Gut microbiota-stimulated cathepsin K secretion mediates TLR4-dependent M2 macrophage polarization and promotes tumor metastasis in colorectal cancer

Cathepsin K associates with lymph node metastasis and poor prognosis in oral squamous cell carcinoma

(2018) Frank K. Leusink et al.   BMC CANCER

The Intestinal Microbiota in Colorectal Cancer

(2018) Herbert Tilg et al.   CANCER CELL

Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages

(2018) Ineta Popēna et al.   Cell Communication and Signaling

Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells

(2018) Liam Chung et al.   Cell Host & Microbe

Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

(2018) Christine M. Dejea et al.   SCIENCE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

A recombinant fungal compound induces anti-proliferative and pro-apoptotic effects on colon cancer cells

(2017) Lili Nimri et al.   Oncotarget

Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation

(2016) S F Jørgensen et al.   Mucosal Immunology

Identification of Cathepsin K in the Peritoneal Metastasis of Ovarian Carcinoma Using In-silico, Gene Expression Analysis

(2016) Haiming Xu et al.   Journal of Cancer

Increasing the Inflammatory Competence of Macrophages with IL-6 or with Combination of IL-4 and LPS Restrains the Invasiveness of Pancreatic Cancer Cells

(2016) Aino N.E. Salmiheimo et al.   Journal of Cancer

Hyaluronan Inhibits Tlr-4-Dependent RANKL Expression in Human Rheumatoid Arthritis Synovial Fibroblasts

(2016) Tatsuo Watanabe et al.   PLoS One

Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice

(2016) Marjo M. P. C. Donners et al.   PLoS One

Myeloid cells in cancer-related inflammation

(2015) Nicoletta Caronni et al.   IMMUNOBIOLOGY

Genetics, diagnosis and management of colorectal cancer (Review)

(2015) MARINA DE ROSA et al.   ONCOLOGY REPORTS

T cell exclusion, immune privilege, and the tumor microenvironment

(2015) J. A. Joyce et al.   SCIENCE

Expression of Toll-like receptors in the mucosa of patients with ulcerative colitis

(2015) YUJING FAN et al.   Experimental and Therapeutic Medicine

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Efficacy of a Cathepsin K Inhibitor in a Preclinical Model for Prevention and Treatment of Breast Cancer Bone Metastasis

(2014) L. T. Duong et al.   MOLECULAR CANCER THERAPEUTICS

High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity

(2014) Manon D. Schulz et al.   NATURE

Expression Analysis of All Protease Genes Reveals Cathepsin K to Be Overexpressed in Glioblastoma

(2014) Urška Verbovšek et al.   PLoS One

Structural basis of collagen fiber degradation by cathepsin K

(2014) Adeleke H. Aguda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correlations of Tumor-associated Macrophage Subtypes with Liver Metastases of Colorectal Cancer

(2013) Yun-Long Cui et al.   Asian Pacific Journal of Cancer Prevention

Cathepsin K: a unique collagenolytic cysteine peptidase

(2013) Marko Novinec et al.   BIOLOGICAL CHEMISTRY

Hyaluronan inhibits TLR-4 dependent cathepsin K and matrix metalloproteinase 1 expression in human fibroblasts

(2012) Shinya Hirabara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Macrophage cathepsin K promotes prostate tumor progression in bone

(2012) M K Herroon et al.   ONCOGENE

The Process of Macrophage Migration Promotes Matrix Metalloproteinase-Independent Invasion by Tumor Cells

(2011) R. Guiet et al.   JOURNAL OF IMMUNOLOGY

Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1

(2010) L. Zhao et al.   GUT

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K

(2009) Yu Sun et al.   CIRCULATION RESEARCH

Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression

(2008) C. G. Kleer et al.   CLINICAL CANCER RESEARCH

Simultaneous expression of Cathepsins B and K in pulmonary adenocarcinomas and squamous cell carcinomas predicts poor recurrence-free and overall survival

(2008) Colja Cordes et al.   LUNG CANCER