Article
Oncology
Jianlei Wang, Jianping Song, Zeyang Liu, Tingxiao Zhang, Yanfeng Liu
Summary: This study investigates the prognostic value of tumor mutation burden (TMB) in colorectal cancer (CRC) and finds that high TMB indicates better prognosis for CRC patients with KRAS mutations. The study also develops a prognostic model using TMB as a predictive indicator, which shows good accuracy and potential clinical applications.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Wei Chong, Xingyu Zhu, Huicheng Ren, Chunshui Ye, Kang Xu, Zhe Wang, Shengtao Jia, Liang Shang, Leping Li, Hao Chen
Summary: This study elucidates the molecular heterogeneity of KRAS-mutant CRC and reveals new biological subtypes and therapeutic possibilities for these tumors.
Article
Immunology
Xiaoyu Liu, Xu Xu, Zhuozhuo Wu, Qungang Shan, Ziyin Wang, Zhiyuan Wu, Xiaoyi Ding, Wei Huang, Zhongmin Wang
Summary: This study analyzed the effects of KRAS/TP53 mutation status and tumor sideness on the immune microenvironment of colorectal cancer using integrated scRNA-seq data. Different functional immune cell subtypes were identified, including exhausted T cell subtypes and macrophages indicating unfavorable prognosis. The study also suggested potential therapeutic targets for dual mutant colorectal cancers and revealed the gradual remodeling of the immune microenvironment in colorectal cancers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jungang Liu, Xiaoliang Huang, Haizhou Liu, Chunyin Wei, Haiming Ru, Haiquan Qin, Hao Lai, Yongsheng Meng, Guo Wu, Weishun Xie, Xianwei Mo, Caroline H. Johnson, Yawei Zhang, Weizhong Tang
Summary: This study revealed that KRAS mutation in CRC is associated with suppressed immune pathways and immune infiltration, with increased Tregs and decreased M1 macrophages and activated CD4 memory T cells. An immune risk model was established to classify CRC patients with distinct clinical outcomes based on gene expression and immune cell abundance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Alessandro Ottaiano, Francesco Sabbatino, Francesco Perri, Marco Cascella, Roberto Sirica, Renato Patrone, Maurizio Capuozzo, Giovanni Savarese, Monica Ianniello, Nadia Petrillo, Luisa Circelli, Vincenza Granata, Massimiliano Berretta, Mariachiara Santorsola, Guglielmo Nasti
Summary: This review discusses the prognostic significance of the KRAS p.G12C mutation in metastatic colorectal cancer and highlights its potential as a promising therapeutic target. The aim is to increase awareness of the factors that can influence the clinical, prognostic, and therapeutic implications associated with distinct mutations within the same protein.
Review
Oncology
Shafia Rahman, Shimon Garrel, Michael Gerber, Radhashree Maitra, Sanjay Goel
Summary: Colorectal cancer is a common cancer in the United States, and approximately 45% of patients with metastatic colorectal cancer have KRAS mutations, requiring a more personalized treatment approach for these patients.
Article
Oncology
Pariyada Tanjak, Amphun Chaiboonchoe, Tharathorn Suwatthanarak, Onchira Acharayothin, Kullanist Thanormjit, Jantappapa Chanthercrob, Thanawat Suwatthanarak, Bundit Wannasuphaphol, Kemmapon Chumchuen, Bhoom Suktitipat, Somponnat Sampattavanich, Krittiya Korphaisarn, Ananya Pongpaibul, Naravat Poungvarin, Harald Grove, Woramin Riansuwan, Atthaphorn Trakarnsanga, Asada Methasate, Manop Pithukpakorn, Vitoon Chinswangwatanakul
Summary: This study investigates the transcriptomic impact of KRAS mutations in colorectal cancers, focusing on the tumor microenvironment and pathways beyond metabolic deregulation. It is found that CRC patients with KRAS mutations are mainly enriched in CMS3 and exhibit specific immune gene signatures in an immunosuppressive TME, leading to worse overall survival. Activation of TGF beta signaling by KRAS mutations is associated with reduced pro-inflammatory and cytokine gene signatures, suppressing immune infiltration. Spatially resolved gene expression profiling suggests up-regulated immune suppression genes in the TME of KRAS-mutated CMS3-classified tissues. This study provides important insights into the complex transcriptomic profile of KRAS mutations in an immunosuppressive TME.
Article
Oncology
Ana Fernandez Montes, Vicente Alonso Orduna, Elena Asensio Martinez, Nuria Rodriguez Salas, Esperanza Torres, Diego Cacho Lavin, Rosa Maria Rodriguez Alonso, Esther Falco, Joan Carles Oliva, Lluis Cirera, Jesus Garcia Gomez, Carles Pericay
Summary: This study evaluated the prognostic value of specific KRAS mutation codon locations in metastatic colorectal cancer (mCRC) patients and the survival outcomes in relation to treatment. The results showed that KRAS mutation location can predict survival outcomes and that combination therapy before and after surgery provides survival benefits for patients.
Article
Oncology
Asimina Koulouridi, Michaela Karagianni, Ippokratis Messaritakis, Maria Sfakianaki, Alexandra Voutsina, Maria Trypaki, Maria Bachlitzanaki, Evangelos Koustas, Michalis Karamouzis, Anastasios Ntavatzikos, Anna Koumarianou, Nikolaos Androulakis, Dimitrios Mavroudis, Maria Tzardi, John Souglakos
Summary: The study reveals that KRAS G12D mutation is associated with better overall survival, while KRAS G12C mutation may indicate worse prognosis in terms of progression-free and overall survival. KRAS exon 3 and exon 4 mutations also have different impacts on progression-free and overall survival.
Review
Medicine, Research & Experimental
Mingjing Meng, Keying Zhong, Ting Jiang, Zhongqiu Liu, Hiu Yee Kwan, Tao Su
Summary: KRAS mutations are a major driver in CRC and significantly impact the prognosis and survival of patients. Research studies focus on exploring potential therapeutics for KRAS mutant CRC, as well as understanding the pathological consequences and treatment response of these mutations. Challenges and difficulties in treating KRAS mutant CRC are also discussed.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Qiming Zhou, Yao Peng, Fenfen Ji, Huarong Chen, Wei Kang, Lam-Shing Chan, Hongyan Gou, Yufeng Lin, Pingmei Huang, Danyu Chen, Qinyao Wei, Hao Su, Cong Liang, Xiang Zhang, Jun Yu, Chi Chun Wong
Summary: SLC25A22 knockout reverts KRAS-mediated immunosuppression in CRC models by suppressing CXCL1 production and impairing MDSC recruitment. Mechanistically, SLC25A22 promotes asparagine-mediated SRC phosphorylation, which drives CXCL1 transcription and MDSC infiltration. Targeting SLC25A22 in combination with anti-PD1 therapy shows promising results in inhibiting MDSC and activating CD8(+) T cells to suppress KRAS-mutant CRC growth.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
YuanLin Sun, Bin Liu, YuJia Chen, YanPeng Xing, Yang Zhang
Summary: This study investigated the role of lipid metabolism in the prognosis of colorectal cancer (CRC) using metabonomics and transcriptomics. The study developed prognostic signatures and a composite nomogram to predict the outcome of CRC patients. The study also explored the potential relationship between tumor microenvironment and immune infiltration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiao-na Chang, Fu-mei Shang, Hong-yu Jiang, Chen Chen, Zhe-yan Zhao, Sheng-he Deng, Jun Fan, Xiao-chuan Dong, Ming Yang, Yan Li, Kai-lin Cai, Li Liu, Hong-li Liu, Xiu Nie
Summary: In Central China, the incidence of colorectal cancer is rising, with high mortality rates. The mutation frequency of KRAS/NRAS/BRAF genes in CRC patients is significant, with BRAF mutation being associated with prognosis.
CURRENT MEDICAL SCIENCE
(2021)
Article
Medical Laboratory Technology
Chengfeng Wang, Diling Pan
Summary: This study investigated the relationship between BRAF, KRAS, and PIK3CA mutations and clinicopathologic features and prognosis of colorectal cancer patients. The results showed that the mutant patterns of BRAF, KRAS, and PIK3CA were not associated with the general and clinicopathological features of patients. However, these mutation patterns could be used as independent prognostic factors for colorectal cancer.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Review
Oncology
Yan Hua Wan, Qi Sheng Liu, Sha Sha Wan, Ri Wei Wang
Summary: Colorectal cancer is a common type of cancer globally, with around 30% of patients having metastases at the time of diagnosis and poor prognosis. Tumor formation is due to aggregation of tumor genes mutations, and early diagnosis can extend patient lifespan.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Immunology
Xin-qiang Liang, Ke-zhi Li, Zhao Li, Ming-zhi Xie, Yan-pin Tang, Jiang-biao Du, Yi Huang, Ji-lin Li, Bang-li Hu
Summary: The study revealed that plasma Hsp90 alpha levels were significantly elevated in gastric cancer patients, correlated with tumor biomarkers and immune cells, but had no predictive value for patient survival.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Ming-zhi Xie, Ke Ding, Yan-ping Tang, Bang-li Hu, Ke-zhi Li, Ji-lin Li, Xin-qiang Liang
Summary: In this study involving 180 gastric cancer patients, it was found that patients with a higher percentage of NK cells had longer survival times and could serve as an independent prognostic indicator for gastric cancer. NK cell percentage was positively correlated with lymphocyte count and albumin, while negatively correlated with CA125 and neutrophil-lymphocyte ratio. NK cells showed predictive value for the 5-year survival rate of gastric cancer, especially when combined with neutrophil-lymphocyte ratio. Patients at early T, N, and clinical stages tended to have a higher percentage of NK cells compared to those at advanced stages.
MEDICAL SCIENCE MONITOR
(2021)
Article
Oncology
Ke-zhi Li, Yi-xin Yin, Yan-ping Tang, Long Long, Ming-zhi Xie, Ji-lin Li, Ke Ding, Bang-li Hu
Summary: Right-sided and left-sided colon cancers have distinct clinical and molecular characteristics. This study identified location-specific lncRNAs as ceRNAs in colon cancer and established a DEL-based prognostic signature. These differences can be used to assess prognosis and determine treatment strategies for patients with colon cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Immunology
Bing Yu, Yi-xin Yin, Yan-ping Tang, Kang-lai Wei, Zhi-gang Pan, Ke-Zhi Li, Xian-wen Guo, Bang-li Hu
Summary: This study identified AQP9, CD27, and HVCN1 as potential diagnostic indicators for Crohn's disease (CD) and AQP9 as a promising predictive indicator for anti-TNF therapy through analyzing the expression of immune-related genes in CD tissues.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yi-xin Yin, Ming-zhi Xie, Xin-qiang Liang, Meng-ling Ye, Ji-lin Li, Bang-li Hu
Summary: The SUVmax in CRC patients is not significantly correlated with tumor biomarkers and the Ki-67 index, but is associated with KRAS mutation and nerve invasion, with differences between colon and rectal cancers. There is no significant association between SUVmax and survival in CRC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan-ping Tang, Yi-xin Yin, Ming-zhi Xie, Xin-qiang Liang, Ji-lin Li, Ke-zhi Li, Bang-li Hu
Summary: The study found that the expression of HMMR is significantly increased in CRC tissues, but not correlated with TNM stage or other clinical parameters. There are variations in the expression of HMMR in different CRC cell lines, and the blood levels of HMMR tend to be higher in patients with CRC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Gastroenterology & Hepatology
Dong-Cheng Lu, Qi-Fang Zhang, Li Li, Xian-Ke Luo, Bin Liang, Yi-Han Lu, Bang-Li Hu, Hai-Xing Jiang
Summary: Hepatitis B and C are globally prevalent viral infections that pose a serious threat to human health. These viruses can lead to severe liver diseases, including cirrhosis and liver cancer.
BMC GASTROENTEROLOGY
(2022)
Article
Cell Biology
Meng-Ling Ye, Si-Qi Li, Yi-Xin Yin, Ke-Zhi Li, Ji-Lin Li, Bang-Li Hu
Summary: Cancer stem cells play crucial roles in colorectal cancer tumorigenesis and treatment response. This study found that the mRNA stemness index (mRNAsi) was associated with the clinical outcome in colorectal cancer (CRC) patients. A stemness-related classification based on mRNAsi scores and RNA sequence data was introduced and showed promise as a prognostic predictor for CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yanping Tang, Kezhi Li, Bangli Hu, Zhengmin Cai, Jilin Li, Hao Tao, Ji Cao
Summary: This study identified the involvement of fatty acid binding protein 5 (FABP5) in hepatocellular carcinoma (HCC). FABP5 promoted HCC cells proliferation, migration, and invasion by improving CREB phosphorylation and upregulating miR-889-5p. This study provides insights into potential strategies for HCC treatment.
CANCER BIOLOGY & THERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Jing-jing Zhang, Chao Shao, Yi-xin Yin, Qiang Sun, Ya-ni Li, Ya-wen Zha, Min-ying Li, Bang-li Hu
Summary: This study identified three hypoxia-related genes associated with patient survival in pancreatic cancer and constructed a prognostic signature. The signature showed better prognostic value in predicting patient survival and was involved in the HIF-1 signaling pathway.
Article
Biotechnology & Applied Microbiology
TingAn Wang, ZiHan Zhou, ChunMiao Wang, YuZhou Qin, Liucheng Wu, BangLi Hu, QinWen Jin, WeiYuan Wei, MingWei Huang
Summary: This study demonstrates a novel function of LTBP2 in regulating ferroptosis in gastric cancer, and reveals the underlying regulatory mechanisms associated with the p62-Keap1-Nrf2 pathway.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Oncology
Xian-Wen Guo, Si-Qi Li, Rong-E Lei, Zhen Ding, Bang-li Hu, Rong Lin
Summary: This study explored the relationship between tumor-infiltrating immune cells (TIICs) and the prognosis of patients with colorectal cancer (CRC) who underwent chemotherapy. The results showed that TIIC-based tumor microenvironment score (TMEscore) was associated with chemotherapy response and survival rate. Key TMEscore-related genes were identified using machine learning methods, and a gene signature was constructed to predict chemotherapy response. The study found that the expression of TMEscore-related genes increased in tumor tissues. These findings provide a new approach to understanding chemotherapy response and prognosis in CRC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Yixin Yin, Siqi Li, Xinqiang Liang, Kezhi Li, Mingzhi Xie, Bangli Hu
Summary: This study identified genes associated with oxaliplatin-based chemotherapy resistance in colorectal cancer patients and established a gene signature that effectively predicted patient prognosis. The prognostic value of the gene signature was validated in independent cohorts and cell line experiments.
Review
Biochemistry & Molecular Biology
Bangli Hu, Yixin Yin, Siqi Li, Xianwen Guo
Summary: Patients with advanced-stage or treatment-resistant colorectal cancer (CRC) may benefit from new therapeutic strategies such as inducing ferroptosis, a type of regulated cell death characterized by lipid reactive oxygen species (ROS) accumulation. Recent studies have identified mechanisms, pathways, and molecules that trigger or inhibit ferroptosis in CRC cells, including coding and non-coding RNA, small-molecule compounds, and nanoparticles. Additionally, gene signatures and clusters with predictive value on CRC have been summarized.
Article
Gastroenterology & Hepatology
Bang-li Hu, Yi-xin Yin, Ke-zhi Li, Si-qi Li, Zhao Li
Summary: The role of serine peptidase inhibitor Kazal type 4 (SPINK4) in colorectal cancer (CRC) and ferroptosis was investigated in this study. It was found that SPINK4 expression was decreased in CRC tissues, and overexpression of SPINK4 promoted cell proliferation and metastasis while inhibiting cell ferroptosis.
BMC GASTROENTEROLOGY
(2023)
