Review
Clinical Neurology
Femke Kremers, Esmee Venema, Martijne Duvekot, Lonneke Yo, Reinoud Bokkers, Geert Lycklama A. Nijeholt, Adriaan van Es, Aad van der Lugt, Charles Majoie, James Burke, Bob Roozenbeek, Hester Lingsma, Diederik Dippel
Summary: This study provides an overview and validation of prediction models for functional outcome after endovascular treatment in acute ischemic stroke patients. The results show that the THRIVE-c score and MR PREDICTS score have good performance in predicting functional outcome.
Article
Cardiac & Cardiovascular Systems
Sanne J. den Hartog, Osama Zaidat, Bob Roozenbeek, Adriaan C. G. M. van Es, Agnetha A. E. Bruggeman, Bart J. Emmer, Charles B. L. M. Majoie, Wim H. van Zwam, Ido R. van den Wijngaard, Pieter Jan van Doormaal, Hester F. Lingsma, James F. Burke, Diederik W. J. Dippel
Summary: The study found that first-pass reperfusion is associated with favorable outcomes in stroke treatment, independently of patient characteristics. Compared with multiple-pass reperfusion, first-pass reperfusion has better results.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Karin Weissenborn, Sam Gruber, Gerrit M. Grosse, Maria Gabriel, Ramona Schuppner, Hans Worthmann, Omar Abu-Fares, Friedrich Goetz
Summary: The study analyzed the workflow and outcomes of mechanical thrombectomy in acute ischemic stroke patients, identifying causes of treatment delays including medical emergencies, lack of hospital emergency staff prenotification, repeated brain imaging, and transfers from other hospitals. The findings suggest the need for improved operational procedures and patient selection criteria to optimize endovascular treatment.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Joao Pinho, Charlotte Kueppers, Omid Nikoubashman, Martin Wiesmann, Joerg B. Schulz, Arno Reich, Cornelius J. Werner
Summary: Frailty is an independent predictor of outcomes in AIS patients undergoing EST, with patients at high frailty risk more likely to have unfavorable results at 3 months.
Article
Radiology, Nuclear Medicine & Medical Imaging
Gianluca Brugnara, Adrian Engel, Jessica Jesser, Peter Arthur Ringleb, Jan Purrucker, Markus A. Moehlenbruch, Martin Bendszus, Ulf Neuberger
Summary: In this study, the influence of small vessel disease and cortical atrophy on clinical outcome after acute ischemic stroke was assessed using native cranial computed tomography (NCCT). The results showed that pre-existing brain deterioration was significantly correlated with clinical outcome. Both age-related white matter changes (ARWMC) and cortical atrophy were independent predictors of clinical outcome after endovascular treatment (EVT).
EUROPEAN RADIOLOGY
(2023)
Article
Hematology
Jae-Chan Ryu, Seunguk Jung, Jae-Han Bae, Sang Hee Ha, Bum Joon Kim, Sang-Beom Jeon, Dong-Wha Kang, Sun U. Kwon, Jong S. Kim, Jun Young Chang
Summary: Thromboelastography (TEG) can be used to predict functional outcome in acute large vessel occlusive stroke patients undergoing intraarterial thrombectomy (IAT), with decreased reaction time (R) associated with improved functional independence.
THROMBOSIS RESEARCH
(2023)
Article
Clinical Neurology
Noor Samuels, Rob A. van de Graaf, Carlijn A. L. van den Berg, Simone M. Uniken Venema, Kujtesa Bala, Pieter Jan van Doormaal, Wouter van der Steen, Elbert Witvoet, Jelis Boiten, Heleen den Hertog, Wouter J. Schonewille, Jeannette Hofmeijer, Floris Schreuder, Tobien A. H. C. M. L. Schreuder, H. Bart van der Worp, Yvo B. W. E. M. Roos, Charles B. L. M. Majoie, James F. Burke, Adriaan C. G. M. van Es, Aad van der Lugt, Bob Roozenbeek, Hester F. Lingsma, Diederik W. J. Dippel
Summary: This study assessed the association between systolic blood pressure (SBP) in the first 6 hours following endovascular treatment (EVT) for ischemic stroke and functional outcome as well as symptomatic intracranial hemorrhage. Results indicated that higher maximum SBP was associated with worse functional outcomes and increased risk of hemorrhage, while the association with minimum SBP was nonlinear with detrimental outcomes at both lower and higher levels. Successful reperfusion did not influence these relationships.
Article
Clinical Neurology
Lucie A. van den Berg, Olvert A. Berkhemer, Puck S. S. Fransen, Debbie Beumer, Hester Lingsma, Charles B. M. Majoie, Diederik W. J. Dippel, Aad van der Lugt, Robert J. van Oostenbrugge, Wim H. van Zwam, Yvo B. Roos, Marcel G. W. Dijkgraaf
Summary: This study aimed to evaluate whether endovascular therapy plus usual care is cost-effective compared to usual care alone in acute ischemic stroke patients. The results showed that endovascular treatment added to usual care is clinically effective and cost-saving in comparison to usual care alone for patients with acute ischemic stroke.
Article
Biology
N. Kappelhof, L. A. Ramos, M. Kappelhof, H. J. A. van Os, V Chalos, K. R. van Kranendonk, N. D. Kruyt, Y. B. W. E. M. Roos, W. H. van Zwam, I. C. van der Schaaf, M. A. A. van Walderveen, M. J. H. Wermer, R. J. van Oostenbrugge, Hester Lingsma, Diederik Dippel, C. B. L. M. Majoie, H. A. Marquering
Summary: A novel evolutionary algorithm for fuzzy decision trees was developed and evaluated to accurately identify patients with poor outcomes after endovascular treatment. Insights into predicted outcomes can help manage expectations after treatment, and the method significantly outperformed traditional decision tree algorithms in terms of accuracy and interpretability.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Nannan Han, Xiaobo Zhang, Yu Zhang, Yu Liu, Yongqin Zhang, Haojun Ma, Hanming Ge, Shilin Li, Xiao Zhang, Xudong Yan, Tengfei Li, Bin Gao, Chengxue Du, Xinchao Ji, Wenzhen Shi, Ye Tian, Mingze Chang
Summary: This study aimed to construct and validate a nomogram for predicting 3-month unfavorable outcome in patients with large ischemic core caused by anterior circulation occlusion who underwent endovascular thrombectomy. The study used retrospective and prospective cohorts to collect diffusion weighted imaging related radiomic features and pre-thrombectomy clinical features. After feature selection, a nomogram predicting unfavorable outcome was established and evaluated using receiver operating characteristic curve. The results showed that the nomogram had good discriminatory value in predicting the risk of unfavorable outcome in patients with LIC caused by anterior circulation occlusion.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Fouzi Bala, Nicolas Bricout, Nasreddine Nouri, Charlotte Cordonnier, Hilde Henon, Barbara Casolla
Summary: This study aimed to evaluate the safety and outcomes of endovascular treatment in patients with very severe and severe neurological deficits. Results showed that in patients with very severe deficits, successful recanalization was strongly associated with better functional outcomes at 90 days.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Lisa Oesch, Marcel Arnold, Corrado Bernasconi, Johannes Kaesmacher, Urs Fischer, Pascal J. Mosimann, Simon Jung, Thomas Meinel, Martina Goeldlin, Mirjam Heldner, Bastian Volbers, Jan Gralla, Hakan Sarikaya
Summary: This study compared stroke patients with preexisting dependency to independent patients who underwent EVT. It found that the dependent patients were older, had more severe strokes, and more risk factors, but the preexisting dependency did not significantly affect clinical outcomes or mortality. Careful selection of care-dependent stroke patients for EVT is needed, as prior dependency does not greatly impact outcomes.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Chunlin Ma, Wenbo Cao, Yang Huang, Qiuyue Tian, Yanfei Chen, Yabing Wang, Jian Chen, Peng Gao, Adam A. Dmytriw, Robert W. Regenhardt, Fei Chen, Qingfeng Ma, Liqun Jiao, Bin Yang
Summary: The study aimed to investigate the effect of two major etiologies (intracranial atherosclerotic stenosis and cardioembolism) on outcomes of acute ischemic stroke patients with large vessel occlusion undergoing endovascular thrombectomy. Clinical data of anterior circulation AIS patients receiving EVT were retrospectively analyzed, and the clinical outcomes were compared. The etiology was not considered as an important factor in functional outcome, despite the differences in baseline characteristics and technical approach.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Jang-Hyun Baek, Ji Hoe Heo, Hyo Suk Nam, Byung Moon Kim, Dong Joon Kim, Young Dae Kim
Summary: This study aimed to evaluate the association between preprocedural D-dimer levels and endovascular and clinical outcomes in patients with acute intracranial large-vessel occlusion. The results showed that preprocedural D-dimer levels were not associated with successful recanalization or thrombus fragmentation, but were positively correlated with the number of passes of the thrombectomy device and the puncture-to-recanalization time. Additionally, higher preprocedural D-dimer levels were associated with unfavorable functional outcomes in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Alexander C. Flint, Sheila L. Chan, Nancy J. Edwards, Vivek A. Rao, Jeffrey G. Klingman, Mai N. Nguyen-Huynh, Bernard Yan, Peter J. Mitchell, Stephen M. Davis, Bruce C. Campbell, Diederik W. Dippel, Yvo B. W. E. M. Roos, Wim H. van Zwam, Jeffrey L. Saver, Chelsea S. Kidwell, Michael D. Hill, Mayank Goyal, Andrew M. Demchuk, Serge Bracard, Martin Bendszus, Geoffrey A. Donnan
Summary: THRIVE-EVT can be combined with the original THRIVE-c calculation to improve outcome probability estimation for patients with acute ischemic stroke and model the potential improvement in outcomes with endovascular treatment based on variables available at initial presentation.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Amy Ying Xin Yu, Peter C. Austin, Mohammed Rashid, Jiming Fang, Joan Porter, Manav V. Vyas, Eric E. Smith, Raed A. Joundi, Jodi D. Edwards, Mathew J. Reeves, Moira K. Kapral
Summary: This study examined whether sex differences in stroke care and outcomes varied with age. Among 61,442 patients with ischemic stroke, female patients had higher odds of receiving endovascular thrombectomy, but between the ages of 50-70 years, the hazard of death was higher in female patients than male patients.
Article
Clinical Neurology
Maryam Ghahremani, Meng Wang, Hung-Yu Chen, Henrik Zetterberg, Eric Smith, Zahinoor Ismail
Summary: This study investigated the association between mild behavioral impairment (MBI) and plasma p-tau181 levels, cognitive function changes, and the risk of developing Alzheimer's disease (AD). The findings showed that compared to individuals with no behavioral symptoms, those with MBI had higher levels of p-tau181, which was associated with declined memory and executive function, and an increased risk of developing AD.
Article
Endocrinology & Metabolism
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfager, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Jordan A. Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the relationship between A beta-PET signal in white matter (WM) regions and diffusion MRI-based microstructural alterations. The results showed that decreased A beta-PET signal in WMH regions was closely associated with higher free water and higher WMH volume, while increased A beta-PET signal in normal-appearing WM was closely associated with higher cortical A beta and lower free water-adjusted FA. Furthermore, cognitive impairment was more closely related to higher free water than to either free water-adjusted FA or WM PET.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Meeting Abstract
Clinical Neurology
Brian C. Mac Grory, DaJuanicia Holmes, Shreyansh Shah, Adrian F. Hernandez, Roland Matsouaka, Gregg C. Fonarow, Jeffrey L. Saver, Deepak Bhatt, Eric E. Smith, Lee H. Schwamm, Mathew J. Reeves, Martin Unverdorben, Mary Birmingham, Eric D. Peterson, Ying Xian
Meeting Abstract
Clinical Neurology
Jay B. Lusk, Ailin Song, Shakthi Unnithan, Hussein R. Al-Khalidi, Jonathan P. Piccini, Ying Xian, Emily C. O'Brien, Brian C. Mac Grory
Meeting Abstract
Clinical Neurology
Shreyansh Shah, Dajuanicia N. Simon, Brian Mac Grory, Roland Matsouaka, Jeffrey L. Saver, Mathew J. Reeves, Deepak Bhatt, Eric E. Smith, Lee H. Schwamm, Gregg C. Fonarow, Adrian F. Hernandez, Eric D. Peterson, Ying Xian
Article
Clinical Neurology
Maryam Ghahremani, Santhosh Nathan, Eric E. E. Smith, Alexander McGirr, Bradley Goodyear, Zahinoor Ismail
Summary: Mild behavioral impairment (MBI) is a syndrome that uses neuropsychiatric symptoms (NPS) to identify individuals at high risk for dementia. The study used rs-fMRI to investigate the functional connectivity (FC) within the default mode network (DMN) and salience network (SN) in MBI. The results showed reduced FC within the DMN and SN in MBI patients, providing insights into the early mechanisms of the disease.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Amgad Mentias, Eric D. Peterson, Neil Keshvani, Dharam J. Kumbhani, Clyde W. Yancy, Alanna A. Morris, Larry A. Allen, Saket Girotra, Gregg C. Fonarow, Randall C. Starling, Paulino Alvarez, Milind Y. Desai, Peter Cram, Ambarish Pandey
Summary: This study found that using race-specific risk adjustment models can more accurately represent hospital performance for patients of Black and other races in terms of heart failure hospitalization and 30-day risk-standardized readmission rate and risk-standardized mortality rate.
Editorial Material
Cardiac & Cardiovascular Systems
Javed Butler, Khawaja M. Talha, Gregg C. Fonarow
Editorial Material
Cardiac & Cardiovascular Systems
Brian R. Lindman, Gregg C. Fonarow, Gary Myers, Heather M. Alger, Christine Rutan, Katie Troll, Angeline Aringo, Melanie Shahriary, Mariell Jessup, Suzanne V. Arnold, Pinak B. Shah, Wilson Y. Szeto, Clyde W. Yancy, Catherine M. Otto
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2023)
Article
Clinical Neurology
Nada El Husseini, Irene L. Katzan, Natalia S. Rost, Margaret Lehman Blake, Eeeseung Byun, Sarah J. Pendlebury, Hugo J. Aparicio, Maria J. Marquine, Rebecca F. Gottesman, Eric E. Smith
Summary: Cognitive impairment after stroke is a common consequence with significant implications for poststroke functioning and quality of life. This scientific statement critically appraises the literature on the prevalence, diagnosis, and management of poststroke cognitive impairment (PSCI) and provides a framework for clinical care while highlighting areas that need further research.
Article
Geriatrics & Gerontology
Ipinuoluwakiye Fatokun, Myrlene Gee, Krista Nelles, Fang Ba, Mahsa Dadar, Simon Duchesne, Breni Sharma, Mario Masellis, Sandra E. Black, Quincy J. Almeida, Eric E. Smith, Frederico Pieruccini-Faria, Manuel Montero-Odasso, Richard Camicioli
Summary: This study aimed to investigate the relationship between dual task cost (DTC) and white matter hyperintensities (WMH) in Lewy body disorders. The results showed that increased DTC was associated with higher frontal WMH burden, and increased age was associated with higher DTC. This indicates the importance of the association between DTC and WMH in Lewy body disorders.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Nicholas K. Brownell, Gregg C. Fonarow
EUROPEAN HEART JOURNAL
(2023)
Article
Medicine, General & Internal
Alexandra J. Mayhew, David Hogan, Parminder Raina, Christina Wolfson, Andrew P. Costa, Aaron Jones, Susan Kirkland, Megan O'Connell, Vanessa Taler, Eric E. Smith, Teresa Liu-Ambrose, Jinhui Ma, Mary Thompson, Changbao Wu, Howard Chertkow, Lauren E. Griffith, CLSA Memory Study Working Grp
Summary: This study aims to validate an NCD ascertainment algorithm to identify CLSA participants with NCDs through self-reported physician diagnosis, medication consumption, and daily function data.
Article
Clinical Neurology
Meaghan Reid, George S. Tadros, Connor C. McDougall, Noaah Reaume, Brooklyn McDougall, Rani Gupta Sah, Meng Wang, Eric E. Smith, Richard Frayne, Shelagh B. Coutts, Tolulope Sajobi, R. Stewart Longman, Christoper D. d'Esterre, Philip Barber
Summary: This exploratory study aimed to investigate whether patients with transient ischemic attack (TIA) have measurable regional cerebral hypoperfusion unrelated to the location of ischemia, and to determine the relationship between regional cerebral blood flow (rCBF) and their cognitive profiles. The results showed that TIA patients had significantly lower cognitive scores and regional hypoperfusion in certain brain regions, which may serve as early markers of future cognitive decline.
CEREBRAL CIRCULATION - COGNITION AND BEHAVIOR
(2023)