Na+,HCO3− cotransporter NBCn1 accelerates breast carcinogenesis

The acid-base transport proteins NHE1 and NBCn1 regulate cell cycle progression in human breast cancer cells

(2018) Mette Flinck et al.   CELL CYCLE

Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths

(2018) Tobias H. Dovmark et al.   FASEB JOURNAL

The net acid extruders NHE1, NBCn1 and MCT4 promote mammary tumor growth through distinct but overlapping mechanisms

(2018) Anne Poder Andersen et al.   INTERNATIONAL JOURNAL OF CANCER

Na+,HCO3–-cotransporter NBCn1 (Slc4a7) accelerates ErbB2-induced breast cancer development and tumor growth in mice

(2018) Soojung Lee et al.   ONCOGENE

Enhanced nitric oxide signaling amplifies vasorelaxation of human colon cancer feed arteries

(2018) Ninna C. S. Voss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Increased NBCn1 expression, Na + /HCO 3 - co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension

(2017) Fu Liang Ng et al.   HUMAN MOLECULAR GENETICS

The Role of Tumor Microenvironment in Chemoresistance: To Survive, Keep Your Enemies Closer

(2017) Dimakatso Alice Senthebane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Connexin-43 channels are a pathway for discharging lactate from glycolytic pancreatic ductal adenocarcinoma cells

(2017) T H Dovmark et al.   ONCOGENE

Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

(2017) Veronica Huber et al.   SEMINARS IN CANCER BIOLOGY

Crosstalk between cardiomyocyte-rich perivascular tissue and coronary arteries is reduced in the Zucker Diabetic Fatty rat model of type 2 diabetes mellitus

(2016) L. Bonde et al.   Acta Physiologica

The Hypertension Risk Variant Rs820430 Functions as an Enhancer ofSLC4A7

(2016) Laiyuan Wang et al.   AMERICAN JOURNAL OF HYPERTENSION

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cellular Immune Responses and Immune Escape Mechanisms in Breast Cancer: Determinants of Immunotherapy

(2016) Christoph Domschke et al.   Breast Care

Disrupting Hypoxia-Induced Bicarbonate Transport Acidifies Tumor Cells and Suppresses Tumor Growth

(2016) Alan McIntyre et al.   CANCER RESEARCH

Na+, HCO3−-cotransporter NBCn1 increases pHigradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling

(2016) Ebbe Boedtkjer et al.   CARDIOVASCULAR RESEARCH

Stromal uptake and transmission of acid is a pathway for venting cancer cell-generated acid

(2016) Alzbeta Hulikova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis

(2016) Simon J. A. van Kuijk et al.   Frontiers in Oncology

The contributions of respiration and glycolysis to extracellular acid production

(2015) Shona A. Mookerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Na+/HCO3−Co-Transporter SLC4A4 Plays a Role in Growth and Migration of Colon and Breast Cancer Cells

(2015) Scott K. Parks et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Extracellular ʜ ᴄ ᴏ3̅ is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ

(2015) Ebbe Boedtkjer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Disrupting Na+,HCO3–-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development

(2015) S Lee et al.   ONCOGENE

Synthesis of N-cyano-substituted sulfilimine and sulfoximine derivatives of S0859 and their biological evaluation as sodium bicarbonate co-transport inhibitors

(2015) Anne-Dorothee Steinkamp et al.   MedChemComm

Targeting lactate transport suppresses in vivo breast tumour growth

(2015) Filipa Morais-Santos et al.   Oncotarget

Na+,HCO3 −-cotransport is functionally upregulated during human breast carcinogenesis and required for the inverted pH gradient across the plasma membrane

(2014) Soojung Lee et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Prognostic Value of Carbonic Anhydrase IX Immunohistochemical Expression in Renal Cell Carcinoma: A Meta-Analysis of the Literature

(2014) Zhihong Zhao et al.   PLoS One

Evaluating 17 breast cancer susceptibility loci in the Nashville breast health study

(2014) Mi-Ryung Han et al.   Breast Cancer

Regulation and roles of bicarbonate transporters in cancer

(2014) Andrej Gorbatenko et al.   Frontiers in Physiology

Tumor hypoxia and metabolism – Towards novel anticancer approaches

(2013) Johanna Chiche et al.   ANNALES D ENDOCRINOLOGIE

The associations between a polygenic score, reproductive and menstrual risk factors and breast cancer risk

(2013) Shaneda Warren Andersen et al.   BREAST CANCER RESEARCH AND TREATMENT

ErbB2 upregulates the Na+,HCO3−-cotransporter NBCn1/SLC4A7 in human breast cancer cells via Akt, ERK, Src, and Krüppel-like factor 4

(2013) Andrej Gorbatenko et al.   FASEB JOURNAL

Intracellular and Extracellular Carbonic Anhydrases Cooperate Non-enzymatically to Enhance Activity of Monocarboxylate Transporters

(2013) Michael Klier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Acidification Alters Myogenic Responsiveness and Vasomotion of Mouse Middle Cerebral Arteries

(2013) Axel BK Thomsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1

(2013) Samer Al-Samir et al.   JOURNAL OF PHYSIOLOGY-LONDON

Facilitation by intracellular carbonic anhydrase of Na+-HCO3−co-transport but not Na+/H+exchange activity in the mammalian ventricular myocyte

(2013) Francisco C. Villafuerte et al.   JOURNAL OF PHYSIOLOGY-LONDON

Influence of tumour micro-environment heterogeneity on therapeutic response

(2013) Melissa R. Junttila et al.   NATURE

The Divergence, Actions, Roles, and Relatives of Sodium-Coupled Bicarbonate Transporters

(2013) Mark D. Parker et al.   PHYSIOLOGICAL REVIEWS

Investigating Mechanisms of Alkalinization for Reducing Primary Breast Tumor Invasion

(2013) Ian F. Robey et al.   Biomed Research International

Transport metabolons with carbonic anhydrases

(2013) Joachim W. Deitmer et al.   Frontiers in Physiology

pH sensing and regulation in cancer

(2013) Mehdi Damaghi et al.   Frontiers in Physiology

The SLC4A7 variant rs4973768 is associated with breast cancer risk: evidence from a case–control study and a meta-analysis

(2012) Wei Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Gram-Scale Solution-Phase Synthesis of Selective Sodium Bicarbonate Co-transport Inhibitor S0859: in vitro Efficacy Studies in Breast Cancer Cells

(2012) Ann M. Larsen et al.   ChemMedChem

A Rationale for the Use of Proton Pump Inhibitors as Antineoplastic Agents

(2012) Angelo De Milito et al.   CURRENT PHARMACEUTICAL DESIGN

Physiology, Pharmacology and Pathophysiology of the pH Regulatory Transport Proteins NHE1 and NBCn1: Similarities, Differences, and Implications for Cancer Therapy

(2012) E. Boedtkjer et al.   CURRENT PHARMACEUTICAL DESIGN

Association analysis between breast cancer genetic variants and mammographic density in a large population-based study (Determinants of Density in Mammographies in Spain) identifies susceptibility loci in TOX3 gene

(2012) Pablo Fernandez-Navarro et al.   EUROPEAN JOURNAL OF CANCER

The role of genetic breast cancer susceptibility variants as prognostic factors

(2012) Peter A. Fasching, Paul D.P. Pharoah, Angela Cox, Heli Nevanlinna, Stig E. Bojesen, Thomas Karn, Annegien Broeks, Flora E. van Leeuwen, Laura J. van 't Veer, Renate Udo, Alison M. Dunning, Dario Greco, Kristiina Aittomäki, Carl Blomqvist, Mitul Shah, Børge G. Nordestgaard, Henrik Flyger, John L. Hopper, Melissa C. Southey, Carmel Apicella, Montserrat Garcia-Closas, Mark Sherman, Jolanta Lissowska, Caroline Seynaeve, Petra E.A. Huijts, Rob A.E.M. Tollenaar, Argyrios Ziogas, Arif B. Ekici, Claudia Rauh, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Irene L. Andrulis, Hilmi Ozcelik, Anna-Marie Mulligan, Gord Glendon, Per Hall, Kamila Czene, Jianjun Liu, Jenny Chang-Claude, Shan Wang-Gohrke, Ursula Eilber, Stefan Nickels, Thilo Dörk, Maria Schiekel, Michael Bremer, Tjoung-Won Park-Simon, Graham G. Giles, Gianluca Severi, Laura Baglietto, Maartje J. Hooning, John W.M. Martens, Agnes Jager, Mieke Kriege, Annika Lindblom, Sara Margolin, Fergus J. Couch, Kristen N. Stevens, Janet E. Olson, Matthew Kosel, Simon S. Cross, Sabapathy P. Balasubramanian, Malcolm W.R. Reed, Alexander Miron, Esther M. John, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Saila Kauppila, Barbara Burwinkel, Frederik Marme, Andreas Schneeweiss, Christof Sohn, Georgia Chenevix-Trench, Diether Lambrechts, Anne-Sophie Dieudonne, Sigrid Hatse, Erik van Limbergen, Javier Benitez, Roger L. Milne, M. Pilar Zamora, José Ignacio Arias Pérez, Bernardo Bonanni, Bernard Peissel, Bernard Loris, Paolo Peterlongo, Preetha Rajaraman, Sara J. Schonfeld, Hoda Anton-Culver, Peter Devilee, Matthias W. Beckmann, Dennis J. Slamon et al.   HUMAN MOLECULAR GENETICS

Contribution of Na+,HCO3−-cotransport to cellular pH control in human breast cancer: A role for the breast cancer susceptibility locus NBCn1 (SLC4A7)

(2012) Ebbe Boedtkjer et al.   INTERNATIONAL JOURNAL OF CANCER

Implication of Tumor Microenvironment in Chemoresistance: Tumor-Associated Stromal Cells Protect Tumor Cells from Cell Death

(2012) Magali Castells et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NHE1 knockout reduces blood pressure and arterial media/lumen ratio with no effect on resting pHiin the vascular wall

(2012) Ebbe Boedtkjer et al.   JOURNAL OF PHYSIOLOGY-LONDON

Vasomotion - what is currently thought?

(2011) C. Aalkjaer et al.   Acta Physiologica

A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population

(2011) Aiko Sueta et al.   BREAST CANCER RESEARCH AND TREATMENT

Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies

(2011) Sihua Peng et al.   BREAST CANCER RESEARCH AND TREATMENT

Common Genetic Variants Associated with Breast Cancer in Korean Women and Differential Susceptibility According to Intrinsic Subtype

(2011) W. Han et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The Na+/H+ exchanger NHE1, but not the Na+, cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2

(2011) Gitte Lauritzen et al.   CANCER LETTERS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Carbonic anhydrase-9 expression in head and neck cancer: a meta-analysis

(2011) Stamatios Peridis et al.   EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: Key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH

(2011) Johanna Chiche et al.   INTERNATIONAL JOURNAL OF CANCER

Dual Role of CO2/HCO3−Buffer in the Regulation of Intracellular pH of Three-dimensional Tumor Growths

(2011) Alzbeta Hulikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Carbonic Anhydrase IX Interacts with Bicarbonate Transporters in Lamellipodia and Increases Cell Migration via Its Catalytic Domain

(2011) Eliska Svastova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium

(2011) D. Campa et al.   JNCI-Journal of the National Cancer Institute

Evaluation of Breast Cancer Susceptibility Loci in Chinese Women

(2010) J. Long et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

(2010) A. C. Antoniou et al.   CANCER RESEARCH

NBCn1 and NHE1 expression and activity in ΔNErbB2 receptor-expressing MCF-7 breast cancer cells: Contributions to pHi regulation and chemotherapy resistance

(2010) G. Lauritzen et al.   EXPERIMENTAL CELL RESEARCH

NHE1 promotes invadopodial ECM proteolysis through acidification of the peri-invadopodial space

(2010) Giovanni Busco et al.   FASEB JOURNAL

Overexpression of carbonic anhydrase XII in tissues from resectable non-small cell lung cancers is a biomarker of good prognosis

(2010) Marius I. Ilie et al.   INTERNATIONAL JOURNAL OF CANCER

Na+-dependent HCO3−Import by theslc4a10Gene Product Involves Cl−Export

(2010) Helle Hasager Damkier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluating the role of carbonic anhydrases in the transport of HCO3−-related species

(2009) Walter F. Boron   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Transcriptional control of the tumor- and hypoxia-marker carbonic anhydrase 9: A one transcription factor (HIF-1) show?

(2009) Stefan Kaluz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

The Potential Role of Systemic Buffers in Reducing Intratumoral Extracellular pH and Acid-Mediated Invasion

(2009) A. S. Silva et al.   CANCER RESEARCH

The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths

(2009) Pawel Swietach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

(2009) Shahana Ahmed et al.   NATURE GENETICS

Insulin inhibits Na+/H+ exchange in vascular smooth muscle and endothelial cells in situ: involvement of H2O2 and tyrosine phosphatase SHP-2

(2008) Ebbe Boedtkjer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

NBCe2 exhibits a 3 HCO3-:1 Na+ stoichiometry in mouse choroid plexus epithelial cells

(2008) Ian D. Millar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH

Protons extruded by NHE1: Digestive or glue?

(2008) C STOCK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Response to Endothelin-1 in Arteries from Human Colorectal Tumours: Role of Endothelin Receptors

(2008) Eduardo Ferrero et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Characterization of Human SLC4A10 as an Electroneutral Na/HCO3Cotransporter (NBCn2) with Cl–Self-exchange Activity

(2008) Mark D. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY