Article
Biochemistry & Molecular Biology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Hung-Ting Tseng, Yi-Hsiang Huang, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: The severity of liver functional reserve is an important prognostic predictor in hepatocellular carcinoma (HCC). Among the five liver reserve models, the ALBI grade is the best surrogate marker to represent liver functional reserve in terms of outcome prediction. These models serve as feasible prognostic markers to indicate liver injury, specifically in HCC patients with renal insufficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jia- Liao, Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: Ascites is highly prevalent in patients with hepatocellular carcinoma (HCC) and is associated with increased mortality. The albumin-bilirubin (ALBI) grade and EZ (easy)-ALBI grade are used to assess liver dysfunction in HCC, and both can stratify overall survival in HCC patients with ascites. Factors such as serum bilirubin level, creatinine level, alpha-fetoprotein level, tumor volume, vascular invasion, distant metastasis, performance status, and treatment type are independently associated with increased mortality in ascitic HCC patients.
Article
Gastroenterology & Hepatology
Heechul Nam, Sung Won Lee, Jung Hyun Kwon, Hae Lim Lee, Sun Hong Yoo, Hee Yeon Kim, Do Seon Song, Pil Soo Sung, U. Im Chang, Chang Wook Kim, Soon Woo Nam, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Jin Mo Yang, Nam Ik Han, Jeong Won Jang
Summary: Antiviral therapy can improve hepatic fibrosis and reduce the incidence of hepatocellular carcinoma (HCC). This study found that changes in noninvasive fibrosis markers (NFM) during therapy are an independent indicator of HCC risk, and the FSAC model incorporating NFM response is a reliable risk score for HCC with better predictive performance than other models.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, Research & Experimental
Minako Inoue-Yuri, Hirayuki Enomoto, Ichiro Wakabayashi, Yukihisa Yuri, Nobuhiro Aizawa, Naoto Ikeda, Tomoyuki Takashima, Aoi Fujiwara, Ryota Yoshioka, Shoki Kawata, Kohei Yoshihara, Shogo Ota, Ryota Nakano, Hideyuki Shiomi, Takashi Nishimura, Shuhei Nishiguchi, Hiroko Iijima
Summary: This study modified the cut-off values of the variables in the ALBI-PLT score and improved the accuracy of identifying patients without HRV while not increasing the proportion of missed diagnosis in HRV patients.
Article
Medicine, General & Internal
Wei-Fan Hsu, Kai-Chih Chang, Te-Hong Chen, Chien-Hung Lin, Ying-Chun Lin, Ming-Hung Tsai, Pei-Yu Chen, Hung-Wei Wang, Chia-Sheng Chu, Cheng-Yuan Peng
Summary: For patients with intermediate-stage hepatocellular carcinoma, the ALBI score shows the highest diagnostic value in predicting overall survival, while the Lok index also demonstrates high predictive value in patients without cirrhosis and those undergoing surgery.
Article
Oncology
Shu-Yein Ho, Po-Hong Liu, Chia-Yang Hsu, Yi-Hsiang Huang, Jia- Liao, Chien-Wei Su, Ming-Chih Hou, Teh-Ia Huo
Summary: Liver functional reserve is critical in managing hepatocellular carcinoma (HCC) patients. This study compared four albumin-based liver reserve models (ALBI/EZ-ALBI/PALBI/PAL) versus MELD in HCC patients undergoing transarterial chemoembolization (TACE) and found that all four albumin-based models were better prognostic tools than MELD scores. Among them, PALBI score was the best model for evaluating liver reserve.
Article
Oncology
Jos B. Poell, Leon J. Wils, Arjen Brink, Ralf Dietrich, Christine Krieg, Eunike Velleuer, Ilkay Evren, Elisabeth R. Brouns, Jan G. de Visscher, Elisabeth Bloemena, Bauke Ylstra, Ruud H. Brakenhoff
Summary: This study developed a noninvasive genetic assay to detect genetically altered fields in the oral cavity. The assay demonstrated high accuracy and predicted the development of oral squamous cell carcinoma in high-risk individuals. This method can be used for cancer screening in high-risk populations and to map the extent of lesions beyond what is visible.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Cem Azili, Selim Tamam, Mehmet Sah Benk, Riza Deryol, Serdar Culcu, Ali Ekrem Unal
Summary: This study aimed to develop and validate the ALBI grade as a preoperative prognostic model for predicting the survival of patients with pancreatic head cancer (PHC). By retrospectively analyzing patients who underwent Whipple procedures, it was found that the ALBI grade directly affected both the overall mortality rate and the hospital rate. Multivariate regression analysis further identified the preoperative ALBI grade as an independent predictor of mortality.
Article
Medicine, Research & Experimental
Fenghui Li, Tao Wang, Jing Liang, Baoxin Qian, Fei Tang, Yanying Gao, Jiayu Lv
Summary: A novel, reliable and non-invasive scoring system was developed to predict the risk of rebleeding in patients with cirrhosis following endoscopic therapy for esophagogastric variceal bleeding. The scoring system showed good predictive ability for early rebleeding and may help guide treatment decisions.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Oncology
Haofeng Zhang, Qingshan Li, Guan Huang, Zhenwei Yang, Kunlun Chen, Bo Meng, Haibo Yu
Summary: This study evaluated the predictive strength of the systemic immune-inflammatory index (SII) and the albumin bilirubin (ALBI) grade in patients with intrahepatic cholangiocarcinoma (ICC). The results showed that the SII+ALBI grade is a reliable prognostic indicator for postoperative overall survival (OS) and recurrence-free survival (RFS) in ICC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jianhua Wang, Zeguo Chen, Liheng Wang, Sijia Feng, Qixuan Qiu, Dongdong Chen, Nianfeng Li, Yao Xiao
Summary: The model based on the inflammatory index and tumor burden score effectively predicts the risk of hepatocellular carcinoma recurrence after liver resection, with better predictive performance than traditional HCC staging models.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Jacob C. Jentzer, Brandon M. Wiley, Nandan S. Anavekar, Sorin Pislaru, Sunil Mankad, Courtney E. Bennett, Gregory W. Barsness, Steven M. Hollenberg, David R. Holmes, Jae K. Oh
Summary: This study defines the hemodynamics associated with each SCAI shock stage and their association with mortality in CICU patients. Noninvasive echocardiographic parameters, particularly low stroke volume index and high E/e' ratio, are strongly associated with hospital mortality.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Oncology
Hung -Wei Wang, Chi-Yi Chen, Hsueh-Chou Lai, Tsung-Hui Hu, Wen-Pang Su, Sheng-Nan Lu, Chao-Hung Hung, Po-Heng Chuang, Jing-Houng Wang, Chien -Hung Chen, Cheng-Yuan Peng
Summary: This study investigated the feasibility and performance of predicting hepatocellular carcinoma (HCC) using a combined albumin-bilirubin (ALBI) and fibrosis-4 (FIB-4)-based model in patients with compensated cirrhosis and chronic hepatitis B (CHB) receiving nucleos(t)ide analog therapy. The combination of ALBI and FIB-4, along with diabetes mellitus and alpha-fetoprotein (AFDA), was found to be independent risk factors for HCC. The combined ALBI and FIB-4-based prediction model stratified the risk of HCC and showed a higher area under the receiver operating characteristic curve compared to other prediction models.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Medicine, General & Internal
Giovanni Marasco, Luigina Vanessa Alemanni, Antonio Colecchia, Davide Festi, Franco Bazzoli, Giuseppe Mazzella, Marco Montagnani, Francesco Azzaroli
Summary: The ALBI grade can accurately predict the risk of PHLF in HCC patients undergoing LR, with individuals classified as ALBI grade 2 and 3 showing higher rates of PHLF compared to those classified as ALBI grade 1.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Xie Liang, Xu Liangliang, Wang Peng, Yan Tao, Zhang Jinfu, Zhang Ming, Xu Mingqing
Summary: The study shows that PNI and ALBI can predict the overall survival and disease-free survival of HBV-HCC patients undergoing RH, while XPI can accurately predict the prognosis of these patients.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Yuxin Chen, Shengxia Yin, Xin Tong, Yue Tao, Jun Ni, Jie Pan, Ming Li, Yawen Wan, Minxin Mao, Yali Xiong, Xiaomin Yan, Yue Yang, Rui Huang, Chao Wu, Han Shen
Summary: This study analyzed the dynamic changes of immune responses after receiving the CoronaVac vaccine. The results showed that CoronaVac can effectively induce circulating and memory B cell and T cell immune responses. Age and interval between doses affect the magnitude of immune responses.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Medical Laboratory Technology
Jun Zhang, Lin Chen, Qin Xu, Yue Tao, Jie Pan, Jianmin Guo, Jing Su, Hui Xie, Yuxin Chen
Summary: An automated and rapid fluorescent immunoassay using testing-on-a-probe (TOP) biosensors was developed for quantifying soluble programmed death-1 (sPD-1) protein. The assay showed good precision and linearity, and correlated well with the established ELISA assay. Furthermore, elevated sPD-1 levels were observed in patients with chronic hepatitis, hepatic cirrhosis, and hepatocarcinoma using this TOP assay.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Medical Laboratory Technology
Yuxin Chen, Yuqing Wang, Xiaojin Liu, Wen Li, Hongyi Fu, Xinyan Liu, Xun Zhang, Xueqin Zhou, Bingzhou Yang, Jie Yao, Xiaolei Ma, Lijun Han, Huan Li, Liheng Zheng
Summary: This study evaluated early diagnostic methods for tuberculosis meningitis (TBM) and found that metagenomic next-generation sequencing (mNGS) combined with Xpert or modified ZN staining can enhance the sensitivity of TBM diagnosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Gastroenterology & Hepatology
Jian Wang, Xiaomin Yan, Li Zhu, Jiacheng Liu, Yuanwang Qiu, Yiguang Li, Yilin Liu, Ruifei Xue, Jie Zhan, Suling Jiang, Yu Geng, Yawen Wan, Ming Li, Minxin Mao, Dongmei Gao, Shengxia Yin, Xin Tong, Juan Xia, Weimao Ding, Yuxin Chen, Jie Li, Chuanwu Zhu, Rui Huang, Chao Wu
Summary: This study investigated liver histology and proposed a management strategy for patients with chronic hepatitis B (CHB) in the grey zone (GZ). The study found that over 70% of GZ CHB patients had significant histological disease. Antiviral treatment is recommended for HBeAg-positive and HBeAg-negative GZ CHB patients with high prothrombin time.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Jian Wang, Jiacheng Liu, Yilin Liu, Ruifei Xue, Jie Zhan, Suling Jiang, Li Wang, Xiaomin Yan, Yali Xiong, Juan Xia, Shengxia Yin, Xin Tong, Yuxin Chen, Jie Li, Rui Huang, Chao Wu
Summary: This study found that lean patients with chronic hepatitis B (CHB) and nonalcoholic fatty liver disease (NAFLD) accounted for 25% of the CHB-NAFLD patients. Compared to nonlean patients, lean patients had a lower proportion of metabolic abnormalities and advanced liver fibrosis, but had higher levels of HBsAg, HBV DNA, and HBeAg-positive proportions.
HEPATOLOGY RESEARCH
(2023)
Review
Immunology
Sha Wei, Tingting Xu, Yuxin Chen, Kai Zhou
Summary: Klebsiella pneumoniae is a highly drug-resistant pathogen that poses a significant threat to global healthcare. The recent emergence of multidrug resistance and hypervirulence in this species has led to high mortality and worsened clinical outcomes. Understanding the mechanisms employed by K. pneumoniae to evade host immune responses, especially autophagy and cell death, is crucial for the development of effective therapeutics. This review summarizes the progress made in deciphering the cell signaling triggered by K. pneumoniae infection, particularly in the manipulation of autophagy, cell death, and cytokine production.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Gastroenterology & Hepatology
Miao Li, Tingting Tan, Yu Geng, Yue Tao, Jie Pan, Jun Zhang, Qin Xu, Han Shen, Lingyun Zuo, Yuxin Chen
Summary: This study reveals that HOXB13 is significantly upregulated in HCC and positively correlated with tumor stage and patient survival. Overexpression of HOXB13 promotes cell proliferation and invasion in HCC, while downregulation of HOXB13 has the opposite effects. In vivo experiments demonstrate that HOXB13 promotes tumor growth in HCC mice by enhancing cell proliferation and inhibiting apoptosis.
ANNALS OF HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jian Wang, Rui Huang, Jiacheng Liu, Ruimin Lai, Yilin Liu, Chuanwu Zhu, Yuanwang Qiu, Zebao He, Shengxia Yin, Yuxin Chen, Xiaomin Yan, Weimao Ding, Qi Zheng, Jie Li, Chao Wu
Summary: This study aimed to establish a predictive model for advanced fibrosis in chronic hepatitis B (CHB) patients with nonalcoholic fatty liver disease (NAFLD). The study found that platelet, prothrombin time, type 2 diabetes, HBeAg positivity, and globulin were significantly associated with advanced fibrosis. A predictive model called PPDHG was developed based on these parameters. PPDHG showed better predicting performance than established models for advanced fibrosis and can reduce the need for liver biopsy in these patients.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyu Chu, Xinyu Ding, Yixuan Yang, Yuchi Lu, Tinghan Li, Yan Gao, Le Zheng, Hang Xiao, Tingting Yang, Hao Cheng, Haibin Huang, Yang Liu, Yang Lou, Chao Wu, Yuxin Chen, Haitao Yang, Xiaoyun Ji, Hangtian Guo
Summary: The COVID-19 pandemic has caused widespread infections and deaths worldwide. The continuous evolution of the SARS-CoV-2 virus has led to the emergence of significant variants, posing ongoing challenges to the prevention and treatment efforts. Studying antibody responses against SARS-CoV-2 is crucial for the development of vaccines and therapeutics. In this study, researchers used cryo-EM to determine the structure of a rabbit monoclonal antibody in complex with the spike protein of the virus. Their findings show that the antibody blocks the virus from binding to its receptor, suggesting its potential for neutralization and therapeutic development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Weigao Zhang, Jiapeng Jie, Qian Xu, Rong Wei, Xin Liao, Danyang Zhang, Yayun Zhang, Jianfa Zhang, Guanyong Su, Yuxin Chen, Dan Weng
Summary: The incidence of obesity and non-alcoholic fatty liver disease (NAFLD) has been increasing rapidly worldwide. Environmental factors such as plastic usage and chemical exposure have been suggested to be important contributors to the obesity epidemic. Acetyl tributyl citrate (ATBC), a commonly used non-phthalate plasticizer, has a high leakage rate from plastics, leading to increased exposure risk. This study aimed to evaluate the safety of subchronic exposure to environmentally-relevant concentrations of ATBC. Results showed that ATBC exposure led to weight gain, increased body fat content, larger adipocytes, and liver steatosis in mice. In vitro experiments also demonstrated increased intracellular lipid accumulation with ATBC treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Microbiology
Keping Chen, Huidi Sun, Yu Geng, Chuankun Yang, Chun Shan, Yuxin Chen
Summary: This study found that the levels of serum ferritin and procalcitonin (PCT) were positively associated with viral load in patients with severe fever with thrombocytopenia syndrome (SFTS), and the levels of ferritin and PCT were significantly higher in non-survivors compared to survivors. Ferritin and PCT could be potential inflammatory biomarkers for predicting the prognosis of patients with SFTS in its early stages.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Hexiang Zheng, Yu Geng, Changgui Gu, Ming Li, Minxin Mao, Yawen Wan, Huijie Yang, Yuxin Chen
Summary: In this study, a machine learning model was developed and validated to predict the potential life-threatening conditions of SFTS. The model showed high accuracy and can greatly improve the early prognosis accuracy of SFTS.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Biology
Hangtian Guo, Yixuan Yang, Tiantian Zhao, Yuchi Lu, Yan Gao, Tinghan Li, Hang Xiao, Xiaoyu Chu, Le Zheng, Wanting Li, Hao Cheng, Haibin Huang, Yang Liu, Yang Lou, Henry C. C. Nguyen, Chao Wu, Yuxin Chen, Haitao Yang, Xiaoyun Ji
Summary: The molecular mechanism of broad-spectrum neutralization of a rabbit monoclonal antibody 1H1 against Omicron sublineages is revealed by cryo-EM. The 1H1 antibody targets a highly conserved region of the spike protein, avoiding most of the circulating Omicron mutations, which explains its broad-spectrum neutralization potency. This research provides a promising model for designing broad-spectrum neutralizing antibodies and developing therapeutic drugs and effective vaccines against newly emerging variants.
COMMUNICATIONS BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jiang Xu, Liam Kerr, Yue Jiang, Wenhao Suo, Lei Zhang, Taotao Lao, Yuxin Chen, Yan Zhang
Summary: This article systematically reviews different types of recently innovated in-lab and commercial antigen diagnostic technologies, emphasizing their strengths and limitations, and discusses the future prospects of assay development.
Article
Gastroenterology & Hepatology
Jiacheng Liu, Jian Wang, Xiaomin Yan, Ruifei Xue, Jie Zhan, Suling Jiang, Yu Geng, Yilin Liu, Minxin Mao, Juan Xia, Shengxia Yin, Xin Tong, Yuxin Chen, Weimao Ding, Rui Huang, Chao Wu
Summary: Liver biopsies are recommended to evaluate liver inflammation in CHB patients with detectable HBV DNA, especially for those with moderate HBV DNA levels, as they may have significant inflammation even with normal ALT levels in the absence of significant fibrosis.
HEPATOLOGY COMMUNICATIONS
(2022)
