Review
Immunology
Xiaoqian Liang, Caixin Ou, Jiayi Zhuang, Jinsheng Li, Fangfei Zhang, Yuanqiu Zhong, Yongfeng Chen
Summary: Psoriasis is a multifactorial immune-mediated disease with incompletely elucidated specific pathogenesis, and the skin microbiota may play a significant role in its provocation or exacerbation, interacting with innate immunity to stimulate T-cell populations and trigger immune cascade responses that ultimately lead to psoriasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Shuting Wen, Long He, Zhuotai Zhong, Runyuan Zhao, Senhui Weng, Hong Mi, Fengbin Liu
Summary: Stigmasterol treatment restores the Treg/Th17 balance and alters the gut microbiota, while also enhancing the production of SCFAs, particularly butyrate. Mechanistically, butyrate activates PPAR gamma and reprograms energy metabolism to promote Treg differentiation and inhibit Th17 differentiation, thus attenuating IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yu Jia, Tiantian He, Di Wu, Jiabing Tong, Jie Zhu, Zegeng Li, Jingcheng Dong
Summary: This study suggests that QBPF may achieve therapeutic effects on COPD by maintaining immune cell balance and regulating the gut-lung axis microbiota.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Ling Li, Jiahui Yang, Tianjing Liu, Yongyan Shi
Summary: Brain injury is a common complication in preterm infants, causing destruction of brain connections and leading to neurodevelopmental disorders with high morbidity and mortality rates. The role of intestinal flora in brain development and immune maturation in infants is important, but the understanding of the gut microbiota-metabolite-brain axis in preterm infants is limited. This review summarizes the mechanisms by which intestinal microbiota contribute to neurodevelopment and brain injury in preterm infants, emphasizing the influence of microorganisms and metabolites on neurocognitive development and neurodevelopmental risks associated with preterm birth, infection, and NEC. The review supports the development and application of therapeutic strategies such as probiotics, prebiotics, synbiotics, and fecal bacteria transplantation for brain injury in preterm infants.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Pan Sun, Chutian Zhang, Yunmei Huang, Juan Yang, Fen Zhou, Jianwei Zeng, Yanping Lin
Summary: This study observed and discussed the mechanism of Jiangu granule in ameliorating bone loss in OVX rats by regulating the gut microbiota-short-chain fatty acids-Treg/Th17 axis. The results showed that Jiangu granule restored the abundance of gut microbiota, increased the content of short-chain fatty acids, prevented bone loss, and enhanced bone strength.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
He-Xi Du, Shao-Yu Yue, Di Niu, Chang Liu, Li-Gang Zhang, Jing Chen, Yang Chen, Yu Guan, Xiao-Liang Hua, Chun Li, Xian-Guo Chen, Li Zhang, Chao-Zhao Liang
Summary: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is an immune-mediated disease, and dysbiosis of gut microflora may contribute to the imbalance of Th17/Treg cell differentiation. Propionic acid may play an important role in CP/CPPS.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chenchen Shi, Lishuang Zhou, Hong Li, Xunlong Shi, Yunyi Zhang, Yan Lu, Haiyan Zhu, Daofeng Chen
Summary: Houttuynia cordata polysaccharides (HCP) exert a therapeutic effect on influenza A virus-induced lung and intestine damage through regulating Th17/Treg balance by influencing gut microbiota.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Jingna Gu, Yizhou Zheng, Hongmei Yang, Yanyang Li, Shuowen Liu, Yequn Wu, Lingzhi Ren, Yang Yu, Yongling Long
Summary: This study found that Cistanche deserticola polysaccharide (CDP) alleviates inflammation in postmenopausal osteoporosis (PMO) by modulating gut microbiota composition, increasing short-chain fatty acid levels, balancing Th17/Treg cells, inhibiting proinflammatory cytokine accumulation, promoting osteoblast differentiation, and improving bone microarchitecture.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Immunology
Yongzhi Hua, Ruiqi Liu, Min Lu, Xueneng Guan, Suyang Zhuang, Yaozhou Tian, Zhenhai Zhang, Li Cui
Summary: Juglone has been found to have therapeutic effects on ulcerative colitis in mice, modulating gut microbiota and restoring Th17/Treg balance. The results show that juglone can alleviate UC symptoms, reduce inflammatory protein levels, and impact gut microbiota and Th17/Treg ratio.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Multidisciplinary Sciences
Yee Teng Lee, Nor Ismaliza Mohd Ismail, Loo Keat Wei
Summary: The relationship between microbiome and ischemic stroke is a novel and important research area. Aging, inflammation, and different microbial compositions may have an impact on the development of ischemic stroke.
Review
Gastroenterology & Hepatology
Esther Caparros, Reiner Wiest, Michael Scharl, Gerhard Rogler, Ana Gutierrez Casbas, Bahtiyar Yilmaz, Marcin Wawrzyniak, Ruben Frances
Summary: This review delves into the modification of the gut microbiota cluster network during CD progression and discusses how this shift compromises the gut barrier integrity, allowing the translocation of microbes and their products. It also retraces gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, providing insights on genetic background, immune inflammatory processes, and potential benefits of targeting a specific gut microbiota.
Review
Pharmacology & Pharmacy
Pilar Abiega-Franyutti, Veronica Freyre-Fonseca
Summary: This study reveals a clear link between food additives and changes in the gut microbiota that lead to various chronic diseases, yet research on the effects of food additives on microbiota is still inadequate, indicating a need for further investigation in this area.
Review
Immunology
Pan Chen, Xiangqi Tang
Summary: Myasthenia gravis is an acquired neurological autoimmune disorder characterized by dysfunctional transmission at the neuromuscular junction, with immune imbalance playing a role in its pathogenesis. Gut microbiota has been identified as a significant factor influencing the balance of Th17/Treg cells in MG patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Takashi Kobayashi, Michihiro Iwaki, Atsushi Nakajima, Asako Nogami, Masato Yoneda
Summary: Global lifestyle changes have led to an increased incidence of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). High-fat and high-fructose diets increase intestinal permeability, exposing the liver to endotoxins. The intestinal axis, including dysbiosis of the gut microbiome and leaky-gut syndrome, is linked to these liver diseases. This review summarizes recent research on the gut microbiome and liver diseases, providing new research directions for understanding the mechanisms and developing novel treatment targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Xiuxing Liu, Chenyang Gu, Jianjie Lv, Qi Jiang, Wen Ding, Zhaohao Huang, Yidan Liu, Yuhan Su, Chun Zhang, Zhuping Xu, Xianggui Wang, Wenru Su
Summary: Autoimmune uveitis (AU) is a common autoimmune disease with a complex etiology and high morbidity. The effects and regulatory mechanisms of progesterone (PRG) on the treatment of AU are unclear. In this study, we found that PRG ameliorated retinal lesions and inflammatory infiltration in AU animal models by regulating inflammatory gene expression and Th17/Treg imbalance. PRG also reversed the pathological signaling pathways involved in AU inflammation. These findings indicate that PRG has the potential to be used as a treatment for AU and other autoimmune diseases.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Federico Perdomo-Celis, Sandra Medina-Moreno, Harry Davis, Joseph Bryant, Natalia A. Taborda, Maria T. Rugeles, Shyamasundaram Kottilil, Juan C. Zapata
Article
Immunology
F. Perdomo-Celis, S. Medina-Moreno, H. Davis, J. Bryant, N. A. Taborda, M. T. Rugeles, S. Kottilil, J. C. Zapata
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2020)
Article
Immunology
Paula Andrea Serna-Ortega, Wbeimar Aguilar-Jimenez, Lizdany Florez-Alvarez, Daria Trabattoni, Maria Teresa Rugeles, Mara Biasin
MICROBES AND INFECTION
(2020)
Article
Immunology
Lizdany Florez-Alvarez, Lanie Ruiz-Perez, Natalia Taborda, Juan C. Hernandez
Article
Integrative & Complementary Medicine
Andres F. Yepes-Perez, Oscar Herrera-Calderon, Cristian A. Oliveros, Lizdany Florez-Alvarez, Maria Zapata-Cardona, Lina Yepes, Wbeimar Aguilar-Jimenez, Maria T. Rugeles, Wildeman Zapata
Summary: The hydroalcoholic extract of Uncaria tomentosa stem bark from Peru showed antiviral potential against SARS-CoV-2 in vitro, reducing viral titers and cytopathic effects. It could be a promising candidate for new therapeutic strategies against COVID-19.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Tropical Medicine
Wbeimar Aguilar-Jimenez, Lizdany Florez-Alvarez, Daniel S. Rincon, Damariz Marin-Palma, Alexandra Sanchez-Martinez, Jahnnyer Martinez, Maria Isabel Zapata, John D. Loaiza, Constanza Cardenas, Fanny Guzman, Paula A. Velilla, Natalia A. Taborda, Wildeman Zapata, Juan C. Hernandez, Francisco J. Diaz, Maria T. Rugeles
Summary: During COVID-19, high levels of proinflammatory cytokines were observed, along with decreased CD56(bright)-NK cell and cytotoxic response. Infected individuals showed a higher frequency of dysfunctional CD8+ T cells CD38(+)HLA-DR- compared to healthy controls.
Article
Genetics & Heredity
Ruben D. Arias-Perez, Salomon Gallego-Quintero, Natalia A. Taborda, Jorge E. Restrepo, Renato Zambrano-Cruz, William Tamayo-Agudelo, Patricia Bermudez, Constanza Duque, Ismael Arroyave, Johanna A. Tejada-Moreno, Andres Villegas-Lanau, Alejandro Mejia-Garcia, Wildeman Zapata, Juan C. Hernandez, Gina Cuartas-Montoya
Summary: Ichthyosis is a group of heterogeneous diseases caused by genetic disorders related to skin formation, with harlequin ichthyosis being a severe type that requires comprehensive medical care and genetic research to improve diagnosis and outcomes.
BMC MEDICAL GENOMICS
(2021)
Article
Biochemistry & Molecular Biology
Damariz Marin-Palma, Jorge H. Tabares-Guevara, Maria I. Zapata-Cardona, Lizdany Florez-alvarez, Lina M. Yepes, Maria T. Rugeles, Wildeman Zapata-Builes, Juan C. Hernandez, Natalia A. Taborda
Summary: Curcumin exhibits antiviral and anti-inflammatory effects against SARS-CoV-2, reducing viral titers and inhibiting inflammatory responses.
Article
Multidisciplinary Sciences
Tulio J. Lopera, Jorge A. Lujan, Eduardo Zurek, Wildeman Zapata, Juan C. Hernandez, Miguel A. Toro, Juan F. Alzate, Natalia A. Taborda, Maria T. Rugeles, Wbeimar Aguilar-Jimenez
Summary: Intestinal microbiota plays a crucial role in individuals with HIV infection and HIV-exposed individuals, influencing immune regulation. The microbiota profile of HIV-exposed individuals is similar to that of HIV-infected individuals, possibly due to cohabitation with their HIV+ partners.
Article
Medicine, General & Internal
Lizdany Florez-Alvarez, Juan C. Hernandez, Wildeman Zapata, Jose Ivan Charry-Zuluaga, Jose R. Jaramillo, Natalia A. Taborda, Juan D. Gonzalez, Larry L. Martinez, Lina M. Yassin
Summary: In this study, the antiviral properties of synthesized silver nanoparticles (AgNPs) against SARS-CoV-2 were investigated using in vitro models. The cytotoxic effect and antiviral activity of AgNPs in Vero E6 cells were evaluated. The results showed that AgNPs significantly reduced the viral titer of SARS-CoV-2 with low cytotoxicity.
Article
Environmental Sciences
Damariz Marin-Palma, Juan D. Gonzalez, Jhon F. Narvaez, Jazmin Porras, Natalia A. Taborda, Juan C. Hernandez
Summary: This study investigated the chemical composition, morphology, and potential health effects of PM10 collected from monitoring stations in the Valle de Aburra, Colombia. The PM10 particles in Valle de Aburra mainly consisted of ashes, volatiles, and fixed carbon, and contained various metals and polycyclic aromatic hydrocarbons (PAHs). The results suggest that the PM10 in Valle de Aburra is mainly derived from construction waste transport, coal combustion, and vehicle emissions, posing a potential health risk to the citizens.
WATER AIR AND SOIL POLLUTION
(2023)
Review
Virology
Mateo Chvatal-Medina, Carolina Lopez-Guzman, Francisco J. J. Diaz, Salomon Gallego, Maria T. T. Rugeles, Natalia A. A. Taborda
Summary: The HIV-1 reservoir, consisting of cells with latent, integrated virus, cannot be eliminated by antiretroviral therapy, posing a barrier to curing the infection. The mechanisms behind the development and persistence of HIV-1 reservoirs, as well as effective strategies for eradication, are still not fully understood.
ARCHIVES OF VIROLOGY
(2023)
Review
Immunology
John D. Loaiza, Mateo Chvatal-Medina, Juan C. Hernandez, Maria T. Rugeles
Summary: Since the identification of HIV as the cause of AIDS, there have been significant advancements in antiretroviral therapy (ART) that have reduced morbidity and mortality. However, the high mutation rate of the viral genome, suboptimal ART regimens, incomplete adherence to therapy, and poor control of viral load have led to the emergence of drug-resistant variants. The licensing of over 30 anti-HIV drugs worldwide, including integrase inhibitors, is a significant milestone as these drugs are potent, well-tolerated, and play a role in CD4 (+) T cell recovery and gut microbiota diversity.
