel Tissier, Laurence Annet, Sophie Aufort, Thierry Yzet, Muriel Cuilleron, Guillaume Baudin, Vered Abitbol, Jacques Cosnes, Arnaud Bourreille, Jean Yves Mary
Summary: This study developed an index to evaluate the severity of small bowel inflammation in Crohn's disease patients for therapeutic decision making. The index, called CDMRIS, is based on features obtained from Magnetic Resonance Enterography, including enhancement intensity, ulceration, fistula, and abscess.
CROHNS & COLITIS 360
(2022)
