Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class TGFβ Inhibitors

Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

(2018) Tamer M.A. Mohamed et al.   CELL

Mechanisms of Cardiac Repair and Regeneration

(2018) Kathleen M. Broughton et al.   CIRCULATION RESEARCH

Getting to the Heart of the Matter

(2015) Andrew Leask   CIRCULATION RESEARCH

Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ/Smad inhibitors

(2015) Daniel Längle et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Medicinal Chemistry Approaches to Heart Regeneration

(2015) Dennis Schade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates

(2015) Brigita Vigante et al.   MOLECULES

Synthesis of 3-hydroxyindanones via potassium salt of amino acid catalyzed regioselective intramolecular aldolization of ortho-diacylbenzenes

(2015) Tanmoy Chanda et al.   TETRAHEDRON LETTERS

Human Induced Pluripotent Stem Cell-Derived Cardiac Progenitor Cells in Phenotypic Screening: A Transforming Growth Factor-β Type 1 Receptor Kinase Inhibitor Induces Efficient Cardiac Differentiation

(2015) Lauren Drowley et al.   Stem Cells Translational Medicine

Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

(2013) Zhenyu Li et al.   Medicinal Chemistry

Small Molecule-Mediated TGF-β Type II Receptor Degradation Promotes Cardiomyogenesis in Embryonic Stem Cells

(2012) Erik Willems et al.   Cell Stem Cell

Synthesis and SAR of b-Annulated 1,4-Dihydropyridines Define Cardiomyogenic Compounds as Novel Inhibitors of TGFβ Signaling

(2012) Dennis Schade et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

(2011) Scott S. Woodard et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Different effects of dihydropyridine calcium channel antagonists on CYP3A4 enzyme of human liver microsomes

(2011) Zongling Xia et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Oxadiazoles in Medicinal Chemistry

(2011) Jonas Boström et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of a Drug Screening Platform Based on Engineered Heart Tissue

(2010) Arne Hansen et al.   CIRCULATION RESEARCH

TGF  family signaling: novel insights in development and disease

(2009) K. Wharton et al.   DEVELOPMENT

The new era of 1,2,4-oxadiazoles

(2009) Andrea Pace et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

(2008) Joseph S. Warmus et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active γ-secretase inhibitors

(2007) Mark D. McBriar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS