Review
Cell Biology
Di Wu, Kenneth M. Yamada, Shaohe Wang
Summary: Multicellular organisms generate diverse tissues through interactions between cells and the extracellular matrix. Cells make decisions based on chemical and mechanical information from their environment, which in turn modifies the tissue morphology.
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Alexandra Pokhilko, Gaia Brezzo, Lahiru Handunnetthi, Raphael Heilig, Rachel Lennon, Colin Smith, Stuart M. Allan, Alessandra Granata, Sanjay Sinha, Tao Wang, Hugh S. Markus, Alexandra Naba, Roman Fischer, Tom Van Agtmael, Karen Horsburgh, M. Zameel Cader
Summary: This study successfully extracted cerebrovascular ECM from mouse and human brain tissues and identified over 1000 proteins in the ECM-enriched fraction. The identification of 147 core ECM proteins in the human brain vascular matrisome and the connection between brain ECM proteins and cerebrovascular diseases, provides unique mechanistic insight and potential drug targets for cerebrovascular diseases.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Medicine, Research & Experimental
Jennifer M. S. Sucre, Fabian Bock, Nicholas M. Negretti, John T. Benjamin, Peter M. Gulleman, Xinyu Dong, Kimberly T. Ferguson, Christopher S. Jetter, Wei Han, Yang Liu, Seunghyi Kook, Jason J. Gokey, Susan H. Guttentag, Jonathan A. Kropski, Timothy S. Blackwell, Roy Zent, Erin J. Plosa
Summary: During alveolar repair, the proliferation and differentiation of alveolar type 2 epithelial cell progenitors into flat alveolar type 1 epithelial cells are essential. The presence of β1-containing integrins is crucial for functional alveolar repair and terminal epithelial differentiation. Failure of β1 integrin leads to severe inflammation, emphysema, increased proliferation of AT2 cells, and impaired differentiation into mature AT1 cells.
Article
Multidisciplinary Sciences
Hui Li, Yue Zheng, Yu Long Han, Shengqiang Cai, Ming Guo
Summary: By conducting pressure-controlled inflation and deflation experiments, the study directly measured the nonlinear mechanics of basement membranes. It was found that basement membranes act as permeable, hyperelastic materials, exhibiting a remarkable nonlinear stiffening behavior to avoid structural softening and maintain sufficient confining stress to enclosed tissues.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Ophthalmology
Aruni K. Makuloluwa, Kevin J. Hamill, Saaeha Rauz, Lucy Bosworth, Atikah Haneef, Vito Romano, Rachel L. Williams, Darlene A. Dartt, Stephen B. Kaye
Summary: The conjunctiva can be damaged by various diseases, requiring conjunctival grafts for restoration of function. Research on ex vivo culture and improvement of substrates is important for tissue grafts. Understanding the composition and structure of conjunctival extracellular matrix (ECM) is crucial for developing better biological substrates.
Article
Ophthalmology
Aruni K. Makuloluwa, Kevin J. Hamill, Saaeha Rauz, Lucy Bosworth, Atikah Haneef, Vito Romano, Rachel L. Williams, Darlene A. Dartt, Stephen B. Kaye
Summary: The conjunctiva, as the largest component of the ocular surface, may require grafts for restoration of function in cases of damage. Studies on biological and synthetic substrates for ex vivo culture of conjunctival epithelial cells have been conducted. This review discusses various types of substrates used for conjunctival transplantation with a focus on those based on the extracellular matrix.
Article
Biochemistry & Molecular Biology
Rebecca Preston, Qing-Jun Meng, Rachel Lennon
Summary: The circadian clock network in mammals is responsible for regulating various physiological processes in the body. Kidney disease is associated with the circadian system and extracellular matrix. Recent evidence suggests that cell-matrix interactions and the biomechanical properties of the matrix play a crucial role in regulating peripheral circadian rhythms. Studying the kidney matrisome can provide insights into the interactions between the extracellular matrix and intracellular time-keeping mechanisms.
Review
Cell Biology
Scott S. Kemp, Prisca K. Lin, Zheying Sun, Maria A. Castano, Ksenia Yrigoin, Marlena R. Penn, George E. Davis
Summary: This article discusses the functional importance and role of pericytes in capillary tube network assembly, as well as their association with EC sprouting behavior and tube formation, and the structure of EC tubes and deposition of basement membranes. It was found that various factors derived from ECs are crucial for pericyte recruitment, proliferation, and basement membrane deposition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Ida Lonsmann, Jane I. Grove, Asma Haider, Philip Kaye, Morten A. Karsdal, Diana J. Leeming, Guruprasad P. Aithal
Summary: This study found that type IV collagen turnover increased with the increase in NAS in patients with NAFL; however, this was not the case in patients with NASH. These findings support the assessments of the BM turnover using biomarkers in patients with early-disease development.
Article
Endocrinology & Metabolism
Anna Goddi, Alanis Carmona, Liesl Schroedl, Jeremy M. White, Matthew J. Piron, Avelino De Leon, Isabel Casimiro, Alexandria Hoffman, Maria A. Gonzalez Porras, Eric M. Brey, Matthew J. Brady, Ronald N. Cohen
Summary: The study found that LAMA4 expression is significantly elevated in humans with obesity as well as in mouse models of obesity. However, following short-term weight loss, no significant difference in Lama4 or LAMA4 expression was observed in either mouse or human samples.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Lisa E. Dorn, William Lawrence, Jennifer M. Petrosino, Xianyao Xu, Thomas J. Hund, Bryan A. Whitson, Matthew S. Stratton, Paul M. L. Janssen, Peter J. Mohler, Anders Schlosser, Grith L. Sorensen, Federica Accornero
Summary: This study identified a novel role for nonmyocyte-derived MFAP4 in cardiac remodeling, playing a crucial role in cardiac adaptation to stress. Lack of MFAP4 resulted in increased cardiac hypertrophy, worsened cardiac function, and dysregulated G protein-coupled receptor and integrin signaling in the heart.
CIRCULATION RESEARCH
(2021)
Article
Engineering, Marine
Rachel Brittany Sidebottom, Sabi Bang, Gary Martin
Summary: This paper presents a morphological description of acellular material lining hemal spaces in a shrimp, focusing on the vasculature and extracellular matrices in the penaeid shrimp. Different types of acellular materials were found covering various cells in different parts of the shrimp, highlighting the importance of further research on hemocyte receptors and extracellular matrices for future understanding.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2021)
Review
Medicine, General & Internal
Simona Pompili, Giovanni Latella, Eugenio Gaudio, Roberta Sferra, Antonella Vetuschi
Summary: The intestinal extracellular matrix (ECM) is a complex network of proteins that plays a crucial role in maintaining tissue structure and function. Interaction between ECM and cells is essential for cell development, proliferation, and apoptosis.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Qi Xing, Mojtaba Parvizi, Manuela Lopera Higuita, Leigh G. Griffiths
Summary: The study found that human mesenchymal stem cells migrated faster on the serous surface than on the fibrous surface, potentially due to increased expression of integrin alpha (3) and alpha (11). Blockade of integrin alpha (3)beta (1) inhibited early hMSC migration on the serous side, while blockade of alpha (11)beta (1) inhibited later hMSC migration.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jennifer L. Bailey, David H. Burk, Susan J. Burke, Scott D. Reed, Sujoy Ghosh, Carrie M. Elks
Summary: This study found that adipocyte-specific LAMA4 deletion is protective in an obesogenic environment, even though overall adiposity is increased. Laminin alpha 4 was found to be highly expressed in human and murine adipocytes.
Article
Multidisciplinary Sciences
Zachary S. Wilson, Hadley Witt, Lauren Hazlett, Michael Harman, Brittany M. Neumann, Andrew Whitman, Mohak Patel, Robert S. Ross, Christian Franck, Jonathan S. Reichner, Craig T. Lefort
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Paola Cattaneo, Debanjan Mukherjee, Simone Spinozzi, Lunfeng Zhang, Veronica Larcher, William B. Stallcup, Hiroshi Kataoka, Ju Chen, Stefanie Dimmeler, Sylvia M. Evans, Nuno Guimaraes-Camboa
Article
Cardiac & Cardiovascular Systems
Jianlin Zhang, Kevin P. Vincent, Angela K. Peter, Matthew Klos, Hongqiang Cheng, Selina M. Huang, Jordan K. Towne, Debbie Ferng, Yusu Gu, Nancy D. Dalton, Yunghang Chan, Ruixia Li, Kirk L. Peterson, Ju Chen, Andrew D. McCulloch, Kirk U. Knowlton, Robert S. Ross
CIRCULATION RESEARCH
(2020)
Article
Multidisciplinary Sciences
Irene Salamon, Simone Serio, Simona Bianco, Christina Pagiatakis, Silvia Crasto, Andrea M. Chiariello, Mattia Conte, Paola Cattaneo, Luca Fiorillo, Arianna Felicetta, Elisa di Pasquale, Paolo Kunderfranco, Mario Nicodemi, Roberto Papait, Gianluigi Condorelli
Article
Cell Biology
Ritusree Biswas, Avinanda Banerjee, Sergio Lembo, Zhihai Zhao, Vairavan Lakshmanan, Ryan Lim, Shimin Le, Manando Nakasaki, Vassily Kutyavin, Graham Wright, Dasaradhi Palakodeti, Robert S. Ross, Colin Jamora, Valeri Vasioukhin, Yan Jie, Srikala Raghavan
Summary: Vinculin, a key mechanotransducer in cell junctions, is essential for maintaining the quiescence of bulge stem cells and regulating hair follicle cycling. Conditional knockout of vinculin in murine skin leads to weakened AJs, despite increased expression of Ecadherin and α-catenin. Mechanistically, vinculin functions by maintaining α-catenin in a stretched/open conformation, which controls the retention of YAP1 at the AJs, revealing a novel regulatory link between mechanical stability of cell junctions and maintenance of stem cell quiescence.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Yoshitake Cho, Shizuko Tachibana, Kayla Lam, Yoh Arita, Shamim Khosrowjerdi, Oliver Zhang, Alex Liang, Ruixia Li, Aleksander Andreyev, Anne N. Murphy, Robert S. Ross
Summary: Perm1 is a novel protein enriched in skeletal and cardiac-muscle mitochondria, interacting with PGC-1 and ERR to promote mitochondrial biogenesis and protect cardiomyocytes from stress-induced damage, potentially serving as a novel therapeutic to restore cardiac dysfunction induced by ischemic injury.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Correction
Biochemistry & Molecular Biology
Yoshitake Cho, Shizuko Tachibana, Kayla Lam, Yoh Arita, Shamim Khosrowjerdi, Oliver Zhang, Alex Liang, Ruixia Li, Aleksander Andreyev, Anastasia Kralli, Anne N. Murphy, Robert S. Ross
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jason M. Duran, Maria Manso, Paul Bushway, Kerry Kao, Tsui-Min Wang, Sofie Maisel, Yusu Gu, Joshua Fong, Chao Chen, Angel Soto-Hermida, Marina Cruz, Wei Feng, Yoshi Cho, Julius Bogomolovas, Robert S. Ross, Ju Chen, Cat A. Makarewich, Andrew D. McCulloch, Michael Regnier, Eric D. Adler
Meeting Abstract
Cardiac & Cardiovascular Systems
Edward Wang, Amanda Lu, Andrew Lin, Robert S. Ross
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Yoshitake Cho, Shizuko Tachibana, Kayla Lam, Yoh Arita, Shamim Khosrowjerdi, Oliver L. Zhang, Alex Liang, Ruixia Li, Aleksander Andreyev, Anne N. Murphy, Robert S. Ross
Meeting Abstract
Cardiac & Cardiovascular Systems
Jason M. Duran, Paul Bushway, Maria Manso, Yusu Gu, Yoshitake Cho, Joshua Fong, Robert S. Ross, Eric D. Adler
Article
Area Studies
Robert S. Ross
Summary: In the twenty-first century, China and Vietnam have experienced heightened conflict in the South China Sea due to China's demand for a sphere of influence on its borders. China has used coercive diplomacy to constrain Vietnam's relationships with outside powers, leading Vietnamese leaders to seek external support.
JOURNAL OF CONTEMPORARY CHINA
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
Yoshitake Cho, Ruixia Li, Ana M. Manso, Robert S. Ross
CIRCULATION RESEARCH
(2020)
Article
International Relations
Robert S. Ross
INTERNATIONAL POLITICS
(2020)
