Article
Pharmacology & Pharmacy
Vinochani Pillay, Lipi Shukla, Prad Herle, Simon Maciburko, Nadeeka Bandara, Isabella Reid, Steven Morgan, Yinan Yuan, Jennii Luu, Karla J. Cowley, Susanne Ramm, Kaylene J. Simpson, Marc G. Achen, Steven A. Stacker, Ramin Shayan, Tara Karnezis
Summary: Surgery and radiotherapy are major cancer treatments that can cause damage to the lymphatic system, leading to lymphoedema. However, the molecular mechanisms underlying this damage to lymphatic vessels and endothelial cells remain poorly understood.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Joshua S. T. Hooks, Fabrice C. Bernard, Ricardo Cruz-Acuna, Zhanna Nepiyushchikh, Yarelis Gonzalez-Vargas, Andres J. Garcia, J. Brandon Dixon
Summary: The lymphatic vasculature plays a crucial role in the body's circulation system, and studying its growth mechanisms and developing related biomaterial strategies is of great importance. Utilizing an engineered hydrogel material, the sprouting and transplantation of lymphatic vessels can be facilitated, providing a promising platform for further research on lymphangiogenesis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zengjie Wu, Qing Lin, Hongming Song, Jingjing Chen, Guanqun Wang, Guangming Fu, Chunxiao Cui, Xiaohui Su, Lili Li, Tiantian Bian
Summary: This study developed a scoring model based on preoperative MRI images to predict lymphatic vessel invasion (LVI) in breast cancer. The model showed satisfactory efficacy in noninvasively predicting LVI status, providing valuable information for personalized therapeutic planning.
ACADEMIC RADIOLOGY
(2023)
Article
Oncology
Sen Liu, Xu Chen, Tianxin Lin
Summary: The article summarizes the molecular mechanisms of lymphatic metastasis in bladder cancer, including lymphangiogenesis, noncoding RNAs, and microenvironment-associated molecules. Newly discovered radiomics and genomics approaches have improved the preoperative diagnostic accuracy of lymph node metastasis, potentially leading to promising therapeutic strategies.
Article
Multidisciplinary Sciences
Esther Redder, Nils Kirschnick, Stefanie Bobe, Rene Haegerling, Nils Rouven Hansmeier, Friedemann Kiefer
Summary: The use of transgenic mouse model Vegfr3-tdTomato allows for effective visualization of lymphatic vessel structure, facilitating the study of lymphatic function and pathofunction. This mouse model inherits the reporter gene, showing stable fluorescence in lymphatic vessels across multiple organs.
Correction
Multidisciplinary Sciences
Eric Song, Tianyang Mao, Huiping Dong, Ligia Simoes Braga Boisserand, Salli Antila, Marcus Bosenberg, Kari Alitalo, Jean-Leon Thomas, Akiko Iwasaki
Summary: A correction to this paper has been published with the provided link.
Article
Medicine, General & Internal
Costanza Chiapponi, Hakan Alakus, Matthias Schmidt, Michael Faust, Christiane J. Bruns, Reinhard Buettner, Marie-Lisa Eich, Anne M. Schultheis
Summary: The documentation of lymphatic vessel invasion in pathology reports of papillary thyroid cancer (PTC) is inconsistent, but the correlation between L1 diagnosis and lymph node metastasis (LNM) suggests its relevance for clinical decision-making.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jian Chen, Fan Zhang, Mengmeng Hua, Xiaobin Song, Shaohua Liu, Zuoqing Dong
Summary: This study demonstrated a significant association between intratumoral lymphatic vessel density (ILVD) and increased lymphatic metastasis, tumor recurrence, and reduced disease-specific survival in patients with oral squamous cell carcinoma. ILVD could be considered as an indicator for predicting the prognosis of OSCC.
Article
Gastroenterology & Hepatology
Sang Sik Cho, Ji Won Park, Gyeong Hoon Kang, Jung Ho Kim, Jeong Mo Bae, Sae-Won Han, Tae-You Kim, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park
Summary: This study aimed to determine whether the location of lymphatic invasion, vascular invasion, and perineural invasion could affect the survival of patients with stage II colon cancer. The results showed that extramural invasion was associated with a worse prognosis, while intramural invasion was not. Therefore, pathologic reports about the location of invasion may be helpful for predicting prognosis and determining the need for adjuvant chemotherapy in stage II colon cancers.
DISEASES OF THE COLON & RECTUM
(2023)
Review
Biochemistry & Molecular Biology
Elisabetta Kuhn, Donatella Gambini, Luca Despini, Dario Asnaghi, Letterio Runza, Stefano Ferrero
Summary: Traditionally, lymphovascular invasion (LVI) has been considered an important pathological feature of malignancy, including breast carcinoma, and is associated with worse prognosis. However, there is inconsistency in interpretation among pathologists, leading to significant interobserver variability and scarce reproducibility. Nonetheless, in selected cases, the presence of LVI impacts adjuvant therapy.
Article
Multidisciplinary Sciences
Ayumi Inoue Nagahara, Jun Homma, Bikei Ryu, Hidekazu Sekine, Yuhei Higashi, Tatsuya Shimizu, Takakazu Kawamata
Summary: This study constructed cell sheets containing a network of lymphatic endothelial cells (LECs) by co-culturing LECs and adipose-derived stem cells (ASCs) and evaluated their lymphangiogenesis-promoting ability through transplantation into rats. The results showed that cell sheets with a specific cell ratio generated networks with more branches and longer branch lengths.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Jia-Mei Chen, Bo Luo, Ru Ma, Xi-Xi Luo, Yong-Shun Chen, Yan Li
Summary: Metastasis via lymphatic or blood vessels is the leading cause of death for breast cancer. However, the research progress for tumor lymphangiogenesis has lagged behind that for angiogenesis due to the lack of specific markers. With the discovery of lymphatic endothelial cell (LEC) markers, it has been shown that LEC plays an active role in various processes related to lymphatic formation, tumor growth, invasion, and antitumor immunity.
Article
Oncology
Hanhao Zheng, Changhao Chen, Yuming Luo, Min Yu, Wang He, Mingjie An, Bowen Gao, Yao Kong, Yiyao Ya, Yan Lin, Yuting Li, Keji Xie, Jian Huang, Tianxin Lin
Summary: In patients with lymph node metastatic bladder cancer, lncRNA BCYRN1 was found to be significantly upregulated in urinary exosomes and associated with BCa LN metastasis. BCYRN1 enhances lymphatic metastasis of BCa by activating Wnt/β-catenin signaling and promoting VEGF-C secretion. Blocking VEGFR3 can impair BCYRN1-induced LN metastasis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Kelly A. Hirko, Meredith M. Regan, Marie C. Remolano, Julia Schlossman, Beth Harrison, Eren Yeh, Heather Jacene, Faina Nakhlis, Caroline Block, Jennifer M. Rosenbluth, Ana C. Garrido-Castro, Beth A. Overmoyer
Summary: DLI was detected in 63.2% of IBC cases, but it was not independently associated with clinical outcomes in terms of survival or recurrence.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Multidisciplinary Sciences
Na Luo, Ying Wen, Qiongyan Zou, Dengjie Ouyang, Qitong Chen, Liyun Zeng, Hongye He, Munawar Anwar, Limeng Qu, Jingfen Ji, Wenjun Yi
Summary: A diagnostic model for assessing axillary lymph node metastasis status in breast cancer was developed using a combination of mRNAs and the T stage of the primary tumor. The model showed high accuracy and was associated with tumor immune infiltration and breast cancer prognosis.
SCIENTIFIC REPORTS
(2022)