Article
Biochemistry & Molecular Biology
Ali Bagherian, Bostan Roudi, Nahid Masoudian, Hamed Mirzaei
Summary: The research showed that nanomicelle-curcumin alone or combined with erlotinib can inhibit the viability of U87 glioblastoma cells, decrease the levels of genes related to angiogenesis and the Wnt pathway, and regulate proteins associated with autophagy and apoptosis.
Article
Biotechnology & Applied Microbiology
Qiong Liang, Yanhang Zhuo, Xiaoran Wu, Shihao Zheng, Jie Zhuang, Kaiyu Wang, Sunhui Chen
Summary: This study aimed to develop a drug-delivery system for the treatment of residual brain glioma after surgery, using a temperature-sensitive gel containing drug-carrying nanopreparations - nanogels. The system directly delivers drugs to residual tumor cells, reducing drug dosage and increasing potency.
Article
Multidisciplinary Sciences
Edikan A. Ogunnaike, Alain Valdivia, Mostafa Yazdimamaghani, Ernesto Leon, Seema Nandi, Hannah Hudson, Hongwei Du, Simon Khagi, Zhen Gu, Barbara Savoldo, Frances S. Ligler, Shawn Hingtgen, Gianpietro Dotti
Summary: The delivery of CAR-T cells within the surgical cavity using a fibrin-based gel demonstrates superior antitumor activity compared to direct inoculation into the tumor resection cavity in a model of subtotal glioblastoma resection.
Article
Chemistry, Multidisciplinary
Yan Zou, Yibin Wang, Sen Xu, Yanjie Liu, Jinlong Yin, David B. Lovejoy, Meng Zheng, Xing-Jie Liang, Jong Bae Park, Yuri M. Efremov, Ilya Ulasovand, Bingyang Shi
Summary: A new type of GBM-cell membrane camouflaged and pH-sensitive biomimetic nanoparticles have been developed for combined TMZ and CDDP therapy for GBM. The results show that these nanoparticles can efficiently transport drugs across the blood-brain barrier and specifically target GBM, allowing for controlled release at GBM sites and demonstrating potent anti-GBM effects without obvious side effects.
ADVANCED MATERIALS
(2022)
Article
Multidisciplinary Sciences
Nur Syahirah Che Razali, Kok Wai Lam, Nor Fadilah Rajab, A. Rahman A. Jamal, Nurul Farahana Kamaluddin, Kok Meng Chan
Summary: Curcuminoid analogues FLDP-5 and FLDP-8 exhibited potent cytotoxicity against LN-18 human glioblastoma cells, with lower IC50 values compared to curcumin. These analogues induced oxidative stress, inhibited cell migration and invasion, and caused cell cycle arrest, leading to reduced proliferation.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Amir R. Afshari, Mohammad Jalili-Nik, Farzaneh Abbasinezhad-Moud, Hossein Javid, Mohammad Karimi, Hamid Mollazadeh, Tannaz Jamialahmadi, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Curcuminoids, extracted from Curcuma Longa, have shown promising therapeutic benefits in experimental studies against GBM by modulating various signaling pathways and molecular targets. They exert anti-GBM effects through regulation of angiogenesis, receptor tyrosine kinases, Sonic Hedgehog, and NF-kappa B, suggesting their potential for clinical translation.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Mohamed Elbadawy, Kimika Hayashi, Hiromi Ayame, Yusuke Ishihara, Amira Abugomaa, Makoto Shibutani, Shim-Mo Hayashi, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Yuta Shinohara, Masahiro Kaneda, Hideyuki Yamawaki, Tatsuya Usui, Kazuaki Sasaki
Summary: Despite the adverse effects, chemotherapy is commonly used for colorectal cancer treatment. Developing supplement preparations targeting cancer stem cells is necessary. In this study, amorphous curcumin (AC) showed anti-carcinogenic properties against human CRC organoids by inhibiting cell viability, cell cycle, and CSC marker expressions while synergizing with anti-cancer drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Alexandra M. Amen, Christof Fellmann, Katarzyna M. Soczek, Shawn M. Ren, Rachel J. Lew, Gavin J. Knott, Jesslyn E. Park, Andrew M. McKinney, Andrew Mancini, Jennifer A. Doudna, Joseph F. Costello
Summary: Mutations in the TERT promoter of glioblastomas create binding sites for GABP transcription factor complexes, leading to reactivation of TERT and maintenance of telomeres. GBM cells with TERT promoter mutations display a dependence on GABPB1L for proliferation, which can be rescued by upregulation of the protein paralogue GABPB2. Inhibition of GABPB1L in combination with chemotherapy results in reduced growth of intracranial GBM tumors by impairing DNA damage response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Edoardo L. M. Gelardi, Diego Caprioglio, Giorgia Colombo, Erika Del Grosso, Daniele Mazzoletti, Daiana Mattoteia, Stefano Salamone, Davide M. Ferraris, Eleonora Aronica, Giulia Nato, Annalisa Buffo, Menico Rizzi, Lorenzo Magrassi, Alberto Minassi, Silvia Garavaglia
Summary: Curcumin-based fluorescent probes are developed to selectively bind to ALDH1A3 and identify glioblastoma cells. These probes show high selectivity and specificity in vitro and in vivo, making them potential useful tools for glioblastoma cell detection.
COMMUNICATIONS BIOLOGY
(2022)
Article
Engineering, Biomedical
Paul S. Sharp, Maria Stylianou, Luis M. Arellano, Juliana C. Neves, Alfredo M. Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby, Kostas Kostarelos
Summary: Graphene-based 2D nanomaterials have unique physicochemical characteristics that can be used in various biomedical applications, such as drug delivery and treatment. This study investigates the distribution of thin graphene oxide (GO) nanosheets in GBM mouse models and designs a novel nano-chemotherapeutic approach using GO sheets as platforms for drug complexation. The results demonstrate enhanced cytotoxic effects of the GO-BTZ complex in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Jingjing Ge, Cheng Li, Fengjun Xue, Shaopei Qi, Zhimeng Gao, Chunjiang Yu, Junping Zhang
Summary: The combination of apatinib and temozolomide shows efficacy in treating recurrent glioblastoma with manageable toxicities. It can be considered as a salvage therapy for patients who have not responded well to other treatments.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Kirit Singh, Kelly M. Hotchkiss, Ian F. Parney, John De Groot, Solmaz Sahebjam, Nader Sanai, Michael Platten, Evanthia Galanis, Michael Lim, Patrick Y. Wen, Giuseppe Minniti, Howard Colman, Timothy F. Cloughesy, Minesh P. Mehta, Marjolein Geurts, Isabel Arrillaga-Romany, Annick Desjardins, Kirk Tanner, Susan Short, David Arons, Elizabeth Duke, Wolfgang Wick, Stephen J. Bagley, David M. Ashley, Priya Kumthekar, Roel Verhaak, Anthony J. Chalmers, Anoop P. Patel, Colin Watts, Peter E. Fecci, Tracy T. Batchelor, Michael Weller, Michael A. Vogelbaum, Matthias Preusser, Mitchel S. Berger, Mustafa Khasraw
Summary: A breakthrough in drug discovery for glioblastoma necessitates the consecutive collection of central nervous system tissue through window of opportunity trials.
Article
Medicine, Research & Experimental
Yuan Yuan Cheng, Xue Yang, Xin Gao, Si Xin Song, Ming Feng Yang, Fang Min Xie
Summary: LGR6 promotes malignancy and chemoresistance in GBM, potentially through activation of the Akt signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Andrew J. Brenner, John Floyd, Lisa Fichtel, Joel Michalek, Kunal P. Kanakia, Shiliang Huang, David Reardon, Patrick Y. Wen, Eudocia Quant Lee
Summary: The study investigated the safety and efficacy of Evo in combination with bevacizumab for treating bevacizumab refractory glioblastoma patients. Results showed a median overall survival of approximately 4.6 months with a median time to disease progression of 53 days from best response. The progression free survival at 4 months (PFS-4) on Evo-Bev treatment demonstrated a statistically significant improvement.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Andrea Arena, Maria Anele Romeo, Rossella Benedetti, Laura Masuelli, Roberto Bei, Maria Saveria Gilardini Montani, Mara Cirone
Summary: Curcumin and resveratrol exhibit anti-inflammatory, anti-oxidant, and anti-cancer properties. When used in combination, they display a stronger cytotoxic effect on Her-2/neu-positive breast and salivary cancer cell lines, potentially through inducing ER stress and modulating autophagy. This study sheds light on novel molecular mechanisms underlying the anti-cancer effects of these polyphenols, suggesting potential therapeutic implications.
Article
Toxicology
Narges Marefati, Farimah Beheshti, Amin Mokhtari-Zaer, Mohammad Naser Shafei, Hossein Salmani, Hamid Reza Sadeghnia, Mahmoud Hosseini
Summary: Olibanum, the resin of Boswellia serrata, is believed to have anti-inflammatory and antioxidant properties and can improve memory impairment induced by lipopolysaccharide (LPS).
Article
Neurosciences
Mohaddeseh Sadat Alavi, Sahar Fanoudi, Azar Hosseini, Mohammad Jalili-Nik, Amirbehzad Bagheri, Hamid R. Sadeghnia
Summary: This study aimed to investigate the neuroprotective potential of everolimus (EVR), a selective and potent mTOR inhibitor, against glutamate-induced toxicity in PC12 cells. The results demonstrated that EVR significantly increased cell viability, inhibited glutamate-induced apoptosis, and regulated the expression of apoptosis-related proteins. This is the first study to discover the protective effect of EVR against glutamate-mediated PC12 cell death through the inhibition of apoptosis.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Review
Toxicology
Hamidreza Sadeghnia, Sara Shahba, Alireza Ebrahimzadeh-Bideskan, Shabnam Mohammadi, Amir Mohammad Malvandi, Abbas Mohammadipour
Summary: Atrazine, a common herbicide, has detrimental effects on cells and can pass through biological barriers. Studies have discussed its harmful impacts on various parts of the brain and the reproductive system.
Article
Multidisciplinary Sciences
Mohammad Ehsan Taghavizadeh Yazdi, Majid Darroudi, Mohammad Sadegh Amiri, Hossein Zarrinfar, Hasan Ali Hosseini, Mohammad Mashreghi, Hamid Mozafarri, Ahmad Ghorbani, Seyed Hadi Mousavi
Summary: Silver nanoparticles (AgNPs) prepared using fruit extract of Berberis integerrima showed high bactericidal and antifungal activity, suitable photocatalytic activity, and good anticancer effects against human liver cancer cell line. The study suggests that these AgNPs could be efficiently applied as antimicrobial/anticancer agents and for purifying water and pollutants solutions in the environment.
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY TRANSACTION A-SCIENCE
(2022)
Article
Endocrinology & Metabolism
Mohaddeseh Sadat Alavi, Sahar Fanoudi, Mahmoud Hosseini, Hamid R. Sadeghnia
Summary: This study evaluated the effects of chronic administration of Levetiracetam on cognitive deficits in a rat model of Alzheimer's disease. The results showed that Levetiracetam attenuated learning and memory impairments, protected hippocampal cells from oxidative damage and inflammation, and inhibited abnormal phosphorylation of tau protein.
METABOLIC BRAIN DISEASE
(2022)
Review
Dermatology
Razieh Froutan, Seyed Hassan Tavousi, Alireza Sedaghat, Hamid Reza Sadeghnia, Mohaddeseh Layegh, Seyed Reza Mazlom
Summary: Inhalation aromatherapy with damask rose and lavender essential oils can effectively reduce the doses of sedative and analgesic drugs administered as well as BIS during donor site dressing change in patients with burns.
ADVANCES IN SKIN & WOUND CARE
(2022)
Review
Pharmacology & Pharmacy
Reza Mohebbati, Hamid Reza Sadeghnia
Summary: This meta-analytic review found that dopamine- or GABA-related microRNAs are mostly upregulated in alcoholism, while approximately 9% of microRNAs are downregulated. Further large-scale studies and clinical work are needed to identify additional or specific microRNAs as potential biomarkers in alcoholism.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Pharmacology & Pharmacy
Fezzeh Memari, Farshad Mirzavi, Mohammad Jalili-Nik, Amir R. Afshari, Ahmad Ghorbani, Mohammad Soukhtanloo
Summary: This study found that zerumbone has anti-cancer effects in CRC by inducing apoptosis and inhibiting cell migration in HT-29 cells. Additionally, zerumbone increases the generation of intracellular reactive oxygen species and decreases the activity of matrix metalloproteinase. These findings suggest that zerumbone could be a promising natural agent for the future treatment of CRC.
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2022)
Article
Chemistry, Medicinal
Roghayeh Rashidi, Farideh Boroomand Jahed Avval, Shirin Ghasemian, Hamid Reza Sadeghnia, Seyed Hadi Mousavi, Sara Hooshmand, Mohammad Jalili-Nik, Mohammad Sadegh Amiri, Ahmad Ghorbani
Summary: The study evaluated the effects of Psoralea drupacea extract (PDE) on HepG2 liver cancer cells. The results showed that PDE inhibited the proliferation, migration, and angiogenesis of liver cancer cells, and enhanced the antiproliferative and proapoptotic activities of doxorubicin.
LETTERS IN DRUG DESIGN & DISCOVERY
(2023)
Article
Food Science & Technology
Azar Hosseini, Elham Pourheidar, Arezoo Rajabian, Elham Asadpour, Hossein Hosseinzadeh, Hamid Reza Sadeghnia
Summary: This study explored the neuroprotective mechanisms of linalool and its enantiomer against oxygen and glucose deprivation/reoxygenation (OGD/R) in PC12 cells, and found that they alleviated oxidative stress and apoptosis.
FOOD SCIENCE & NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Mohaddeseh Sadat Alavi, Hamid Reza Sadeghnia, Niloufar Nikpasand, Sajad Sahab Negah, Roghayeh Rashidi, Gholamreza Naseri, Ahmad Ghorbani
Summary: This study investigated the effects of mephedrone exposure on the proliferation, differentiation, and apoptosis of rat embryonic NS/PC. The results showed that mephedrone significantly decreased the proliferation of NS/PC, induced cell cycle arrest, and increased the percentage of apoptotic and necrotic cells.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mohaddeseh Sadat Alavi, Hamid Reza Sadeghnia, Niloufar Nikpasand, Sajad Sahab Negah, Roghayeh Rashidi, Gholamreza Naseri, Ahmad Ghorbani
Summary: This study found that mephedrone exposure negatively affects the proliferation, differentiation, and apoptosis of rat embryonic neural stem/progenitor cells (NS/PC). Mephedrone at concentrations of 20-640 μM significantly reduced NS/PC proliferation, induced cell cycle arrest, and increased apoptosis and necrosis. Additionally, mephedrone decreased the expressions of DCX and NeuN neuronal markers. These findings suggest that mephedrone exposure during fetal or neonatal life may impair neurogenesis and subsequent brain development.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Seyyed Abbas Zojaji, Hooman Mosannen Mozaffari, Pouya Ghaderi, Faegheh Zojaji, Mousa-Al-Reza Hadjzadeh, Monireh Seyfimoqadam, Ahmad Ghorbani
Summary: This study investigated the hepatoprotective effects of a polyherbal compound containing five plants with antioxidant, anti-inflammatory, and hypolipidemic properties on patients with non-alcoholic fatty liver disease (NAFLD). The results showed that the herbal compound significantly improved liver enzymes and total cholesterol levels, as well as the grade of fatty liver.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Veterinary Sciences
Zohreh Arab, Mahmoud Hosseini, Narges Marefati, Farimah Beheshti, Akbar Anaeigoudari, Hamid Reza Sadeghnia, Mohammad Hossein Boskabady
Summary: The study aimed to evaluate the effects of Zataria multiflora extract on brain tissue oxidative damage, interleukin-6 (IL-6), and learning and memory capacity in lipopolysaccharide (LPS) - challenged rats. The results showed that Zataria multiflora extract improved learning and memory dysfunction in LPS-challenged rats by alleviating inflammatory responses and brain tissue oxidative damage.
VETERINARY RESEARCH FORUM
(2022)
Article
Chemistry, Medicinal
Shahriar Dashti, Mousa-Al-Reza Hadjzadehz, Ahmad Ghorbani, Masoud Mohebbi, Zahra Gholamnezhad
Summary: The hydro-ethanolic extract of Ribes khorassanicum showed significant antihyperglycemic and hypolipidemic effects in type 2 diabetic patients without causing any adverse effects.
AVICENNA JOURNAL OF PHYTOMEDICINE
(2022)