Review
Nutrition & Dietetics
Ludovico Abenavoli, Tiziana Larussa, Alessandro Corea, Anna Caterina Procopio, Luigi Boccuto, Marcello Dallio, Alessandro Federico, Francesco Luzza
Summary: NAFLD, characterized by a wide spectrum of liver disorders, is considered a major public health issue globally. Polyphenols, known for their anti-inflammatory and antioxidant properties, are believed to have potential benefits in preventing and treating NAFLD, though limited human clinical trials are available.
Article
Endocrinology & Metabolism
Yi Chen, Xueyang Chen, Qiang Chen, Chaohui Yu
Summary: The prevalence of NAFLD is higher in PA patients compared to non-PA patients, with hypokalemic PA patients having a worse metabolic status. Although NAFLD is more common in PA patients, the patterns of obesity, dyslipidemia, and insulin resistance are similar. This study provides new insights for further investigations into metabolic imbalance in patients with aldosteronism.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mayuko Chikamatsu, Hiroshi Watanabe, Yuhi Shintani, Ryota Murata, Masako Miyahisa, Ayano Nishinoiri, Tadashi Imafuku, Mei Takano, Nanaka Arimura, Kohichi Yamada, Miya Kamimura, Baki Mukai, Takao Satoh, Hitoshi Maeda, Toru Maruyama
Summary: Non-alcoholic fatty liver disease (NAFLD) affects 25% of the world's population, but there are currently no approved treatments. This study evaluates the therapeutic effect of a protein called HSA-FGF21 on NAFLD induced by high-fat diets. The administration of HSA-FGF21 showed improvements in body weight, glucose levels, and lipid accumulation in the liver. It also suppressed the expression of fatty acid uptake receptors and inflammatory cytokines. HSA-FGF21 has potential as a therapeutic agent for NAFLD.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nutrition & Dietetics
Jun-Hyuk Lee, Yu-Jin Kwon, Kyongmin Park, Hye Sun Lee, Hoon-Ki Park, Jee Hye Han, Sang Bong Ahn
Summary: This study found that metabolic score for IR (METS-IR) was inversely associated with ALF in patients with NAFLD, and its predictive ability for ALF was higher than that of triglyceride-glucose (TyG) index and homeostatic model assessment for IR (HOMA-IR).
Article
Biochemistry & Molecular Biology
Seol Hwa Seo, Eunhwan Kim, Minguen Yoon, Soung-Hoon Lee, Byung-Hyun Park, Kang-Yell Choi
Summary: This study found that the small molecule KY19334 can effectively treat obesity-related liver disease NASH by activating the Wnt/β-catenin signaling pathway. The treatment suppressed inflammation, steatosis, oxidative stress, and cell death, reversed liver fibrosis, and enhanced liver regeneration.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hsiu-Chen Huang, Chiung-Ju Chen, Yu-Heng Lai, Yu-Chun Lin, Wei-Chung Chiou, Hsu-Feng Lu, Ying-Fang Chen, Yu-Hsin Chen, Cheng Huang
Summary: Momordica cochinchinensis aril (MCA) has preventive effects on obesity, non-alcoholic fatty liver disease, and insulin resistance induced by high-fat diet. MCA inhibits adipose tissue expansion and hepatic fat accumulation, regulates gut microbiota composition, and activates the AMPK and PPAR-alpha signaling pathways. These mechanisms contribute to the prevention of fat-induced metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Dieter Furthner, Christian-Heinz Anderwald, Peter Bergsten, Anders Forslund, Joel Kullberg, Hakan Ahlstrom, Hannes Manell, Iris Ciba, Harald Mangge, Katharina Maruszczak, Pia Koren, Sebastian Schuetz, Susanne Maria Brunner, Anna Maria Schneider, Daniel Weghuber, Katharina Moerwald
Summary: SPISE is a novel and cost-effective index of hepatic insulin resistance, showing superior diagnostic ability in children and adolescents with obesity. It is significantly lower in patients with NAFLD, indicating sensitivity and specificity for hepatic IR better than established indices.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Minxuan Xu, Jun Tan, Wei Dong, Benkui Zou, Xuepeng Teng, Liancai Zhu, Chenxu Ge, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Tingting Tang, Junjie Zhao, Longyan Wang, Jin Liu, Hao Wei, Yan Sun, Qiufeng Yang, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Mingxin Xiong, Jing Feng, Chufeng Zhang, Bochu Wang
Summary: This study reveals that Trim31 acts as an endogenous inhibitor of Rhbdf2 in mice, mitigating the development of NASH and potentially serving as a therapeutic target for treating NAFLD/NASH and associated metabolic disorders.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Marta Carrillo-Palau, Alejandro Hernandez-Camba, Noemi Hernandez Alvarez-Buylla, Laura Ramos, Inmaculada Alonso-Abreu, Anjara Hernandez-Perez, Milagros Vela, Laura Arranz, Manuel Hernandez-Guerra, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study found that insulin resistance (IR) is not increased in inflammatory bowel disease (IBD) patients with low disease activity compared to controls. However, the presence of nonalcoholic fatty liver disease (NAFLD) favors the development of IR in patients with IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Microbiology
Fan Du, Rongfeng Huang, Dan Lin, Yuying Wang, Xiaohuang Yang, Xiaoyun Huang, Biyun Zheng, Zhixin Chen, Yuehong Huang, Xiaozhong Wang, Fenglin Chen
Summary: Resveratrol has shown therapeutic effects in reducing liver steatosis and insulin resistance in NAFLD, by significantly altering the diversity and composition of gut microbiota, resulting in decreased pathways related to lipid and glucose metabolism, ultimately improving metabolic indicators of NAFLD.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Endocrinology & Metabolism
Serena Scapaticci, Ebe D'Adamo, Angelika Mohn, Francesco Chiarelli, Cosimo Giannini
Summary: NAFLD is the most prevalent form of chronic liver disease in children and adolescents worldwide, with a significant increase in affected young people in recent decades, mainly due to childhood obesity. Insulin resistance and abnormal glucose tolerance are key features of NAFLD, which is also closely associated with Metabolic Syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Angel Arturo Lopez-Gonzalez, Barbara Altisench Jane, Luis Masmiquel Comas, Sebastiana Arroyo Bote, Hilda Maria Gonzalez San Miguel, Jose Ignacio Ramirez Manent
Summary: The unhealthy lifestyle modifications during the COVID-19 lockdown resulted in an increase in non-alcoholic fatty liver disease and metabolic alterations, leading to a worsening of cardiovascular risk factors.
Review
Biology
Saad Emhmed Ali, Mindie H. Nguyen
Summary: The prevalence of non-alcoholic fatty liver disease (NAFLD) is continuously increasing, closely associated with metabolic disorders such as obesity and insulin resistance. Sarcopenia and sarcopenic obesity have a negative impact on outcomes for individuals with NAFLD, and are expected to rise as obesity rates increase. Further research is needed to better define and manage these conditions.
Article
Biochemistry & Molecular Biology
Jun Cao, Lin Hua, Shipei Zhang, Jinping Tang, Fan Ke, Zhouhuan Wu, Guohui Xue
Summary: This study found that serum IL-38 levels were elevated in patients with non-alcoholic fatty liver disease (NAFLD), and correlated with insulin resistance, inflammation, and liver enzyme parameters. Serum IL-38 could potentially serve as a biochemical marker for diagnosing NAFLD.
LIPIDS IN HEALTH AND DISEASE
(2022)
Review
Cell Biology
Yicheng Zhou, Zhangwang Li, Minxuan Xu, Deju Zhang, Jitao Ling, Peng Yu, Yunfeng Shen
Summary: This review discusses the crucial role of O-GlcNAcylation in the development of NAFLD, explores the impact of therapeutic approaches on O-GlcNAcylation, and presents novel insights into the pathogenesis and treatments of NAFLD.
Review
Nutrition & Dietetics
Omid Eslami, Farzad Shidfar
Summary: Some evidence suggests that breastfeeding may influence food preferences in later years. A systematic review of observational studies was conducted to investigate the association between breastfeeding exposure and duration with data-driven or hypothesis-driven dietary patterns after 1 year of age. The review found that breastfeeding and longer duration of breastfeeding were associated with higher scores on healthy dietary patterns, characterized by fruits, vegetables, and whole grains. On the other hand, there was a negative association with unhealthy dietary patterns rich in added sugar, salt, and saturated fats. The review also highlighted the need for further research to overcome methodological limitations and provide more solid evidence.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Cardiac & Cardiovascular Systems
Somaye Fatahi, Mohammad Hassan Sohouli, Elma Izze da Silva Magalhaes, Victor Nogueira da Cruz Silveira, Fernando Zanghelini, Parisa Rahmani, Hamed Kord-Varkaneh, Farzad Shidfar
Summary: This study evaluated and compared the effects of DHA and EPA monotherapy on cardiovascular risk factors through meta-analysis. The results showed that DHA and EPA have similar effects on LDL-C, but their effects on other risk factors are not significant, with slight changes in blood glucose and insulin.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Neurosciences
Fereshteh Dehghani, Shima Abdollahi, Farzad Shidfar, Cain C. T. Clark, Sepideh Soltani
Summary: This systematic review and meta-analysis found that probiotics supplementation may be effective in elevating brain-derived neurotrophic factor (BDNF) levels in patients with depression and neurological disorders. A mixture of Lactobacillus and Bifidobacterium genera appeared to show greater efficacy than single genus supplements. However, the low quality of evidence suggests the need for more large-scale, high-quality randomized controlled trials for reliable conclusions.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Food Science & Technology
Reyhaneh Darvish Damavandi, Farzad Shidfar, Mohammad Najafi, Leila Janani, Mohsen Masoodi, Javad Heshmati, Somayeh Ziaei
Summary: Non-alcoholic fatty liver disease (NAFLD) affects nearly one-quarter of the worldwide adult population and is a serious liver disease. Recent studies have shown beneficial effects of purslane intake on oxidative stress and inflammation in NAFLD patients. This randomized double-blinded clinical trial investigated the efficacy and safety of purslane intake in NAFLD patients. The results showed a significant decrease in NF-kB p65 nuclear activity in the purslane group compared to the placebo group, suggesting that purslane intake may be a useful therapy for managing hyper inflammation in NAFLD patients.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Integrative & Complementary Medicine
Mostafa Safari, Akbar Asadi, Naheed Aryaeian, Hasan Fallah Huseini, Farzad Shidfar, Shima Jazayeri, Mojtaba Malek, Agha Fateme Hosseini, Zahra Hamidi
Summary: This study aimed to determine the efficacy of M. officinalis extract on depression, anxiety, and sleep quality in patients with type 2 diabetes with depressive symptoms. The results showed a significant decrease in depression and anxiety severity in the intervention group compared to the baseline, but no significant differences were observed in FBS, hs-CRP, anthropometric indices, sleep quality, and blood pressure.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Integrative & Complementary Medicine
Atieh Ghafouri, Sahar Jafari Karegar, Ghazaleh Hajiluian, Sharieh Hosseini, Shahrzad Shidfar, Mohammad Kamalinejad, Agha Fatemeh Hosseini, Iraj Heydari, Farzad Shidfar
Summary: This study investigated the effects of Rheum ribes supplementation on glycemic indices and apolipoproteins in patients with type 2 diabetes mellitus. The results showed that Rheum ribes intake reduced insulin levels and insulin resistance, as well as improved apolipoprotein levels in type 2 diabetic patients. These findings suggest a positive role of Rheum ribes in insulin resistance and apolipoproteins in type 2 diabetes.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Nutrition & Dietetics
Abolfazl Lari, Farzad Shidfar, Azadeh Aminianfar, Ammar Hassanzadeh Keshteli, Ahmad Esmaillzadeh, Peyman Adibi, Fatemeh Mehravar
Summary: The study aimed to evaluate the association between dietary phytochemical index (DPI) and irritable bowel syndrome (IBS). The results showed a negative correlation between the intake of phytochemicals and the severity of IBS, particularly in women. However, there was no significant association between DPI and the odds of developing IBS.
CLINICAL NUTRITION ESPEN
(2023)
Review
Chemistry, Medicinal
Haniyeh Golafrouz, Farzad Shidfar, Arezoo Piran, Zohreh Sajadi Hezaveh
Summary: A systematic review of controlled trials was conducted to explore the impact of CoQ10 supplementation on periodontitis. The results showed that CoQ10 supplementation significantly reduced clinical attachment loss and gingival index, but did not have a significant effect on plaque index, probing depth, and bleeding index. Further research is needed to draw conclusive results.
Article
Nutrition & Dietetics
Maryam Khazdouz, Naser Ebrahimi Daryani, Makan Cheraghpour, Foroogh Alborzi, Motahareh Hasani, Shaghayegh Baradaran Ghavami, Farzad Shidfar
Summary: The purpose of this study was to investigate the therapeutic effects of selenium supplementation in ulcerative colitis patients with mild-to-moderate disease activity. The study found that taking selenomethionine capsules significantly reduced disease activity and improved quality of life.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Review
Nutrition & Dietetics
Omid Eslami, Geraldine J. Cuskelly, Aine O'Connor
Summary: There is generally poor adherence to vitamin D supplementation guidelines in children under five years of age, with limited research conducted mainly in infants and high methodological heterogeneity. Further research is needed to identify effective health promotion interventions to increase adherence and reduce the risk of vitamin D deficiency at this critical life stage.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Niloufar Haghshenas, Fatemeh Hosseini Baharanchi, Ebru Melekoglu, Mohammad Hassan Sohouli, Farzad Shidfar
Summary: This study investigated the relationship between dietary inflammatory index (DII) and food-based dietary inflammatory index (FDII) with quality of life and menopausal symptoms, comparing their predictive power. The findings showed that both DII and FDII were significantly associated with the severity of sexual symptoms and had predictive power in predicting poor quality of life and sexual symptoms. The conclusion suggests that following an anti-inflammatory diet may improve quality of life and reduce the severity of menopausal symptoms, especially sexual symptoms.
Review
Nutrition & Dietetics
Morvarid Noormohammadi, Zeinab Ghorbani, Hossein Shahinfar, Farzad Shidfar
Summary: This study investigated the hepatic adverse effects of Rice Bran Arabinoxylan Compound (RBAC) and found that RBAC has immunomodulatory, anti-oxidant, and anti-inflammatory effects on the liver. The results suggest that RBAC supplementation does not have any harmful effects on the liver, and supplementation with RBAC powder or for three months or more may decrease serum AST levels. Further studies are needed to confirm these findings.
CLINICAL NUTRITION ESPEN
(2023)
Article
Biochemistry & Molecular Biology
Elham Sharifi-Zahabi, Nayebali Rezvani, Fatemeh Hajizadeh-Sharafabad, Fatemeh Sadat Hosseini-Baharanchi, Farzad Shidfar, Mehrali Rahimi
Summary: The study found that supplementation of pure theobromine (TB) combined with a low-calorie diet had beneficial effects on overweight and obese individuals with metabolic syndrome. It significantly reduced waist circumference and improved lipid and metabolic markers. This suggests that TB may be an effective adjunctive treatment.
Meeting Abstract
Nutrition & Dietetics
O. Eslami, G. J. Cuskelly, A. O'Connor
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)
