Journal
BRITISH JOURNAL OF NUTRITION
Volume 121, Issue 11, Pages 1223-1234Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114519000552
Keywords
EPA; DHA; Variability; TAG; Intra-individual variations
Categories
Funding
- Canadian Institutes for Health Research (CIHR) [MOP-123494]
- CIHR
- Fonds de recherche du Quebec-Sante
- European Marie Sklodowska-Curie Actions
- Canadian Institutes for Health Research
- Natural Sciences and Engineering Research Council of Canada
- Agriculture and Agri-Food Canada (Dairy Farmers of Canada)
- Agriculture and Agri-Food Canada (Canola Council of Canada)
- Agriculture and Agri-Food Canada (Flax Council of Canada)
- Agriculture and Agri-Food Canada (Dow Agrosciences)
- Dairy Research Institute
- Dairy Australia
- Merck Frosst
- Atrium Innovations
- Fonds de recherche du Quebec -Sante
- Fondation de l'Institut universitaire de cardiologie et de pneumologie de Quebec
- Medtronic
Ask authors/readers for more resources
Studies have shown that the reduction in serum TAG concentrations with long-chain n-3 fatty acid supplementation is highly variable among individuals. The objectives of the present study were to compare the proportions of individuals whose TAG concentrations lowered after high-dose DHA and EPA, and to identify the predictors of response to both modalities. In a double-blind, controlled, crossover study, 154 men and women were randomised to three supplemented phases of 10 weeks each: (1) 2 center dot 7 g/d of DHA, (2) 2 center dot 7 g/d of EPA and (3) 3 g/d of maize oil, separated by 9-week washouts. As secondary analyses, the mean intra-individual variation in TAG was calculated using the standard deviation from the mean of four off-treatment samples. The response remained within the intra-individual variation (+/- 0 center dot 25 mmol/l) in 47 and 57 % of participants after DHA and EPA, respectively. Although there was a greater proportion of participants with a reduction >0 center dot 25 mmol/l after DHA than after EPA (45 upsilon. 32 %; P < 0 center dot 001), the mean TAG reduction was comparable between groups (-0 center dot 59 (sem 0 center dot 04) upsilon. -0 center dot 57 (sem 0 center dot 05) mmol/l). Participants with a reduction >0 center dot 25 mmol/l after both DHA and EPA had higher non-HDL-cholesterol, TAG and insulin concentrations compared with other responders at baseline (all P < 0 center dot 05). In conclusion, supplementation with 2 center dot 7 g/d DHA or EPA had no meaningful effect on TAG concentrations in a large proportion of individuals with normal mean TAG concentrations at baseline. Although DHA lowered TAG in a greater proportion of individuals compared with EPA, the magnitude of TAG lowering among them was similar.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available