Article
Biotechnology & Applied Microbiology
Jianjie Li, Xiaoyue Xu, Chunhui Liu, Xiaoxue Xi, Yang Wang, Xiaotang Wu, Hua Li
Summary: miR-181a-2-3p promotes GC cell progression by targeting MYLK and enhancing tumor growth. The promoting effect of miR-181a-2-3p on GC cells is reversed when miR-181a-2-3p and MYLK are simultaneously overexpressed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Oncology
Michelle Xin Liu, Kent-Man Chu
Summary: This study aims to investigate the functional roles of miR-410-3p in primary gastric cancer and the roles of exosomes in regulating miR-410-3p expression. It was found that miR-410-3p was downregulated in gastric cancer and its overexpression inhibited cancer cell proliferation, migration, and invasion. Exosomal miR-410-3p expression was significantly higher than its endogenous expression and exosomes from gastric cancer cells regulated miR-410-3p expression in other cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Baolin Qian, Qi Liu, Chaoqun Wang, Shounan Lu, Shanjia Ke, Bing Yin, Xinglong Li, Hongjun Yu, Yaohua Wu, Yong Ma
Summary: This study constructed a prognostic model based on the MIR600HG/hsa-miR-342-3p/ANLN network and found that it may function in tumor immunity.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
John T. Lafin, Cinzia G. Scarpini, Armon Amini, Bendu Konneh, Jeffrey M. Howard, Thomas Gerald, Michelle Nuno, Jin Piao, Anna Savelyeva, Zhaohui Wang, Jeffrey Gagan, Liwei Jia, Cheryl M. Lewis, Sarah Murray, Yun C. Sawa, Vitaly Margulis, Solomon L. Woldu, Douglas W. Strand, Nicholas Coleman, James F. Amatruda, A. Lindsay Frazier, Matthew J. Murray, Aditya Bagrodia
Summary: Circulating miR-371a-3p has excellent performance in detecting viable germ cell tumors before surgery, but its ability to detect hidden diseases is underexplored. A revised assay using raw Cq values and incorporating an indeterminate range improves accuracy in detecting occult germ cell tumors. The protocol should include reference genes for quality control and retesting of indeterminate samples.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Lei Jin, Xuemei Ma, Nan Zhang, Qian Zhang, Xueming Chen, Zhongtao Zhang, Guoqian Ding, Hongzhi Yu
Summary: miR-181a-2-3p was identified as a unique miRNA among the common differentially expressed miRNAs in three DDP-resistant and DDP-sensitive gastric cancer cell lines. It exhibited higher expression in larger tumors, higher T stage, and chemotherapy-resistant patients. miR-181a-2-3p could differentiate between chemosensitive and chemoresistant GC patients and serve as a valid biomarker for predicting overall survival. Upregulation of miR-181a-2-3p enhanced the effects of DDP, while downregulation decreased these effects, indicating its potential as a therapeutic target and tumor biomarker for gastric cancer.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Heike Goebel, Barbara Koeditz, Manuel Huerta, Ersen Kameri, Tim Nestler, Thomas Kamphausen, Johannes Friemann, Matthias Hamdorf, Timo Ohrmann, Philipp Koehler, Oliver A. Cornely, Manuel Montesinos-Rongen, David Nicol, Hubert Schorle, Peter Boor, Alexander Quaas, Christian Pallasch, Axel Heidenreich, Melanie von Brandenstein
Summary: This study found that the upregulation of miR-371a-3p in the testis of COVID-19 patients is associated with the downregulation of AR and decreased spermatogenesis. This suggests that the SARS-CoV-2 virus may have an impact on fertility.
Article
Cell Biology
Lei Ren, Qiang Ren, Jianmei Wang, Yonghong He, Hong Deng, Xing Wang, Chunfeng Liu
Summary: In this study, it was found that DDR2 levels are significantly elevated in peritoneal metastasis (PM) lesions of gastric cancer, and high DDR2 expression is associated with worse overall survival and tumor staging. DDR2 is involved in maintaining gastric cancer stem cells through mediating the expression of pluripotency factor SOX2 and controlling cell progression by recruiting NFATc1-SOX2 complex to Snai1. DDR2 also promotes peritoneal dissemination of gastric cancer in a mouse model.
CELLULAR SIGNALLING
(2023)
Article
Cell Biology
Ben Liu, Meng Zhou, Xiangchun Li, Xining Zhang, Qinghua Wang, Luyang Liu, Meng Yang, Da Yang, Yan Guo, Qiang Zhang, Hong Zheng, Qiong Wang, Lian Li, Xinlei Chu, Wei Wang, Haixin Li, Fengju Song, Yuan Pan, Wei Zhang, Kexin Chen
Summary: Gender bias in gastric cancer may be related to sex chromosome abnormalities and AR signaling dysregulation, especially in female patients. The combination of AR and miR-125b is associated with poor prognosis, with AR antagonist bicalutamide showing potential therapeutic benefits in treating GC.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Zhengwo Jia, Xiaofang Tang, Xicheng Zhang, Jingen Shen, Yuanlong Sun, Lifen Qian
Summary: miR-153-3p suppresses the growth and metastasis of gastric cancer cells by regulating SphK2, suggesting a potential novel biomarker for the treatment of gastric cancer.
BIOCHEMICAL GENETICS
(2022)
Article
Oncology
Shengkui Qiu, Li Xie, Chen Lu, Chao Gu, Yiwen Xia, Jialun Lv, Zhe Xuan, Lang Fang, Jing Yang, Lu Zhang, Zheng Li, Weizhi Wang, Hao Xu, Bowen Li, Zekuan Xu
Summary: This study found that miR-519a-3p expression levels in exosomes were higher in gastric cancer liver metastasis (GC-LM) patients, and high expression indicated a worse prognosis. GC-derived exosomes mainly accumulated in the liver and were internalized by intrahepatic macrophages. Further research revealed that miR-519a-3p activated the MAPK/ERK pathway by targeting DUSP2, inducing M2-like polarization of macrophages and promoting angiogenesis and intrahepatic premetastatic niche formation. These findings suggest that miR-519a-3p plays a critical role in the interaction between primary GC cells and intrahepatic macrophages.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Reiko Mitsueda, Hiroko Toda, Yoshiaki Shinden, Kosuke Fukuda, Ryutaro Yasudome, Mayuko Kato, Naoko Kikkawa, Takao Ohtsuka, Akihiro Nakajo, Naohiko Seki
Summary: Accumulating evidence indicates that the miR-30 family plays a critical role in various human cancers, acting as either tumor suppressors or oncogenes. The downregulation of miR-30c-1-3p and miR-30c-2-3p in cancer tissues is associated with worse prognosis in breast cancer (BrCa) patients, and overexpression of these miRNAs inhibits cancer cell aggressiveness, suggesting their tumor-suppressor function in BrCa cells. Furthermore, TRIP13 is identified as a direct target of these two miRNAs and its inactivation attenuates BrCa cell aggressiveness and prevents malignant transformation. Understanding the molecular networks controlled by miRNAs, including passenger strands, may lead to the identification of diagnostic markers and therapeutic targets for BrCa.
Article
Endocrinology & Metabolism
Yao Wang, Yuanyuan Guo, Tianchi Zhuang, Ting Xu, Minghui Ji
Summary: Growing evidence suggests that LINC00659, a newly identified long noncoding RNA, plays a critical role in gastric cancer. Upregulation of LINC00659 is associated with tumor progression, lymphatic metastasis, and poorer prognosis. It functions as a competing endogenous RNA for miR-370, leading to the upregulation of its target gene AQP3. This study provides insights into the pathogenesis of gastric cancer and may contribute to the identification of potential therapeutic targets.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhouxiao Li, Ye Cheng, Kai Fu, Qiaowei Lin, Tianyu Zhao, Weiwei Tang, Lei Xi, Lulu Sheng, Hao Zhang, Yangbai Sun
Summary: This study identified a novel circRNA, circ-PTPDC1, with a regulatory role in gastric cancer. Overexpression of circ-PTPDC1 was found to be associated with poor clinical outcomes.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
