Article
Hematology
Cuc Do, O. Giles Best, Lauren Thurgood, Anya Hotinski, Sinoula Apostolou, Stephen P. Mulligan, Karen Lower, Bryone Kuss
Summary: The clinical significance of low-frequency deletions of 17p13 in patients with chronic lymphocytic leukaemia (CLL) is currently unclear. This study found that patients with low del17p, without TP53 mutation, had significantly longer survival durations than those with high del17p clones. The data challenge the notion of del13q as a founding event in CLL.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Cell Biology
Michal K. Zarobkiewicz, Agnieszka A. Bojarska-Junak
Summary: CLL is the most common leukemia among adults, and currently there is no cure. Despite the dysfunction of gamma delta T cells in CLL patients, they can still be used for immunotherapy.
Article
Biochemistry & Molecular Biology
Valentina Rubino, Flavia Carriero, Anna Teresa Palatucci, Angela Giovazzino, Stefania Leone, Valerio Nicolella, Martina Calabro, Rosangela Montanaro, Vincenzo Brancaleone, Fabrizio Pane, Federico Chiurazzi, Giuseppina Ruggiero, Giuseppe Terrazzano
Summary: Chronic lymphocytic leukaemia (CLL) is characterized by the expansion of a neoplastic mature B cell clone. The clinical outcome of CLL is very heterogeneous, and it is influenced by genetic and epigenetic alterations and a pro-inflammatory microenvironment. The involvement of immune-mediated mechanisms in CLL control needs further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Hematology
Marta Kulis, Jose Ignacio Martin-Subero
Summary: Chronic lymphocytic leukaemia (CLL) is characterized by both driver genetic alterations and extensive epigenetic changes. Epigenomic studies have revealed the DNA methylome, chromatin accessibility, histone modifications, and 3D genome architecture of CLL. The DNA methylome contains information about the cellular origin and proliferative history of CLL cells, which are independent prognostic factors. Integrative analyses of chromatin marks have identified novel regulatory elements and altered transcription factor networks in CLL. Additionally, CLL cells display disease-specific patterns of 3D genome interactions. Single-cell analyses are becoming increasingly important in CLL research.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Pathology
Anya K. Hotinski, Oliver G. Best, Bryone J. Kuss
Summary: Chronic lymphocytic leukaemia (CLL) is a clonally complex disease with high intra-tumoural and inter-patient heterogeneity, requiring accurate prognostic tests. The emergence of new targeted agents in recent years has also created a need for improved predictive tests in therapy.
Article
Medicine, General & Internal
Tanya Siddiqi, David G. Maloney, Saad S. Kenderian, Danielle M. Brander, Kathleen Dorritie, Jacob Soumerai, Peter A. Riedell, Nirav N. Shah, Rajneesh Nath, Bita Fakhri, Deborah M. Stephens, Shuo Ma, Tatyana Feldman, Scott R. Solomon, Stephen J. Schuster, Serena K. Perna, Sherilyn A. Tuazon, San -San Ou, Eniko Papp, Leanne Peiser, Yizhe Chen, William G. Wierda
Summary: In this study, lisocabtagene maraleucel (liso-cel) was evaluated for its efficacy and safety in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. The results showed that liso-cel induced complete response or remission in patients, including those who had previously failed treatment with a BTK inhibitor and venetoclax. The safety profile was manageable.
Article
Biochemistry & Molecular Biology
Rui Gao, Kaixin Du, Jinhua Liang, Yi Xia, Jiazhu Wu, Yue Li, Bihui Pan, Li Wang, Jianyong Li, Wei Xu
Summary: This study aims to evaluate the prognostic value of cholesterol levels in CLL and develop a prognostic nomogram that incorporates lipid metabolism. The results showed that lower cholesterol levels at diagnosis were associated with worse prognosis, and post-therapeutic elevation of cholesterol levels correlated with better survival. Therefore, cholesterol profiles can be used as a cheap and readily accessible tool for predicting prognosis in CLL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Shenmiao Yang, Abraham M. Varghese, Nitin Sood, Carlos Chiattone, Norah O. Akinola, Xiaojun Huang, Robert Peter Gale
Summary: East Asians, Asian Indians, and Amerindians have a significantly lower incidence rate of chronic lymphocytic leukemia compared to persons of European descent, suggesting a genetic rather than environmental basis for this disparity. These populations have different genetic admixtures with archaic hominins, potentially explaining the varying CLL incidences among them, as well as differences in clinical and molecular covariates of CLL. Further research is needed to determine the exact reasons behind these population variances in CLL and other lymphomas and cancers.
Article
Medicine, General & Internal
Bor-Sheng Ko, Li-Ju Chen, Huai-Hsuan Huang, Ho-Min Chen, Fei-Yuan Hsiao
Summary: This study is the first population-based study in Asia and provides comprehensive evidence of epidemiology, treatment patterns, and survivals of CLL/SLL in an Asian population.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Oncology
Qinlu Li, Shugang Xing, Heng Zhang, Xiao Mao, Min Xiao, Ying Wang
Summary: IGH-t is not uncommon among Chinese CLL patients, with diverse partner genes and distinct gene mutational profiles compared to the non-IGH-t group. Identifying IGH-t and its partner genes may refine risk stratification and enhance accurate management in CLL patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Andrea Sitlinger, Michael A. Deal, Erwin Garcia, Dana K. Thompson, Tiffany Stewart, Grace A. MacDonald, Nicolas Devos, David Corcoran, Janet S. Staats, Jennifer Enzor, Kent J. Weinhold, Danielle M. Brander, J. Brice Weinberg, David B. Bartlett
Summary: Higher physical fitness in CLL patients is associated with altered CLL-like cell line growth in vitro and with altered circulating and cellular factors indicative of better immune functions and tumor control.
Article
Hematology
Lukas Smolej, Peter Turcsanyi, Zuzana Kubova, Jana Zuchnicka, Jana Mihalyova, Martin Simkovic, Pavel Vodarek, Maria Krcmeryova, Heidi Mocikova, Martin Brejcha, Martin Spacek
Summary: The study validated the IPS-E prognostic scoring system for early-stage CLL patients and proposed a modified AIPS-E scoring system, utilizing cytogenetic aberrations, fluorescence in situ hybridisation, and ALC to assess patient prognosis.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Medicine, General & Internal
Shenmiao Yang, Xiaojun Huang, Robert Peter Gale
Summary: Transplantation has been used to treat chronic lymphocytic leukemia for over 35 years, but is only considered for less than 1% of highly selected patients. While some patients may achieve long-term leukemia-free survival with transplants, they also come with significant morbidity and mortality. The anti-leukemia effects of transplants are influenced by various factors, including drugs, radiation, and immune mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Hua-Jay J. Cherng, Nadya Jammal, Shilpa Paul, Xuemei Wang, Koji Sasaki, Philip Thompson, Jan Burger, Alessandra Ferrajoli, Zeev Estrov, Susan O'Brien, Michael Keating, William G. Wierda, Nitin Jain
Summary: CLL rarely presents in AYA patients aged 15-39 years. Disease characteristics and outcomes of AYA patients are not well understood. Analysis of 227 AYA patients diagnosed in the last two decades showed median TTFT of 2.2 years and five- and 10-year OS of 90% and 78%, respectively. Pre-treatment factors and genetic mutations were associated with shorter TTFT and OS in AYA CLL patients. Within the subgroup receiving oral targeted therapy, specific genetic mutations were associated with shorter OS. Age was significantly associated with OS and time to Richter transformation.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Genetics & Heredity
Qiuyi Zhang, Ying Gao, Shuchun Lin, Lynn R. Goldin, Yonghong Wang, Holly Stevenson, Daniel C. Edelman, Keith Killian, Gerald Marti, Paul S. Meltzer, Song Xiang, Neil E. Caporaso
Summary: This study investigated the DNA methylation aberrations in malignant B lymphocytes of CLL patients and identified differentially methylated positions (DMPs) and differentially methylated and expressed genes (DMEGs) associated with CLL by integrating public databases. The direction of each DMEG in CLL was observed based on DMPs in the promoter and the body region, and the methylation heterogeneity of CLL subgroups and the effect of B cell maturation on CLL were explored. The findings suggest the importance of DNA methylation in the pathogenesis of CLL and provide potential markers for diagnostic and therapeutic purposes.
FRONTIERS IN GENETICS
(2023)
Article
Pathology
Yi-Sian Lu, Po-Min Chiang, Yi-Ching Huang, Shiang-Jie Yang, Liang-Yi Hung, L. Jeffrey Medeiros, Ya-Ping Chen, Tsai-Yun Chen, Ming-Shi Chang, Kung-Chao Chang
Summary: Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma worldwide. This study found that interleukin-20 (IL-20) is frequently expressed in different types of lymphoma, especially in follicular lymphoma, Burkitt lymphoma, and mantle cell lymphoma. Overexpression of IL-20 promotes cell apoptosis in DLBCL.
Letter
Pathology
Tsung-Heng Tsai, Che-Wei Hsu, L. Jeffrey Medeiros, Kung-Chao Chang
Article
Pathology
Jie Xu, Shaoying Li, C. Cameron Yin, Keyur P. Patel, Guilin Tang, Wei Wang, Roberto N. Miranda, Sofia Garces, Zhenya Tang, Pei Lin, L. Jeffrey Medeiros
Summary: Granulomatous reactions can occur in patients with Hodgkin lymphoma and have distinct clinical and pathological features. These patients are predominantly male and usually over 40 years old. They commonly present with lymphadenopathy, particularly in the neck and supraclavicular areas. Advanced stage disease and B symptoms are frequently observed. The histiocytes in the granulomas express PD-L1 and pSTAT3, but not pERK and cyclin D1. The 5-year overall survival rate for these patients is 78%.
Article
Pathology
Zhihong Hu, L. Jeffrey Medeiros, Mina Xu, Ji Yuan, Deniz Peker, Lina Shao, Zhenya Tang, Brenda Mai, Beenu Thakral, Adan Rios, Shimin Hu, Wei Wang
Summary: This study aimed to investigate the clinicopathologic features and molecular profile of T-PLL associated with t(X;14)(q28;q11.2). The results showed that T-PLL patients with t(X;14)(q28;q11.2) frequently have lymphocytosis, morphological abnormalities in leukemic cells, complex karyotypes, and mutations involving JAK/STAT pathway. The overall survival rate was poor, with 8 out of 15 patients dying during the follow-up period.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Letter
Hematology
Victoria A. Vardell, Daniel A. Ermann, Lindsey A. Fitzgerald, Harsh R. Shah, Boyu Hu, Deborah M. Stephens
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Hematology
Fatima Zahra Jelloul, Mark. J. Routbort, Courtney D. DiNardo, Carlos E. Bueso-Ramos, Rashmi Kanagal-Shamanna, Beenu Thakral, Zhuang Zuo, C. Cameron Yin, Sanam Loghavi, Chi Young. Ok, Sa A. Wang, Zhenya Tang, M. James You, Keyur P. Patel, L. Jeffrey Medeiros, Andres E. Quesada
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Editorial Material
Hematology
Karen. A. A. Nahmod, Koji Sasaki, Chi Young Ok, Sanam Loghavi
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Pathology
Siba El Hussein, L. Jeffrey Medeiros, Stephen K. Gruschkus, Peng Wei, Ellen Schlette, Hong Fang, Fatima Zahra Jelloul, Wei Wang, Warren Fiskus, Rashmi Kanagal-Shamanna, Sanam Loghavi, Hong Yang, Shaoying Li, Jie Xu, Zhenya Tang, Beenu Thakral, Nitin Jain, William G. Wierda, Keyur Patel, Kapil N. Bhalla, Joseph D. Khoury
Summary: Immune checkpoint inhibitors (PD-1 inhibitors) have shown clinical activity in Richter transformation-diffuse large B-cell lymphoma variant (RT-DLBCL), providing a novel therapeutic approach. A study group of 64 RT-DLBCL patients was assessed for expression of PD-1, PD-L1, CD30, and microsatellite instability (MSI), as well as evaluated for immune evasion phenotype (IEP) and PD1-positive tumor-infiltrating lymphocytes (TILs). Brisk PD1+ TIL level was more common in IEP+ tumors, and CD30 expression was significantly more common in IEP+ RT-DLBCL. There was no significant difference in age, sex, or time to transformation between the two groups. Notably, patients with brisk PD1+ TILs had better overall survival.
Article
Oncology
Guilin Tang, Shaoying Li, Gokce A. Toruner, Preetesh Jain, Zhenya Tang, Shimin Hu, Jie Xu, Joanne Cheng, Melissa Robinson, Francisco Vega, L. Jeffrey Medeiros
Summary: FISH analysis using MYC break-apart probes is a commonly used technique to assess for MYC rearrangement. However, atypical signal patterns can occur, such as gain or loss of 5'MYC or 3'MYC. This study evaluated patients with aggressive B-cell lymphomas who exhibited atypical FISH signal patterns and found that 5'MYC gain is associated with MYC expression and a poorer prognosis, while 3'MYC deletions are not associated with MYC expression or a poorer prognosis and may be unrelated to MYC-R.
Article
Medical Laboratory Technology
Sa A. Wang, Jeffrey L. Jorgensen, Shimin Hu, Fuli Jia, Shaoying Li, Sanam Loghavi, Chi Young Ok, Beenu Thakral, Jie Xu, L. Jeffrey Medeiros, Wei Wang
Summary: Through this study, we successfully validated a 12-color AML MRD flow cytometry assay to meet stringent regulatory requirements, and tested its clinical value in 61 patients. The validation met all criteria and obtained FDA IDE approval.
CYTOMETRY PART B-CLINICAL CYTOMETRY
(2023)
Letter
Oncology
Preetesh Jain, Krystle Nomie, Nikita Kotlov, Vitaiy Segodin, Holly Hill, Chi Young Ok, Ahmed Fetooh, Rashmi Kanagal-Shamanna, Francisco Vega, Alexander Bagaev, Nathan Fowler, Christopher R. Flowers, Michael Wang
BLOOD CANCER JOURNAL
(2023)
Meeting Abstract
Medicine, Research & Experimental
Meng Liu, Xiaoqiong Wang, E. Shuyu, Guilin Tang, Wei Wang, Fatima Zahra Jelloul, Pei Lin, L. Jeffrey Medeiros, Shimin Hu
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Karen Nahmod, Beenu Thakral, Wei Wang, Fnu Aakash, Keyur Patel, Mark Routbort, Rashmi Kanagal-Shamanna, Chi Young Ok, Guilin Tang, Francisco Vega, L. Jeffrey Medeiros, Sa Wang, Sanam Loghavi
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Karen Nahmod, Sa Wang, Shaoying Li, Zhenya Tang, Fnu Aakash, Jie Xu, Shimin Hu, L. Jeffrey Medeiros, Guilin Tang
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Karen Nahmod, Zhenya Tang, Pei Lin, Gokce Toruner, Shaoying Li, Jie Xu, Shimin Hu, L. Jeffrey Medeiros, Guilin Tang
LABORATORY INVESTIGATION
(2023)