Journal
DEVELOPMENTAL NEUROBIOLOGY
Volume 79, Issue 5, Pages 437-452Publisher
WILEY
DOI: 10.1002/dneu.22669
Keywords
spinal cord regeneration; salamander; amphibians
Categories
Funding
- National Science Foundation [1606128, 1656429]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1656429] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1606128] Funding Source: National Science Foundation
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In some vertebrates, a grave injury to the central nervous system (CNS) results in functional restoration, rather than in permanent incapacitation. Understanding how these animals mount a regenerative response by activating resident CNS stem cell populations is of critical importance in regenerative biology. Amphibians are of a particular interest in the field because the regenerative ability is present throughout life in urodele species, but in anuran species it is lost during development. Studying amphibians, who transition from a regenerative to a nonregenerative state, could give insight into the loss of ability to recover from CNS damage in mammals. Here, we highlight the current knowledge of spinal cord regeneration across vertebrates and identify commonalities and differences in spinal cord regeneration between amphibians.
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