mTOR Is Key to T Cell Transdifferentiation

T cell transdifferentiation to functionally distinct subsets can play a key role in balancing the protective and pathogenic features of the T cell response. In a new study, Karmaus et al. (2019) showed that mTORC1 activity influences metabolic heterogeneity within a T cell population to modulate transdifferentiation and disease pathogenesis in a setting of chronic inflammation-driven autoimmunity.