Article
Immunology
Maya Amitai, Shaked Kaffman, Eitan Kroizer, Maya Lebow, Iddo Magen, Noa Benaroya-Milshtein, Silvana Fennig, Abraham Weizman, Alan Apter, Alon Chen
Summary: The study found that NLR and PLR may be associated with suicidal behavior in children and adolescents with depression and anxiety, with NLR being a better predictor of suicide attempts.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hossein Jadvar, Andre Luis Abreu, Leslie K. Ballas, David I. Quinn
Summary: According to the spectrum theory of metastatic disease, oligometastatic state is considered an intermediate step in the progression of cancer, characterized by a few metastatic lesions that can be targeted with metastasis-directed therapy. Prostate cancer has seen an increasing recognition of oligometastatic disease, thanks to the development of new-generation imaging agents. Clinical trials have shown promising results in delaying systematic therapy and improving patient outcome in selected cases. However, further research is needed to understand the underlying biology, identify predictive and prognostic biomarkers, and optimize treatment strategies in order to enhance short-term and long-term patient outcome in prostate cancer.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Adrian Vasile Muresan, Eliza Russu, Emil Marian Arbanasi, Reka Kaller, Ioan Hosu, Eliza Mihaela Arbanasi, Septimiu Toader Voidazan
Summary: This study found that the neutrophil-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) are effective markers for assessing the outcome of end-stage kidney disease (ESKD) patients. Elevated values of these ratios are associated with higher mortality rates, longer hospital stays, and more dialysis sessions.
Article
Medicine, General & Internal
Mai Ly Thi Nguyen, Chi Pham, Quoc Vuong Le, Phuong Linh Thi Nham, Doanh Hieu Tran, Thanh Son Le, Van Tong Hoang, Van Mao Can, Linh Toan Nguyen, Khac Cuong Bui
Summary: Gastric cancer is a major concern in cancer-associated health burden, and PLR and NLR have significant value in the diagnosis and prognosis of gastric cancer.
Article
Oncology
Cristina Dalmiglio, Lucia Brilli, Michele Campanile, Cristina Ciuoli, Alessandra Cartocci, Maria Grazia Castagna
Summary: This study found that the baseline Controlling Nutritional Status (CONUT score) is significantly associated with the prognosis of advanced thyroid cancer patients treated with tyrosine kinase inhibitors (TKI). The CONUT score can serve as a useful screening tool to predict the prognosis of thyroid cancer patients before the initiation of anti-tumoral treatment.
Article
Andrology
Xinyu Shi, Junjie Fan, Xinqi Pei, Yuzhao Wang, Guodong Guo, Tao Yang, Xinyang Wang, Dalin He, Lei Li
Summary: The study revealed that concurrently high NLR and PLR values are markers for predicting poor chemotherapy outcomes after androgen deprivation therapy failure in patients with mCRPC.
Article
Endocrinology & Metabolism
Licheng Du, Xueting Hu, Beibei Zhang, Xiaqi Miao, Jianing Wang, Jiamin Shen, Keke Ding, Tian Zeng, Fangyue Sun, Hong Yang, Hai Lin
Summary: This study found that a high platelet-to-lymphocyte ratio (PLR) is associated with cognitive decline in patients with type 2 diabetes mellitus. PLR may help identify high-risk patients and offer clues for preventing cognitive dysfunction in these patients.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Cell Biology
Susanna Theophilus Yesupatham, C. D. Dayanand, S. M. Azeem Mohiyuddin, M. L. Harendra Kumar
Summary: This study aimed to investigate the levels of survivin in buccal tissue of South Indian tobacco chewers and its association with pretreatment hematological parameters, as well as analyze the sequence of the BIRC5 gene. The results showed that survivin levels were significantly higher in tobacco chewers with oral squamous cell carcinoma (OSCC) compared to healthy subjects, and levels of absolute monocyte count (AMC), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR) were also significantly correlated with survivin levels. Sequence analysis of the BIRC5 gene identified unique mutations associated with survivin concentrations.
Article
Endocrinology & Metabolism
Xu Zhong, TingWei Su, Yifan Yang, Lei Ye, Lei Jiang, Yan Qi, Jing Xie, Yiran Jiang, Weiwei Zhou, Cui Zhang, Luming Wu, Hongyuan Zhu, Guang Ning, Weiqing Wang
Summary: This study investigated the prognostic significance of inflammatory biomarkers in patients with pheochromocytomas and paragangliomas (PPGLs). The results showed that high neutrophil-lymphocyte ratio (NLR) and high platelet-lymphocyte ratio (PLR) were associated with poor prognosis in PPGLs. These markers could serve as convenient predictive indicators in daily clinical practice.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Beat Bojaxhiu, Dubravko Sinovcic, Olgun Elicin, Arnoud J. Templeton, Mohamed Shelan, Jan Wartenberg, Ian Alberts, Axel Rominger, Daniel M. Aebersold, Kathrin Zaugg
Summary: This study evaluated the correlation between markers of host inflammation and FDG-PET/CT metabolic parameters. The results showed that platelet-to-lymphocyte ratio was associated with tumor metabolic volume and total lesion glycolysis, while systemic inflammation was not correlated with FDG-PET/CT parameters.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Zeyao Ye, Pengfei Yu, Yang Cao, Tengjiao Chai, Sha Huang, Xiangdong Cheng, Yian Du
Summary: This study explores the association of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and D-dimer (DDI) with peritoneal cancer index (PCI) in gastric cancer patients. The study found that NLR, PLR, and DDI are independent risk factors for high PCI. The NPD scoring system can help predict PCI and prognosis in patients with peritoneal metastasis of gastric cancer.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Health Care Sciences & Services
Deyao Zhang, Huilan Zeng, Yangxun Pan, Yumo Zhao, Xin Wang, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Zhongguo Zhou, Li Xu, Minshan Chen, Dandan Hu
Summary: This study investigated the prognostic significance of liver tumor markers and blood cell indexes for predicting the site of recurrence or metastasis after surgery in patients with intrahepatic cholangiocarcinoma (ICC). The results showed that CA19-9, CEA, HALP score, and NLR can be used as reliable and cost-effective indexes for predicting the specific site of recurrence or metastasis. Patients with high HALP scores and NLR have a higher risk of intrahepatic and lymph node metastasis recurrence.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Infectious Diseases
Haotian Wu, Chunxia Li, Song Liu, Shuangquan Yao, Zhaohui Song, Dong Ren, Pengcheng Wang
Summary: This study aimed to investigate the independent association of neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and red blood cell distribution width (RDW) with mortality in necrotizing fasciitis (NF). The results showed that NLR > 11.1 and PLR > 196.0 were independently associated with an increased risk of mortality in NF patients.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Medicine, General & Internal
Steven D. Nathan, Jayesh Mehta, John Stauffer, Elizabeth Morgenthien, Ming Yang, Susan L. Limb, Sangeeta Bhorade
Summary: This study examined the relationship between NLR and PLR changes and clinical outcomes in IPF patients over 12 months, and found that patients with the greatest NLR or PLR changes experienced the worst outcomes. Further research is needed to determine the utility of NLR and PLR as prognostic biomarkers in IPF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Yejin Kim, Jong-Hee Sohn, Chulho Kim, So Young Park, Sang-Hwa Lee
Summary: This study evaluated the impact of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on hematoma expansion (HE) and worse outcomes in patients with intracranial hemorrhage (ICH). The results showed that NLR and PLR were associated with HE and could reliably predict its occurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Yadong Guo, Ruiliang Wang, Wentao Zhang, Shiyu Mao, Yuan Wu, Ji Liu, Wenchao Ma, Zongtai Zheng, Junfeng Zhang, Xudong Yao, Yongzhen Liu
Summary: This study found that a high-risk NRI value is an independent prognostic factor for shorter PSA-PFS in OM-PC patients. The AUC value of the NRI score was higher than other conventional nutritional indicators, indicating its potential use as a new prognostic indicator for PSA-PFS.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2021)
Article
Oncology
Zongtai Zheng, Shiyu Mao, Zhuoran Gu, Ruiliang Wang, Yadong Guo, Wentao Zhang, Xudong Yao
Summary: A genomic-clinicopathologic nomogram was developed to predict lymph node invasion in prostate cancer patients. The 37-gene-based SVM model showed optimal performance in both training and validation sets. Dysregulated expression of hub genes between PCa and LNI samples was validated, suggesting potential for further functional studies and mechanistic analyses.
JOURNAL OF ONCOLOGY
(2021)
Article
Oncology
Shiyu Mao, Wentao Zhang, Fuhan Yang, Yadong Guo, Hong Wang, Yuan Wu, Ruiliang Wang, Niraj Maskey, Zongtai Zheng, Cheng Li, Wenchao Ma, Junfeng Zhang, Yang Yan, Xudong Yao
Summary: The study identified circ_0004296 as a circRNA associated with PCa metastasis through high-throughput RNA sequencing. Circ_0004296 was found to be downregulated in PCa tissues, blood, and urine, and its overexpression inhibited ETS1 expression, leading to the suppression of PCa metastasis. The downstream binding protein EIF4A3 was also identified as a potential therapeutic target for PCa.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Andrology
Fuhan Yang, Cheng Li, Yadong Guo, Yang Yu, Shiyu Mao, Ruiliang Wang, Wentao Zhang, Aihong Zhang, Xudong Yao
Summary: The study revealed that patients receiving different treatments for bladder cancer had varying risks of heart-specific death, with the highest risk observed in the RT group, especially among patients over 65 years of age. Patients in all age groups receiving RC, RT, or CT had higher heart-specific and overall mortality rates compared to the general population.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Cell Biology
Yadong Guo, Xiaohui Dong, Shiyu Mao, Fuhan Yang, Ruiliang Wang, Wenchao Ma, Ji Liu, Cheng Li, Zongtai Zheng, Wentao Zhang, Aihong Zhang, Xudong Yao
Summary: This study examines the causes and risks of noncancer death in patients with prostate cancer during different follow-up periods after diagnosis. The results show that the largest proportion of noncancer deaths occur within 5 to 10 years after diagnosis, with cardiovascular and cerebrovascular diseases and chronic obstructive pulmonary disease being the most common causes. The risk of noncancer death is influenced by treatment, ethnicity, and staging differences.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Endocrinology & Metabolism
Yadong Guo, Anil Shrestha, Niraj Maskey, Xiaohui Dong, Zongtai Zheng, Fuhan Yang, Ruiliang Wang, Wenchao Ma, Ji Liu, Cheng Li, Wentao Zhang, Shiyu Mao, Aihong Zhang, Shenghua Liu, Xudong Yao
Summary: This study comprehensively investigates the recent trends in the epidemiological and prognostic factors of clear cell adenocarcinoma (CCA). The results show that the incidence of CCA and the survival of these patients have improved over time, especially in grade IV CCA. This may be attributed to earlier diagnosis and improved treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yadong Guo, Zongtai Zheng, Shiyu Mao, Fuhan Yang, Ruiliang Wang, Hong Wang, Ji Liu, Cheng Li, Qinwan Wang, Wentao Zhang, Xudong Yao, Shenghua Liu
Summary: This study aimed to investigate the relationship between metabolism and immune microenvironment in bladder cancer and construct a metabolic-associated signature for prognostic prediction. The findings suggest that high-risk bladder cancer patients have advanced clinicopathological features and poor survival outcomes, and exhibit lower response rates to anti-PD-L1 treatment. The downregulation of TST and S100A16 promotes invasion and migration of bladder cancer cells, affects immune cell infiltration and expression of PD-L1 and CD47.
MOLECULAR CARCINOGENESIS
(2022)
Review
Biochemistry & Molecular Biology
Haotian Chen, Wentao Zhang, Niraj Maskey, Fuhan Yang, Zongtai Zheng, Cheng Li, Ruiliang Wang, Pengfei Wu, Shiyu Mao, Junfeng Zhang, Yang Yan, Wei Li, Xudong Yao
Summary: Urological cancers are common malignant tumors worldwide. Traditional two-dimensional cell cultures and animal models cannot fully simulate the complexity of tumors and their interactions with the surrounding environment. The emergence of three-dimensional organoid models provides a new solution for studying urological cancers but still faces some challenges.
CELL AND BIOSCIENCE
(2022)
Review
Endocrinology & Metabolism
Jingcheng Zhang, Wentao Zhang, Yuchao Liu, Man Pi, Yufeng Jiang, Ailiyaer Ainiwaer, Shiyu Mao, Haotian Chen, Yuefei Ran, Shuwen Sun, Wei Li, Xudong Yao, Zhengyan Chang, Yang Yan
Summary: The piRNA is a small molecule, non-coding RNA with a length of 24-32nt. It was originally found in germ cells and is considered a regulator of germ cell function. It can interact with PIWI protein and play a role in gene transcription regulation and transposable factors silencing. Abnormal expression of piRNAs has been found in various cancer tissues and patient fluids, making them potential diagnostic tools, therapeutic targets, staging markers, and prognostic evaluation tools for cancer. This article reviews recent research on piRNA, focusing on its structural characteristics, production mechanism, applications, and role in urological tumors, providing valuable insights for the regulation of urological tumors by piRNA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Multidisciplinary Sciences
Wentao Zhang, Fuhan Yang, Shiyu Mao, Ruiliang Wang, Haotian Chen, Yuefei Ran, Shenghua Liu, Pengfei Wu, Yang Yan, Wei Li, Junfeng Zhang, Xudong Yao
Summary: Recent evidence suggests that the genitourinary microbiome plays a significant role in the development and progression of urological tumors, including bladder cancer. However, there is limited information available about the interaction between bladder cancer and the genitourinary microbiome, compared to the gut microbiota and gastrointestinal tumors. This expanding field merits further investigation for its potential impact on bladder cancer diagnosis, prevention, and treatment prospects.
Article
Urology & Nephrology
Niraj Maskey, Shiyu Mao, Guanjie Yang, Yadong Guo, Aimaitiaji Kadier, Jing Yuan, Jun Xie, Changcheng Guo, Bin Yang, Xudong Yao
Summary: This study aimed to assess the safety of cytoreductive radical prostatectomy (CRP) for patients with oligometastatic hormone-sensitive prostate cancer (omHSPC) by monitoring the perioperative change of circulating tumor cells (CTCs) and investigating its impact on long-term oncologic outcomes. The results showed that there was no significant difference in long-term oncologic outcomes between the perioperative CTC increase and non-increase groups, indicating that CRP potentially represents a safe procedure for the treatment of patients with omHSPC.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haotian Chen, Donghui Shi, Changfeng Guo, Wentao Zhang, Yadong Guo, Fuhan Yang, Ruiliang Wang, Junfeng Zhang, Zujun Fang, Yang Yan, Shiyu Mao, Xudong Yao
Summary: This study uncovered the role of uric acid in bladder cancer metabolism and immunotherapy. High uric acid levels were associated with worse prognosis and poor response to immunotherapy in bladder cancer patients. Experimental findings in a mouse model and multi-omic analysis revealed the impact of uric acid on tumor growth and immune cell alterations.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Yadong Guo, Zongtai Zheng, Wentao Zhang, Shiyu Mao, Fuhan Yang, Wei Li, Yang Yan, Xudong Yao
Summary: The effect of gender and metastasis sites on the prognosis of bladder cancer is assessed in this study. A gender-associated signature is identified and validated, and a radiomics signature is developed for predicting the gender-associated signature. These results provide additional evidence for individualized treatment in bladder cancer.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Letter
Urology & Nephrology
Haotian Chen, Ziwei Zhang, Wentao Zhang, Fuhan Yang, Shiyu Mao, Yuan Wu, Junfeng Zhang, Yang Yan, Xudong Yao
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Oncology
Ruiliang Wang, Zongtai Zheng, Shiyu Mao, Wentao Zhang, Ji Liu, Cheng Li, Shenghua Liu, Xudong Yao
Summary: By analyzing RNA-Sequence data and gene co-expression network, researchers established a novel eight-gene risk signature that can predict the progression and prognosis of bladder cancer patients. The study found that this signature was closely related to the malignant clinical features of BC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Dan Hu, Ying Wang, Genxin Ji, Yu Liu
Summary: This study constructed prognostic models for advanced NPC patients treated with IMRT using machine learning algorithms. Random forest (RF) showed the best predictive performance and identified the most important predictors. RF was proposed as a simple and accurate tool for evaluating the prognosis of advanced NPC patients.
CURRENT PROBLEMS IN CANCER
(2024)
Article
Oncology
Leena Gupta, Pratibha Suku, Aishwarya Dash, Parveen Bose, Praveen Sharma, Nabhajit Mallik, Sreejesh Sreedharanunni, Neelam Varma, Aditya Jandial, Pankaj Malhotra, Man Updesh Singh Sachdeva
Summary: This study evaluated the load and characteristics of circulating tumor plasma cells (CTPCs) and circulating normal plasma cells (CNPCs) in newly diagnosed multiple myeloma patients using flow cytometry. Increased burden of CTPCs was associated with poor prognostic markers and poor response to therapy. CNPCs were lower in patients with thrombocytopenia and hypoalbuminemia.
CURRENT PROBLEMS IN CANCER
(2024)
