Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

The Effects and Mechanism of YK-4-279 in Combination with Docetaxel on Prostate Cancer

(2017) Lin Yu et al.   International Journal of Medical Sciences

The Effect of Metformin Use during Docetaxel Chemotherapy on Prostate Cancer Specific and Overall Survival of Diabetic Patients with Castration Resistant Prostate Cancer

(2017) Michelle J. Mayer et al.   JOURNAL OF UROLOGY

LuCaP Prostate Cancer Patient-Derived Xenografts Reflect the Molecular Heterogeneity of Advanced Disease an­­d Serve as Models for Evaluating Cancer Therapeutics

(2017) Holly M. Nguyen et al.   PROSTATE

Targeting metabolism and AMP-activated kinase with metformin to sensitize non-small cell lung cancer (NSCLC) to cytotoxic therapy: translational biology and rationale for current clinical trials

(2017) Michael Troncone et al.   Oncotarget

Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation

(2017) Alicia Bort et al.   Oncotarget

Metformin and Prostate Cancer: a New Role for an Old Drug

(2017) Jessica Whitburn et al.   Current Urology Reports

miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1

(2016) Yuan Wang et al.   Molecular Cancer

Improving Taxane-Based Chemotherapy in Castration-Resistant Prostate Cancer

(2016) Jan Kroon et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Suppression of prostate cancer progression by cancer cell stemness inhibitor napabucasin

(2016) Yiming Zhang et al.   Cancer Medicine

Global Cancer Incidence and Mortality Rates and Trends--An Update

(2015) L. A. Torre et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells

(2015) LONG ZHENG et al.   Molecular Medicine Reports

Brassinin Combined with Capsaicin Enhances Apoptotic and Anti-metastatic Effects in PC-3 Human Prostate Cancer Cells

(2015) Sung-Moo Kim et al.   PHYTOTHERAPY RESEARCH

PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

(2015) Min-Sik Lee et al.   Nature Communications

Capsaicin Enhances the Drug Sensitivity of Cholangiocarcinoma through the Inhibition of Chemotherapeutic-Induced Autophagy

(2015) Zai-Fa Hong et al.   PLoS One

Novel combination of docetaxel and thymoquinone induces synergistic cytotoxicity and apoptosis in DU-145 human prostate cancer cells by modulating PI3K–AKT pathway

(2014) A. Dirican et al.   Clinical & Translational Oncology

Nanoways to overcome docetaxel resistance in prostate cancer

(2014) Aditya Ganju et al.   DRUG RESISTANCE UPDATES

Bioavailability of capsaicin and its implications for drug delivery

(2014) William D. Rollyson et al.   JOURNAL OF CONTROLLED RELEASE

Dual PI3K/mTOR Inhibitor NVP-BEZ235 Sensitizes Docetaxel in Castration Resistant Prostate Cancer

(2013) Yota Yasumizu et al.   JOURNAL OF UROLOGY

Metastatic castration-resistant prostate cancer: new therapies, novel combination strategies and implications for immunotherapy

(2013) C G Drake et al.   ONCOGENE

Docetaxel

(2012) Kate McKeage   DRUGS

Cross-Talk between AMPK and mTOR in Regulating Energy Balance

(2011) Jia Xu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Additivity Versus Synergy: A Theoretical Analysis of Implications for Anesthetic Mechanisms

(2009) Steven L. Shafer et al.   ANESTHESIA AND ANALGESIA