Journal
CHROMOSOMA
Volume 128, Issue 3, Pages 317-330Publisher
SPRINGER
DOI: 10.1007/s00412-019-00698-5
Keywords
Meiosis; Chromosome movement; LINC complex; Mouse; C; elegans
Funding
- Austrian Science Fund FWF [P 31275] Funding Source: Medline
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Vigorous chromosome movement during the extended prophase of the first meiotic division is conserved in most eukaryotes. The movement is crucial for the faithful segregation of homologous chromosomes into daughter cells, and thus for fertility. A prerequisite for meiotic chromosome movement is the stable and functional attachment of telomeres or chromosome ends to the nuclear envelope and their cytoplasmic coupling to the cytoskeletal forces responsible for generating movement. Important advances in understanding the components, mechanisms, and regulation of chromosome end attachment and movement have recently been made. This review focuses on insights gained from experiments into two major metazoan model organisms: the mouse, Mus musculus, and the nematode, Caenorhabditis elegans.
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