Article
Endocrinology & Metabolism
Hanan Amadid, Pernille F. Ronn, Maria B. N. Dunbar, Jakob S. Knudsen, Bendix Carstensen, Frederik Persson, Marit E. Jorgensen
Summary: The use of lipid-lowering drugs (LLDs) among type 2 diabetes patients in Denmark has decreased since 2012, with only 55% using LLDs in 2017. Levels of total cholesterol and LDL-C have decreased, while triglycerides have increased from 2010 to 2017. LLD users had lower LDL-C levels and a higher rate of achieving LDL-C goals compared to non-users.
DIABETES OBESITY & METABOLISM
(2021)
Article
Medicine, General & Internal
Ben S. Gerber, Alana Biggers, Jessica J. Tilton, Daphne E. Smith Marsh, Rachel Lane, Dan Mihailescu, Jungae Lee, Lisa K. Sharp
Summary: Clinical pharmacists and health coaches using mobile health tools can improve blood glucose levels in African American and Latinx populations with type 2 diabetes.
Article
Endocrinology & Metabolism
Sebastian M. N. Heimburger, Chris N. Nielsen, Salvatore Calanna, Jens J. Holst, Tina Vilsboll, Filip K. Knop, Mikkel B. Christensen
Summary: The study showed that exogenous GIP can increase plasma glycerol and free fatty acid concentrations in patients with type 1 diabetes during hyperglycemia and stable basal insulin levels, indicating a direct lipolytic effect of GIP at high glucose and low levels of plasma insulin.
DIABETES OBESITY & METABOLISM
(2022)
Article
Medicine, General & Internal
Steven J. Russell, Roy W. Beck, Edward R. Damiano, Firas H. El-Khatib, Katrina J. Ruedy, Zoey Li, Courtney A. Balliro, Peter Calhoun, R. Paul Wadwa, Bruce Buckingham, Keren Zhou, Mark Daniels, Philip Raskin, Perrin C. White, Jane Lynch, Jeremy Pettus, Irl B. Hirsch, Robin Goland, John B. Buse, Davida Kruger, Nelly Mauras, Andrew Muir, Janet B. McGill, Fran Cogen, Jill Weissberg-Benchell, Jordan S. Sherwood, Luz E. Castellanos, Mallory A. Hillard, Marwa Tuffaha, Melissa S. Putman, Mollie Y. Sands, Gregory Forlenza, Robert Slover, Laurel H. Messer, Erin Cobry, Viral N. Shah, Sarit Polsky, Rayhan Lal, Laya Ekhlaspour, Michael S. Hughes, Marina Basina, Betul Hatipoglu, Leann Olansky, Amrit Bhangoo, Nikta Forghani, Himala Kashmiri, Francoise Sutton, Abha Choudhary, Jimmy Penn, Rabab Jafri, Maria Rayas, Elia Escaname, Catherine Kerr, Ruby Favela-Preza, Schafer Boeder, Subbulaxmi Trikudanathan, Kristen M. Williams, Natasha Leibel, M. Sue Kirkman, Kate Bergamo, Klara R. Klein, Jean M. Dostou, Sriram Machineni, Laura A. Young, Jamie C. Diner, Arti Bhan, J. Kimberly Jones, Matthew Benson, Keisha Bird, Kimberly Englert, Andrea Cedeno, Joe Permuy, Kristina Cossen, Eric Felner, Maamoun Salam, Julie M. Silverstein, Samantha Adamson, Seema Meighan, Andrew Dauber
Summary: In this 13-week, randomized trial, the use of a bionic pancreas was shown to be more effective in reducing glycated hemoglobin levels compared to standard care.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Food Science & Technology
Xiaxia Cai, Qinyu Dang, Lan Liu, Zhihong Ma, Xiaoyan Zhao, Mingyuan Zhang, Zhuoran Xiao, Aliya Yijiati, Leilei Ren, Huanling Yu
Summary: This study aimed to evaluate the effects of oat nutritious meal (ONM) on blood glucose and lipid metabolism in elderly patients with type 2 diabetes mellitus (T2DM). The results showed that ONM significantly reduced total cholesterol and low-density lipoprotein cholesterol levels, but had no effect on glucose metabolism in elderly patients.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Cardiac & Cardiovascular Systems
Li-Da Wu, Nan Zhou, Jin-yu Sun, Hao Yu, Ru-Xing Wang
Summary: Sitagliptin alone or in combination with other antidiabetic agents significantly reduces serum total cholesterol and LDL-C in patients with type 2 diabetes mellitus, while no significant difference was observed in serum triglycerides or HDL-C.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Lebohang Pitso, Thabiso Rafaki Petrus Mofokeng, Riette Nel
Summary: The study found a high prevalence of dyslipidaemia among DM patients, despite the use of lipid-lowering therapy, emphasizing the need to educate healthcare providers and improve treatment strategies.
BMC ENDOCRINE DISORDERS
(2021)
Article
Medicine, General & Internal
Jennifer McVean, Gregory P. Forlenza, Roy W. Beck, Colleen Bauza, Ryan Bailey, Bruce Buckingham, Linda A. DiMeglio, Jennifer L. Sherr, Mark Clements, Anna Neyman, Carmella Evans-Molina, Emily K. Sims, Laurel H. Messer, Laya Ekhlaspour, Ryan McDonough, Michelle Van Name, Diana Rojas, Shannon Beasley, Stephanie DuBose, Craig Kollman, Antoinette Moran, CLVer Study Grp
Summary: The study aimed to determine the effectiveness of intensive diabetes management to achieve near normalization of glucose levels on preservation of pancreatic beta cell function in youth with newly diagnosed type 1 diabetes. The results showed that although the intensive management group achieved excellent glucose control, it did not affect the decline in pancreatic C-peptide secretion at 52 weeks.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Jin Matsushita, Hiroshi Okada, Yuki Okada, Takashi Sekiyama, Hideto Iida, Atsushi Shindo, Hiroaki Murata, Michiaki Fukui
Summary: This study investigated the effects of physical therapists' exercise instructions on glycemic control in Japanese patients with type 2 diabetes. The results showed that patients who received exercise instructions from physical therapists had reduced HbA1c levels, increased daily steps, energy expenditure, lower extremity muscle strength, and improved transtheoretical model after 8 weeks.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Deborah J. Wexler, Ian H. de Boer, Alokananda Ghosh, Naji Younes, Ionut Bebu, Silvio Inzucchi, Janet B. McGill, Sunder Mudaliar, David Schade, Michael W. Steffes, William Tamborlane, Meng H. Tan, Faramarz Ismail-Beigi
Summary: This study aimed to evaluate the impact of four classes of glucose-lowering medications on kidney function in patients with type 2 diabetes. The results showed that adding sitagliptin, glimepiride, liraglutide, or insulin to metformin treatment did not significantly affect kidney outcomes.
JAMA INTERNAL MEDICINE
(2023)
Article
Urology & Nephrology
Austin G. Stack, Nalina Dronamraju, Joanna Parkinson, Susanne Johansson, Eva Johnsson, Fredrik Erlandsson, Robert Terkeltaub
Summary: In patients with hyperuricemia and type 2 diabetes mellitus, treatment with verinurad combined with febuxostat lowered albuminuria levels and serum urate concentrations without impacting kidney function. Larger clinical studies are needed to definitively assess their combined impact on kidney preservation.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Pharmacology & Pharmacy
Haoran Wu, Xinyi Fang, De Jin, Runyu Miao, Jiahua Wei, Tianyu Zhao, Dan Dai, Jiangquan Liao, Jia Wang, Fengmei Lian, Jiaxing Tian
Summary: This study aims to examine the therapeutic mechanism of JTTZ in patients with T2DM and dyslipidaemia by evaluating its efficacy and modulation of gut microbiota through clinical trial and metabolomics analysis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Michael Joubert, Victoria Opigez, Barbora Pavlikova, Laure Peyro Saint Paul, Nathalie Jeandidier, Anais R. Briant, Jean-Jacques Parienti, Yves Reznik
Summary: The study aimed to assess the safety and efficacy of the short-acting glucagon-like peptide-1 receptor agonist exenatide in a population of patients with type 2 diabetes primarily treated with continuous subcutaneous insulin injection (CSII). The results showed that exenatide treatment led to a significant reduction in HbA1c and body weight, with good overall safety, in T2D patients with uncontrolled HbA1c despite intensified insulin therapy.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wenying Yang, Xiangjin Xu, Tao Lei, Jianhua Ma, Ling Li, Jie Shen, Binqi Ye, Sandy Zhu, Thomas Meinicke
Summary: The 24-week clinical trial in Chinese patients with T2DM showed that adding linagliptin to insulin therapy was more effective in improving glycemic control compared to placebo, with good tolerability and safety profile. There was no increased risk of hypoglycemia or weight gain observed, indicating that linagliptin could be a beneficial add-on therapy for these patients.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Anna Obermayer, Norbert J. Tripolt, Peter N. Pferschy, Harald Kojzar, Faisal Aziz, Alexander Mueller, Markus Schauer, Abderrahim Oulhaj, Felix Aberer, Caren Sourij, Hansjoerg Habisch, Tobias Madl, Thomas Pieber, Barbara Obermayer-Pietsch, Vanessa Stadlbauer, Harald Sourij
Summary: The study investigated the safety and feasibility of 3 nonconsecutive days of intermittent fasting per week in insulin-treated individuals with type 2 diabetes. The results showed that the intermittent fasting group achieved a significant reduction in HbA(1c) and body weight over 12 weeks, with no severe hypoglycemia.
Article
Cardiac & Cardiovascular Systems
Akihiro Hirashiki, Atsuya Shimizu, Noriyuki Suzuki, Kenichiro Nomoto, Manabu Kokubo, Taiki Sugimoto, Kakeru Hashimoto, Kenji Sato, Takashi Sakurai, Toyoaki Murohara, Yukihiko Washimi, Hidenori Arai
Summary: Cerebral white matter hyperintensity (WMH) is associated with frailty and exercise capacity in older adults with cardiovascular disease (CVD).
INTERNATIONAL HEART JOURNAL
(2022)
Article
Social Work
Yoshihisa Hirakawa, Kaoruko Aita, Mitsunori Nishikawa, Hidenori Arai, Hisayuki Miura
Summary: Completing advance care planning for older COPD patients living alone presents challenges such as information sharing, patient readiness, desired place of death, economic constraints, and care at the time of and after death. Social work knowledge and skills are crucial in facilitating the completion of ACP for this population.
JOURNAL OF SOCIAL WORK IN END-OF-LIFE & PALLIATIVE CARE
(2022)
Article
Multidisciplinary Sciences
Erina Eto, Yasutaka Maeda, Noriyuki Sonoda, Naoki Nakashima, Kunihisa Kobayashi, Ryoichi Takayanagi, Yoshihiro Ogawa, Toyoshi Inoguchi
Summary: This study found an association between serum total bilirubin levels and the progression of diabetic nephropathy and end-stage kidney disease. Patients with lower bilirubin levels were more likely to experience progressive renal decline and end-stage kidney disease. Serum total bilirubin levels may be useful in identifying high-risk patients for end-stage kidney disease.
Letter
Geriatrics & Gerontology
Kaori Kinoshita, Shosuke Satake, Kenta Murotani, Jiaqi Li, Mikako Yasuoka, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Susumu Sato, Shinjiro Miyazaki, Akira Tamaki, Yoshihiro Yoshimura, Hidenori Arai, Dai Fujiwara, Hideki Katsura, Atsuyoshi Kawagoshi, Ryo Kozu, Keisuke Maeda, Sumito Ogawa, Jun Ueki, Hidetaka Wakabayashi
Summary: Respiratory sarcopenia, characterized by respiratory muscle weakness and decreased respiratory muscle mass, is an important condition that has not been adequately evaluated in clinical practice. This position paper provides an overview of the basic knowledge, diagnostic and assessment methods, mechanisms, involvement in respiratory diseases, intervention and treatment methods, and future perspectives on respiratory sarcopenia. The consensus on respiratory sarcopenia is also summarized, with recommendations for evaluating respiratory muscle strength and mass. Further research is needed to establish cutoff values for defining decreased respiratory muscle mass.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Editorial Material
Endocrinology & Metabolism
Hirotaka Araki, Takeshi Matsumura, Noboru Furukawa, Eiichi Araki
Summary: This article explores the mechanisms of dipeptidyl peptidase-4 inhibitors, glucagon-like peptide-1 receptor agonists, and glucagon-like peptide-1 receptor/glucose-dependent insulinotropic polypeptide receptor dual-agonists in glycemic control and/or weight loss.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Geriatrics & Gerontology
Yuto Nakao, Koki Kawamura, Taku Iwase, Aiko Osawa, Shinichiro Maeshima, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Mihoko Ogita, Mika Okura, Ryo Katayose, Naomi Miyamatsu, Hidenori Arai
Summary: This study aimed to examine the association between participation in health and frailty check-ups and functional outcomes and mortality among Japanese community-dwelling older adults. The results showed that long-term care and mortality risks were significantly lower among those aged <75 years who used health screening. In those aged >= 75 years, the risk for long-term care was lower in individuals participating in both health and frailty check-ups and in those who participated in the frailty check-ups only.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Tomoki Tanaka, Hirohiko Hirano, Kazunori Ikebe, Takayuki Ueda, Masanori Iwasaki, Maki Shirobe, Shunsuke Minakuchi, Masahiro Akishita, Hidenori Arai, Katsuya Iijima
Summary: To assess oral frailty in older adults, a five-item checklist called OF-5 was developed and found to have predictive validity for physical frailty, physical disability, and mortality.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Wei-Min Chu, Hsin-En Ho, Chih-Jung Yeh, James Cheng-Chung Wei, Hidenori Arai, Meng-Chih Lee
Summary: This study explores the association between multimorbidity patterns with/ without frailty and future mortality among Taiwanese middle-aged and older adults. Frailty plays an important role in mortality among middle-aged and older adults with distinct multimorbidity patterns.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Shinichiro Maeshima, Aiko Osawa, Koki Kawamura, Takako Yoshimura, Eri Otaka, Yayoi Sato, Ikue Ueda, Naoki Itoh, Izumi Kondo, Hidenori Arai
Summary: The study investigated assessment tools used by dementia specialists, reasons for their use, and related factors. Most specialists use neuropsychological tests for diagnosis and to assess behavioral and psychological symptoms. Screening tools like the Hasegawa Dementia Scale-Revised and Mini-Mental State Examination are commonly used, while direct assessments include the Mini-Mental State Examination, Clock Drawing Test, and Cube Copying Test. Quality of life and care burden assessments are less common in clinical practice.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Sayuri Sable-Morita, Saiko Sugiura, Hirokazu Suzuki, Hideki Fukuoka, Yasumoto Matsui, Hidenori Arai
Summary: This study aimed to clarify the relationship between frailty and the senses of sight, hearing, smell, and taste. Olfactory impairment had the strongest correlation with frailty. Although the sense of smell decreases with disease and aging, olfactory impairment may be correlated with frailty as a symptom of neurodegenerative diseases.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Letter
Geriatrics & Gerontology
Yasuhiro Yamaguchi, Jiro Okochi, Tomohiko Urano, Takae Ebihara, Takafumi Kadono, Hidenori Arai, Katsuya Iijima, Shinya Ishii, Masafumi Kuzuya, Hiromi Rakugi, Masahiro Akishita, Kentaro Higashi, Koichi Kozaki
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Letter
Geriatrics & Gerontology
Minoru Yamada, Hidenori Arai
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Wei-Min Chu, Yukiko Nishita, Chikako Tange, Shu Zhang, Kanae Furuya, Hiroshi Shimokata, Meng-Chih Lee, Hidenori Arai, Rei Otsuka
Summary: Smoking, especially when combined with secondhand smoke exposure, is associated with future physical frailty among older adults.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2023)