Article
Medicine, Research & Experimental
Tae Won Kim, Haein Ji, Nak Hyeon Yun, Chang Hoon Shin, Hyeon Ho Kim, Yong Beom Cho
Summary: This study identified AFAP1-AS1 and MLK7-AS1 as ceRNAs that promote the progression of colorectal cancer by reducing the levels of tumor-suppressing miRNAs miR-149-5p and miR-485-5p.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Oncology
Yuanyong Wang, Minge Ma, Chuan Li, Yuling Yang, Maolong Wang
Summary: The study revealed that GAS6-AS1 is downregulated in LUAD and overexpression of GAS6-AS1 can inhibit lung cancer cell migration and invasion, potentially serving as a diagnostic biomarker for LUAD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yanjie Mou, Qinguo Sun
Summary: This study found that ASMTL-AS1 plays a carcinogenic role in hepatocellular carcinoma (HCC) by interacting with miR-1343-3p and LAMC1 through the competing endogenous RNA (ceRNA) mechanism, thereby interfering with the malignant behavior of HCC cells.
Article
Biochemistry & Molecular Biology
Duan Tong, Lili Fan
Summary: The study found that long non-coding RNA ZNF667-AS1 plays an important role in the carcinogenesis and progression of colon cancer. The overexpression of ZNF667-AS1 can attenuate the proliferation and migration of colon cancer cells, restore inactivated apoptosis, and inhibit tumor growth. This finding suggests a potential novel anticancer strategy for combating colon cancer.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaowei Yang, Yuejie Qu, Jixian Zhang
Summary: The study aimed to reveal the specific functions and molecular mechanisms of FEZ family zinc finger 1-antisense RNA 1 (FEZF1-AS1) in cervical cancer (CC) cells. The results showed that FEZF1-AS1 was highly expressed in CC cells, and its depletion suppressed cell proliferation, migration, invasion, and induced apoptosis. Mechanism experiments confirmed the interaction between FEZF1-AS1, miR-367-3p, and solute carrier family 12 member 5 (SLC12A5).
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Tao Deng, Yang Liu, Yanlong Yang, Leyong Yuan, Fangfang Liu, Xiaobo Wang, Qiuying Zhang, Mingshui Xie
Summary: The study reveals that the high expression of circular RNA circ_0000285 in gliomas promotes tumor growth and invasion by binding to miR-197-3p and silencing CKS1B. This highlights a novel competing endogenous RNA circuit in glioma progression.
Article
Oncology
Shuai Xue, Fengqin Lu, Chunhui Sun, Jingjing Zhao, Honghua Zhen, Xin Li
Summary: The study revealed that ZEB1-AS1 is upregulated and miR-23c is downregulated in HCC tissues and cell lines. Knockdown of ZEB1-AS1 inhibited the proliferation and invasion of HCC cells, and it was shown that miR-23c is a target of ZEB1-AS1.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Zizhen Si, Lei Yu, Haoyu Jing, Lun Wu, Xidi Wang
Summary: In this study, it was found that ZNF561-AS1 promotes CRC progression via the miR-26a-3p/miR-128-5p-SRSF6 axis. This study provides new insights into the role of ZNF561-AS1 in CRC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Qixuan Cai, Xin Zhao, Yanbing Wang, Shuai Li, Jincheng Wang, Zhuoyuan Xin, Fan Li
Summary: The study identified that LINC01614 is significantly upregulated in osteosarcoma tissues and promotes the proliferation and invasion activities of osteosarcoma cells through the miR-520a-3p/SNX3 axis.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Yue Jiang, Xiangpan Li, Yu Yang, Jiajun Luo, Xunshan Ren, Jingwen Yuan, Qiang Tong
Summary: This study found that HOXC-AS1 is overexpressed in gastric cancer and is associated with poor prognosis. Silencing HOXC-AS1 significantly inhibits the proliferation of gastric cancer cells. HOXC-AS1 promotes the progression of gastric cancer cells by sponging miR-99a-3p and upregulating MMP8.
Article
Gastroenterology & Hepatology
Ji-Hye Choi, So M. Kwon, Sung U. Moon, Sarah Yoon, Masaud Shah, Byoung G. Lee, Jieun Yang, Young N. Park, Hee-Jung Wang, Hyun G. Woo
Summary: Through RNA-Seq analysis, the study identified TPRG1-AS1 as a potential driver noncoding RNA that promotes heterogeneous progression of liver cancer. TPRG1-AS1 induces tumor suppressor RBM24, activating apoptotic tumor cell death to suppress tumor growth, and acts as a ceRNA interfering with the binding of miR-4691-5p and miR-3659 to RBM24.
LIVER INTERNATIONAL
(2021)
Article
Oncology
Shilong Liu, Ning Zhan, Chunzi Gao, Piao Xu, Hong Wang, Siyu Wang, Shiqi Piao, Suwei Jing
Summary: CBR3-AS1 plays a role in promoting tumorigenesis and reducing radiosensitivity in non-small cell lung cancer, possibly through regulating the miR-409-3p/SOD1 pathway.
Article
Oncology
Cailin Zhu, Weiyun Bi, Hongtao Li, Wen Wang
Summary: The study revealed that circLONP2 is upregulated in ESCC and promotes ESCC aggressiveness through the regulation of the miR-27b-3p/ZEB1 axis, suggesting circLONP2 may serve as an oncogenic circRNA and a prognostic biomarker in ESCC progression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yunfeng Niu, Yanli Guo, Yan Li, Supeng Shen, Jia Liang, Wei Guo, Zhiming Dong
Summary: This study revealed that GATA2-AS1, expressed at low levels in ESCC, plays a crucial role in the progression of ESCC by targeting the miR-940/PTPN12 axis. These findings contribute to a better understanding of the molecular mechanisms underlying ESCC and provide a potential therapeutic target for the treatment of ESCC patients.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Xiufang Yang, Huilan Du, Wenhui Bian, Qingxue Li, Hairu Sun
Summary: This study demonstrated that FOXD3-AS1 is upregulated in cervical cancer tissues and cells, promoting cell proliferation, migration, and invasion. High FOXD3-AS1 expression is associated with poor tumor differentiation, increased tumor size, and lymph node metastasis. FOXD3-AS1 directly targets miR-128-3p, leading to upregulation of LIMK1 expression in cervical cancer cells, thus facilitating cervical cancer progression.
Article
Oncology
Jun-Peng Pei, Zhe-Ming Zhao, Zhe Sun, Wan-Jie Gu, Jiang Zhu, Ji Zhu, Si-Ping Ma, Yu Liang, Rui Guo, Rui Zhang, Chun-Dong Zhang
Summary: This study developed a novel TLODDS classification for colon and rectal cancers, which showed better discriminatory ability, model-fitting, and net benefits compared to the existing TNM classification.
Article
Gastroenterology & Hepatology
Wan-Jie Gu, Fei-Long Ning, Hao-Ran Jin, Zhe-Ming Zhao, Jun Lyu, Jun-Peng Pei, Shi-Yi Cao, Yong-Ji Zeng, Masanobu Abe, Kazuhiro Nishiyama, Chun-Dong Zhang
Summary: This study examined the burden and trends of IBD in 5 Asian countries, the United States, and the United Kingdom, and found significant variations in incidence and death rates between these countries over the past 3 decades.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Oncology
Fei-Long Ning, Nan-Nan Zhang, Zhe-Ming Zhao, Wan-Ying Du, Yong-Ji Zeng, Masanobu Abe, Jun-Peng Pei, Chun-Dong Zhang
Summary: In 2019, there were substantial differences in the incidence and death rates of early-, intermediate-, and later-onset gastric cancer globally. From 1990 to 2019, early-onset gastric cancer showed a slower decrease in incidence rate compared to intermediate and later-onset gastric cancer, while the mortality rates of early and later-onset gastric cancer decreased slower than that of intermediate-onset gastric cancer. Predictions show that the incidence of early-onset gastric cancer is expected to increase substantially, while that of later-onset gastric cancer is expected to slightly increase, and that of intermediate-onset gastric cancer is predicted to remain stable from 2020 to 2035.
Review
Medicine, Research & Experimental
Xue-Ping Zhang, Jun-Peng Pei, Chun-Dong Zhang, Maimaititusun Yusupu, Ming-Hao Han, Dong-Qiu Dai
Summary: Recent studies have shown that circRNAs can regulate the tumor microenvironment through exosomes and serve as therapeutic targets. This review discusses the roles and potential applications of exosomal circRNAs in angiogenesis, as well as the related technological advancements.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Jianpeng Han, Yan Zhou, Chundong Zhang, Jianyong Feng, Junhao Wang, Kuo Guo, Wenbin Chen, Yongzhang Li
Summary: Discordant abundances of different immune cell subtypes is regarded to be an essential feature of tumour tissue. Direct studies in Prostate cancer (PC) of intratumoral immune heterogeneity characterized by immune cell subtype, are still lacking. Using the single sample gene set enrichment analysis (ssGSEA) algorithm, the abundance of 28 immune cells infiltration (ICI) were determined for PC. A NMF was performed to determine tumour-sample clustering based on the abundance of ICI and PFS information. Hub genes of clusters were identified via weighted gene co-expression network analysis (WGCNA). The multivariate dimensionality reduction analysis of hub genes expression matrix was carried out via principal component analysis (PCA) to obtain immune score (IS). We analysed the correlation between clustering, IS and clinical phenotype. We divided the 495 patients into clusterA (n = 193) and clusterB (n = 302) on the basis of ICI and PFS via NMF. The progression-free survival (PFS) were better for clusterA than for clusterB (p < 0.001). Each immune cell subtypes was more abundant in clusterA than in clusterB (p < 0.001). The expression levels of CTAL-4 and PD-L1 were lower in clusterB than in clusterA (p < 0.001 and p = 0.006). We obtained 103 hub genes via WGCNA. In the training and validation cohorts, the prognosis of high IS group was worse than that of the low IS group (p < 0.05). IS had good predictive effect on 5-year PFS. The expression of immune checkpoint genes was higher in the low IS group than in the high IS group (p < 0.01). Patients with low IS and receiving hormone therapy had better prognosis than other groups. The combination of IS and clinical characteristics including lymph node metastasis and gleason score can better differentiate patient outcomes than using it alone. IS was a practical algorithm to predict the prognosis of patients. Advanced PC patients with low IS may be more sensitive to hormone therapy. CXCL10, CXCL5, MMP1, CXCL12, CXCL11, CXCL2, STAT1, IL-6 and TLR2 were hub genes, which may drive the homing of immune cells in tumours and promote immune cell differentiation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Letter
Medicine, General & Internal
Chundong Zhang, Meicong Feng, Qinmao Fang, Heping Deng, Weiwei Zhang, Xia Wu, Bo Zhang, Yiman Guan
Correction
Biology
Longhao Li, Chundong Zhang, Yi Li, Ying Zhang, Yunlong Lei
Article
Chemistry, Medicinal
Xinyan Wan, Junqi Xiang, Hui Fan, Ying Jiang, Yiting Lu, Chundong Zhang, Ying Zhang, Quanmei Chen, Yunlong Lei
Summary: Hepatocellular carcinoma is a prevalent and deadly cancer, but early identification and diagnosis remain challenging. The synthetic antifungal agent, Ciclopirox olamine (CPX), has shown potential as an anti-cancer drug for hepatocellular carcinoma, although its specific mechanisms of action have not been fully elucidated. This study demonstrates that CPX inhibits HCC cell proliferation by arresting the cell cycle, while also triggering ROS accumulation and downregulating DJ-1. CPX also induces complete autophagic flux, although this can mitigate its anti-cancer effects, and it induces glycogen clustering in HCC cells. Overall, this research provides new insights into the molecular mechanisms of CPX as an anti-cancer therapy for hepatocellular carcinoma.
Article
Cell Biology
Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chundong Zhang, Zhongjun Zhou, Xiu-Wu Bian, Guoxiang Jin
Summary: This study reveals the dual role of PRMT1-mediated RIP3 methylation in necroptotic cancer cell death and tumor immune escape. PRMT1 methylates RIP3 and inhibits its interaction with RIP1, thereby suppressing necrosome complex formation and necroptosis activation. The protein levels of PRMT1 and RIP3(ADMA) are positively correlated in cancer tissues and both serve as valuable prognostic markers for colon cancer.
CELL DEATH & DISEASE
(2023)
Review
Surgery
Fei-Long Ning, Wan-Jie Gu, Zhe-Ming Zhao, Wan-Ying Du, Min Sun, Shi-Yi Cao, Yong-Ji Zeng, Masanobu Abe, Chun-Dong Zhang
Summary: This study found that the risk of postoperative mortality after gastric cancer surgery is influenced by the hospital surgical case volume. Hospitals with higher surgical case volumes have lower postgastrectomy mortality rates. The postgastrectomy mortality rate remains stable or decreases after the hospital volume reaches a plateau of 100 gastrectomy cases per year.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Biology
Lian Zhang, Jing Yu, Mingyue Zheng, Hui Zhen, Qingqiang Xie, Chundong Zhang, Zhongjun Zhou, Guoxiang Jin
Summary: The lysosome protein RAGA interacts with and promotes lysosome localization and degradation of the macrophage-specific immune checkpoint protein CD47, with possible relevance to lung adenocarcinoma. RAGA deficiency leads to CD47 accumulation, increased membrane/intracellular CD47 expression ratio, and reduced phagocytic clearance of cancer cells, promoting tumor growth. Clinical analysis shows a negative correlation between RAGA and CD47 proteins in lung adenocarcinoma patient samples, with high RAGA protein level associated with longer patient survival. RAGA(high)CD47(low) patients exhibit the longest overall survival, suggesting RAGA as a potential diagnostic biomarker of lung adenocarcinoma.
COMMUNICATIONS BIOLOGY
(2023)
Review
Surgery
Qing Wang, Shinji Mine, Motomi Nasu, Tetsu Fukunaga, Shuko Nojiri, Chun-Dong Zhang
Summary: This study found that esophageal cancer patients who undergo esophagectomy in high-volume hospitals have a higher overall survival rate compared to those in low-volume hospitals.
FRONTIERS IN SURGERY
(2023)
Article
Energy & Fuels
Ruxing Gao, Leiyu Zhang, Lei Wang, Chundong Zhang, Ki-Won Jun, Seok Ki Kim, Tiansheng Zhao, Hui Wan, Guofeng Guan
Summary: To achieve efficient utilization of CO2 and produce clean alternative fuel, CO2-to-DME (CTD) technology is considered a feasible and promising solution. In this study, four different CTD processes were proposed and compared in terms of technical and economic performance. Case 4 showed the highest energy efficiency (77.42%), exergy efficiency (88.46%), and net CO2 mitigation rate (67.71%) from a technical perspective. On the other hand, Case 2 had the lowest total product cost (1327.14 $/tonne DME), while Case 4 had the lowest net CO2 mitigation cost (589.34 $/tonne CO2). Improvement measures were also proposed for optimizing Case 4, resulting in increased net CO2 mitigation rate and decreased net CO2 mitigation cost.
Meeting Abstract
Oncology
Fengfei Liu, Bei He, Zhe Liu, Jingjing Xie, Yan Li, Jihong Ma, Chundong Zhang, Peng Wang, Fei Wu
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhili Wei, Ru Wang, Xun Yin, Lian Zhang, Yunlong Lei, Ying Zhang, Yi Li, Jiaqian Wu, Youquan Bu, Guoxiang Jin, Chundong Zhang
Summary: PRR11 participates in filopodia formation, focal adhesion turnover and cell motility in Non-Small Cell Lung Cancer cells through the ARP2/3 complex. Dysregulation of PRR11 expression may facilitate tumor metastasis.
