Article
Neurosciences
Giacomo Bertazzoli, Romina Esposito, Tuomas P. Mutanen, Clarissa Ferrari, Risto J. Ilmoniemi, Carlo Miniussi, Marta Bortoletto
Summary: This study found that different preprocessing pipelines can lead to variability in TEP waveforms, with noticeable differences in TEP amplitudes and GMFP between different preprocessing pipelines, but high correlation in topographies of TEPs at latencies over 100 ms.
Editorial Material
Neurosciences
Po-Yu Fong, Danny Spampinato, Kevin Michell, Marco Mancuso, Katlyn Brown, Jaime Ibanez, Alessandro Di Santo, Anna Latorre, Kailash Bhatia, John C. Rothwell, Lorenzo Rocchi
Summary: This commentary article compares the differences between their recently published paper on cerebellar transcranial magnetic stimulation (TMS) induced electroencephalographic responses and Gassmann et al.'s previous work on the same topic. The authors agree that the differences mainly stem from the use of different magnetic stimulation coils but raise two unanswered questions: (1) which method is most likely to achieve optimal activation of cerebellar output, and (2) to what extent are the evoked cerebellar responses contaminated by concomitant sensory input? They emphasize the importance of careful experimental design and combining electrophysiological and behavioral data for obtaining reliable TMS-EEG data.
Article
Psychology, Multidisciplinary
Matteo Maran, Ole Numssen, Gesa Hartwigsen, Emiliano Zaccarella
Summary: Categorical predictions are proposed as a key mechanism supporting rapid syntactic composition in language, with previous research pointing towards Broca's area as a crucial cortical region. However, causal evidence for this hypothesis is still lacking in this study.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Chemistry, Analytical
RaviPrakash Magisetty, Sung-Min Park
Summary: Bioelectronic devices have become indispensable in medical preparation, making significant achievements through the integration of engineering and scientific knowledge, as well as advancements in micro and nanotechnologies. In the future, bioelectronics will lead the way to more efficient diagnosis and treatment.
Review
Urology & Nephrology
James T. Kearns, Brian T. Helfand, Jianfeng Xu
Summary: This mini review discusses recent advances in our understanding of how genetic factors influence a man's risk of developing prostate cancer. This information has the potential to improve screening, diagnosis, and patient counseling following a diagnosis of prostate cancer.
EUROPEAN UROLOGY FOCUS
(2022)
Editorial Material
Chemistry, Multidisciplinary
Cosimo Cumbo, Crescenzio Francesco Minervini, Francesco Albano
Summary: The widespread adoption of next-generation sequencing (NGS) in clinical practice has significantly expanded the understanding of various disorders at the genomic level. The recent introduction of third-generation sequencing has revolutionized the field of clinical genomics by overcoming the limitations of conventional NGS technologies and achieving previously perceived as unattainable. What was once impractical in terms of potential and affordability has now become achievable. This new era of sequencing will enhance diagnostic and therapeutic approaches, providing clinicians with valuable support in their healthcare practice.
APPLIED SCIENCES-BASEL
(2022)
Article
Neurosciences
Elias Paolo Casula, Gaetano Tieri, Lorenzo Rocchi, Rachele Pezzetta, Michele Maiella, Enea Francesco Pavone, Salvatore Maria Aglioti, Giacomo Koch
Summary: Immersive virtual reality can lead to a strong feeling of embodiment over artificial body parts, but the neural mechanisms behind this phenomenon are not yet fully understood. By tracking real-time brain dynamics, researchers found that observing virtual body parts is associated with a rapid decrease in cortical activity in the hand region of the primary motor cortex, as well as rapid changes in activity within a fronto-parietal circuit. These findings suggest that changes in bodily representations are supported by dynamic interactions within a highly plastic network.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Health Care Sciences & Services
Yoshihiro Noda
Summary: The study aimed to investigate the acute neurophysiological effects of 1Hz transcranial magnetic stimulation (TMS) on the right dorsolateral prefrontal cortex (DLPFC) in healthy participants. The results showed that 1Hz-TMS significantly increased TMS-related power in alpha, beta, and gamma bands at the stimulation site during the resting state, while only alpha and beta bands were affected during verbal fluency tasks (VFTs). In addition, 1Hz-TMS to the right DLPFC increased TMS-related coherence in alpha and beta bands during the resting-state, but no significant changes were observed during the VFTs with left DLPFC stimulation.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Qian Ding, Jixiang Chen, Shunxi Zhang, Songbin Chen, Xiaotong Li, Yuan Peng, Yujie Chen, Junhui Chen, Kang Chen, Guiyuan Cai, Guangqing Xu, Yue Lan
Summary: This study aimed to explore the differences in stroke recovery mechanisms based on the functional integrity of the ipsilesional corticomotor pathway and motor function. The results showed that low-functioning individuals without elicitable motor evoked potentials (MEPs) had a significant increase in functional connectivity, which had a positive effect on motor recovery. In higher-functioning individuals without elicitable MEPs, functional connectivity increased gradually and the influence from the contralesional hemisphere played a key role in motor recovery. In individuals with elicitable MEPs, there was a negative correlation between interhemispheric functional connectivity and motor function, suggesting that the influence from the contralesional hemisphere may be detrimental to motor recovery.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Environmental Studies
Ana Peric, Milutin Miljus
Summary: This paper investigates the regeneration process of military brownfields in Serbia through a deliberative planning approach. It highlights the importance of public deliberation procedure and the role of the moderator, as well as collaboration among various national bodies and agencies in the regeneration process. The paper contributes to understanding the limits and potentials of deliberative practice for regeneration of military brownfields and proposes a mechanism to tackle critical issues in this process, which can be applied in similar socio-spatial contexts beyond Serbia.
Article
Biology
Yong Wang, Yuanyuan Dang, Yang Bai, Xiaoyu Xia, Xiaoli Li
Summary: Spinal cord stimulation (SCS) has the potential to modulate cortical activity in patients with disorders of consciousness (DOC). Transcranial magnetic stimulation combined with EEG (TMS-EEG) can be used to evaluate the effect of SCS on DOC. This study found that SCS can alter cortical activity, including temporal complexity and natural frequency, and these changes are related to the level of consciousness in DOC patients.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Ioannis Vlachos, Marietta Tzirini, Evangelia Chatzikyriakou, Ioannis Markakis, Maria Anastasia Rouni, Theodoros Samaras, Yiftach Roth, Abraham Zangen, Alexander Rotenberg, Dimitris Kugiumtzis, Vasilios K. Kimiskidis
Summary: The study investigates the relation between induced electric fields (E-fields) and the brain's response to transcranial magnetic stimulation (TMS). The results show significant correlations between the characteristics of the induced E-field and the intensity of brain activity. These findings provide new insights into the relationship between E-field and cortical activation and support the use of personalized approaches in non-invasive brain stimulation.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Multidisciplinary
Konstantinos Pastiadis, Ioannis Vlachos, Evangelia Chatzikyriakou, Yiftach Roth, Samuel Zibman, Abraham Zangen, Dimitris Kugiumtzis, Vasilios K. K. Kimiskidis
Summary: This study introduces a novel and perceptually motivated method, named TMS-click AFTS, for suppressing auditory evoked EEG artifacts caused by concurrent TMS recordings. The method utilizes a psychophysically-matched wide-band noise masking stimulus that is individually constructed for each patient/subject. An adaptive procedure is employed to optimize the masking noise level, considering both the subject's comfort and the degree of AEP reduction.
APPLIED SCIENCES-BASEL
(2023)
Editorial Material
Neurosciences
Lukas Ga, Pedro Caldana Gordon, Ulf Ziemann
Summary: Recently, discrepancies were found in EEG responses in the cerebral cortex elicited by cerebellar TMS. The authors discussed possible reasons for the observed differences and highlighted the significance of reliably measuring cbTMS-evoked EEG responses in testing cerebellum-to-cortex connectivity.
Article
Multidisciplinary Sciences
Joelle A. M. Schroeen, Thomas C. Gunter, Ole Numssen, Leon O. H. Kroczek, Gesa Hartwigsen, Angela D. Friederici
Summary: Recent neurobiological models suggest that auditory sentence comprehension is supported by a left-dominant brain network involving the pIFG, pSTG/STS, and AG. TMS-EEG experiments reveal bidirectional information flow from left pSTG/STS to left pIFG during auditory sentence processing. The left pSTG/STS may be supported by the left AG in a state-dependent manner.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Editorial Material
Neurosciences
Giacomo Koch, Carlo Caltagirone
NEUROSCIENCE LETTERS
(2020)
Article
Clinical Neurology
Alberto Benussi, Mario Grassi, Fernando Palluzzi, Giacomo Koch, Vincenzo Di Lazzaro, Raffaele Nardone, Valentina Cantoni, Valentina Dell'Era, Enrico Premi, Alessandro Martorana, Francesco di Lorenzo, Sonia Bonni, Federico Ranieri, Fioravante Capone, Gabriella Musumeci, Maria Sofia Cotelli, Alessandro Padovani, Barbara Borroni
ANNALS OF NEUROLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria Ricci, Agostino Chiaravalloti, Alessandro Martorana, Giacomo Koch, Vincenzo De Lucia, Gaetano Barbagallo, Orazio Schillaci
ANNALS OF NUCLEAR MEDICINE
(2020)
Article
Neurosciences
Martina Assogna, Elias Paolo Casula, Ilaria Borghi, Sonia Bonni, Domenico Sama, Caterina Motta, Francesco Di Lorenzo, Alessia D'Acunto, Francesco Porrazzini, Marilena Minei, Carlo Caltagirone, Alessandro Martorana, Giacomo Koch
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Review
Clinical Neurology
Marina de Tommaso, Viviana Betti, Tommaso Bocci, Nadia Bolognini, Francesco Di Russo, Francesco Fattapposta, Raffaele Ferri, Sara Invitto, Giacomo Koch, Carlo Miniussi, Francesco Piccione, Aldo Ragazzoni, Ferdinando Sartucci, Simone Rossi, Massimiliano Valeriani
NEUROLOGICAL SCIENCES
(2020)
Review
Neurosciences
Giacomo Koch
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Medicine, General & Internal
Giacomo Koch, Caterina Motta, Sonia Bonni, Maria Concetta Pellicciari, Silvia Picazio, Elias Paolo Casula, Michele Maiella, Francesco Di Lorenzo, Viviana Ponzo, Clarissa Ferrari, Eugenia Scaricamazza, Carlo Caltagirone, Alessandro Martorana
Article
Neurosciences
Laura Bonanni, Davide Moretti, Alberto Benussi, Laura Ferri, Mirella Russo, Claudia Carrarini, Filomena Barbone, Dario Arnaldi, Nicola Walter Falasca, Giacomo Koch, Annachiara Cagnin, Flavio Nobili, Claudio Babiloni, Barbara Borroni, Alessandro Padovani, Marco Onofrj, Raffaella Franciotti
Summary: The study found significant changes in functional cortical connectivity in patients with frontotemporal dementia (FTD) and Alzheimer's disease (AD) during the course of the diseases, with hyperconnectivity in the early stages disappearing during follow-up.
Article
Clinical Neurology
Marina Diomedi, Alessandro Rocco, Chiara Giuseppina Bonomi, Alfredo Paolo Mascolo, Vincenzo De Lucia, Federico Marrama, Fabrizio Sallustio, Giacomo Koch, Alessandro Martorana
Summary: The study found that measures of hypoperfusion in patients with Alzheimer's disease varied along the AD continuum, and hypoperfusion was inversely correlated with CSF amyloid beta 42 levels.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Philipp J. Koch, Chang-Hyun Park, Gabriel Girard, Elena Beanato, Philip Egger, Giorgia Giulia Evangelista, Jungsoo Lee, Maximilian J. Wessel, Takuya Morishita, Giacomo Koch, Jean-Philippe Thiran, Adrian G. Guggisberg, Charlotte Rosso, Yun-Hee Kim, Friedhelm C. Hummel
Summary: Stroke patients vary in outcomes, with some showing natural recovery proportional to initial impairment. Predicting individual recovery potential through structural connectome analysis, especially in severely impaired patients, allows for personalized neuro-rehabilitation decisions. Understanding neuronal network mechanisms underlying recovery is crucial for predicting and facilitating stroke rehabilitation.
Article
Neurosciences
Elias Paolo Casula, Gaetano Tieri, Lorenzo Rocchi, Rachele Pezzetta, Michele Maiella, Enea Francesco Pavone, Salvatore Maria Aglioti, Giacomo Koch
Summary: Immersive virtual reality can lead to a strong feeling of embodiment over artificial body parts, but the neural mechanisms behind this phenomenon are not yet fully understood. By tracking real-time brain dynamics, researchers found that observing virtual body parts is associated with a rapid decrease in cortical activity in the hand region of the primary motor cortex, as well as rapid changes in activity within a fronto-parietal circuit. These findings suggest that changes in bodily representations are supported by dynamic interactions within a highly plastic network.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Lucia Mencarelli, Lucia Monti, Sara Romanella, Francesco Neri, Giacomo Koch, Ricardo Salvador, Giulio Ruffini, Giulia Sprugnoli, Simone Rossi, Emiliano Santarnecchi
Summary: This study found that stimulating the left and right DLPFC with 40 Hz tACS can increase blood oxygenation level-dependent activity in the targeted DLPFCs and surrounding areas according to biophysical modeling. However, off-target effects on visual cortices, SMA, left subgenual cingulate, and right superior temporal gyrus were also observed.
Article
Clinical Neurology
Giacomo Koch, Elias Paolo Casula, Sonia Bonni, Ilaria Borghi, Martina Assogna, Marilena Minei, Maria Concetta Pellicciari, Caterina Motta, Alessia D'Acunto, Francesco Porrazzini, Michele Maiella, Clarissa Ferrari, Carlo Caltagirone, Emiliano Santarnecchi, Marco Bozzali, Alessandro Martorana
Summary: In a 24-week trial, repetitive transcranial magnetic stimulation of the precuneus was found to slow down cognitive and functional decline in patients with Alzheimer's disease. The study suggests that targeting the default mode network could be a novel therapeutic approach for Alzheimer's disease patients.
Letter
Clinical Neurology
Giacomo Koch, Alessandro Martorana
Article
Clinical Neurology
Matilde Bruno, Chiara Giuseppina Bonomi, Francesco Ricci, Martina Gaia Di Donna, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana, Caterina Motta
Summary: This study investigated the relationship between BBB permeability and neuroinflammation in AD patients. The findings suggest that different neuroinflammatory profiles can be associated with different levels of BBB permeability in AD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
