Discovery, Optimization, and Biological Characterization of 2,3,6‐Trisubstituted Pyridine‐Containing M 4 Positive Allosteric Modulators

Best practice in the management of behavioural and psychological symptoms of dementia

(2017) Olivier Pierre Tible et al.   Therapeutic Advances in Neurological Disorders

Discovery of VU0467485/AZ13713945: An M4 PAM Evaluated as a Preclinical Candidate for the Treatment of Schizophrenia

(2016) Michael R. Wood et al.   ACS Medicinal Chemistry Letters

Quantitative analysis of receptor allosterism and its implication for drug discovery

(2015) Rumin Zhang et al.   Expert Opinion on Drug Discovery

Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents

(2014) Michael Bubser et al.   ACS Chemical Neuroscience

Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters

(2013) Michael D. Shultz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Probing Structural Requirements of Positive Allosteric Modulators of the M4 Muscarinic Receptor

(2013) Tracey Huynh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

(2012) James M. Salovich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SAR Matrices: Automated Extraction of Information-Rich SAR Tables from Large Compound Data Sets

(2012) Anne Mai Wassermann et al.   Journal of Chemical Information and Modeling

Muscarinic and Nicotinic Acetylcholine Receptor Agonists and Allosteric Modulators for the Treatment of Schizophrenia

(2011) Carrie K Jones et al.   NEUROPSYCHOPHARMACOLOGY

The antipsychotic potential of muscarinic allosteric modulation

(2010) T.M. Bridges et al.   DRUG NEWS & PERSPECTIVES

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

(2009) Cuyue Tang et al.   BIOCHEMICAL PHARMACOLOGY

Enhanced SAR Maps: Expanding the Data Rendering Capabilities of a Popular Medicinal Chemistry Tool

(2009) Jeremy Kolpak et al.   Journal of Chemical Information and Modeling

Utility of unbound plasma drug levels and P-glycoprotein transport data in prediction of central nervous system exposure

(2009) H. He et al.   XENOBIOTICA

Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia

(2008) Anantha Shekhar et al.   AMERICAN JOURNAL OF PSYCHIATRY

Attenuation of amphetamine-induced activity by the non-selective muscarinic receptor agonist, xanomeline, is absent in muscarinic M4 receptor knockout mice and attenuated in muscarinic M1 receptor knockout mice

(2008) Marie L. Woolley et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats

(2008) A. E. Brady et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

(2008) W. Y. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA