Article
Cell Biology
Diego Quintana-Torres, Alejandra Valle-Cao, Pablo Bousquets-Munoz, Sandra Freitas-Rodriguez, Francisco Rodriguez, Alejandro Lucia, Carlos Lopez-Otin, Alejandro Lopez-Soto, Alicia R. Folgueras
Summary: This study conducted a global plasma proteomic analysis in progeroid mouse models and found several upregulated proteins related to cardiovascular disease, the main cause of death in HGPS patients. The plasma proteome of progeroid mice exhibited an old signature, indicating accelerated aging. Furthermore, specific differences were observed in the circulating proteins between physiological and premature aging, highlighting potential biomarkers and therapeutic targets.
Review
Cell Biology
Edward V. Prochownik, Huabo Wang
Summary: Despite being extensively studied, the role of MYC in normal development remains uncertain due to the limited lifespan of Myc-/- mice. Recent research delaying Myc inactivation has allowed for the study of its complete loss and its impact on aging. Surprisingly, MycKO mice lived longer than wild-type mice but displayed accelerated aging phenotypes, potentially due to a reduced incidence of cancer. Myc loss accelerated the accumulation of Aging Hallmarks in both mice and humans, suggesting that the strong association between aging and cancer can be genetically separated and is maintained by a single gene.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Akaitz Dorronsoro, Fernando E. Santiago, Diego Grassi, Tianpeng Zhang, Ruenn Chai Lai, Sara J. McGowan, Luise Angelini, Mitra Lavasani, Lana Corbo, Aiping Lu, Robert W. Brooks, Marta Garcia-Contreras, Donna B. Stolz, Antonio Amelio, Siddaraju V. Boregowda, Mohammad Fallahi, Adrian Reich, Camillo Ricordi, Donald G. Phinney, Johnny Huard, Sai Kiang Lim, Laura J. Niedernhofer, Paul D. Robbins
Summary: The injection of BM-MSCs from young mice can prolong lifespan and healthspan, while conditioned media (CM) from young BM-MSCs can rescue the function of aged stem cells and senescent fibroblasts. Extracellular vesicles (EVs) from young BM-MSC CM can extend lifespan in mice, and EVs from MSCs generated from human ES cells can reduce senescence and improve healthspan.
Review
Cell Biology
Chisaka Kuehnemann, Christopher D. Wiley
Summary: Cellular senescence, originally observed in primary cell cultures, is now recognized as a driving force behind aging and disease in animal models and humans. Senescent cells release a complex collection of molecules, known as the senescence-associated secretory phenotype, with potent biological activities. The presence of senescent cells is associated with age-related conditions, but they also contribute to beneficial processes such as wound healing and tissue homeostasis.
Article
Biochemistry & Molecular Biology
Jon Macicior, Daniel Fernandez, Silvia Ortega-Gutierrez
Summary: Hutchinson-Gilford progeria syndrome (HGPS), also known as progeria, is a rare genetic disease that causes premature aging and significantly reduces life expectancy. Currently, there is only one approved drug for treating progeria, but its efficacy is limited. Progerin levels are believed to be the most important biomarker related to disease severity.
BIOORGANIC CHEMISTRY
(2024)
Review
Cell & Tissue Engineering
Yaping Wang, Tianyun Gao, Bin Wang
Summary: Senescence is a hot topic due to the accumulation of senescent cells and inflammatory factors, leading to various senescence-related diseases. Stem cell-based therapy, particularly using mesenchymal stromal cells (MSCs), is considered a promising strategy to alleviate or cure these diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemical Research Methods
Solenn M. Guilbert, Deborah Cardoso, Nicolas Levy, Antoine Muchir, Xavier Nissan
Summary: Drug repurposing is an efficient and low-cost strategy, which has made significant progress in treating rare diseases in recent years.
Article
Endocrinology & Metabolism
Jiatong Liu, Xi Lin, Andrew McDavid, Yutiancheng Yang, Hengwei Zhang, Brendan F. F. Boyce, Lianping Xing
Summary: Cellular senescence plays a crucial role in age-related diseases, such as musculoskeletal disorders, but the interaction between senescent cells (SCs) and inflammatory cells (Inf-Cs) during fracture repair is not well understood. This study analyzed single cell RNA sequencing data of aged mouse fracture callus stromal cells and identified three cell subclusters associated with inflammation and senescence. The researchers found that Inf-SCs and SCs had similar gene expression profiles and upregulated pathways related to DNA damage/oxidation-reduction and cellular senescence, while Inf-Cs expressed different gene signatures mainly related to inflammation. They also demonstrated that SCs and Inf-SCs could potentially affect Inf-Cs as target cells through the production of active ligands. Furthermore, cell culture experiments showed that SC-conditioned medium promoted inflammatory gene expression and reduced osteoblast differentiation capacity in callus-derived mesenchymal progenitor cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Seth D. Thompson, Rajeswari Pichika, Richard L. Lieber, Mitra Lavasani
Summary: This study demonstrates that systemic transplantation of young MDSPCs can prevent age-associated AC degeneration and promote tissue regeneration, highlighting their therapeutic potential.
Review
Engineering, Biomedical
Robert S. Rosen, Martin L. Yarmush
Summary: The process of aging poses risks to health and functionality and has been the subject of investigation for potential therapeutics. However, identifying impactful treatments has been challenging due to limited experimental validation and study design. This review explores the biological mechanisms of aging, discusses promising therapeutic strategies, and proposes a unified approach for evaluating and vetting current and future treatments.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING
(2023)
Article
Geriatrics & Gerontology
Lei Liu, Xianlin Yue, Zewei Sun, William S. Hambright, Jianming Wei, Ying Li, Polina Matre, Yan Cui, Zhihui Wang, George Rodney, Johnny Huard, Paul D. Robbins, Xiaodong Mu
Summary: This study found that using senolytics in the muscles of patients with progeria can effectively remove senescent cells and improve the function of muscle progenitor/stem cells.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Plant Sciences
Yung-Ming Chang, Marthandam Asokan Shibu, Chih-Sheng Chen, Shanmugam Tamilselvi, Chuan-Te Tsai, Chin-Chuan Tsai, Kannan Ashok Kumar, Hung-Jen Lin, B. Mahalakshmi, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study investigated the effect of the anti-aging herbal medicine AoF on enhancing the cardiac restorative function of adipose-derived mesenchymal stem cells (ADMSCs) in aging conditions, and found that AoF has potential therapeutic properties in improving heart function in aging individuals.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cell Biology
Zhuang Zhuang Han, Alex Fleet, Delphine Larrieu
Summary: Ageing is the main risk factor for late-onset neurodegenerative diseases. Modelling biological ageing in experimental animals helps to investigate the molecular origin of pathogenic tau and develop potential therapeutic interventions. The underlying mechanisms by which ageing leads to abnormal tau accumulation are still poorly understood. Mutations associated with human progeroid syndromes are used to mimic ageing environment in animal models.
Review
Cell Biology
Mingjia Cheng, Weihao Yuan, Alireza Moshaverinia, Bo Yu
Summary: Advanced age is a shared risk factor for chronic skeletal diseases. The senescence of mesenchymal stem cells (MSCs) exacerbates inflammatory microenvironment and disrupts bone remodeling, contributing to age-related bone diseases. Understanding the molecular and epigenetic mechanisms of MSC senescence, such as oxidative stress and mitochondrial dysfunction, could present rejuvenation strategies for skeletal aging restoration.
Review
Biochemistry & Molecular Biology
Quentin Alle, Enora Le Borgne, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Aging is traditionally seen as an unavoidable process, but new strategies have been developed to delay or reverse aging. Some of these approaches may have medical applications to improve healthspan and longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.